| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Zhaoxu Zhang, Ruiping Zhao, Jiping Qi, Shirong Wen, Ying Tang, Desheng Wan. Inhibition of glycogen synthase kinase-3β by Angelica sinensis extract decreases β-amyloid-induced neurotoxicity and tau phosphorylation in cultured cortical neurons. Journal of neuroscience research. vol 89. issue 3. 2011-05-03. PMID:21259330. |
recently, tau hyperphosphorylation by glycogen synthase kinase-3β (gsk-3β) activation has been emphasized as one of the pathogenic mechanisms of alzheimer's disease (ad). |
2011-05-03 |
2023-08-12 |
Not clear |
| Wanjoo Chun, Geoffrey S Waldo, Gail V W Johnso. Split GFP complementation assay for quantitative measurement of tau aggregation in situ. Methods in molecular biology (Clifton, N.J.). vol 670. 2011-05-02. PMID:20967587. |
a primary pathological hallmark of alzheimer disease brain is the presence of neurofibrillary tangles, which are highly aggregated and insoluble accumulations of the microtubule-associated protein tau. |
2011-05-02 |
2023-08-12 |
Not clear |
| Dewen Yang, Zhiyong Xie, Diane Stephenson, Daniel Morton, Carol D Hicks, Tracy M Brown, Renuka Sriram, Sharon O'Neill, David Raunig, Thomas Boca. Volumetric MRI and MRS provide sensitive measures of Alzheimer's disease neuropathology in inducible Tau transgenic mice (rTg4510). NeuroImage. vol 54. issue 4. 2011-05-02. PMID:21035554. |
volumetric mri and mrs provide sensitive measures of alzheimer's disease neuropathology in inducible tau transgenic mice (rtg4510). |
2011-05-02 |
2023-08-12 |
mouse |
| Dewen Yang, Zhiyong Xie, Diane Stephenson, Daniel Morton, Carol D Hicks, Tracy M Brown, Renuka Sriram, Sharon O'Neill, David Raunig, Thomas Boca. Volumetric MRI and MRS provide sensitive measures of Alzheimer's disease neuropathology in inducible Tau transgenic mice (rTg4510). NeuroImage. vol 54. issue 4. 2011-05-02. PMID:21035554. |
the purpose of this study was to determine if in vivo high resolution 3d mri and localized (1)h mr spectroscopy (mrs) can detect brain findings resembling alzheimer's disease in a transgenic mouse model of tau pathology. |
2011-05-02 |
2023-08-12 |
mouse |
| Michael S Wolf. Alzheimer's Disease Drug Discovery--11th International Conference--Targeting Pathological Tau. 27-28 September 2010, Jersey City, NJ, USA. IDrugs : the investigational drugs journal. vol 13. issue 12. 2011-05-02. PMID:21154135. |
alzheimer's disease drug discovery--11th international conference--targeting pathological tau. |
2011-05-02 |
2023-08-12 |
Not clear |
| Michael S Wolf. Alzheimer's Disease Drug Discovery--11th International Conference--Targeting Pathological Tau. 27-28 September 2010, Jersey City, NJ, USA. IDrugs : the investigational drugs journal. vol 13. issue 12. 2011-05-02. PMID:21154135. |
this conference report highlights selected presentations on targeting pathological tau for the prevention or treatment of alzheimer's disease. |
2011-05-02 |
2023-08-12 |
Not clear |
| Lian-Feng Lin, Huan-Min Lu. Screening of treatment targets for Alzheimer's disease from the molecular mechanisms of impairment by β-amyloid aggregation and tau hyperphosphorylation. Neuroscience bulletin. vol 27. issue 1. 2011-05-02. PMID:21270904. |
screening of treatment targets for alzheimer's disease from the molecular mechanisms of impairment by β-amyloid aggregation and tau hyperphosphorylation. |
2011-05-02 |
2023-08-12 |
Not clear |
| Lian-Feng Lin, Huan-Min Lu. Screening of treatment targets for Alzheimer's disease from the molecular mechanisms of impairment by β-amyloid aggregation and tau hyperphosphorylation. Neuroscience bulletin. vol 27. issue 1. 2011-05-02. PMID:21270904. |
β-amyloid (aβ) over-expression and tau hyperphosphorylation are considered to be the central events in the pathogenesis of alzheimer's disease (ad). |
2011-05-02 |
2023-08-12 |
Not clear |
| Xiao-Ping Hong, Cai-Xia Peng, Wei Wei, Qing Tian, Ying-Hua Liu, Fu-Yuan Cao, Qun Wang, Jian-Zhi Wan. Relationship of adult neurogenesis with tau phosphorylation and GSK-3β activity in subventricular zone. Neurochemical research. vol 36. issue 2. 2011-04-29. PMID:21061060. |
altered neurogenesis has been reported in alzheimer disease (ad), the most common neurodegenerative disorder characterized with hyperphosphorylated tau and accumulation of β-amyloid (aβ). |
2011-04-29 |
2023-08-12 |
mouse |
| Anindita Bose, François Mouton-Liger, Claire Paquet, Pierre Mazot, Marc Vigny, Françoise Gray, Jacques Hugo. Modulation of tau phosphorylation by the kinase PKR: implications in Alzheimer's disease. Brain pathology (Zurich, Switzerland). vol 21. issue 2. 2011-04-28. PMID:21029237. |
modulation of tau phosphorylation by the kinase pkr: implications in alzheimer's disease. |
2011-04-28 |
2023-08-12 |
Not clear |
| Tobias Bittner, Martin Fuhrmann, Steffen Burgold, Simon M Ochs, Nadine Hoffmann, Gerda Mitteregger, Hans Kretzschmar, Frank M LaFerla, Jochen Herm. Multiple events lead to dendritic spine loss in triple transgenic Alzheimer's disease mice. PloS one. vol 5. issue 11. 2011-04-27. PMID:21103384. |
the pathology of alzheimer's disease (ad) is characterized by the accumulation of amyloid-β (aβ) peptide, hyperphosphorylated tau protein, neuronal death, and synaptic loss. |
2011-04-27 |
2023-08-12 |
mouse |
| Claire Thornton, Nicola J Bright, Magdalena Sastre, Phillip J Muckett, David Carlin. AMP-activated protein kinase (AMPK) is a tau kinase, activated in response to amyloid β-peptide exposure. The Biochemical journal. vol 434. issue 3. 2011-04-25. PMID:21204788. |
hyperphosphorylation of tau is a hallmark of alzheimer's disease and other tauopathies. |
2011-04-25 |
2023-08-12 |
mouse |
| Anne Gauthier-Kemper, Carina Weissmann, Nataliya Golovyashkina, Zsofia Sebö-Lemke, Gerard Drewes, Volker Gerke, Jürgen J Heinisch, Roland Brand. The frontotemporal dementia mutation R406W blocks tau's interaction with the membrane in an annexin A2-dependent manner. The Journal of cell biology. vol 192. issue 4. 2011-04-25. PMID:21339331. |
changes of the microtubule-associated protein tau are central in alzheimer's disease (ad) and frontotemporal dementia with parkinsonism linked to chromosome 17 (ftdp-17). |
2011-04-25 |
2023-08-12 |
Not clear |
| Anders M Fjell, Kristine B Walhovd, Christine Fennema-Notestine, Linda K McEvoy, Donald J Hagler, Dominic Holland, Kaj Blennow, James B Brewer, Anders M Dal. Brain atrophy in healthy aging is related to CSF levels of Aβ1-42. Cerebral cortex (New York, N.Y. : 1991). vol 20. issue 9. 2011-04-21. PMID:20051356. |
reduced levels of beta-amyloid(1-42) (abeta1-42) and increased levels of tau proteins in the cerebrospinal fluid (csf) are found in alzheimer's disease (ad), likely reflecting abeta deposition in plaques and neuronal and axonal damage. |
2011-04-21 |
2023-08-12 |
Not clear |
| Xi Li, Ying Liu, Xin Zhang, Haifeng Yuan, Qiankun Qua. [Effect of ginsenoside Rg1 on expressions of phosphory protein tau and N-methyl-D-aspartate receptor subunits NR1 and NR2B in rat brain slice model of Alzheimer's disease]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 35. issue 24. 2011-04-12. PMID:21438403. |
[effect of ginsenoside rg1 on expressions of phosphory protein tau and n-methyl-d-aspartate receptor subunits nr1 and nr2b in rat brain slice model of alzheimer's disease]. |
2011-04-12 |
2023-08-12 |
rat |
| Xi Li, Ying Liu, Xin Zhang, Haifeng Yuan, Qiankun Qua. [Effect of ginsenoside Rg1 on expressions of phosphory protein tau and N-methyl-D-aspartate receptor subunits NR1 and NR2B in rat brain slice model of Alzheimer's disease]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 35. issue 24. 2011-04-12. PMID:21438403. |
to investigate the effect of ginsenoside rg1 on the expressions of phosphory protein tau (p-tau), n-methyl-d-aspartate receptor subunit 1 (nr1) and n-methyl-d-aspartate receptor subunit 2b(nr2b) in rat brain slice model of alzheimer's disease. |
2011-04-12 |
2023-08-12 |
rat |
| Mei Ning, Zhou Zhang, Zhuo Chen, Teng Zhao, Di Zhang, Daizhan Zhou, Weidong Li, Yun Liu, Yifeng Yang, Sheng Li, Lin H. Genetic evidence that vascular dementia is related to Alzheimer's disease: genetic association between tau polymorphism and vascular dementia in the Chinese population. Age and ageing. vol 40. issue 1. 2011-04-11. PMID:21044986. |
genetic evidence that vascular dementia is related to alzheimer's disease: genetic association between tau polymorphism and vascular dementia in the chinese population. |
2011-04-11 |
2023-08-12 |
Not clear |
| Jane A Driver, Kun Ping L. Pin1: a new genetic link between Alzheimer's disease, cancer and aging. Current aging science. vol 3. issue 3. 2011-04-08. PMID:20735350. |
the loss of active pin1 leads to the accumulation of abnormal tau and the overproduction of β-amyloid, the cardinal features of alzheimer's disease. |
2011-04-08 |
2023-08-12 |
mouse |
| Olivia A Shipton, Julie R Leitz, Jenny Dworzak, Christine E J Acton, Elizabeth M Tunbridge, Franziska Denk, Hana N Dawson, Michael P Vitek, Richard Wade-Martins, Ole Paulsen, Mariana Vargas-Caballer. Tau protein is required for amyloid {beta}-induced impairment of hippocampal long-term potentiation. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 31. issue 5. 2011-04-01. PMID:21289177. |
amyloid β (aβ) and tau protein are both implicated in memory impairment, mild cognitive impairment (mci), and early alzheimer's disease (ad), but whether and how they interact is unknown. |
2011-04-01 |
2023-08-12 |
mouse |
| Astrid Sydow, Ann Van der Jeugd, Fang Zheng, Tariq Ahmed, Detlef Balschun, Olga Petrova, Dagmar Drexler, Lepu Zhou, Gabriele Rune, Eckhard Mandelkow, Rudi D'Hooge, Christian Alzheimer, Eva-Maria Mandelko. Tau-induced defects in synaptic plasticity, learning, and memory are reversible in transgenic mice after switching off the toxic Tau mutant. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 31. issue 7. 2011-04-01. PMID:21325519. |
only pro-aggregant mice show pronounced changes typical for tau pathology in alzheimer's disease (aggregation, missorting, hyperphosphorylation, synaptic and neuronal loss), indicating that the β-propensity and hence the ability to aggregate is a key factor in the disease. |
2011-04-01 |
2023-08-12 |
mouse |