| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Valerio Leon. The effect of apolipoprotein E (ApoE) genotype on biomarkers of amyloidogenesis, tau pathology and neurodegeneration in Alzheimer's disease. Clinical chemistry and laboratory medicine. vol 49. issue 3. 2011-07-27. PMID:21388338. |
the effect of apolipoprotein e (apoe) genotype on biomarkers of amyloidogenesis, tau pathology and neurodegeneration in alzheimer's disease. |
2011-07-27 |
2023-08-12 |
Not clear |
| Henry Brodaty, Monique M B Breteler, Steven T Dekosky, Pascale Dorenlot, Laura Fratiglioni, Christoph Hock, Paul-Ariel Kenigsberg, Philip Scheltens, Bart De Stroope. The world of dementia beyond 2020. Journal of the American Geriatrics Society. vol 59. issue 5. 2011-07-26. PMID:21488846. |
counterpoised against dire projections of the tripling of the prevalence of dementia over the next 40 years are major developments in diagnostic biomarkers, neuroimaging, the molecular biology of alzheimer's disease (ad), epidemiology of risk and protective factors, and drug treatments-mainly targeting the amyloid pathway, tau protein, and immunotherapy-that may have the potential to modify the progression of ad. |
2011-07-26 |
2023-08-12 |
Not clear |
| José Luis Vázquez-Higuera, Ana Martínez-García, Pascual Sánchez-Juan, Eloy Rodríguez-Rodríguez, Ignacio Mateo, Ana Pozueta, Ana Frank, Fernando Valdivieso, José Berciano, María J Bullido, Onofre Combarro. Genetic variations in tau-tubulin kinase-1 are linked to Alzheimer's disease in a Spanish case-control cohort. Neurobiology of aging. vol 32. issue 3. 2011-07-19. PMID:20096481. |
neurofibrillary tangles, one of the characteristic neuropathological lesions found in alzheimer's disease (ad) brains, are composed of abnormally hyperphosphorylated tau protein. |
2011-07-19 |
2023-08-12 |
human |
| Tetsuo Fukushima, Asako Nakamura, Noboru Iwakami, Yasushi Nakada, Hiroshi Hattori, Satoru Hoki, Hidetoshi Yamaguchi, Masaya Nakagawa, Nobuo Terashima, Hirokazu Narit. T-817MA, a neuroprotective agent, attenuates the motor and cognitive impairments associated with neuronal degeneration in P301L tau transgenic mice. Biochemical and biophysical research communications. vol 407. issue 4. 2011-07-19. PMID:21439944. |
tau pathology is implicated in mechanisms of neurodegenerative tauopathies, including alzheimer's disease (ad) and hereditary frontotemporal dementia and parkinsonism linked to chromosome 17 (ftdp-17). |
2011-07-19 |
2023-08-12 |
mouse |
| Rakez Kaye. Anti-tau oligomers passive vaccination for the treatment of Alzheimer disease. Human vaccines. vol 6. issue 11. 2011-07-15. PMID:20980799. |
the aggregation and accumulation of the microtubule-associated protein (tau) is a pathological hallmark of alzheimer's disease (ad) and many neurodegenerative diseases. |
2011-07-15 |
2023-08-12 |
mouse |
| Ismael Santa-Maria, Félix Hernández, Joaquín Del Rio, Francisco J Moreno, Jesús Avil. Tramiprosate, a drug of potential interest for the treatment of Alzheimer's disease, promotes an abnormal aggregation of tau. Molecular neurodegeneration. vol 2. 2011-07-14. PMID:17822548. |
tramiprosate, a drug of potential interest for the treatment of alzheimer's disease, promotes an abnormal aggregation of tau. |
2011-07-14 |
2023-08-12 |
Not clear |
| Ismael Santa-Maria, Félix Hernández, Joaquín Del Rio, Francisco J Moreno, Jesús Avil. Tramiprosate, a drug of potential interest for the treatment of Alzheimer's disease, promotes an abnormal aggregation of tau. Molecular neurodegeneration. vol 2. 2011-07-14. PMID:17822548. |
alzheimer's disease (ad) is characterized by the presence of two histopathological hallmarks; the senile plaques, or extracellular deposits mainly composed of amyloid-beta peptide (abeta), and the neurofibrillary tangles, or intraneuronal inclusions composed of hyperphosphorylated tau protein.since abeta aggregates are found in the pathological cases, several strategies are under way to develop drugs that interact with abeta to reduce its assembly. |
2011-07-14 |
2023-08-12 |
Not clear |
| Yao Zhang, Qing Tian, Qi Zhang, Xinwen Zhou, Shijie Liu, Jian-Zhi Wan. Hyperphosphorylation of microtubule-associated tau protein plays dual role in neurodegeneration and neuroprotection. Pathophysiology : the official journal of the International Society for Pathophysiology. vol 16. issue 4. 2011-07-14. PMID:19410438. |
in the brain of alzheimer's disease (ad) patients, tau protein is abnormally hyperphosphorylated and thus become incompetent in promoting microtubule assemble and maintaining the stability of the microtubules. |
2011-07-14 |
2023-08-12 |
Not clear |
| Olivia Engmann, Karl Peter Gies. Crosstalk between Cdk5 and GSK3beta: Implications for Alzheimer's Disease. Frontiers in molecular neuroscience. vol 2. 2011-07-14. PMID:19521544. |
gsk3beta and cdk5 are the two kinases in the center of research on alzheimer's disease (ad), involved in the pathological symptoms of ad, abeta plaque formation, tau hyperphosphorylation and neurodegeneration. |
2011-07-14 |
2023-08-12 |
mouse |
| Kaj Blennow, Henrik Zetterber. Is it time for biomarker-based diagnostic criteria for prodromal Alzheimer's disease? Alzheimer's research & therapy. vol 2. issue 2. 2011-07-14. PMID:20441609. |
recent research advances have resulted in promising biomarkers, including cerebrospinal fluid analyses for tau and abeta, magnetic resonance imaging measurement of atrophy, and positron emission tomography imaging of glucose metabolism and abeta pathology, which allow identification of prodromal alzheimer's disease. |
2011-07-14 |
2023-08-12 |
Not clear |
| Daniela Serbinek, Celine Ullrich, Michael Pirchl, Tanja Hochstrasser, Rainald Schmidt-Kastner, Christian Humpe. S100b counteracts neurodegeneration of rat cholinergic neurons in brain slices after oxygen-glucose deprivation. Cardiovascular psychiatry and neurology. vol 2010. 2011-07-14. PMID:20508809. |
alzheimer's disease is a severe chronic neurodegenerative disorder characterized by beta-amyloid plaques, tau pathology, cerebrovascular damage, inflammation, reactive gliosis, and cell death of cholinergic neurons. |
2011-07-14 |
2023-08-12 |
rat |
| Lidia Blazquez-Llorca, Virginia Garcia-Marin, Javier Defelip. Pericellular innervation of neurons expressing abnormally hyperphosphorylated tau in the hippocampal formation of Alzheimer's disease patients. Frontiers in neuroanatomy. vol 4. 2011-07-14. PMID:20631843. |
pericellular innervation of neurons expressing abnormally hyperphosphorylated tau in the hippocampal formation of alzheimer's disease patients. |
2011-07-14 |
2023-08-12 |
Not clear |
| Mirko Bibl, Hermann Esselmann, Piotr Lewczuk, Claudia Trenkwalder, Markus Otto, Johannes Kornhuber, Jens Wiltfang, Brit Mollenhaue. Combined Analysis of CSF Tau, Aβ42, Aβ1-42% and Aβ1-40% in Alzheimer's Disease, Dementia with Lewy Bodies and Parkinson's Disease Dementia. International journal of Alzheimer's disease. vol 2010. 2011-07-14. PMID:20862375. |
combined analysis of csf tau, aβ42, aβ1-42% and aβ1-40% in alzheimer's disease, dementia with lewy bodies and parkinson's disease dementia. |
2011-07-14 |
2023-08-12 |
Not clear |
| Charlotte E Teunissen, Niek A Verwey, Maartje I Kester, Kees van Uffelen, Marinus A Blankenstei. Standardization of Assay Procedures for Analysis of the CSF Biomarkers Amyloid β((1-42)), Tau, and Phosphorylated Tau in Alzheimer's Disease: Report of an International Workshop. International journal of Alzheimer's disease. vol 2010. 2011-07-14. PMID:20936143. |
standardization of assay procedures for analysis of the csf biomarkers amyloid β((1-42)), tau, and phosphorylated tau in alzheimer's disease: report of an international workshop. |
2011-07-14 |
2023-08-12 |
Not clear |
| John C O'Leary, Qingyou Li, Paul Marinec, Laura J Blair, Erin E Congdon, Amelia G Johnson, Umesh K Jinwal, John Koren, Jeffrey R Jones, Clara Kraft, Melinda Peters, Jose F Abisambra, Karen E Duff, Edwin J Weeber, Jason E Gestwicki, Chad A Dicke. Phenothiazine-mediated rescue of cognition in tau transgenic mice requires neuroprotection and reduced soluble tau burden. Molecular neurodegeneration. vol 5. 2011-07-14. PMID:21040568. |
it has traditionally been thought that the pathological accumulation of tau in alzheimer's disease and other tauopathies facilitates neurodegeneration, which in turn leads to cognitive impairment. |
2011-07-14 |
2023-08-12 |
mouse |
| Timothy Me Scales, Pascal Derkinderen, Kit-Yi Leung, Helen L Byers, Malcolm A Ward, Caroline Price, Ian N Bird, Timothy Perera, Stuart Kellie, Ritchie Williamson, Brian H Anderton, C Hugh Reynold. Tyrosine phosphorylation of tau by the SRC family kinases lck and fyn. Molecular neurodegeneration. vol 6. 2011-07-14. PMID:21269457. |
tau protein is the principal component of the neurofibrillary tangles found in alzheimer's disease, where it is hyperphosphorylated on serine and threonine residues, and recently phosphotyrosine has been demonstrated. |
2011-07-14 |
2023-08-12 |
Not clear |
| Jing L Guo, Virginia M-Y Le. Seeding of normal Tau by pathological Tau conformers drives pathogenesis of Alzheimer-like tangles. The Journal of biological chemistry. vol 286. issue 17. 2011-07-14. PMID:21372138. |
neurofibrillary tangles (nfts) in alzheimer disease and related tauopathies are composed of insoluble hyperphosphorylated tau protein, but the mechanisms underlying the conversion of highly soluble tau into insoluble nfts remain elusive. |
2011-07-14 |
2023-08-12 |
Not clear |
| Kumar Sambamurti, K S Jagannatha Rao, Miguel A Pappoll. Frontiers in the pathogenesis of Alzheimer's disease. Indian journal of psychiatry. vol 51 Suppl 1. 2011-07-14. PMID:21416019. |
alzheimer's disease (ad) is characterized by progressive dementia and brain deposits of the amyloid β protein (aβ) as senile plaques and the microtubule-associated protein, tau, as neurofibrillary tangles (nft). |
2011-07-14 |
2023-08-12 |
mouse |
| Paul D Dinkel, Ayisha Siddiqua, Huy Huynh, Monil Shah, Martin Margitta. Variations in filament conformation dictate seeding barrier between three- and four-repeat tau. Biochemistry. vol 50. issue 20. 2011-07-14. PMID:21510682. |
tau filaments are the pathological hallmark of >20 neurodegenerative diseases including alzheimer's disease. |
2011-07-14 |
2023-08-12 |
Not clear |
| Christopher Medway, Hui Shi, James Bullock, Holly Black, Kristelle Brown, Baharak Vafadar-Isfahani, Balwir Matharoo-Ball, Graham Ball, Robert Rees, Noor Kalsheker, Kevin Morga. Using In silico LD clumping and meta-analysis of genome-wide datasets as a complementary tool to investigate and validate new candidate biomarkers in Alzheimer's disease. International journal of molecular epidemiology and genetics. vol 1. issue 2. 2011-07-14. PMID:21537386. |
genes encoding current alzheimer's biomarkers; app (aβ), mapt (tau) and apoe were also included. |
2011-07-14 |
2023-08-12 |
Not clear |