| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Francesco Panza, Vittorio Dibello, Rodolfo Sardone, Fabio Castellana, Roberta Zupo, Luisa Lampignano, Ilaria Bortone, Roberta Stallone, Nicoletta Cirillo, Christian Damiani, Mario Altamura, Antonello Bellomo, Antonio Daniele, Vincenzo Solfrizzi, Madia Lozupon. Clinical Development of Passive Tau-Based Immunotherapeutics for Treating Primary and Secondary Tauopathies. Expert opinion on investigational drugs. 2023-07-05. PMID:37405389. |
alzheimer's disease (ad), tau deposition can be observed, but tau coexists with another protein (amyloid-β). |
2023-07-05 |
2023-08-14 |
Not clear |
| Mark A Dubbelman, Kayden J Mimmack, Emily H Sprague, Rebecca E Amariglio, Patrizia Vannini, Gad A Marshal. Regional cerebral tau predicts decline in everyday functioning across the Alzheimer's disease spectrum. Alzheimer's research & therapy. vol 15. issue 1. 2023-07-05. PMID:37408004. |
regional cerebral tau predicts decline in everyday functioning across the alzheimer's disease spectrum. |
2023-07-05 |
2023-08-14 |
Not clear |
| Angelina Holcom, Matias Fuentealba, Renuka Sivapatham, Christina D King, Hadley Osman, Anna Foulger, Dipa Bhaumik, Birgit Schilling, David Furman, Julie K Andersen, Gordon J Lithgo. Simultaneous neuronal expression of human amyloid-β and Tau genes drives global phenotypic and multi-omic changes in bioRxiv : the preprint server for biology. 2023-07-03. PMID:37398058. |
simultaneous neuronal expression of human amyloid-β and tau genes drives global phenotypic and multi-omic changes in alzheimer's disease and alzheimer's related diseases (adrd) are a class of prevalent age-related neurodegenerative disorders characterized by the accumulation of amyloid- β (aβ) plaques and tau neurofibrillary tangles. |
2023-07-03 |
2023-08-14 |
human |
| Michael Ta, Cornelis Blauwendraat, Tarek Antar, Hampton L Leonard, Andrew B Singleton, Mike A Nalls, Hirotaka Iwak. Genome-wide meta-analysis of CSF biomarkers in Alzheimer's disease and Parkinson's disease cohorts. medRxiv : the preprint server for health sciences. 2023-07-03. PMID:37398091. |
amyloid beta (aβ), phosphorylated tau (p-tau), and total tau (t-tau) in cerebrospinal fluid are established biomarkers for alzheimer's disease (ad). |
2023-07-03 |
2023-08-14 |
Not clear |
| Avi J Samelson, Nabeela Ariqat, Justin McKetney, Gita Rohanitazangi, Celeste Parra Bravo, Darrin Goodness, Ruilin Tian, Parker Grosjean, Romany Abskharon, David Eisenberg, Nicholas M Kanaan, Li Gan, Carlo Condello, Danielle L Swaney, Martin Kampman. CRISPR screens in iPSC-derived neurons reveal principles of tau proteostasis. bioRxiv : the preprint server for biology. 2023-07-03. PMID:37398204. |
aggregation of the protein tau defines tauopathies, which include alzheimer's disease and frontotemporal dementia. |
2023-07-03 |
2023-08-14 |
human |
| Grant Kauwe, Kristeen A Pareja-Navarro, Lei Yao, Jackson H Chen, Ivy Wong, Rowan Saloner, Helen Cifuentes, Alissa L Nana, Samah Shah, Yaqiao Li, David Le, Salvatore Spina, Lea T Grinberg, William W Seeley, Joel H Kramer, Todd C Sacktor, Birgit Schilling, Li Gan, Kaitlin B Casaletto, Tara E Trac. KIBRA repairs synaptic plasticity and promotes resilience to tauopathy-related memory loss. bioRxiv : the preprint server for biology. 2023-07-03. PMID:37398236. |
synaptic plasticity is obstructed by pathogenic tau in the brain, representing a key mechanism that underlies memory loss in alzheimer's disease (ad) and related tauopathies. |
2023-07-03 |
2023-08-14 |
mouse |
| Jinlei Wang, Ying Lin, Xiaoyu Xu, Yonghui Wang, Qiong Xi. Identification of Tau-Tubulin Kinase 1 Inhibitors by Microfluidics-based Mobility Shift Assay from a Kinase Inhibitor Library. SLAS discovery : advancing life sciences R & D. 2023-07-03. PMID:37399991. |
hyperphosphorylated tau is the main cause of tauopathy, such as alzheimer's disease (ad). |
2023-07-03 |
2023-08-14 |
human |
| Jae Myeong Kang, Jeong-Hyeon Shin, Woo-Ram Kim, Seongho Seo, Haeun Seo, Sang-Yoon Lee, Kee Hyung Park, Duk L Na, Nobuyuki Okamura, Joon-Kyoung Seong, Young No. Effects of the APOEɛ4 Allele on the Relationship Between Tau and Amyloid-β in Early- and Late-Onset Alzheimer's Disease. Journal of Alzheimer's disease : JAD. 2023-07-02. PMID:37393505. |
effects of the apoeɛ4 allele on the relationship between tau and amyloid-β in early- and late-onset alzheimer's disease. |
2023-07-02 |
2023-08-14 |
Not clear |
| Jae Myeong Kang, Jeong-Hyeon Shin, Woo-Ram Kim, Seongho Seo, Haeun Seo, Sang-Yoon Lee, Kee Hyung Park, Duk L Na, Nobuyuki Okamura, Joon-Kyoung Seong, Young No. Effects of the APOEɛ4 Allele on the Relationship Between Tau and Amyloid-β in Early- and Late-Onset Alzheimer's Disease. Journal of Alzheimer's disease : JAD. 2023-07-02. PMID:37393505. |
little is known regarding the differential effects of the apolipoprotein e (apoe) ɛ4 on the regional topography of amyloid and tau in patients with both early-onset (eoad) and late-onset alzheimer's disease (load). |
2023-07-02 |
2023-08-14 |
Not clear |
| Jasvinder Singh Bhatti, Satinder Kaur, Jayapriya Mishra, Harikrishnareddy Dibbanti, Arti Singh, Arubala P Reddy, Gurjit Kaur Bhatti, P Hemachandra Redd. Targeting dynamin-related protein-1 as a potential therapeutic approach for mitochondrial dysfunction in Alzheimer's disease. Biochimica et biophysica acta. Molecular basis of disease. 2023-07-01. PMID:37392948. |
alzheimer's disease (ad) is a neurodegenerative disease that manifests its pathology through synaptic damage, mitochondrial abnormalities, microrna deregulation, hormonal imbalance, increased astrocytes & microglia, accumulation of amyloid β (aβ) and phosphorylated tau in the brains of ad patients. |
2023-07-01 |
2023-08-14 |
Not clear |
| Collyn M Kellogg, Kevin Pham, Adeline H Machalinski, Hunter L Porter, Harris E Blankenship, Kyla B Tooley, Michael B Stout, Heather C Rice, Amanda L Sharpe, Michael J Beckstead, Ana J Chucair-Elliott, Sarah R Ocañas, Willard M Freema. Microglial MHC-I induction with aging and Alzheimer's is conserved in mouse models and humans. GeroScience. 2023-07-01. PMID:37393197. |
neuronal mhc-i is proposed to regulate developmental synapse elimination and tau pathology in alzheimer's disease (ad). |
2023-07-01 |
2023-08-14 |
mouse |
| Taeko Kimura, Haruaki Sato, Maria Kano, Lisa Tatsumi, Taisuke Tomit. Novel aspects of the phosphorylation and structure of pathological tau: implications for tauopathy biomarkers. FEBS open bio. 2023-06-30. PMID:37391389. |
the deposition of highly phosphorylated and aggregated tau is characteristic of tauopathies, including alzheimer disease. |
2023-06-30 |
2023-08-14 |
Not clear |
| Miho Ota, Noriko Sato, Moto Nakaya, Yoko Shigemoto, Yukio Kimura, Emiko Chiba, Yuma Yokoi, Tadashi Tsukamoto, Hiroshi Matsud. Relationship between the tau protein and choroid plexus volume in Alzheimer's disease. Neuroreport. vol 34. issue 11. 2023-06-29. PMID:37384934. |
relationship between the tau protein and choroid plexus volume in alzheimer's disease. |
2023-06-29 |
2023-08-14 |
human |
| Miho Ota, Noriko Sato, Moto Nakaya, Yoko Shigemoto, Yukio Kimura, Emiko Chiba, Yuma Yokoi, Tadashi Tsukamoto, Hiroshi Matsud. Relationship between the tau protein and choroid plexus volume in Alzheimer's disease. Neuroreport. vol 34. issue 11. 2023-06-29. PMID:37384934. |
tau protein accumulation in the brain is thought to be one of the causes of alzheimer's disease (ad). |
2023-06-29 |
2023-08-14 |
human |
| Congwei Wang, Marco Terrigno, Juan Li, Tania Distler, Nikhil J Pandya, Martin Ebeling, Stefka Tyanova, Jeroen J M Hoozemans, Anke A Dijkstra, Luisa Fuchs, Shengqi Xiang, Azad Bonni, Fiona Grüninger, Ravi Jagasi. Increased G3BP2-Tau interaction in tauopathies is a natural defense against Tau aggregation. Neuron. 2023-06-29. PMID:37385246. |
in the human brain, the interaction of g3bp2 and tau is dramatically increased in multiple tauopathies, and it is independent of neurofibrillary tangle (nft) formation in alzheimer's disease (ad). |
2023-06-29 |
2023-08-14 |
human |
| Pei-Pei Guan, Tong-Qi Ge, Pu Wan. As a Potential Therapeutic Target, C1q Induces Synapse Loss Via Inflammasome-activating Apoptotic and Mitochondria Impairment Mechanisms in Alzheimer's Disease. Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology. 2023-06-29. PMID:37386257. |
c1q, the initiator of the classical pathway of the complement system, is activated during alzheimer's disease (ad) development and progression and is especially associated with the production and deposition of β-amyloid protein (aβ) and phosphorylated tau in β-amyloid plaques (aps) and neurofibrillary tangles (nfts). |
2023-06-29 |
2023-08-14 |
Not clear |
| Katherine Fodder, Rohan de Silva, Thomas T Warner, Conceição Bettencour. The contribution of DNA methylation to the (dys)function of oligodendroglia in neurodegeneration. Acta neuropathologica communications. vol 11. issue 1. 2023-06-29. PMID:37386505. |
however, a central feature consists of regional aggregation of proteins in the brain, such as the accumulation of β-amyloid plaques in alzheimer's disease (ad), inclusions of hyperphosphorylated microtubule-binding tau in ad and other tauopathies, or inclusions containing α-synuclein in parkinson's disease (pd), dementia with lewy bodies (dlb) and multiple system atrophy (msa). |
2023-06-29 |
2023-08-14 |
Not clear |
| Carlos M Hernandez, Rachel E Barkey, Kristen M Craven, Karin A Pedemonte, Bernadette Alisantosa, Jonathan O Sanchez, Jane M Flin. Transfusion with Blood Plasma from Young Mice Affects rTg4510 Transgenic Tau Mice Modeling of Alzheimer's Disease. Brain sciences. vol 13. issue 6. 2023-06-28. PMID:37371321. |
transfusion with blood plasma from young mice affects rtg4510 transgenic tau mice modeling of alzheimer's disease. |
2023-06-28 |
2023-08-14 |
mouse |
| Kasper Hobin, Marta Costas-Rodríguez, Elien Van Wonterghem, Roosmarijn E Vandenbroucke, Frank Vanhaeck. Alzheimer's Disease and Age-Related Changes in the Cu Isotopic Composition of Blood Plasma and Brain Tissues of the APP Biology. vol 12. issue 6. 2023-06-28. PMID:37372142. |
alzheimer's disease and age-related changes in the cu isotopic composition of blood plasma and brain tissues of the app alzheimer's' disease (ad) is characterized by the formation of β-amyloid (aβ) plaques and neurofibrillary tangles of tau protein in the brain. |
2023-06-28 |
2023-08-14 |
Not clear |
| Khoren K Epremyan, Dmitry V Mamaev, Renata A Zvyagilskay. Alzheimer's Disease: Significant Benefit from the Yeast-Based Models. International journal of molecular sciences. vol 24. issue 12. 2023-06-28. PMID:37372938. |
alzheimer's disease (ad) is an age-related, multifaceted neurological disorder associated with accumulation of aggregated proteins (amyloid aβ and hyperphosphorylated tau), loss of synapses and neurons, and alterations in microglia. |
2023-06-28 |
2023-08-14 |
Not clear |