| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Marjelo A Mines, Eleonore Beurel, Richard S Jop. Regulation of cell survival mechanisms in Alzheimer's disease by glycogen synthase kinase-3. International journal of Alzheimer's disease. vol 2011. 2011-07-14. PMID:21629713. |
evidence for the involvement of gsk3 in alzheimer's disease pathology and neuronal loss comes from studies of gsk3 overexpression, gsk3 localization studies, multiple relationships between gsk3 and amyloid β-peptide (aβ), interactions between gsk3 and the microtubule-associated tau protein, and gsk3-mediated apoptotic cell death. |
2011-07-14 |
2023-08-12 |
Not clear |
| Jari Koistinaho, Tarja Malm, Gundars Goldstein. Glycogen synthase kinase-3β: a mediator of inflammation in Alzheimer's disease? International journal of Alzheimer's disease. vol 2011. 2011-07-14. PMID:21629736. |
glycogen synthase kinase-3β has been extensively investigated in connection to tau and amyloid β toxicity, whereas reports on the role of this enzyme in neuroinflammation in alzheimer's disease are negligible. |
2011-07-14 |
2023-08-12 |
Not clear |
| Herman Moreno, Soonwook Choi, Eunah Yu, Janaina Brusco, Jesus Avila, Jorge E Moreira, Mutsuyuki Sugimori, Rodolfo R Lliná. Blocking Effects of Human Tau on Squid Giant Synapse Transmission and Its Prevention by T-817 MA. Frontiers in synaptic neuroscience. vol 3. 2011-07-14. PMID:21629767. |
filamentous tau inclusions are hallmarks of alzheimer's disease and related neurodegenerative tauopathies, but the molecular mechanisms involved in tau-mediated changes in neuronal function and their possible effects on synaptic transmission are unknown. |
2011-07-14 |
2023-08-12 |
human |
| Cristian A Lasagna-Reeves, Diana L Castillo-Carranza, Urmi Sengupta, Audra L Clos, George R Jackson, Rakez Kaye. Tau oligomers impair memory and induce synaptic and mitochondrial dysfunction in wild-type mice. Molecular neurodegeneration. vol 6. 2011-07-14. PMID:21645391. |
the correlation between neurofibrillary tangles of tau and disease progression in the brains of alzheimer's disease (ad) patients remains an area of contention. |
2011-07-14 |
2023-08-12 |
mouse |
| Gurdeep Marwarha, Jaya Rp Prasanthi, Jared Schommer, Bhanu Dasari, Othman Ghrib. Molecular interplay between leptin, insulin-like growth factor-1, and β-amyloid in organotypic slices from rabbit hippocampus. Molecular neurodegeneration. vol 6. issue 1. 2011-07-14. PMID:21651786. |
evidence shows that the insulin-like growth factor-1 (igf-1) and leptin reduce β-amyloid (aβ) production and tau phosphorylation, two major hallmarks of alzheimer's disease (ad). |
2011-07-14 |
2023-08-12 |
rabbit |
| Mikio Shoj. Biomarkers of the dementia. International journal of Alzheimer's disease. vol 2011. 2011-07-14. PMID:21660205. |
csf aβ40, aβ42, total tau, and phosphorylated tau are the most sensitive biomarkers for diagnosis of alzheimer's disease (ad) and prediction of onset of ad from mild cognitive impairment (mci). |
2011-07-14 |
2023-08-12 |
Not clear |
| Peter Wostyn, Debby Van Dam, Kurt Audenaert, Peter Paul De Dey. Increased Cerebrospinal Fluid Production as a Possible Mechanism Underlying Caffeine's Protective Effect against Alzheimer's Disease. International journal of Alzheimer's disease. vol 2011. 2011-07-14. PMID:21660211. |
alzheimer's disease (ad), the most common type of dementia among older people, is characterized by the accumulation of β-amyloid (aβ) senile plaques and neurofibrillary tangles composed of hyperphosphorylated tau in the brain. |
2011-07-14 |
2023-08-12 |
human |
| Cristina Solé-Padullés, Albert Lladó, David Bartrés-Faz, Juan Fortea, Raquel Sánchez-Valle, Beatriz Bosch, Anna Antonell, José Luis Molinuevo, Lorena Ram. Association between cerebrospinal fluid tau and brain atrophy is not related to clinical severity in the Alzheimer's disease continuum. Psychiatry research. vol 192. issue 3. 2011-07-12. PMID:21546220. |
association between cerebrospinal fluid tau and brain atrophy is not related to clinical severity in the alzheimer's disease continuum. |
2011-07-12 |
2023-08-12 |
human |
| Brittany N Dugger, Michael Tu, Melissa E Murray, Dennis W Dickso. Disease specificity and pathologic progression of tau pathology in brainstem nuclei of Alzheimer's disease and progressive supranuclear palsy. Neuroscience letters. vol 491. issue 2. 2011-07-05. PMID:21236314. |
disease specificity and pathologic progression of tau pathology in brainstem nuclei of alzheimer's disease and progressive supranuclear palsy. |
2011-07-05 |
2023-08-12 |
Not clear |
| Brittany N Dugger, Michael Tu, Melissa E Murray, Dennis W Dickso. Disease specificity and pathologic progression of tau pathology in brainstem nuclei of Alzheimer's disease and progressive supranuclear palsy. Neuroscience letters. vol 491. issue 2. 2011-07-05. PMID:21236314. |
previous studies have shown tau pathology in the inferior colliculus (ic) and superior colliculus (sc) in alzheimer's disease (ad); however, it has not been compared to other tauopathies, such as progressive supranuclear palsy (psp), or characterized with respect to progression of tau pathology in ad. |
2011-07-05 |
2023-08-12 |
Not clear |
| Tibor Hortobágyi, Claire Troakes, Agnes L Nishimura, Caroline Vance, John C van Swieten, Harro Seelaar, Andrew King, Safa Al-Sarraj, Boris Rogelj, Christopher E Sha. Optineurin inclusions occur in a minority of TDP-43 positive ALS and FTLD-TDP cases and are rarely observed in other neurodegenerative disorders. Acta neuropathologica. vol 121. issue 4. 2011-07-01. PMID:21360076. |
optn-positive inclusions were identified in a few alzheimer's disease (ad) cases but did not co-localise with tau and tdp-43. |
2011-07-01 |
2023-08-12 |
Not clear |
| Ming Jin, Nina Shepardson, Ting Yang, Gang Chen, Dominic Walsh, Dennis J Selko. Soluble amyloid beta-protein dimers isolated from Alzheimer cortex directly induce Tau hyperphosphorylation and neuritic degeneration. Proceedings of the National Academy of Sciences of the United States of America. vol 108. issue 14. 2011-07-01. PMID:21421841. |
soluble amyloid beta-protein dimers isolated from alzheimer cortex directly induce tau hyperphosphorylation and neuritic degeneration. |
2011-07-01 |
2023-08-12 |
human |
| Michelle T Fodero-Tavoletti, Nobuyuki Okamura, Shozo Furumoto, Rachel S Mulligan, Andrea R Connor, Catriona A McLean, Diana Cao, Angela Rigopoulos, Glenn A Cartwright, Graeme O'Keefe, Sylvia Gong, Paul A Adlard, Kevin J Barnham, Christopher C Rowe, Colin L Masters, Yukitsuka Kudo, Roberto Cappai, Kazuhiko Yanai, Victor L Villemagn. 18F-THK523: a novel in vivo tau imaging ligand for Alzheimer's disease. Brain : a journal of neurology. vol 134. issue Pt 4. 2011-07-01. PMID:21436112. |
18f-thk523: a novel in vivo tau imaging ligand for alzheimer's disease. |
2011-07-01 |
2023-08-12 |
mouse |
| Michelle T Fodero-Tavoletti, Nobuyuki Okamura, Shozo Furumoto, Rachel S Mulligan, Andrea R Connor, Catriona A McLean, Diana Cao, Angela Rigopoulos, Glenn A Cartwright, Graeme O'Keefe, Sylvia Gong, Paul A Adlard, Kevin J Barnham, Christopher C Rowe, Colin L Masters, Yukitsuka Kudo, Roberto Cappai, Kazuhiko Yanai, Victor L Villemagn. 18F-THK523: a novel in vivo tau imaging ligand for Alzheimer's disease. Brain : a journal of neurology. vol 134. issue Pt 4. 2011-07-01. PMID:21436112. |
while considerable effort has focused on developing positron emission tomography β-amyloid imaging radiotracers for the early diagnosis of alzheimer's disease, no radiotracer is available for the non-invasive quantification of tau. |
2011-07-01 |
2023-08-12 |
mouse |
| Michelle T Fodero-Tavoletti, Nobuyuki Okamura, Shozo Furumoto, Rachel S Mulligan, Andrea R Connor, Catriona A McLean, Diana Cao, Angela Rigopoulos, Glenn A Cartwright, Graeme O'Keefe, Sylvia Gong, Paul A Adlard, Kevin J Barnham, Christopher C Rowe, Colin L Masters, Yukitsuka Kudo, Roberto Cappai, Kazuhiko Yanai, Victor L Villemagn. 18F-THK523: a novel in vivo tau imaging ligand for Alzheimer's disease. Brain : a journal of neurology. vol 134. issue Pt 4. 2011-07-01. PMID:21436112. |
autoradiographic and histofluorescence analysis of human hippocampal serial sections with alzheimer's disease exhibited positive thk523 binding that co-localized with immunoreactive tau pathology, but failed to highlight β-amyloid plaques. |
2011-07-01 |
2023-08-12 |
mouse |
| Erkan Kiris, Donovan Ventimiglia, Mehmet E Sargin, Michelle R Gaylord, Alphan Altinok, Kenneth Rose, B S Manjunath, Mary Ann Jordan, Leslie Wilson, Stuart C Feinstei. Combinatorial Tau pseudophosphorylation: markedly different regulatory effects on microtubule assembly and dynamic instability than the sum of the individual parts. The Journal of biological chemistry. vol 286. issue 16. 2011-06-28. PMID:21288907. |
errors in tau action are associated with alzheimer disease and related dementias. |
2011-06-28 |
2023-08-12 |
Not clear |
| Jianhua Shi, Wei Qian, Xiaomin Yin, Khalid Iqbal, Inge Grundke-Iqbal, Xiaosong Gu, Fei Ding, Cheng-Xin Gong, Fei Li. Cyclic AMP-dependent protein kinase regulates the alternative splicing of tau exon 10: a mechanism involved in tau pathology of Alzheimer disease. The Journal of biological chemistry. vol 286. issue 16. 2011-06-28. PMID:21367856. |
cyclic amp-dependent protein kinase regulates the alternative splicing of tau exon 10: a mechanism involved in tau pathology of alzheimer disease. |
2011-06-28 |
2023-08-12 |
human |
| Jianhua Shi, Wei Qian, Xiaomin Yin, Khalid Iqbal, Inge Grundke-Iqbal, Xiaosong Gu, Fei Ding, Cheng-Xin Gong, Fei Li. Cyclic AMP-dependent protein kinase regulates the alternative splicing of tau exon 10: a mechanism involved in tau pathology of Alzheimer disease. The Journal of biological chemistry. vol 286. issue 16. 2011-06-28. PMID:21367856. |
hyperphosphorylation and deposition of tau into neurofibrillary tangles is a hallmark of alzheimer disease (ad). |
2011-06-28 |
2023-08-12 |
human |
| James E Galvi. Dementia screening, biomarkers and protein misfolding: Implications for public health and diagnosis. Prion. vol 5. issue 1. 2011-06-21. PMID:21164279. |
for example creutzfeldt-jacob disease is associated with aggregation of prion protein, lewy body dementia and parkinson disease with α-synuclein and forms of frontotemporal dementia with tau, tdp 43 and host of other proteins, alzheimer disease (ad), the most common cause of dementia, and its prodromal syndrome mild cognitive impairment (mci) are an increasing public health problem and a diagnostic challenge to may clinicians. |
2011-06-21 |
2023-08-12 |
Not clear |
| Sabine Ott, Andreas Wolfram Henkel, Maria Kerstin Henkel, Zoran B Redzic, Johannes Kornhuber, Jens Wiltfan. Pre-aggregated Aβ1-42 peptide increases tau aggregation and hyperphosphorylation after short-term application. Molecular and cellular biochemistry. vol 349. issue 1-2. 2011-06-20. PMID:21113648. |
neuritic amyloid plaques and neurofibrillary tangles, consisting of hyperphosphorylated tau protein, are the hallmarks of alzheimer disease. |
2011-06-20 |
2023-08-12 |
Not clear |