| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Giacomo Koch, Zaira Esposito, Hajime Kusayanagi, Fabrizia Monteleone, Claudia Codecá, Francesco Di Lorenzo, Carlo Caltagirone, Giorgio Bernardi, Alessandro Martoran. CSF tau levels influence cortical plasticity in Alzheimer's disease patients. Journal of Alzheimer's disease : JAD. vol 26. issue 1. 2012-01-10. PMID:21606570. |
csf tau levels influence cortical plasticity in alzheimer's disease patients. |
2012-01-10 |
2023-08-12 |
Not clear |
| Charles Y Shao, Suzanne S Mirra, Hameetha B R Sait, Todd C Sacktor, Einar M Sigurdsso. Postsynaptic degeneration as revealed by PSD-95 reduction occurs after advanced Aβ and tau pathology in transgenic mouse models of Alzheimer's disease. Acta neuropathologica. vol 122. issue 3. 2012-01-10. PMID:21630115. |
postsynaptic degeneration as revealed by psd-95 reduction occurs after advanced aβ and tau pathology in transgenic mouse models of alzheimer's disease. |
2012-01-10 |
2023-08-12 |
mouse |
| Mohsen Mohammadi, Razieh Yazdanparas. Modulation of H2O2-induced mitogen-activated protein kinases activation and cell death in SK-N-MC cells by EUK134, a salen derivative. Basic & clinical pharmacology & toxicology. vol 108. issue 6. 2012-01-09. PMID:21205220. |
alzheimer's disease is a neurodegenerative disorder that is characterized by the accumulation of senile plaques containing amyloid β (aβ) and neurofibrillary tangles composed of hyperphosphorylated tau protein in the brain. |
2012-01-09 |
2023-08-12 |
human |
| Susanne M Pritchard, Philip J Dolan, Alisa Vitkus, Gail V W Johnso. The toxicity of tau in Alzheimer disease: turnover, targets and potential therapeutics. Journal of cellular and molecular medicine. vol 15. issue 8. 2012-01-09. PMID:21348938. |
the toxicity of tau in alzheimer disease: turnover, targets and potential therapeutics. |
2012-01-09 |
2023-08-12 |
human |
| Susanne M Pritchard, Philip J Dolan, Alisa Vitkus, Gail V W Johnso. The toxicity of tau in Alzheimer disease: turnover, targets and potential therapeutics. Journal of cellular and molecular medicine. vol 15. issue 8. 2012-01-09. PMID:21348938. |
it has been almost 25 years since the initial discovery that tau was the primary component of the neurofibrillary tangles (nfts) in alzheimer disease (ad) brain. |
2012-01-09 |
2023-08-12 |
human |
| Rahul S Desikan, Linda K McEvoy, Wesley K Thompson, Dominic Holland, J Cooper Roddey, Kaj Blennow, Paul S Aisen, James B Brewer, Bradley T Hyman, Anders M Dal. Amyloid-β associated volume loss occurs only in the presence of phospho-tau. Annals of neurology. vol 70. issue 4. 2012-01-04. PMID:22002658. |
the relationship between neurodegeneration and the 2 hallmark proteins of alzheimer's disease, amyloid-β (aβ) and tau, is still unclear. |
2012-01-04 |
2023-08-12 |
human |
| Mathias Jucker, Lary C Walke. Pathogenic protein seeding in Alzheimer disease and other neurodegenerative disorders. Annals of neurology. vol 70. issue 4. 2012-01-04. PMID:22028219. |
in alzheimer disease (the most prevalent cerebral proteopathy), the two principal aggregating proteins are β-amyloid (aβ) and tau. |
2012-01-04 |
2023-08-12 |
human |
| Changlin Liu, Yong Zhan. Nucleic acid-mediated protein aggregation and assembly. Advances in protein chemistry and structural biology. vol 84. 2011-12-29. PMID:21846561. |
for example, in the brain tissues from victims of alzheimer's disease, nucleic acids have been detected in neurofibrillary tangles and intracellular inclusions primarily composed of the tau protein, as well as in senile plaques composed of the amyloid-β peptides. |
2011-12-29 |
2023-08-12 |
Not clear |
| C J Carte. Alzheimer's disease plaques and tangles: cemeteries of a pyrrhic victory of the immune defence network against herpes simplex infection at the expense of complement and inflammation-mediated neuronal destruction. Neurochemistry international. vol 58. issue 3. 2011-12-27. PMID:21167244. |
along this route, the virus deletes mitochondrial dna, as seen in alzheimer's disease, sequesters the neuroprotective peptide, adnp, and interferes with key proteins related to amyloid precursor protein processing and signalling as well as beta-amyloid processing, microtubule stability and tau phosphorylation, the core pathologies of alzheimer's disease. |
2011-12-27 |
2023-08-12 |
mouse |
| Adriana Ferreira, Eileen H Bigi. Calpain-mediated tau cleavage: a mechanism leading to neurodegeneration shared by multiple tauopathies. Molecular medicine (Cambridge, Mass.). vol 17. issue 7-8. 2011-12-27. PMID:21442128. |
recently, we obtained data suggesting that calpain-mediated tau cleavage leading to the generation of a neurotoxic tau fragment might play an important role in alzheimer's disease. |
2011-12-27 |
2023-08-12 |
Not clear |
| Jordan R Jensen, Katryna Cisek, Nicolette S Honson, Jeff Kure. Ligand polarizability contributes to tau fibril binding affinity. Bioorganic & medicinal chemistry. vol 19. issue 17. 2011-12-20. PMID:21803586. |
to identify these features, analogs of compounds discovered by high-throughput screening, including phenothiazine, triarylmethine, benzothiazole, and oxindole derivatives, were tested for their ability to displace fluorescent thioflavin dyes from filaments made from recombinant tau protein or authentic paired helical filaments purified from alzheimer's disease tissue. |
2011-12-20 |
2023-08-12 |
Not clear |
| Luka Kulic, M Axel Wollmer, Virginie Rhein, Lucia Pagani, Katrin Kuehnle, Susann Cattepoel, Jay Tracy, Anne Eckert, Roger M Nitsc. Combined expression of tau and the Harlequin mouse mutation leads to increased mitochondrial dysfunction, tau pathology and neurodegeneration. Neurobiology of aging. vol 32. issue 10. 2011-12-15. PMID:19942317. |
mitochondrial dysfunction and oxidative stress play an important role in ageing and have been implicated in several age-related neurodegenerative conditions including alzheimer's disease (ad) and other tauopathies characterized by the presence of intracellular accumulations of the hyperphosphorylated microtubule-associated protein tau. |
2011-12-15 |
2023-08-12 |
mouse |
| Maria Thom, Joan Y W Liu, Pam Thompson, Rahul Phadke, Marta Narkiewicz, Lillian Martinian, Derek Marsdon, Matthias Koepp, Luis Caboclo, Claudia B Catarino, Sanjay M Sisodiy. Neurofibrillary tangle pathology and Braak staging in chronic epilepsy in relation to traumatic brain injury and hippocampal sclerosis: a post-mortem study. Brain : a journal of neurology. vol 134. issue Pt 10. 2011-12-15. PMID:21903728. |
in a post-mortem series of 138 patients with long-term, mainly drug-resistant epilepsy, we carried out braak staging for alzheimer's disease neurofibrillary pathology using tau protein immunohistochemistry. |
2011-12-15 |
2023-08-12 |
Not clear |
| Philip J Dolan, Youngnam N Jin, Woong Hwang, Gail V W Johnso. Decreases in valosin-containing protein result in increased levels of tau phosphorylated at Ser262/356. FEBS letters. vol 585. issue 21. 2011-12-14. PMID:21983102. |
reported dysfunctions of these processes in alzheimer disease (ad), along with the linkage of vcp/p97 to inclusion body myopathy with paget's disease and frontotemporal dementia (ibmpfd) led us to examine the possible linkage of vcp to the ad-relevant protein, tau. |
2011-12-14 |
2023-08-12 |
mouse |
| Pamela J McMillan, Brian C Kraemer, Linda Robinson, James B Leverenz, Murray Raskind, Gerard Schellenber. Truncation of tau at E391 promotes early pathologic changes in transgenic mice. Journal of neuropathology and experimental neurology. vol 70. issue 11. 2011-12-08. PMID:22002427. |
proteolytic cleavage of tau at glutamic acid 391 (e391) is linked to the pathogenesis of alzheimer disease (ad). |
2011-12-08 |
2023-08-12 |
mouse |
| Gennady Ermak, Melanie A Pritchard, Sladjana Dronjak, Brenda Niu, Kelvin J A Davie. Do RCAN1 proteins link chronic stress with neurodegeneration? FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 25. issue 10. 2011-12-07. PMID:21680892. |
we further show that transgenic mice overexpressing the rcan1-1l protein exhibit accumulation of hyperphosphorylated tau protein (at8 antibody), an early precursor to the formation of neurofibrillary tangles and neurodegeneration of the kind seen in alzheimer disease. |
2011-12-07 |
2023-08-12 |
mouse |
| Jürgen Götz, Naeman N Göt. Animal models for Alzheimer's disease and frontotemporal dementia: a perspective. ASN neuro. vol 1. issue 4. 2011-12-06. PMID:19839939. |
these will reveal how key players in the pathogenesis of alzheimer's disease and frontotemporal dementia, such as the peptide aβ (amyloid β) and the protein tau, cause neuronal dysfunction and eventually, neuronal demise. |
2011-12-06 |
2023-08-12 |
mouse |
| D F F Silva, A R Esteves, C R Oliveira, S M Cardos. Mitochondria: the common upstream driver of amyloid-β and tau pathology in Alzheimer's disease. Current Alzheimer research. vol 8. issue 5. 2011-12-05. PMID:21244356. |
mitochondria: the common upstream driver of amyloid-β and tau pathology in alzheimer's disease. |
2011-12-05 |
2023-08-12 |
Not clear |
| Lorena Arranz, Nuria M De Castro, Isabel Baeza, Lydia Giménez-Llort, Mónica De la Fuent. Effect of environmental enrichment on the immunoendocrine aging of male and female triple-transgenic 3xTg-AD mice for Alzheimer's disease. Journal of Alzheimer's disease : JAD. vol 25. issue 4. 2011-11-29. PMID:21593564. |
we have previously shown that 3xtgad mice (triple-transgenic mice for alzheimer's disease, harboring ps1(m146v), aβpp(swe), tau(p301l) transgenes) suffer detrimental changes in some key lymphocyte functions, described as health and longevity markers, with males being more affected than females and showing higher mortality rates. |
2011-11-29 |
2023-08-12 |
mouse |
| I Goze. Tau pathology and future therapeutics. Current Alzheimer research. vol 7. issue 8. 2011-11-23. PMID:20678069. |
the current review discusses microtubules and tau in the healthy brain and move on to the underling pathology of alzheimer's disease (ad) with emphasis on tau and neurofibrillary tangles. |
2011-11-23 |
2023-08-12 |
Not clear |