All Relations between Alzheimer Disease and microtubule-associated protein tau

Publication Sentence Publish Date Extraction Date Species
Michelle T Fodero-Tavoletti, Nobuyuki Okamura, Shozo Furumoto, Rachel S Mulligan, Andrea R Connor, Catriona A McLean, Diana Cao, Angela Rigopoulos, Glenn A Cartwright, Graeme O'Keefe, Sylvia Gong, Paul A Adlard, Kevin J Barnham, Christopher C Rowe, Colin L Masters, Yukitsuka Kudo, Roberto Cappai, Kazuhiko Yanai, Victor L Villemagn. 18F-THK523: a novel in vivo tau imaging ligand for Alzheimer's disease. Brain : a journal of neurology. vol 134. issue Pt 4. 2011-07-01. PMID:21436112. autoradiographic and histofluorescence analysis of human hippocampal serial sections with alzheimer's disease exhibited positive thk523 binding that co-localized with immunoreactive tau pathology, but failed to highlight β-amyloid plaques. 2011-07-01 2023-08-12 mouse
Erkan Kiris, Donovan Ventimiglia, Mehmet E Sargin, Michelle R Gaylord, Alphan Altinok, Kenneth Rose, B S Manjunath, Mary Ann Jordan, Leslie Wilson, Stuart C Feinstei. Combinatorial Tau pseudophosphorylation: markedly different regulatory effects on microtubule assembly and dynamic instability than the sum of the individual parts. The Journal of biological chemistry. vol 286. issue 16. 2011-06-28. PMID:21288907. errors in tau action are associated with alzheimer disease and related dementias. 2011-06-28 2023-08-12 Not clear
Jianhua Shi, Wei Qian, Xiaomin Yin, Khalid Iqbal, Inge Grundke-Iqbal, Xiaosong Gu, Fei Ding, Cheng-Xin Gong, Fei Li. Cyclic AMP-dependent protein kinase regulates the alternative splicing of tau exon 10: a mechanism involved in tau pathology of Alzheimer disease. The Journal of biological chemistry. vol 286. issue 16. 2011-06-28. PMID:21367856. cyclic amp-dependent protein kinase regulates the alternative splicing of tau exon 10: a mechanism involved in tau pathology of alzheimer disease. 2011-06-28 2023-08-12 human
Jianhua Shi, Wei Qian, Xiaomin Yin, Khalid Iqbal, Inge Grundke-Iqbal, Xiaosong Gu, Fei Ding, Cheng-Xin Gong, Fei Li. Cyclic AMP-dependent protein kinase regulates the alternative splicing of tau exon 10: a mechanism involved in tau pathology of Alzheimer disease. The Journal of biological chemistry. vol 286. issue 16. 2011-06-28. PMID:21367856. hyperphosphorylation and deposition of tau into neurofibrillary tangles is a hallmark of alzheimer disease (ad). 2011-06-28 2023-08-12 human
James E Galvi. Dementia screening, biomarkers and protein misfolding: Implications for public health and diagnosis. Prion. vol 5. issue 1. 2011-06-21. PMID:21164279. for example creutzfeldt-jacob disease is associated with aggregation of prion protein, lewy body dementia and parkinson disease with α-synuclein and forms of frontotemporal dementia with tau, tdp 43 and host of other proteins, alzheimer disease (ad), the most common cause of dementia, and its prodromal syndrome mild cognitive impairment (mci) are an increasing public health problem and a diagnostic challenge to may clinicians. 2011-06-21 2023-08-12 Not clear
Sabine Ott, Andreas Wolfram Henkel, Maria Kerstin Henkel, Zoran B Redzic, Johannes Kornhuber, Jens Wiltfan. Pre-aggregated Aβ1-42 peptide increases tau aggregation and hyperphosphorylation after short-term application. Molecular and cellular biochemistry. vol 349. issue 1-2. 2011-06-20. PMID:21113648. neuritic amyloid plaques and neurofibrillary tangles, consisting of hyperphosphorylated tau protein, are the hallmarks of alzheimer disease. 2011-06-20 2023-08-12 Not clear
Sabine Ott, Andreas Wolfram Henkel, Maria Kerstin Henkel, Zoran B Redzic, Johannes Kornhuber, Jens Wiltfan. Pre-aggregated Aβ1-42 peptide increases tau aggregation and hyperphosphorylation after short-term application. Molecular and cellular biochemistry. vol 349. issue 1-2. 2011-06-20. PMID:21113648. taken together, these experiments suggest that pathological preaggregated aβ1-42 in physiological concentrations quickly induces hyperphosphorylation and pathological structural changes of tau protein and thereby directly linking the 'amyloid hypothesis' to tau pathology, observed in alzheimer disease. 2011-06-20 2023-08-12 Not clear
Ludovic Martin, Xenia Latypova, Faraj Terr. Post-translational modifications of tau protein: implications for Alzheimer's disease. Neurochemistry international. vol 58. issue 4. 2011-06-17. PMID:21215781. post-translational modifications of tau protein: implications for alzheimer's disease. 2011-06-17 2023-08-12 Not clear
Ludovic Martin, Xenia Latypova, Faraj Terr. Post-translational modifications of tau protein: implications for Alzheimer's disease. Neurochemistry international. vol 58. issue 4. 2011-06-17. PMID:21215781. alzheimer's disease (ad) belongs to a group of neurodegenerative diseases collectively designated as "tauopathies", because they are characterized by the aggregation of abnormally phosphorylated tau protein. 2011-06-17 2023-08-12 Not clear
Hyun Jung Jung, Seok Soon Park, Ji Oh Mok, Tae Kyeong Lee, Choon Sik Park, Sun Ah Par. Increased expression of three-repeat isoforms of tau contributes to tau pathology in a rat model of chronic type 2 diabetes. Experimental neurology. vol 228. issue 2. 2011-06-17. PMID:21281635. however, the role of altered 3r/4r tau ratio in alzheimer's disease (ad) remains controversial. 2011-06-17 2023-08-12 rat
Jing Zheng, Cong Liu, Michael R Sawaya, Balraju Vadla, Shafiullah Khan, R Jeremy Woods, David Eisenberg, Warren J Goux, James S Nowic. Macrocyclic β-sheet peptides that inhibit the aggregation of a tau-protein-derived hexapeptide. Journal of the American Chemical Society. vol 133. issue 9. 2011-06-17. PMID:21319744. the tau-derived peptide ac-vqivyk-nh(2) (acphf6) aggregates in solution through β-sheet interactions to form straight and twisted filaments similar to those formed by tau protein in alzheimer's neurofibrillary tangles. 2011-06-17 2023-08-12 Not clear
Suman Jayadev, David Nochlin, Parvoneh Poorkaj, Ellen J Steinbart, James A Mastrianni, Thomas J Montine, Bernardino Ghetti, Gerard D Schellenberg, Thomas D Bird, James B Leveren. Familial prion disease with Alzheimer disease-like tau pathology and clinical phenotype. Annals of neurology. vol 69. issue 4. 2011-06-17. PMID:21416485. familial prion disease with alzheimer disease-like tau pathology and clinical phenotype. 2011-06-17 2023-08-12 Not clear
Haruka Sudo, Peter W Baa. Strategies for diminishing katanin-based loss of microtubules in tauopathic neurodegenerative diseases. Human molecular genetics. vol 20. issue 4. 2011-06-14. PMID:21118899. it is commonly stated that microtubules gradually disintegrate as tau becomes dissociated from them in tauopathies such as alzheimer's disease. 2011-06-14 2023-08-12 rat
Andrea C Wilson, Brittany N Dugger, Dennis W Dickson, Deng-Shun Wan. TDP-43 in aging and Alzheimer's disease - a review. International journal of clinical and experimental pathology. vol 4. issue 2. 2011-06-14. PMID:21326809. while initially thought to be relatively specific to als and ftld-tdp, tdp-43 pathology has now been detected in a number of other neurodegenerative diseases, many associated with tau pathology, including guam parkinson dementia complex and alzheimer's disease (ad). 2011-06-14 2023-08-12 Not clear
D Ciavardelli, E Silvestri, A Del Viscovo, M Bomba, D De Gregorio, M Moreno, C Di Ilio, F Goglia, L M T Canzoniero, S L Sens. Alterations of brain and cerebellar proteomes linked to Aβ and tau pathology in a female triple-transgenic murine model of Alzheimer's disease. Cell death & disease. vol 1. 2011-06-14. PMID:21368863. alterations of brain and cerebellar proteomes linked to aβ and tau pathology in a female triple-transgenic murine model of alzheimer's disease. 2011-06-14 2023-08-12 mouse
D Ciavardelli, E Silvestri, A Del Viscovo, M Bomba, D De Gregorio, M Moreno, C Di Ilio, F Goglia, L M T Canzoniero, S L Sens. Alterations of brain and cerebellar proteomes linked to Aβ and tau pathology in a female triple-transgenic murine model of Alzheimer's disease. Cell death & disease. vol 1. 2011-06-14. PMID:21368863. the triple-transgenic alzheimer (3 × tg-ad) mouse expresses mutant ps1(m146v), app(swe), and tau(p301l) transgenes and progressively develops plaques and neurofibrillary tangles with a temporal- and region-specific profile that resembles the neuropathological progression of alzheimer's disease (ad). 2011-06-14 2023-08-12 mouse
Ming Cheng Liu, Firas Kobeissy, Wenrong Zheng, Zhiqun Zhang, Ronald L Hayes, Kevin K W Wan. Dual vulnerability of tau to calpains and caspase-3 proteolysis under neurotoxic and neurodegenerative conditions. ASN neuro. vol 3. issue 1. 2011-06-10. PMID:21359008. axonally specific microtubule-associated protein tau is an important component of neurofibrillary tangles found in ad (alzheimer's disease) and other tauopathy diseases such as cte (chronic traumatic encephalopathy). 2011-06-10 2023-08-12 rat
Andreas Haldenwanger, Paul Eling, Andreas Kastrup, Helmut Hildebrand. Correlation between cognitive impairment and CSF biomarkers in amnesic MCI, non-amnesic MCI, and Alzheimer's disease. Journal of Alzheimer's disease : JAD. vol 22. issue 3. 2011-06-09. PMID:20858947. decreased delayed recall, decreased amyloid-β peptides (aβ1-42), and increased tau protein concentration in cerebrospinal fluid (csf) are generally regarded to be valid neuropsychological and biological markers for alzheimer's disease (ad). 2011-06-09 2023-08-12 Not clear
Bruno Bulic, Marcus Pickhardt, Eva-Maria Mandelkow, Eckhard Mandelko. Tau protein and tau aggregation inhibitors. Neuropharmacology. vol 59. issue 4-5. 2011-06-07. PMID:20149808. alzheimer disease is characterized by pathological aggregation of two proteins, tau and abeta-amyloid, both of which are considered to be toxic to neurons. 2011-06-07 2023-08-12 Not clear
Rawan Tarawneh, David M Holtzma. Biomarkers in translational research of Alzheimer's disease. Neuropharmacology. vol 59. issue 4-5. 2011-06-07. PMID:20394760. the identification and characterization of amyloid-beta (abeta) and tau as the main pathological substrates of alzheimer's disease (ad) have driven many efforts in search for suitable biomarkers for ad. 2011-06-07 2023-08-12 Not clear