| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Hien T Tran, Frank M LaFerla, David M Holtzman, David L Brod. Controlled cortical impact traumatic brain injury in 3xTg-AD mice causes acute intra-axonal amyloid-β accumulation and independently accelerates the development of tau abnormalities. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 31. issue 26. 2011-09-13. PMID:21715616. |
alzheimer's disease (ad) is a neurodegenerative disorder characterized pathologically by progressive neuronal loss, extracellular plaques containing the amyloid-β (aβ) peptides, and neurofibrillary tangles composed of hyperphosphorylated tau proteins. |
2011-09-13 |
2023-08-12 |
mouse |
| Tara L Spires-Jones, Alix de Calignon, Melanie Meyer-Luehmann, Brian J Bacskai, Bradley T Hyma. Monitoring protein aggregation and toxicity in Alzheimer's disease mouse models using in vivo imaging. Methods (San Diego, Calif.). vol 53. issue 3. 2011-09-09. PMID:21163350. |
aggregation of amyloid beta peptide into senile plaques and hyperphosphorylated tau protein into neurofibrillary tangles in the brain are the pathological hallmarks of alzheimer's disease. |
2011-09-09 |
2023-08-12 |
mouse |
| Kristina R Patterson, Christine Remmers, Yifan Fu, Sarah Brooker, Nicholas M Kanaan, Laurel Vana, Sarah Ward, Juan F Reyes, Keith Philibert, Marc J Glucksman, Lester I Binde. Characterization of prefibrillar Tau oligomers in vitro and in Alzheimer disease. The Journal of biological chemistry. vol 286. issue 26. 2011-09-09. PMID:21550980. |
characterization of prefibrillar tau oligomers in vitro and in alzheimer disease. |
2011-09-09 |
2023-08-12 |
Not clear |
| Kristina R Patterson, Christine Remmers, Yifan Fu, Sarah Brooker, Nicholas M Kanaan, Laurel Vana, Sarah Ward, Juan F Reyes, Keith Philibert, Marc J Glucksman, Lester I Binde. Characterization of prefibrillar Tau oligomers in vitro and in Alzheimer disease. The Journal of biological chemistry. vol 286. issue 26. 2011-09-09. PMID:21550980. |
neurofibrillary tangles, composed of insoluble aggregates of the microtubule-associated protein tau, are a pathological hallmark of alzheimer disease (ad) and other tauopathies. |
2011-09-09 |
2023-08-12 |
Not clear |
| Nicholas M Kanaan, Gerardo A Morfini, Nichole E LaPointe, Gustavo F Pigino, Kristina R Patterson, Yuyu Song, Athena Andreadis, Yifan Fu, Scott T Brady, Lester I Binde. Pathogenic forms of tau inhibit kinesin-dependent axonal transport through a mechanism involving activation of axonal phosphotransferases. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 31. issue 27. 2011-09-09. PMID:21734277. |
aggregated filamentous forms of hyperphosphorylated tau (a microtubule-associated protein) represent pathological hallmarks of alzheimer's disease (ad) and other tauopathies. |
2011-09-09 |
2023-08-12 |
human |
| C Ballatore, K R Brunden, J Q Trojanowski, V M-Y Lee, A B Smith, D M Hury. Modulation of protein-protein interactions as a therapeutic strategy for the treatment of neurodegenerative tauopathies. Current topics in medicinal chemistry. vol 11. issue 3. 2011-09-08. PMID:21320060. |
the recognition that malfunction of the microtubule (mt) associated protein tau is likely to play a defining role in the onset and/or progression of a number of neurodegenerative diseases, including alzheimer's disease, has resulted in the initiation of drug discovery programs that target this protein. |
2011-09-08 |
2023-08-12 |
Not clear |
| Johannes Attems, Arne Ittner, Kurt Jellinger, Roger M Nitsch, Magdalena Maj, Ludwig Wagner, Jürgen Götz, Mathias Heikenwalde. Reduced secretagogin expression in the hippocampus of P301L tau transgenic mice. Journal of neural transmission (Vienna, Austria : 1996). vol 118. issue 5. 2011-09-08. PMID:21442354. |
neuropathological features in alzheimer's disease (ad) include the presence of hyperphosphorylated forms of the microtubule-associated tau protein (tau) in hippocampal neurones. |
2011-09-08 |
2023-08-12 |
mouse |
| Xiu-Qing Yao, Xiao-Xue Zhang, Yang-Yang Yin, Bin Liu, Dan-Ju Luo, Dan Liu, Ning-Ning Chen, Zhong-Fei Ni, Xiong Wang, Qun Wang, Jian-Zhi Wang, Gong-Ping Li. Glycogen synthase kinase-3β regulates Tyr307 phosphorylation of protein phosphatase-2A via protein tyrosine phosphatase 1B but not Src. The Biochemical journal. vol 437. issue 2. 2011-09-02. PMID:21554241. |
gsk-3β (glycogen synthase kinase-3β), a crucial tau kinase, negatively regulates pp2a (protein phosphatase 2a), the most active tau phosphatase that is suppressed in the brain in ad (alzheimer's disease). |
2011-09-02 |
2023-08-12 |
Not clear |
| Na Zhang, Jin-Tai Yu, Ying Yang, Jing Yang, Wei Zhang, Lan Ta. Association analysis of GSK3B and MAPT polymorphisms with Alzheimer's disease in Han Chinese. Brain research. vol 1391. 2011-08-30. PMID:21443865. |
aberrant phosphorylated tau is the major component of the neurofibrillary tangles in alzheimer's disease (ad) brains. |
2011-08-30 |
2023-08-12 |
human |
| Na Zhang, Jin-Tai Yu, Ying Yang, Jing Yang, Wei Zhang, Lan Ta. Association analysis of GSK3B and MAPT polymorphisms with Alzheimer's disease in Han Chinese. Brain research. vol 1391. 2011-08-30. PMID:21443865. |
to determine whether polymorphisms in the gsk3b gene and microtubule associated protein tau (mapt) gene underpin susceptibility to late-onset alzheimer's disease (load), we conducted a case-control study in a chinese cohort of 257 load cases and 326 healthy controls matched for sex and age. |
2011-08-30 |
2023-08-12 |
human |
| Matthew Phillips, Erik Boman, Hanna Osterman, David Willhite, Matthias Lask. Olfactory and visuospatial learning and memory performance in two strains of Alzheimer's disease model mice--a longitudinal study. PloS one. vol 6. issue 5. 2011-08-30. PMID:21573167. |
using a longitudinal study design, two strains of alzheimer's disease (ad) model mice, one expressing β-amyloid plaques and one expressing tau protein-associated neurofibrillary tangles were assessed for olfactory and visuospatial learning and memory and their performance compared to that of age-matched controls. |
2011-08-30 |
2023-08-12 |
mouse |
| J R Walto. Evidence for participation of aluminum in neurofibrillary tangle formation and growth in Alzheimer's disease. Journal of Alzheimer's disease : JAD. vol 22. issue 1. 2011-08-29. PMID:20847423. |
this study examines hippocampal ca1 cells from brains of aged humans, with and without alzheimer's disease, for hyperphosphorylated tau and aluminum during early neurofibrillary tangle (nft) formation and growth. |
2011-08-29 |
2023-08-12 |
Not clear |
| Juan F Reyes, Yifan Fu, Laurel Vana, Nicholas M Kanaan, Lester I Binde. Tyrosine nitration within the proline-rich region of Tau in Alzheimer's disease. The American journal of pathology. vol 178. issue 5. 2011-08-26. PMID:21514440. |
tyrosine nitration within the proline-rich region of tau in alzheimer's disease. |
2011-08-26 |
2023-08-12 |
human |
| D S Kern, K N Maclean, H Jiang, E Y Synder, J R Sladek, K B Bjugsta. Neural stem cells reduce hippocampal tau and reelin accumulation in aged Ts65Dn Down syndrome mice. Cell transplantation. vol 20. issue 3. 2011-08-23. PMID:20875225. |
tau accumulation, in the form of neurofibrillary tangles (nft), is an early neuropathological characteristic of alzheimer's disease (ad) and early onset ad frequently seen in down syndrome (ds). |
2011-08-23 |
2023-08-12 |
mouse |
| Stuart A Sievers, John Karanicolas, Howard W Chang, Anni Zhao, Lin Jiang, Onofrio Zirafi, Jason T Stevens, Jan Münch, David Baker, David Eisenber. Structure-based design of non-natural amino-acid inhibitors of amyloid fibril formation. Nature. vol 475. issue 7354. 2011-08-19. PMID:21677644. |
using known atomic structures of segments of amyloid fibrils as templates, we have designed and characterized an all-d-amino-acid inhibitor of the fibril formation of the tau protein associated with alzheimer's disease, and a non-natural l-amino-acid inhibitor of an amyloid fibril that enhances sexual transmission of human immunodeficiency virus. |
2011-08-19 |
2023-08-12 |
human |
| Yuan Tian, Victor Bustos, Marc Flajolet, Paul Greengar. A small-molecule enhancer of autophagy decreases levels of Abeta and APP-CTF via Atg5-dependent autophagy pathway. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 25. issue 6. 2011-08-18. PMID:21368103. |
the hallmarks of alzheimer's disease are the aggregates of amyloid-β (Αβ) peptide and tau protein. |
2011-08-18 |
2023-08-12 |
Not clear |
| Zhaoxu Zhang, Ruiping Zhao, Ying Tang, Shirong Wen, Desheng Wang, Jiping Q. Fuzhisan, a Chinese herbal medicine, inhibits beta-amyloid-induced neurotoxicity and tau phosphorylation through calpain/Cdk5 pathway in cultured cortical neurons. Neurochemical research. vol 36. issue 5. 2011-08-16. PMID:21243427. |
it has been shown that β-amyloid (aβ) induced hyperphosphorylation of tau is implicated in the pathogenesis of alzheimer's disease (ad), and deregulation of cyclin-dependent kinase 5 (cdk5) activity is involved in the abnormal tau phosphorylation. |
2011-08-16 |
2023-08-12 |
Not clear |
| Mazhar Malik, Michael D Fenko, Ashfaq M Sheikh, Guang Wen, Xiaohong L. A novel approach for characterization of cathepsin D protease and its effect on tau and β-amyloid proteins. Neurochemical research. vol 36. issue 5. 2011-08-16. PMID:21267651. |
both tau and app are involved in the pathogenesis of alzheimer's disease. |
2011-08-16 |
2023-08-12 |
Not clear |
| Anthony Daccache, Cedric Lion, Nathalie Sibille, Melanie Gerard, Christian Slomianny, Guy Lippens, Philippe Cotell. Oleuropein and derivatives from olives as Tau aggregation inhibitors. Neurochemistry international. vol 58. issue 6. 2011-08-16. PMID:21333710. |
in alzheimer's disease and related tauopathies, tau aggregation into fibrillary tangles contributes to intraneuronal and glial lesions. |
2011-08-16 |
2023-08-12 |
Not clear |
| Samuel S Ye. Proteasome degradation of brain cytosolic tau in Alzheimer's disease. International journal of clinical and experimental pathology. vol 4. issue 4. 2011-08-16. PMID:21577325. |
proteasome degradation of brain cytosolic tau in alzheimer's disease. |
2011-08-16 |
2023-08-12 |
human |