All Relations between Alzheimer Disease and microtubule-associated protein tau

Publication Sentence Publish Date Extraction Date Species
Eva Alonso, Carmen Vale, Mercedes R Vieytes, Frank M Laferla, Lydia Giménez-Llort, Luis M Botan. The cholinergic antagonist gymnodimine improves Aβ and tau neuropathology in an in vitro model of Alzheimer disease. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology. vol 27. issue 6. 2011-10-18. PMID:21691095. the cholinergic antagonist gymnodimine improves aβ and tau neuropathology in an in vitro model of alzheimer disease. 2011-10-18 2023-08-12 Not clear
Wei Qian, Hongwei Liang, Jianhua Shi, Nana Jin, Inge Grundke-Iqbal, Khalid Iqbal, Cheng-Xin Gong, Fei Li. Regulation of the alternative splicing of tau exon 10 by SC35 and Dyrk1A. Nucleic acids research. vol 39. issue 14. 2011-10-17. PMID:21470964. therefore, upregulation of dyrk1a in down syndrome brain or alzheimer's brain may cause dysregulation of tau exon 10 splicing through sc35, and probably together with other splicing factors, leading to the imbalance in 3r-tau and 4r-tau expression, which may initiate or accelerate tau pathology and cause neurofibrillary degeneration in the diseases. 2011-10-17 2023-08-12 Not clear
Richard Killick, Maria Niklison-Chirou, Richard Tomasini, Daniele Bano, Alessandro Rufini, Francesca Grespi, Tania Velletri, Paola Tucci, Berna S Sayan, Franco Conforti, Ewen Gallagher, Pierluigi Nicotera, Tak W Mak, Gerry Melino, Richard A Knight, Massimiliano Agostin. p73: a multifunctional protein in neurobiology. Molecular neurobiology. vol 43. issue 2. 2011-10-14. PMID:21380933. recent evidence has also suggested that p73 isoforms are deregulated in neurodegenerative pathologies such as alzheimer's disease, with abnormal tau phosphorylation. 2011-10-14 2023-08-12 mouse
Xia Jiang, Qing Tian, Yue Wang, Xin-Wen Zhou, Jia-Zhao Xie, Jian-Zhi Wang, Ling-Qiang Zh. Acetyl-L-carnitine ameliorates spatial memory deficits induced by inhibition of phosphoinositol-3 kinase and protein kinase C. Journal of neurochemistry. vol 118. issue 5. 2011-10-14. PMID:21689104. acetyl-l-carnitine ameliorates spatial memory deficits induced by inhibition of phosphoinositol-3 kinase and protein kinase c. glycogen synthase kinase-3β (gsk-3β) plays a crucial role in memory deficits and tau hyperphosphorylation as seen in alzheimer's disease, the most common dementia in the aged population. 2011-10-14 2023-08-12 rat
Xia Jiang, Qing Tian, Yue Wang, Xin-Wen Zhou, Jia-Zhao Xie, Jian-Zhi Wang, Ling-Qiang Zh. Acetyl-L-carnitine ameliorates spatial memory deficits induced by inhibition of phosphoinositol-3 kinase and protein kinase C. Journal of neurochemistry. vol 118. issue 5. 2011-10-14. PMID:21689104. we also found that alcar arrested microtubule-associated protein tau hyperphosphorylation at multiple alzheimer's disease sites in vivo and in vitro. 2011-10-14 2023-08-12 rat
Diego Sepulveda-Falla, Jakob Matschke, Christian Bernreuther, Christian Hagel, Berta Puig, Andres Villegas, Gloria Garcia, Julian Zea, Baltazar Gomez-Mancilla, Isidre Ferrer, Francisco Lopera, Markus Glatze. Deposition of hyperphosphorylated tau in cerebellum of PS1 E280A Alzheimer's disease. Brain pathology (Zurich, Switzerland). vol 21. issue 4. 2011-10-04. PMID:21159009. deposition of hyperphosphorylated tau in cerebellum of ps1 e280a alzheimer's disease. 2011-10-04 2023-08-12 Not clear
Alessia Usardi, Amy M Pooler, Anjan Seereeram, C Hugh Reynolds, Pascal Derkinderen, Brian Anderton, Diane P Hanger, Wendy Noble, Ritchie Williamso. Tyrosine phosphorylation of tau regulates its interactions with Fyn SH2 domains, but not SH3 domains, altering the cellular localization of tau. The FEBS journal. vol 278. issue 16. 2011-10-03. PMID:21692989. recent reports have demonstrated that interactions between the microtubule-associated protein tau and the nonreceptor tyrosine kinase fyn play a critical role in mediating synaptic toxicity and neuronal loss in response to β-amyloid (aβ) in models of alzheimer's disease. 2011-10-03 2023-08-12 Not clear
Aikaterini Rousaki, Yoshinari Miyata, Umesh K Jinwal, Chad A Dickey, Jason E Gestwicki, Erik R P Zuiderwe. Allosteric drugs: the interaction of antitumor compound MKT-077 with human Hsp70 chaperones. Journal of molecular biology. vol 411. issue 3. 2011-10-03. PMID:21708173. however, they also have the ability to inhibit tumor apoptosis and contribute to aberrant accumulation of hyperphosphorylated tau in neuronal cells affected by tauopathies, including alzheimer's disease. 2011-10-03 2023-08-12 human
Donna M Barten, Gregory W Cadelina, Nina Hoque, Lynn B DeCarr, Valerie L Guss, Ling Yang, Sethu Sankaranarayanan, Paul D Wes, Marianne E Flynn, Jere E Meredith, Michael K Ahlijanian, Charles F Albrigh. Tau transgenic mice as models for cerebrospinal fluid tau biomarkers. Journal of Alzheimer's disease : JAD. vol 24 Suppl 2. 2011-09-30. PMID:21422517. levels of tau in cerebrospinal fluid (csf) are elevated in alzheimer's disease (ad) patients. 2011-09-30 2023-08-12 mouse
Alexander V Shkumatov, Subashchandrabose Chinnathambi, Eckhard Mandelkow, Dmitri I Svergu. Structural memory of natively unfolded tau protein detected by small-angle X-ray scattering. Proteins. vol 79. issue 7. 2011-09-30. PMID:21560166. we present here a study of temperature induced transitions in tau, a natively unfolded protein involved in alzheimer's disease. 2011-09-30 2023-08-12 Not clear
Cristina Lorenzi, Alessandra Marcone, Adele Pirovano, Elena Marino, Francesco Cordici, Chiara Cerami, Dario Delmonte, Stefano F Cappa, Placido Bramanti, Enrico Smerald. Serotonin transporter and saitohin genes in risk of Alzheimer's disease and frontotemporal lobar dementia: preliminary findings. Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology. vol 31. issue 6. 2011-09-28. PMID:20852909. serotonergic transmission impairment and abnormal phosphorylation of tau protein have been implicated in the physiopathology of alzheimer's disease (ad) and frontotemporal lobar dementia (ftld). 2011-09-28 2023-08-12 human
Dee Shen, Jack Coleman, Eric Chan, Thomas P Nicholson, Lijun Dai, Paul W Sheppard, Wayne F Patto. Novel cell- and tissue-based assays for detecting misfolded and aggregated protein accumulation within aggresomes and inclusion bodies. Cell biochemistry and biophysics. vol 60. issue 3. 2011-09-28. PMID:21132543. with minor modification, the assay was also adapted to the analysis of frozen or formalin-fixed, paraffin-embedded tissue sections, with demonstration of co-localization of aggregated cargo with β-amyloid and tau proteins in brain tissue sections from alzheimer's disease patients. 2011-09-28 2023-08-12 human
Michael Voronkov, Steven P Braithwaite, Jeffry B Stoc. Phosphoprotein phosphatase 2A: a novel druggable target for Alzheimer's disease. Future medicinal chemistry. vol 3. issue 7. 2011-09-28. PMID:21644827. tau hyperphosphorylation is thought to play an important role in the etiology of alzheimer's disease by facilitating the formation of neurofibrillary tangles. 2011-09-28 2023-08-12 Not clear
Caroline C Rodger. Dental X-ray exposure and Alzheimer's disease: a hypothetical etiological association. Medical hypotheses. vol 77. issue 1. 2011-09-26. PMID:21458164. degenerated microglia lose their neuroprotective properties, resulting in the formation of neurofibrillary tau tangles and consequently, the neuronal death that causes alzheimer's dementia. 2011-09-26 2023-08-12 human
Karen D B Smith, Richard Paylor, Robia G Pautle. R-flurbiprofen improves axonal transport in the Tg2576 mouse model of Alzheimer's disease as determined by MEMRI. Magnetic resonance in medicine. vol 65. issue 5. 2011-09-22. PMID:21500269. these data indicate that both aβ42 and tau comprise a role in axonal transport rate deficits in the tg2576 model of alzheimer's disease. 2011-09-22 2023-08-12 mouse
E Cavedo, G B Frison. The dynamic marker hypothesis of Alzheimer's disease and its implications for clinical imaging. The quarterly journal of nuclear medicine and molecular imaging : official publication of the Italian Association of Nuclear Medicine (AIMN) [and] the International Association of Radiopharmacology (IAR), [and] Section of the Society of.... vol 55. issue 3. 2011-09-20. PMID:21532538. the most widely used biomarkers for the alzheimer's disease are: abeta42 and tau levels in the cerebrospinal fluid (csf); brain glucose hypometabolism detected by positron emission tomography (pet) using the 2-deoxy-2-[18f]fluoro-d-glucose ([18f]fdg); brain structural and functional changes detected by magnetic resonance imaging and amyloid burden by pet using carbon-11-labelled pittsburgh compound-b [(11)c]pib). 2011-09-20 2023-08-12 Not clear
Frank Kozielski, Tahira Riaz, Salvatore DeBonis, Christian J Koehler, Mario Kroening, Isabel Panse, Margarita Strozynski, Ian M Donaldson, Bernd Thied. Proteome analysis of microtubule-associated proteins and their interacting partners from mammalian brain. Amino acids. vol 41. issue 2. 2011-09-16. PMID:20567863. analysis of the ms/ms data revealed many posttranslational modifications, amino acid changes, and alternative splice variants, particularly in tau, a key protein implicated in alzheimer's disease. 2011-09-16 2023-08-12 cattle
Thomas Haggerty, Joel Credle, Olga Rodriguez, Jonathan Wills, Adam W Oaks, Eliezer Masliah, Anita Sidh. Hyperphosphorylated Tau in an α-synuclein-overexpressing transgenic model of Parkinson's disease. The European journal of neuroscience. vol 33. issue 9. 2011-09-16. PMID:21453448. at 11 months of age, large and progressive increases in p-tau in transgenic mice, hyperphosphorylated at sites reminiscent of alzheimer's disease, were noted, along with elevated levels of α-synuclein and glycogen synthase kinase 3β phosphorylated at tyr216 (p-gsk-3β), a major kinase involved in the hyperphosphorylation of tau. 2011-09-16 2023-08-12 mouse
Allal Boutajangout, Johanna Ingadottir, Peter Davies, Einar M Sigurdsso. Passive immunization targeting pathological phospho-tau protein in a mouse model reduces functional decline and clears tau aggregates from the brain. Journal of neurochemistry. vol 118. issue 4. 2011-09-16. PMID:21644996. targeting hyperphosphorylated tau by immunotherapy is emerging as a promising approach to treat tauopathies such as alzheimer's disease and frontotemporal dementia. 2011-09-16 2023-08-12 mouse
Günter U Höglinger, Nadine M Melhem, Dennis W Dickson, Patrick M A Sleiman, Li-San Wang, Lambertus Klei, Rosa Rademakers, Rohan de Silva, Irene Litvan, David E Riley, John C van Swieten, Peter Heutink, Zbigniew K Wszolek, Ryan J Uitti, Jana Vandrovcova, Howard I Hurtig, Rachel G Gross, Walter Maetzler, Stefano Goldwurm, Eduardo Tolosa, Barbara Borroni, Pau Pastor, Laura B Cantwell, Mi Ryung Han, Allissa Dillman, Marcel P van der Brug, J Raphael Gibbs, Mark R Cookson, Dena G Hernandez, Andrew B Singleton, Matthew J Farrer, Chang-En Yu, Lawrence I Golbe, Tamas Revesz, John Hardy, Andrew J Lees, Bernie Devlin, Hakon Hakonarson, Ulrich Müller, Gerard D Schellenber. Identification of common variants influencing risk of the tauopathy progressive supranuclear palsy. Nature genetics. vol 43. issue 7. 2011-09-15. PMID:21685912. brain diseases with abnormal tau deposits are called tauopathies, the most common of which is alzheimer's disease. 2011-09-15 2023-08-12 Not clear