| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jun Maeda, Ming-Rong Zhang, Takashi Okauchi, Bin Ji, Maiko Ono, Satoko Hattori, Katsushi Kumata, Nobuhisa Iwata, Takaomi C Saido, John Q Trojanowski, Virginia M-Y Lee, Matthias Staufenbiel, Takami Tomiyama, Hiroshi Mori, Toshimitsu Fukumura, Tetsuya Suhara, Makoto Higuch. In vivo positron emission tomographic imaging of glial responses to amyloid-beta and tau pathologies in mouse models of Alzheimer's disease and related disorders. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 31. issue 12. 2011-05-27. PMID:21430171. |
core pathologies of alzheimer's disease (ad) are aggregated amyloid-β peptides (aβ) and tau, and the latter is also characteristic of diverse neurodegenerative tauopathies. |
2011-05-27 |
2023-08-12 |
mouse |
| Xuesong Chen, John F Wagener, Daniel H Morgan, Liang Hui, Othman Ghribi, Jonathan D Geige. Endolysosome mechanisms associated with Alzheimer's disease-like pathology in rabbits ingesting cholesterol-enriched diet. Journal of Alzheimer's disease : JAD. vol 22. issue 4. 2011-05-25. PMID:20930277. |
alzheimer's disease (ad) is characterized clinically by progressive disturbances in memory, judgment, reasoning, and olfaction, and pathologically by loss of synaptic integrity, extracellular accumulations of amyloid-β (aβ) containing plaques, and intraneuronal tangles composed of hyperphosphorylated tau. |
2011-05-25 |
2023-08-12 |
Not clear |
| Davide Chiasserini, Lucilla Parnetti, Ulf Andreasson, Henrik Zetterberg, David Giannandrea, Paolo Calabresi, Kaj Blenno. CSF levels of heart fatty acid binding protein are altered during early phases of Alzheimer's disease. Journal of Alzheimer's disease : JAD. vol 22. issue 4. 2011-05-25. PMID:20930282. |
to evaluate the value of this protein as an early marker of alzheimer's disease (ad), we analyzed hfabp level and the classical biomarkers amyloid-β (aβ)1-42, total tau (t-tau), and phosphorylated tau (p-tau) in cerebrospinal fluid (csf) of patients with mild cognitive impairment (mci) followed up for four years (n=41), ad (n=32), and subjects with other neurological diseases without dementia (ond, n=25). |
2011-05-25 |
2023-08-12 |
human |
| Shufen Chen, Kirk Townsend, Terry E Goldberg, Peter Davies, Concepcion Conejero-Goldber. MAPT isoforms: differential transcriptional profiles related to 3R and 4R splice variants. Journal of Alzheimer's disease : JAD. vol 22. issue 4. 2011-05-25. PMID:20930284. |
tau aggregation in neurofibrillary tangles is a pathological hallmark in tauopathies including alzheimer's disease (ad). |
2011-05-25 |
2023-08-12 |
human |
| Lluís Samaranch, Sebastián Cervantes, Ana Barabash, Alvaro Alonso, José Antonio Cabranes, Isabel Lamet, Inés Ancín, Elena Lorenzo, Pablo Martínez-Lage, Alberto Marcos, Jordi Clarimón, Daniel Alcolea, Alberto Lleó, Rafael Blesa, Teresa Gómez-Isla, Pau Pasto. The effect of MAPT H1 and APOE ε4 on transition from mild cognitive impairment to dementia. Journal of Alzheimer's disease : JAD. vol 22. issue 4. 2011-05-25. PMID:20930301. |
microtubule-associated protein tau (mapt) and apolipoprotein e (apoe) are involved in the pathogenic mechanisms of alzheimer's disease (ad). |
2011-05-25 |
2023-08-12 |
human |
| Kunie Ando, Karelle Leroy, Céline Héraud, Zehra Yilmaz, Michèle Authelet, Valèrie Suain, Robert De Decker, Jean-Pierre Brio. Accelerated human mutant tau aggregation by knocking out murine tau in a transgenic mouse model. The American journal of pathology. vol 178. issue 2. 2011-05-23. PMID:21281813. |
the tg30 line is a tau transgenic mouse model overexpressing human 1n4r double-mutant tau (p301s and g272v) that develops alzheimer's disease-like neurofibrillary tangles in an age-dependent manner. |
2011-05-23 |
2023-08-12 |
mouse |
| Mirko Bibl, Brit Mollenhauer, Piotr Lewczuk, Hermann Esselmann, Stefanie Wolf, Markus Otto, Johannes Kornhuber, Eckart Rüther, Jens Wiltfan. Cerebrospinal fluid tau, p-tau 181 and amyloid-β38/40/42 in frontotemporal dementias and primary progressive aphasias. Dementia and geriatric cognitive disorders. vol 31. issue 1. 2011-05-19. PMID:21135556. |
we determined cerebrospinal fluid (csf) concentrations of amyloid-β (aβ)(1-38), aβ(1-40), aβ(1-42), total tau and phospho-tau (p-tau) in order to study their differential expression in frontotemporal dementia (ftd, n = 25) and primary progressive aphasia (ppa, n = 12) as compared to alzheimer's dementia (ad, n = 25) and nondemented controls (n = 20). |
2011-05-19 |
2023-08-12 |
Not clear |
| Jürgen Götz, Lars M Ittner, Nicole Schonrock, Roberto Cappa. An update on the toxicity of Abeta in Alzheimer's disease. Neuropsychiatric disease and treatment. vol 4. issue 6. 2011-05-18. PMID:19337449. |
alzheimer's disease is characterized histopathologically by deposition of insoluble forms of the peptide abeta and the protein tau in brain. |
2011-05-18 |
2023-08-12 |
Not clear |
| Aoife Hunt, Peter Schönknecht, Markus Henze, Pablo Toro, Uwe Haberkorn, Johannes Schröde. CSF tau protein and FDG PET in patients with aging-associated cognitive decline and Alzheimer's disease. Neuropsychiatric disease and treatment. vol 2. issue 2. 2011-05-17. PMID:19412465. |
csf tau protein and fdg pet in patients with aging-associated cognitive decline and alzheimer's disease. |
2011-05-17 |
2023-08-12 |
Not clear |
| Aoife Hunt, Peter Schönknecht, Markus Henze, Pablo Toro, Uwe Haberkorn, Johannes Schröde. CSF tau protein and FDG PET in patients with aging-associated cognitive decline and Alzheimer's disease. Neuropsychiatric disease and treatment. vol 2. issue 2. 2011-05-17. PMID:19412465. |
in alzheimer's disease (ad), accelerated neurofibrillary tangle formation occurs which is associated with increased tau protein release into the cerebrospinal fluid (csf). |
2011-05-17 |
2023-08-12 |
Not clear |
| Kazunori Saeki, Mayumi Machida, Yutaro Kinoshita, Ryoko Takasawa, Sei-ichi Tanum. Glycogen synthase kinase-3β2 has lower phosphorylation activity to tau than glycogen synthase kinase-3β1. Biological & pharmaceutical bulletin. vol 34. issue 1. 2011-05-16. PMID:21212533. |
glycogen synthase kinase-3β (gsk-3β) is a serine/threonine kinase that phosphorylate protein substrates involved in alzheimer's disease (ad), such as microtubule-associated protein tau and amyloid precursor protein (app). |
2011-05-16 |
2023-08-12 |
Not clear |
| Carola Romberg, Mark P Mattson, Mohamed R Mughal, Timothy J Bussey, Lisa M Saksid. Impaired attention in the 3xTgAD mouse model of Alzheimer's disease: rescue by donepezil (Aricept). The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 31. issue 9. 2011-05-13. PMID:21368062. |
several mouse models of alzheimer's disease (ad) with abundant β-amyloid and/or aberrantly phosphorylated tau develop memory impairments. |
2011-05-13 |
2023-08-12 |
mouse |
| Péter Z Almos, Szatmár Horváth, Agnes Czibula, István Raskó, Nóra Domján, Anna Juhász, Zoltán Janka, János Kálmá. Tau haplotypes and ApoE4 do not act in synergy on Alzheimer's disease. Psychiatry research. vol 186. issue 2-3. 2011-05-12. PMID:20837363. |
tau haplotypes and apoe4 do not act in synergy on alzheimer's disease. |
2011-05-12 |
2023-08-12 |
Not clear |
| Eva Kickstein, Sybille Krauss, Paul Thornhill, Désirée Rutschow, Raphael Zeller, John Sharkey, Ritchie Williamson, Melanie Fuchs, Andrea Köhler, Hartmut Glossmann, Rainer Schneider, Calum Sutherland, Susann Schweige. Biguanide metformin acts on tau phosphorylation via mTOR/protein phosphatase 2A (PP2A) signaling. Proceedings of the National Academy of Sciences of the United States of America. vol 107. issue 50. 2011-05-12. PMID:21098287. |
hyperphosphorylated tau plays an important role in the formation of neurofibrillary tangles in brains of patients with alzheimer's disease (ad) and related tauopathies and is a crucial factor in the pathogenesis of these disorders. |
2011-05-12 |
2023-08-12 |
mouse |
| Yea-Hyun Leem, Young-Ik Lee, Hee-Jeong Son, Sang-Ho Le. Chronic exercise ameliorates the neuroinflammation in mice carrying NSE/htau23. Biochemical and biophysical research communications. vol 406. issue 3. 2011-05-12. PMID:21329662. |
these findings suggest that chronic endurance exercise may alleviate neuroinflammation in the tau pathology of alzheimer's disease. |
2011-05-12 |
2023-08-12 |
mouse |
| James L Hickey, Peter J Crouch, Sithorn Mey, Aphrodite Caragounis, Jonathan M White, Anthony R White, Paul S Donnell. Copper(II) complexes of hybrid hydroxyquinoline-thiosemicarbazone ligands: GSK3β inhibition due to intracellular delivery of copper. Dalton transactions (Cambridge, England : 2003). vol 40. issue 6. 2011-05-10. PMID:21173986. |
cognitive decline associated with alzheimer's disease appears to be related to the hyper-phosphorylation of the protein tau as a consequence of increased activity of glycogen synthase kinase 3β (gsk3β), and subsequent formation of neurotoxic neurofibrillary tangles. |
2011-05-10 |
2023-08-12 |
Not clear |
| Paula van Tijn, Willem Kamphuis, Michael W Marlatt, Elly M Hol, Paul J Lucasse. Presenilin mouse and zebrafish models for dementia: focus on neurogenesis. Progress in neurobiology. vol 93. issue 2. 2011-05-06. PMID:21056616. |
autosomal dominant mutations in the presenilin gene psen cause familial alzheimer's disease (ad), a neurological disorder pathologically characterized by intraneuronal accumulation and extracellular deposition of amyloid-β in plaques and intraneuronal, hyperphosphorylated tau aggregation in neurofibrillary tangles. |
2011-05-06 |
2023-08-12 |
mouse |
| Antero Salminen, Johanna Ojala, Kai Kaarniranta, Mikko Hiltunen, Hilkka Soinine. Hsp90 regulates tau pathology through co-chaperone complexes in Alzheimer's disease. Progress in neurobiology. vol 93. issue 1. 2011-05-06. PMID:21056617. |
hsp90 regulates tau pathology through co-chaperone complexes in alzheimer's disease. |
2011-05-06 |
2023-08-12 |
Not clear |
| Antero Salminen, Johanna Ojala, Kai Kaarniranta, Mikko Hiltunen, Hilkka Soinine. Hsp90 regulates tau pathology through co-chaperone complexes in Alzheimer's disease. Progress in neurobiology. vol 93. issue 1. 2011-05-06. PMID:21056617. |
alzheimer's disease is a tauopathy which involves the deposition of microtubule-associated tau proteins into neurofibrillary tangles. |
2011-05-06 |
2023-08-12 |
Not clear |
| Antero Salminen, Johanna Ojala, Kai Kaarniranta, Mikko Hiltunen, Hilkka Soinine. Hsp90 regulates tau pathology through co-chaperone complexes in Alzheimer's disease. Progress in neurobiology. vol 93. issue 1. 2011-05-06. PMID:21056617. |
we will review the role of hsp90 chaperone network in the regulation of tau biology and pathology in alzheimer's disease. |
2011-05-06 |
2023-08-12 |
Not clear |