| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Hugo Vanderstichele, Mirko Bibl, Sebastiaan Engelborghs, Nathalie Le Bastard, Piotr Lewczuk, Jose Luis Molinuevo, Lucilla Parnetti, Armand Perret-Liaudet, Leslie M Shaw, Charlotte Teunissen, Dirk Wouters, Kaj Blenno. Standardization of preanalytical aspects of cerebrospinal fluid biomarker testing for Alzheimer's disease diagnosis: a consensus paper from the Alzheimer's Biomarkers Standardization Initiative. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 8. issue 1. 2012-05-31. PMID:22047631. |
numerous studies show that the cerebrospinal fluid biomarkers total tau (t-tau), tau phosphorylated at threonine 181 (p-tau(181p)), and amyloid-β (1-42) (aβ(1-42)) have high diagnostic accuracy for alzheimer's disease. |
2012-05-31 |
2023-08-12 |
Not clear |
| Charles R Harringto. The molecular pathology of Alzheimer's disease. Neuroimaging clinics of North America. vol 22. issue 1. 2012-05-29. PMID:22284730. |
neurofibrillary pathology in alzheimer's disease consists of paired helical filaments comprising tau protein. |
2012-05-29 |
2023-08-12 |
Not clear |
| Vladimir P Skulache. Mitochondria-targeted antioxidants as promising drugs for treatment of age-related brain diseases. Journal of Alzheimer's disease : JAD. vol 28. issue 2. 2012-05-24. PMID:21987592. |
in the second article, the authors identified molecular mechanisms by which amyloid-β-induced mros can mediate hyperphosphorylation of the tau protein, a key event in alzheimer's disease. |
2012-05-24 |
2023-08-12 |
rat |
| Y X Shen, A M Sun, S Fang, L J Feng, Q Li, H L Hou, C Liu, H P Wang, J L Shen, J Luo, J N Zho. Hrd1 facilitates tau degradation and promotes neuron survival. Current molecular medicine. vol 12. issue 2. 2012-05-24. PMID:22280354. |
intraneuronal accumulation of abnormal phosphorylated tau (p-tau) is a molecular pathology in many neurodegenerative tauopathies, including alzheimer's disease (ad) and frontotemporal dementia with parkinsonism-linked to chromosome 17 (ftdp-17). |
2012-05-24 |
2023-08-12 |
human |
| Edmond Teng, Vladimir Kepe, Sally A Frautschy, Jie Liu, Nagichettiar Satyamurthy, Fusheng Yang, Ping-Ping Chen, Graham B Cole, Mychica R Jones, Sung-Cheng Huang, Dorothy G Flood, Stephen P Trusko, Gary W Small, Gregory M Cole, Jorge R Barri. [F-18]FDDNP microPET imaging correlates with brain Aβ burden in a transgenic rat model of Alzheimer disease: effects of aging, in vivo blockade, and anti-Aβ antibody treatment. Neurobiology of disease. vol 43. issue 3. 2012-05-21. PMID:21605674. |
in vivo detection of alzheimer's disease (ad) neuropathology in living patients using positron emission tomography (pet) in conjunction with high affinity molecular imaging probes for β-amyloid (aβ) and tau has the potential to assist with early diagnosis, evaluation of disease progression, and assessment of therapeutic interventions. |
2012-05-21 |
2023-08-12 |
mouse |
| Scott A Yuzwa, Xiaoyang Shan, Matthew S Macauley, Thomas Clark, Yuliya Skorobogatko, Keith Vosseller, David J Vocadl. Increasing O-GlcNAc slows neurodegeneration and stabilizes tau against aggregation. Nature chemical biology. vol 8. issue 4. 2012-05-21. PMID:22366723. |
oligomerization of tau is a key process contributing to the progressive death of neurons in alzheimer's disease. |
2012-05-21 |
2023-08-12 |
mouse |
| Pavan K Krishnamurthy, Einar M Sigurdsso. Therapeutic applications of antibodies in non-infectious neurodegenerative diseases. New biotechnology. vol 28. issue 5. 2012-05-15. PMID:21473943. |
neurodegenerative diseases such as alzheimer's disease (ad), parkinson's disease, huntington's disease (hd) or amyotrophic lateral sclerosis (als) are all characterised histologically by the presence of deposits of misfolded proteins, tau and amyloid-β, α-synuclein, huntingtin or superoxide dismutase, respectively. |
2012-05-15 |
2023-08-12 |
Not clear |
| Maartje I Kester, Nicolaas A Verwey, Evert J van Elk, Marinus A Blankenstein, Philip Scheltens, Wiesje M van der Flie. Progression from MCI to AD: predictive value of CSF Aβ42 is modified by APOE genotype. Neurobiology of aging. vol 32. issue 8. 2012-05-14. PMID:19748159. |
to study csf biomarkers amyloid-beta 1-42 (aβ42) and total tau (tau) in relation to apoe genotype in their ability to predict progression from mild cognitive impairment (mci) to alzheimer's disease (ad). |
2012-05-14 |
2023-08-12 |
Not clear |
| Karen Neumann, Gonzalo Farías, Andrea Slachevsky, Patricio Perez, Ricardo B Maccion. Human platelets tau: a potential peripheral marker for Alzheimer's disease. Journal of Alzheimer's disease : JAD. vol 25. issue 1. 2012-05-14. PMID:21368381. |
human platelets tau: a potential peripheral marker for alzheimer's disease. |
2012-05-14 |
2023-08-12 |
human |
| Emmalee M Jones, Manish Dubey, Phillip J Camp, Briana C Vernon, Jacek Biernat, Eckhard Mandelkow, Jaroslaw Majewski, Eva Y Ch. Interaction of tau protein with model lipid membranes induces tau structural compaction and membrane disruption. Biochemistry. vol 51. issue 12. 2012-05-14. PMID:22401494. |
the misfolding and aggregation of the intrinsically disordered, microtubule-associated tau protein into neurofibrillary tangles is implicated in the pathogenesis of alzheimer's disease. |
2012-05-14 |
2023-08-12 |
Not clear |
| Xifei Yang, Ying Yang, Jianjun Liu, Geng Li, Edward Yan. Increased phosphorylation of tau and synaptic protein loss in the aged transgenic mice expressing familiar Alzheimer's disease-linked presenilin 1 mutation. Neurochemical research. vol 37. issue 1. 2012-05-09. PMID:21842270. |
increased phosphorylation of tau and synaptic protein loss in the aged transgenic mice expressing familiar alzheimer's disease-linked presenilin 1 mutation. |
2012-05-09 |
2023-08-12 |
mouse |
| Tamanna Mustafiz, Erik Portelius, Mikael K Gustavsson, Mikko Hölttä, Henrik Zetterberg, Kaj Blennow, Agneta Nordberg, Christina Unger Lithne. Characterization of the brain β-amyloid isoform pattern at different ages of Tg2576 mice. Neuro-degenerative diseases. vol 8. issue 5. 2012-05-08. PMID:21346320. |
our objective was to investigate the consequences of aβ, especially on tau phosphorylation at specific epitopes important for alzheimer's disease. |
2012-05-08 |
2023-08-12 |
mouse |
| Andrea Fuso, Sigfrido Scarp. One-carbon metabolism and Alzheimer's disease: is it all a methylation matter? Neurobiology of aging. vol 32. issue 7. 2012-05-07. PMID:21524430. |
in this commentary we would like to highlight the role of 1-carbon metabolism in epigenetics and alzheimer's disease and evidence the co-involvement of this metabolism in amyloid and tau pathways. |
2012-05-07 |
2023-08-12 |
Not clear |
| Karim Belarbi, Sylvie Burnouf, Francisco-Jose Fernandez-Gomez, Cyril Laurent, Sophie Lestavel, Martin Figeac, Audrey Sultan, Laetitia Troquier, Antoine Leboucher, Raphaëlle Caillierez, Marie-Eve Grosjean, Dominique Demeyer, Hélène Obriot, Ingrid Brion, Bérangère Barbot, Marie-Christine Galas, Bart Staels, Sandrine Humez, Nicolas Sergeant, Susanna Schraen-Maschke, Anne Muhr-Tailleux, Malika Hamdane, Luc Buée, David Blu. Beneficial effects of exercise in a transgenic mouse model of Alzheimer's disease-like Tau pathology. Neurobiology of disease. vol 43. issue 2. 2012-05-07. PMID:21569847. |
beneficial effects of exercise in a transgenic mouse model of alzheimer's disease-like tau pathology. |
2012-05-07 |
2023-08-12 |
mouse |
| Karim Belarbi, Sylvie Burnouf, Francisco-Jose Fernandez-Gomez, Cyril Laurent, Sophie Lestavel, Martin Figeac, Audrey Sultan, Laetitia Troquier, Antoine Leboucher, Raphaëlle Caillierez, Marie-Eve Grosjean, Dominique Demeyer, Hélène Obriot, Ingrid Brion, Bérangère Barbot, Marie-Christine Galas, Bart Staels, Sandrine Humez, Nicolas Sergeant, Susanna Schraen-Maschke, Anne Muhr-Tailleux, Malika Hamdane, Luc Buée, David Blu. Beneficial effects of exercise in a transgenic mouse model of Alzheimer's disease-like Tau pathology. Neurobiology of disease. vol 43. issue 2. 2012-05-07. PMID:21569847. |
tau pathology is encountered in many neurodegenerative disorders known as tauopathies, including alzheimer's disease. |
2012-05-07 |
2023-08-12 |
mouse |
| Karim Belarbi, Sylvie Burnouf, Francisco-Jose Fernandez-Gomez, Cyril Laurent, Sophie Lestavel, Martin Figeac, Audrey Sultan, Laetitia Troquier, Antoine Leboucher, Raphaëlle Caillierez, Marie-Eve Grosjean, Dominique Demeyer, Hélène Obriot, Ingrid Brion, Bérangère Barbot, Marie-Christine Galas, Bart Staels, Sandrine Humez, Nicolas Sergeant, Susanna Schraen-Maschke, Anne Muhr-Tailleux, Malika Hamdane, Luc Buée, David Blu. Beneficial effects of exercise in a transgenic mouse model of Alzheimer's disease-like Tau pathology. Neurobiology of disease. vol 43. issue 2. 2012-05-07. PMID:21569847. |
to address this question, we investigated the effects of long-term voluntary exercise in the thy-tau22 transgenic model of alzheimer's disease-like tau pathology, characterized by the progressive development of tau pathology, cholinergic alterations and subsequent memory impairments. |
2012-05-07 |
2023-08-12 |
mouse |
| Antero Salminen, Kai Kaarniranta, Annakaisa Haapasalo, Mikko Hiltunen, Hilkka Soininen, Irina Alafuzof. Emerging role of p62/sequestosome-1 in the pathogenesis of Alzheimer's disease. Progress in neurobiology. vol 96. issue 1. 2012-05-07. PMID:22138392. |
in alzheimer's disease (ad), p62 protein is associated with neurofibrillary tangles composed primarily of hyperphosphorylated tau protein and ubiquitin. |
2012-05-07 |
2023-08-12 |
mouse |
| José L Molinuevo Gui. [Role of biomarkers in the early diagnosis of Alzheimer's disease]. Revista espanola de geriatria y gerontologia. vol 46 Suppl 1. 2012-05-07. PMID:22152914. |
patients with alzheimer's disease show reduced aβ₄₂-amyloid levels and increased total and phosphorylated tau levels in cerebrospinal fluid. |
2012-05-07 |
2023-08-12 |
Not clear |
| Kai Liao, Dan Liu, Ling-Qiang Zh. Enriched odor exposure decrease tau phosphorylation in the rat hippocampus and cortex. Neuroscience letters. vol 507. issue 1. 2012-05-04. PMID:22155098. |
abnormally hyperphosphorylated microtubule-associated protein tau is the main component of the neurofibrillary tangles (nft), a hallmark pathological feature of alzheimer's disease (ad). |
2012-05-04 |
2023-08-12 |
rat |
| Yue Wang, Zhe Cheng, Wei Qin, Jianping Ji. Val97Leu mutant presenilin-1 induces tau hyperphosphorylation and spatial memory deficit in mice and the underlying mechanisms. Journal of neurochemistry. vol 121. issue 1. 2012-05-03. PMID:21929538. |
although the pathological role of presenilin-1 mutation in early onset familial alzheimer's disease has been widely studied, few focused on how the presenilin-1 mutations result in memory impairment and tau hyperphosphorylation. |
2012-05-03 |
2023-08-12 |
mouse |