| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| John Koren, Umesh K Jinwal, Zachary Davey, Janine Kiray, Karthik Arulselvam, Chad A Dicke. Bending tau into shape: the emerging role of peptidyl-prolyl isomerases in tauopathies. Molecular neurobiology. vol 44. issue 1. 2011-11-04. PMID:21523562. |
the hsp90-associated cis-trans peptidyl-prolyl isomerase--fk506 binding protein 51 (fkbp51)--was recently found to co-localize with the microtubule (mt)-associated protein tau in neurons and physically interact with tau in brain tissues from humans who died from alzheimer's disease (ad). |
2011-11-04 |
2023-08-12 |
Not clear |
| Anne M Fagan, Leslie M Shaw, Chengjie Xiong, Hugo Vanderstichele, Mark A Mintun, John Q Trojanowski, Els Coart, John C Morris, David M Holtzma. Comparison of analytical platforms for cerebrospinal fluid measures of β-amyloid 1-42, total tau, and p-tau181 for identifying Alzheimer disease amyloid plaque pathology. Archives of neurology. vol 68. issue 9. 2011-11-02. PMID:21555603. |
comparison of analytical platforms for cerebrospinal fluid measures of β-amyloid 1-42, total tau, and p-tau181 for identifying alzheimer disease amyloid plaque pathology. |
2011-11-02 |
2023-08-12 |
Not clear |
| Isabelle Landrieu, Caroline Smet-Nocca, Laziza Amniai, Justin Vijay Louis, Jean-Michel Wieruszeski, Jozef Goris, Veerle Janssens, Guy Lippen. Molecular implication of PP2A and Pin1 in the Alzheimer's disease specific hyperphosphorylation of Tau. PloS one. vol 6. issue 6. 2011-11-02. PMID:21731772. |
molecular implication of pp2a and pin1 in the alzheimer's disease specific hyperphosphorylation of tau. |
2011-11-02 |
2023-08-12 |
Not clear |
| Isabelle Landrieu, Caroline Smet-Nocca, Laziza Amniai, Justin Vijay Louis, Jean-Michel Wieruszeski, Jozef Goris, Veerle Janssens, Guy Lippen. Molecular implication of PP2A and Pin1 in the Alzheimer's disease specific hyperphosphorylation of Tau. PloS one. vol 6. issue 6. 2011-11-02. PMID:21731772. |
tau phosphorylation and dephosphorylation regulate in a poorly understood manner its physiological role of microtubule stabilization, and equally its integration in alzheimer disease (ad) related fibrils. |
2011-11-02 |
2023-08-12 |
Not clear |
| Richard J O'Brien, Philip C Won. Amyloid precursor protein processing and Alzheimer's disease. Annual review of neuroscience. vol 34. 2011-10-25. PMID:21456963. |
alzheimer's disease (ad), the leading cause of dementia worldwide, is characterized by the accumulation of the β-amyloid peptide (aβ) within the brain along with hyperphosphorylated and cleaved forms of the microtubule-associated protein tau. |
2011-10-25 |
2023-08-12 |
Not clear |
| Jedsada Thaweepoksomboon, Vorapun Senanarong, Niphon Poungvarin, Tipa Chakorn, Nopwan Siwasariyanon, Lerdchai Washirutmangkur, Suthipol Udompunthuru. Assessment of cerebrospinal fluid (CSF) beta-amyloid (1-42), phosphorylated tau (ptau-181) and total Tau protein in patients with Alzheimer's disease (AD) and other dementia at Siriraj Hospital, Thailand. Journal of the Medical Association of Thailand = Chotmaihet thangphaet. vol 94 Suppl 1. 2011-10-25. PMID:21721431. |
assessment of cerebrospinal fluid (csf) beta-amyloid (1-42), phosphorylated tau (ptau-181) and total tau protein in patients with alzheimer's disease (ad) and other dementia at siriraj hospital, thailand. |
2011-10-25 |
2023-08-12 |
Not clear |
| Danielle Frost, Bessie Meechoovet, Tong Wang, Stephen Gately, Marco Giorgetti, Irina Shcherbakova, Travis Dunckle. β-carboline compounds, including harmine, inhibit DYRK1A and tau phosphorylation at multiple Alzheimer's disease-related sites. PloS one. vol 6. issue 5. 2011-10-24. PMID:21573099. |
β-carboline compounds, including harmine, inhibit dyrk1a and tau phosphorylation at multiple alzheimer's disease-related sites. |
2011-10-24 |
2023-08-12 |
Not clear |
| Danielle Frost, Bessie Meechoovet, Tong Wang, Stephen Gately, Marco Giorgetti, Irina Shcherbakova, Travis Dunckle. β-carboline compounds, including harmine, inhibit DYRK1A and tau phosphorylation at multiple Alzheimer's disease-related sites. PloS one. vol 6. issue 5. 2011-10-24. PMID:21573099. |
we and others have implicated dyrk1a in the phosphorylation of tau protein on multiple sites associated with tau pathology in down syndrome and in alzheimer's disease (ad). |
2011-10-24 |
2023-08-12 |
Not clear |
| Eva Alonso, Carmen Vale, Mercedes R Vieytes, Frank M Laferla, Lydia Giménez-Llort, Luis M Botan. The cholinergic antagonist gymnodimine improves Aβ and tau neuropathology in an in vitro model of Alzheimer disease. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology. vol 27. issue 6. 2011-10-18. PMID:21691095. |
the cholinergic antagonist gymnodimine improves aβ and tau neuropathology in an in vitro model of alzheimer disease. |
2011-10-18 |
2023-08-12 |
Not clear |
| Wei Qian, Hongwei Liang, Jianhua Shi, Nana Jin, Inge Grundke-Iqbal, Khalid Iqbal, Cheng-Xin Gong, Fei Li. Regulation of the alternative splicing of tau exon 10 by SC35 and Dyrk1A. Nucleic acids research. vol 39. issue 14. 2011-10-17. PMID:21470964. |
therefore, upregulation of dyrk1a in down syndrome brain or alzheimer's brain may cause dysregulation of tau exon 10 splicing through sc35, and probably together with other splicing factors, leading to the imbalance in 3r-tau and 4r-tau expression, which may initiate or accelerate tau pathology and cause neurofibrillary degeneration in the diseases. |
2011-10-17 |
2023-08-12 |
Not clear |
| Richard Killick, Maria Niklison-Chirou, Richard Tomasini, Daniele Bano, Alessandro Rufini, Francesca Grespi, Tania Velletri, Paola Tucci, Berna S Sayan, Franco Conforti, Ewen Gallagher, Pierluigi Nicotera, Tak W Mak, Gerry Melino, Richard A Knight, Massimiliano Agostin. p73: a multifunctional protein in neurobiology. Molecular neurobiology. vol 43. issue 2. 2011-10-14. PMID:21380933. |
recent evidence has also suggested that p73 isoforms are deregulated in neurodegenerative pathologies such as alzheimer's disease, with abnormal tau phosphorylation. |
2011-10-14 |
2023-08-12 |
mouse |
| Xia Jiang, Qing Tian, Yue Wang, Xin-Wen Zhou, Jia-Zhao Xie, Jian-Zhi Wang, Ling-Qiang Zh. Acetyl-L-carnitine ameliorates spatial memory deficits induced by inhibition of phosphoinositol-3 kinase and protein kinase C. Journal of neurochemistry. vol 118. issue 5. 2011-10-14. PMID:21689104. |
acetyl-l-carnitine ameliorates spatial memory deficits induced by inhibition of phosphoinositol-3 kinase and protein kinase c. glycogen synthase kinase-3β (gsk-3β) plays a crucial role in memory deficits and tau hyperphosphorylation as seen in alzheimer's disease, the most common dementia in the aged population. |
2011-10-14 |
2023-08-12 |
rat |
| Xia Jiang, Qing Tian, Yue Wang, Xin-Wen Zhou, Jia-Zhao Xie, Jian-Zhi Wang, Ling-Qiang Zh. Acetyl-L-carnitine ameliorates spatial memory deficits induced by inhibition of phosphoinositol-3 kinase and protein kinase C. Journal of neurochemistry. vol 118. issue 5. 2011-10-14. PMID:21689104. |
we also found that alcar arrested microtubule-associated protein tau hyperphosphorylation at multiple alzheimer's disease sites in vivo and in vitro. |
2011-10-14 |
2023-08-12 |
rat |
| Diego Sepulveda-Falla, Jakob Matschke, Christian Bernreuther, Christian Hagel, Berta Puig, Andres Villegas, Gloria Garcia, Julian Zea, Baltazar Gomez-Mancilla, Isidre Ferrer, Francisco Lopera, Markus Glatze. Deposition of hyperphosphorylated tau in cerebellum of PS1 E280A Alzheimer's disease. Brain pathology (Zurich, Switzerland). vol 21. issue 4. 2011-10-04. PMID:21159009. |
deposition of hyperphosphorylated tau in cerebellum of ps1 e280a alzheimer's disease. |
2011-10-04 |
2023-08-12 |
Not clear |
| Alessia Usardi, Amy M Pooler, Anjan Seereeram, C Hugh Reynolds, Pascal Derkinderen, Brian Anderton, Diane P Hanger, Wendy Noble, Ritchie Williamso. Tyrosine phosphorylation of tau regulates its interactions with Fyn SH2 domains, but not SH3 domains, altering the cellular localization of tau. The FEBS journal. vol 278. issue 16. 2011-10-03. PMID:21692989. |
recent reports have demonstrated that interactions between the microtubule-associated protein tau and the nonreceptor tyrosine kinase fyn play a critical role in mediating synaptic toxicity and neuronal loss in response to β-amyloid (aβ) in models of alzheimer's disease. |
2011-10-03 |
2023-08-12 |
Not clear |
| Aikaterini Rousaki, Yoshinari Miyata, Umesh K Jinwal, Chad A Dickey, Jason E Gestwicki, Erik R P Zuiderwe. Allosteric drugs: the interaction of antitumor compound MKT-077 with human Hsp70 chaperones. Journal of molecular biology. vol 411. issue 3. 2011-10-03. PMID:21708173. |
however, they also have the ability to inhibit tumor apoptosis and contribute to aberrant accumulation of hyperphosphorylated tau in neuronal cells affected by tauopathies, including alzheimer's disease. |
2011-10-03 |
2023-08-12 |
human |
| Donna M Barten, Gregory W Cadelina, Nina Hoque, Lynn B DeCarr, Valerie L Guss, Ling Yang, Sethu Sankaranarayanan, Paul D Wes, Marianne E Flynn, Jere E Meredith, Michael K Ahlijanian, Charles F Albrigh. Tau transgenic mice as models for cerebrospinal fluid tau biomarkers. Journal of Alzheimer's disease : JAD. vol 24 Suppl 2. 2011-09-30. PMID:21422517. |
levels of tau in cerebrospinal fluid (csf) are elevated in alzheimer's disease (ad) patients. |
2011-09-30 |
2023-08-12 |
mouse |
| Alexander V Shkumatov, Subashchandrabose Chinnathambi, Eckhard Mandelkow, Dmitri I Svergu. Structural memory of natively unfolded tau protein detected by small-angle X-ray scattering. Proteins. vol 79. issue 7. 2011-09-30. PMID:21560166. |
we present here a study of temperature induced transitions in tau, a natively unfolded protein involved in alzheimer's disease. |
2011-09-30 |
2023-08-12 |
Not clear |
| Cristina Lorenzi, Alessandra Marcone, Adele Pirovano, Elena Marino, Francesco Cordici, Chiara Cerami, Dario Delmonte, Stefano F Cappa, Placido Bramanti, Enrico Smerald. Serotonin transporter and saitohin genes in risk of Alzheimer's disease and frontotemporal lobar dementia: preliminary findings. Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology. vol 31. issue 6. 2011-09-28. PMID:20852909. |
serotonergic transmission impairment and abnormal phosphorylation of tau protein have been implicated in the physiopathology of alzheimer's disease (ad) and frontotemporal lobar dementia (ftld). |
2011-09-28 |
2023-08-12 |
human |
| Dee Shen, Jack Coleman, Eric Chan, Thomas P Nicholson, Lijun Dai, Paul W Sheppard, Wayne F Patto. Novel cell- and tissue-based assays for detecting misfolded and aggregated protein accumulation within aggresomes and inclusion bodies. Cell biochemistry and biophysics. vol 60. issue 3. 2011-09-28. PMID:21132543. |
with minor modification, the assay was also adapted to the analysis of frozen or formalin-fixed, paraffin-embedded tissue sections, with demonstration of co-localization of aggregated cargo with β-amyloid and tau proteins in brain tissue sections from alzheimer's disease patients. |
2011-09-28 |
2023-08-12 |
human |