| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Rhiannon L Killian, Jessica D Flippin, Cheryl M Herrera, Angels Almenar-Queralt, Lawrence S B Goldstei. Kinesin light chain 1 suppression impairs human embryonic stem cell neural differentiation and amyloid precursor protein metabolism. PloS one. vol 7. issue 1. 2012-06-11. PMID:22272245. |
the etiology of sporadic alzheimer disease (ad) is largely unknown, although evidence implicates the pathological hallmark molecules amyloid beta (aβ) and phosphorylated tau. |
2012-06-11 |
2023-08-12 |
human |
| Hai-Li Zhu, Sheng-Rong Meng, Jun-Bao Fan, Jie Chen, Yi Lian. Fibrillization of human tau is accelerated by exposure to lead via interaction with His-330 and His-362. PloS one. vol 6. issue 9. 2012-06-08. PMID:21966400. |
neurofibrillary tangles, mainly consisted of bundles of filaments formed by the microtubule-associated protein tau, are a hallmark of alzheimer disease. |
2012-06-08 |
2023-08-12 |
human |
| Hai-Li Zhu, Sheng-Rong Meng, Jun-Bao Fan, Jie Chen, Yi Lian. Fibrillization of human tau is accelerated by exposure to lead via interaction with His-330 and His-362. PloS one. vol 6. issue 9. 2012-06-08. PMID:21966400. |
however, it has not been reported so far whether pb(2+) plays a role in the pathology of alzheimer disease through interaction with human tau protein and thereby mediates tau filament formation. |
2012-06-08 |
2023-08-12 |
human |
| Shih-Yuan Chen, Ta-Fu Chen, Liang-Chuan Lai, Jen-Hau Chen, Yu Sun, Li-Li Wen, Ping-Keung Yip, Yi-Min Chu, Yen-Ching Che. Sequence variants of interleukin 6 (IL-6) are significantly associated with a decreased risk of late-onset Alzheimer's disease. Journal of neuroinflammation. vol 9. 2012-06-06. PMID:22272811. |
interleukin 6 (il-6) has been related to beta-amyloid aggregation and the appearance of hyperphosphorylated tau in alzheimer's disease (ad) brain. |
2012-06-06 |
2023-08-12 |
Not clear |
| Kazuhiro Nakamura, Alex Greenwood, Lester Binder, Eileen H Bigio, Sarah Denial, Linda Nicholson, Xiao Zhen Zhou, Kun Ping L. Proline isomer-specific antibodies reveal the early pathogenic tau conformation in Alzheimer's disease. Cell. vol 149. issue 1. 2012-06-04. PMID:22464332. |
proline isomer-specific antibodies reveal the early pathogenic tau conformation in alzheimer's disease. |
2012-06-04 |
2023-08-12 |
Not clear |
| Kazuhiro Nakamura, Alex Greenwood, Lester Binder, Eileen H Bigio, Sarah Denial, Linda Nicholson, Xiao Zhen Zhou, Kun Ping L. Proline isomer-specific antibodies reveal the early pathogenic tau conformation in Alzheimer's disease. Cell. vol 149. issue 1. 2012-06-04. PMID:22464332. |
pin1 converts cis to trans p-tau to prevent alzheimer's tau pathology. |
2012-06-04 |
2023-08-12 |
Not clear |
| Hugo Vanderstichele, Mirko Bibl, Sebastiaan Engelborghs, Nathalie Le Bastard, Piotr Lewczuk, Jose Luis Molinuevo, Lucilla Parnetti, Armand Perret-Liaudet, Leslie M Shaw, Charlotte Teunissen, Dirk Wouters, Kaj Blenno. Standardization of preanalytical aspects of cerebrospinal fluid biomarker testing for Alzheimer's disease diagnosis: a consensus paper from the Alzheimer's Biomarkers Standardization Initiative. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 8. issue 1. 2012-05-31. PMID:22047631. |
numerous studies show that the cerebrospinal fluid biomarkers total tau (t-tau), tau phosphorylated at threonine 181 (p-tau(181p)), and amyloid-β (1-42) (aβ(1-42)) have high diagnostic accuracy for alzheimer's disease. |
2012-05-31 |
2023-08-12 |
Not clear |
| Charles R Harringto. The molecular pathology of Alzheimer's disease. Neuroimaging clinics of North America. vol 22. issue 1. 2012-05-29. PMID:22284730. |
neurofibrillary pathology in alzheimer's disease consists of paired helical filaments comprising tau protein. |
2012-05-29 |
2023-08-12 |
Not clear |
| Vladimir P Skulache. Mitochondria-targeted antioxidants as promising drugs for treatment of age-related brain diseases. Journal of Alzheimer's disease : JAD. vol 28. issue 2. 2012-05-24. PMID:21987592. |
in the second article, the authors identified molecular mechanisms by which amyloid-β-induced mros can mediate hyperphosphorylation of the tau protein, a key event in alzheimer's disease. |
2012-05-24 |
2023-08-12 |
rat |
| Y X Shen, A M Sun, S Fang, L J Feng, Q Li, H L Hou, C Liu, H P Wang, J L Shen, J Luo, J N Zho. Hrd1 facilitates tau degradation and promotes neuron survival. Current molecular medicine. vol 12. issue 2. 2012-05-24. PMID:22280354. |
intraneuronal accumulation of abnormal phosphorylated tau (p-tau) is a molecular pathology in many neurodegenerative tauopathies, including alzheimer's disease (ad) and frontotemporal dementia with parkinsonism-linked to chromosome 17 (ftdp-17). |
2012-05-24 |
2023-08-12 |
human |
| Edmond Teng, Vladimir Kepe, Sally A Frautschy, Jie Liu, Nagichettiar Satyamurthy, Fusheng Yang, Ping-Ping Chen, Graham B Cole, Mychica R Jones, Sung-Cheng Huang, Dorothy G Flood, Stephen P Trusko, Gary W Small, Gregory M Cole, Jorge R Barri. [F-18]FDDNP microPET imaging correlates with brain Aβ burden in a transgenic rat model of Alzheimer disease: effects of aging, in vivo blockade, and anti-Aβ antibody treatment. Neurobiology of disease. vol 43. issue 3. 2012-05-21. PMID:21605674. |
in vivo detection of alzheimer's disease (ad) neuropathology in living patients using positron emission tomography (pet) in conjunction with high affinity molecular imaging probes for β-amyloid (aβ) and tau has the potential to assist with early diagnosis, evaluation of disease progression, and assessment of therapeutic interventions. |
2012-05-21 |
2023-08-12 |
mouse |
| Scott A Yuzwa, Xiaoyang Shan, Matthew S Macauley, Thomas Clark, Yuliya Skorobogatko, Keith Vosseller, David J Vocadl. Increasing O-GlcNAc slows neurodegeneration and stabilizes tau against aggregation. Nature chemical biology. vol 8. issue 4. 2012-05-21. PMID:22366723. |
oligomerization of tau is a key process contributing to the progressive death of neurons in alzheimer's disease. |
2012-05-21 |
2023-08-12 |
mouse |
| Pavan K Krishnamurthy, Einar M Sigurdsso. Therapeutic applications of antibodies in non-infectious neurodegenerative diseases. New biotechnology. vol 28. issue 5. 2012-05-15. PMID:21473943. |
neurodegenerative diseases such as alzheimer's disease (ad), parkinson's disease, huntington's disease (hd) or amyotrophic lateral sclerosis (als) are all characterised histologically by the presence of deposits of misfolded proteins, tau and amyloid-β, α-synuclein, huntingtin or superoxide dismutase, respectively. |
2012-05-15 |
2023-08-12 |
Not clear |
| Maartje I Kester, Nicolaas A Verwey, Evert J van Elk, Marinus A Blankenstein, Philip Scheltens, Wiesje M van der Flie. Progression from MCI to AD: predictive value of CSF Aβ42 is modified by APOE genotype. Neurobiology of aging. vol 32. issue 8. 2012-05-14. PMID:19748159. |
to study csf biomarkers amyloid-beta 1-42 (aβ42) and total tau (tau) in relation to apoe genotype in their ability to predict progression from mild cognitive impairment (mci) to alzheimer's disease (ad). |
2012-05-14 |
2023-08-12 |
Not clear |
| Karen Neumann, Gonzalo Farías, Andrea Slachevsky, Patricio Perez, Ricardo B Maccion. Human platelets tau: a potential peripheral marker for Alzheimer's disease. Journal of Alzheimer's disease : JAD. vol 25. issue 1. 2012-05-14. PMID:21368381. |
human platelets tau: a potential peripheral marker for alzheimer's disease. |
2012-05-14 |
2023-08-12 |
human |
| Emmalee M Jones, Manish Dubey, Phillip J Camp, Briana C Vernon, Jacek Biernat, Eckhard Mandelkow, Jaroslaw Majewski, Eva Y Ch. Interaction of tau protein with model lipid membranes induces tau structural compaction and membrane disruption. Biochemistry. vol 51. issue 12. 2012-05-14. PMID:22401494. |
the misfolding and aggregation of the intrinsically disordered, microtubule-associated tau protein into neurofibrillary tangles is implicated in the pathogenesis of alzheimer's disease. |
2012-05-14 |
2023-08-12 |
Not clear |
| Xifei Yang, Ying Yang, Jianjun Liu, Geng Li, Edward Yan. Increased phosphorylation of tau and synaptic protein loss in the aged transgenic mice expressing familiar Alzheimer's disease-linked presenilin 1 mutation. Neurochemical research. vol 37. issue 1. 2012-05-09. PMID:21842270. |
increased phosphorylation of tau and synaptic protein loss in the aged transgenic mice expressing familiar alzheimer's disease-linked presenilin 1 mutation. |
2012-05-09 |
2023-08-12 |
mouse |
| Tamanna Mustafiz, Erik Portelius, Mikael K Gustavsson, Mikko Hölttä, Henrik Zetterberg, Kaj Blennow, Agneta Nordberg, Christina Unger Lithne. Characterization of the brain β-amyloid isoform pattern at different ages of Tg2576 mice. Neuro-degenerative diseases. vol 8. issue 5. 2012-05-08. PMID:21346320. |
our objective was to investigate the consequences of aβ, especially on tau phosphorylation at specific epitopes important for alzheimer's disease. |
2012-05-08 |
2023-08-12 |
mouse |
| Andrea Fuso, Sigfrido Scarp. One-carbon metabolism and Alzheimer's disease: is it all a methylation matter? Neurobiology of aging. vol 32. issue 7. 2012-05-07. PMID:21524430. |
in this commentary we would like to highlight the role of 1-carbon metabolism in epigenetics and alzheimer's disease and evidence the co-involvement of this metabolism in amyloid and tau pathways. |
2012-05-07 |
2023-08-12 |
Not clear |
| Karim Belarbi, Sylvie Burnouf, Francisco-Jose Fernandez-Gomez, Cyril Laurent, Sophie Lestavel, Martin Figeac, Audrey Sultan, Laetitia Troquier, Antoine Leboucher, Raphaëlle Caillierez, Marie-Eve Grosjean, Dominique Demeyer, Hélène Obriot, Ingrid Brion, Bérangère Barbot, Marie-Christine Galas, Bart Staels, Sandrine Humez, Nicolas Sergeant, Susanna Schraen-Maschke, Anne Muhr-Tailleux, Malika Hamdane, Luc Buée, David Blu. Beneficial effects of exercise in a transgenic mouse model of Alzheimer's disease-like Tau pathology. Neurobiology of disease. vol 43. issue 2. 2012-05-07. PMID:21569847. |
beneficial effects of exercise in a transgenic mouse model of alzheimer's disease-like tau pathology. |
2012-05-07 |
2023-08-12 |
mouse |