| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Karim Belarbi, Sylvie Burnouf, Francisco-Jose Fernandez-Gomez, Cyril Laurent, Sophie Lestavel, Martin Figeac, Audrey Sultan, Laetitia Troquier, Antoine Leboucher, Raphaëlle Caillierez, Marie-Eve Grosjean, Dominique Demeyer, Hélène Obriot, Ingrid Brion, Bérangère Barbot, Marie-Christine Galas, Bart Staels, Sandrine Humez, Nicolas Sergeant, Susanna Schraen-Maschke, Anne Muhr-Tailleux, Malika Hamdane, Luc Buée, David Blu. Beneficial effects of exercise in a transgenic mouse model of Alzheimer's disease-like Tau pathology. Neurobiology of disease. vol 43. issue 2. 2012-05-07. PMID:21569847. |
tau pathology is encountered in many neurodegenerative disorders known as tauopathies, including alzheimer's disease. |
2012-05-07 |
2023-08-12 |
mouse |
| Karim Belarbi, Sylvie Burnouf, Francisco-Jose Fernandez-Gomez, Cyril Laurent, Sophie Lestavel, Martin Figeac, Audrey Sultan, Laetitia Troquier, Antoine Leboucher, Raphaëlle Caillierez, Marie-Eve Grosjean, Dominique Demeyer, Hélène Obriot, Ingrid Brion, Bérangère Barbot, Marie-Christine Galas, Bart Staels, Sandrine Humez, Nicolas Sergeant, Susanna Schraen-Maschke, Anne Muhr-Tailleux, Malika Hamdane, Luc Buée, David Blu. Beneficial effects of exercise in a transgenic mouse model of Alzheimer's disease-like Tau pathology. Neurobiology of disease. vol 43. issue 2. 2012-05-07. PMID:21569847. |
to address this question, we investigated the effects of long-term voluntary exercise in the thy-tau22 transgenic model of alzheimer's disease-like tau pathology, characterized by the progressive development of tau pathology, cholinergic alterations and subsequent memory impairments. |
2012-05-07 |
2023-08-12 |
mouse |
| Antero Salminen, Kai Kaarniranta, Annakaisa Haapasalo, Mikko Hiltunen, Hilkka Soininen, Irina Alafuzof. Emerging role of p62/sequestosome-1 in the pathogenesis of Alzheimer's disease. Progress in neurobiology. vol 96. issue 1. 2012-05-07. PMID:22138392. |
in alzheimer's disease (ad), p62 protein is associated with neurofibrillary tangles composed primarily of hyperphosphorylated tau protein and ubiquitin. |
2012-05-07 |
2023-08-12 |
mouse |
| José L Molinuevo Gui. [Role of biomarkers in the early diagnosis of Alzheimer's disease]. Revista espanola de geriatria y gerontologia. vol 46 Suppl 1. 2012-05-07. PMID:22152914. |
patients with alzheimer's disease show reduced aβ₄₂-amyloid levels and increased total and phosphorylated tau levels in cerebrospinal fluid. |
2012-05-07 |
2023-08-12 |
Not clear |
| Kai Liao, Dan Liu, Ling-Qiang Zh. Enriched odor exposure decrease tau phosphorylation in the rat hippocampus and cortex. Neuroscience letters. vol 507. issue 1. 2012-05-04. PMID:22155098. |
abnormally hyperphosphorylated microtubule-associated protein tau is the main component of the neurofibrillary tangles (nft), a hallmark pathological feature of alzheimer's disease (ad). |
2012-05-04 |
2023-08-12 |
rat |
| Yue Wang, Zhe Cheng, Wei Qin, Jianping Ji. Val97Leu mutant presenilin-1 induces tau hyperphosphorylation and spatial memory deficit in mice and the underlying mechanisms. Journal of neurochemistry. vol 121. issue 1. 2012-05-03. PMID:21929538. |
although the pathological role of presenilin-1 mutation in early onset familial alzheimer's disease has been widely studied, few focused on how the presenilin-1 mutations result in memory impairment and tau hyperphosphorylation. |
2012-05-03 |
2023-08-12 |
mouse |
| Lin Li, Zhi-Feng Zhang, Christian Holscher, Chong Gao, Yuan-Hong Jiang, Yue-Ze Li. (Val⁸) glucagon-like peptide-1 prevents tau hyperphosphorylation, impairment of spatial learning and ultra-structural cellular damage induced by streptozotocin in rat brains. European journal of pharmacology. vol 674. issue 2-3. 2012-05-03. PMID:22115895. |
the results shown that streptozotocin induced a series of alzheimer disease -like changes in behaviour, a significant decline in learning and memory formation, an increased expression of total tau and an increased ratio of phosphorylated tau, and damage to nucleus and nucleolus as seen in electron micrographs. |
2012-05-03 |
2023-08-12 |
rat |
| Dorthe Matenia, Cindy Hempp, Thomas Timm, Annika Eikhof, Eva-Maria Mandelko. Microtubule affinity-regulating kinase 2 (MARK2) turns on phosphatase and tensin homolog (PTEN)-induced kinase 1 (PINK1) at Thr-313, a mutation site in Parkinson disease: effects on mitochondrial transport. The Journal of biological chemistry. vol 287. issue 11. 2012-05-01. PMID:22238344. |
the kinase mark2/par-1 plays key roles in several cell processes, including neurodegeneration such as alzheimer disease by phosphorylating tau and detaching it from microtubules. |
2012-05-01 |
2023-08-12 |
Not clear |
| Bin Zhang, Jenna Carroll, John Q Trojanowski, Yuemang Yao, Michiyo Iba, Justin S Potuzak, Anne-Marie L Hogan, Sharon X Xie, Carlo Ballatore, Amos B Smith, Virginia M-Y Lee, Kurt R Brunde. The microtubule-stabilizing agent, epothilone D, reduces axonal dysfunction, neurotoxicity, cognitive deficits, and Alzheimer-like pathology in an interventional study with aged tau transgenic mice. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 32. issue 11. 2012-05-01. PMID:22423084. |
neurodegenerative tauopathies, such as alzheimer's disease (ad), are characterized by insoluble deposits of hyperphosphorylated tau protein within brain neurons. |
2012-05-01 |
2023-08-12 |
mouse |
| Diana A T Nijholt, Elise S van Haastert, Annemieke J M Rozemuller, Wiep Scheper, Jeroen J M Hoozeman. The unfolded protein response is associated with early tau pathology in the hippocampus of tauopathies. The Journal of pathology. vol 226. issue 5. 2012-04-27. PMID:22102449. |
previously, we reported that the activation of the upr closely correlates with the presence of phosphorylated tau (p-tau) in alzheimer's disease (ad). |
2012-04-27 |
2023-08-12 |
Not clear |
| Elisabete Ferreiro, Cláudia M F Pereir. Endoplasmic reticulum stress: a new playER in tauopathies. The Journal of pathology. vol 226. issue 5. 2012-04-27. PMID:22190226. |
recent observations suggest that er stress plays an important role in the pathogenesis of various neurodegenerative disorders such as alzheimer's disease, which is characterized by the deposition of amyloid-beta (aβ) and hyperphosphorylated tau in susceptible brain regions. |
2012-04-27 |
2023-08-12 |
Not clear |
| Yousuf O Ali, Kai Ruan, R Grace Zha. NMNAT suppresses tau-induced neurodegeneration by promoting clearance of hyperphosphorylated tau oligomers in a Drosophila model of tauopathy. Human molecular genetics. vol 21. issue 2. 2012-04-26. PMID:21965302. |
tauopathies, including alzheimer's disease, are a group of neurodegenerative diseases characterized by abnormal tau hyperphosphorylation that leads to formation of neurofibrillary tangles. |
2012-04-26 |
2023-08-12 |
human |
| M Cecilia Ljungberg, Yousuf O Ali, Jie Zhu, Chia-Shan Wu, Kazuhiro Oka, R Grace Zhai, Hui-Chen L. CREB-activity and nmnat2 transcription are down-regulated prior to neurodegeneration, while NMNAT2 over-expression is neuroprotective, in a mouse model of human tauopathy. Human molecular genetics. vol 21. issue 2. 2012-04-26. PMID:22027994. |
tauopathies, characterized by neurofibrillary tangles (nfts) of phosphorylated tau proteins, are a group of neurodegenerative diseases, including frontotemporal dementia and both sporadic and familial alzheimer's disease. |
2012-04-26 |
2023-08-12 |
mouse |
| Niko-Petteri Nykänen, Kai Kysenius, Prasanna Sakha, Päivi Tammela, Henri J Huttune. γ-Aminobutyric acid type A (GABAA) receptor activation modulates tau phosphorylation. The Journal of biological chemistry. vol 287. issue 9. 2012-04-25. PMID:22235112. |
abnormal phosphorylation and aggregation of the microtubule-associated protein tau are hallmarks of various neurodegenerative diseases, such as alzheimer disease. |
2012-04-25 |
2023-08-12 |
Not clear |
| Suk Ling Ma, Lucia Pastorino, Xiao Zhen Zhou, Kun Ping L. Prolyl isomerase Pin1 promotes amyloid precursor protein (APP) turnover by inhibiting glycogen synthase kinase-3β (GSK3β) activity: novel mechanism for Pin1 to protect against Alzheimer disease. The Journal of biological chemistry. vol 287. issue 10. 2012-04-24. PMID:22184106. |
alzheimer disease (ad) is characterized by the presence of senile plaques of amyloid-β (aβ) peptides derived from amyloid precursor protein (app) and neurofibrillary tangles made of hyperphosphorylated tau. |
2012-04-24 |
2023-08-12 |
Not clear |
| Mian Bi, Arne Ittner, Yazi D Ke, Jürgen Götz, Lars M Ittne. Tau-targeted immunization impedes progression of neurofibrillary histopathology in aged P301L tau transgenic mice. PloS one. vol 6. issue 12. 2012-04-23. PMID:22174735. |
in alzheimer's disease (ad) brains, the microtubule-associated protein tau and amyloid-β (aβ) deposit as intracellular neurofibrillary tangles (nfts) and extracellular plaques, respectively. |
2012-04-23 |
2023-08-12 |
mouse |
| Meaghan Morris, Akihiko Koyama, Eliezer Masliah, Lennart Muck. Tau reduction does not prevent motor deficits in two mouse models of Parkinson's disease. PloS one. vol 6. issue 12. 2012-04-23. PMID:22206005. |
the tau protein has been implicated in the pathogenesis of diverse neurodegenerative disorders, including alzheimer's disease (ad) and parkinson's disease (pd). |
2012-04-23 |
2023-08-12 |
mouse |
| Kourosh Shahpasand, Isao Uemura, Taro Saito, Tsunaki Asano, Kenji Hata, Keitaro Shibata, Yoko Toyoshima, Masato Hasegawa, Shin-Ichi Hisanag. Regulation of mitochondrial transport and inter-microtubule spacing by tau phosphorylation at the sites hyperphosphorylated in Alzheimer's disease. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 32. issue 7. 2012-04-23. PMID:22396417. |
regulation of mitochondrial transport and inter-microtubule spacing by tau phosphorylation at the sites hyperphosphorylated in alzheimer's disease. |
2012-04-23 |
2023-08-12 |
mouse |
| Kourosh Shahpasand, Isao Uemura, Taro Saito, Tsunaki Asano, Kenji Hata, Keitaro Shibata, Yoko Toyoshima, Masato Hasegawa, Shin-Ichi Hisanag. Regulation of mitochondrial transport and inter-microtubule spacing by tau phosphorylation at the sites hyperphosphorylated in Alzheimer's disease. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 32. issue 7. 2012-04-23. PMID:22396417. |
the microtubule-associated protein tau is a major component of the neurofibrillary tangles that serve as a neuropathological hallmark of alzheimer's disease. |
2012-04-23 |
2023-08-12 |
mouse |
| Kourosh Shahpasand, Isao Uemura, Taro Saito, Tsunaki Asano, Kenji Hata, Keitaro Shibata, Yoko Toyoshima, Masato Hasegawa, Shin-Ichi Hisanag. Regulation of mitochondrial transport and inter-microtubule spacing by tau phosphorylation at the sites hyperphosphorylated in Alzheimer's disease. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 32. issue 7. 2012-04-23. PMID:22396417. |
however, the physiological functions of tau phosphorylation or how it may contribute mechanistically to alzheimer's pathophysiology are not completely understood. |
2012-04-23 |
2023-08-12 |
mouse |