| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Margrethe A Olesen, Rodrigo A Quintanill. Pathological Impact of Tau Proteolytical Process on Neuronal and Mitochondrial Function: a Crucial Role in Alzheimer's Disease. Molecular neurobiology. 2023-06-18. PMID:37332018. |
research interest has focused on studying the role of post-translational tau modifications in mitochondrial failure, oxidative damage, and synaptic impairment in alzheimer's disease (ad). |
2023-06-18 |
2023-08-14 |
Not clear |
| Yi Yao, Yanmin Chang, Shaomin Li, Jiahui Zhu, Yanqing Wu, Xingjun Jiang, Lulu Li, Ruitian Liu, Rong Ma, Gang L. Complement C3a Receptor Antagonist Alleviates Tau Pathology and Ameliorates Cognitive Deficits in P301S Mice. Brain research bulletin. 2023-06-17. PMID:37330021. |
human tauopathies, including alzheimer's disease (ad), are a major class of neurodegenerative diseases characterized by intracellular deposition of pathological hyperphosphorylated forms of tau protein. |
2023-06-17 |
2023-08-14 |
mouse |
| Yamah Hamsafar, Qian Chen, Alexander D Borowsky, Thomas G Beach, Geidy E Serrano, Lucia I Sue, Charles H Adler, Douglas G Walker, Brittany N Dugge. Biochemical analyses of tau and other neuronal markers in the submandibular gland and frontal cortex across stages of Alzheimer's disease. Neuroscience letters. 2023-06-17. PMID:37330193. |
biochemical analyses of tau and other neuronal markers in the submandibular gland and frontal cortex across stages of alzheimer's disease. |
2023-06-17 |
2023-08-14 |
human |
| Yamah Hamsafar, Qian Chen, Alexander D Borowsky, Thomas G Beach, Geidy E Serrano, Lucia I Sue, Charles H Adler, Douglas G Walker, Brittany N Dugge. Biochemical analyses of tau and other neuronal markers in the submandibular gland and frontal cortex across stages of Alzheimer's disease. Neuroscience letters. 2023-06-17. PMID:37330193. |
hyperphosphorylation of the microtubule-associated protein tau is hypothesized to lead to the development of neurofibrillary tangles in select brain regions during normal aging and in alzheimer's disease (ad). |
2023-06-17 |
2023-08-14 |
human |
| Cory M Nadel, Aye C Thwin, Matthew Callahan, Kanghyun Lee, Emily Connelly, Charles S Craik, Daniel R Southworth, Jason E Gestwick. The E3 Ubiquitin Ligase, CHIP/STUB1, Inhibits Aggregation of Phosphorylated Proteoforms of Microtubule-associated Protein Tau (MAPT). Journal of molecular biology. 2023-06-17. PMID:37330289. |
hyper-phosphorylated tau accumulates as insoluble fibrils in alzheimer's disease (ad) and related dementias. |
2023-06-17 |
2023-08-14 |
Not clear |
| Tobias Mothes, Benjamin Portal, Evangelos Konstantinidis, Khalid Eltom, Sylwia Libard, Linn Streubel-Gallasch, Martin Ingelsson, Jinar Rostami, Maria Lindskog, Anna Erlandsso. Astrocytic uptake of neuronal corpses promotes cell-to-cell spreading of tau pathology. Acta neuropathologica communications. vol 11. issue 1. 2023-06-17. PMID:37330529. |
tau deposits in astrocytes are frequently found in alzheimer's disease (ad) and other tauopathies. |
2023-06-17 |
2023-08-14 |
human |
| Theodore J Zwang, Benjamin Woost, Joshua Bailey, Zachary Hoglund, Douglas S Richardson, Rachel E Bennett, Bradley T Hyma. Spatial characterization of tangle-bearing neurons and ghost tangles in the human inferior temporal gyrus with three-dimensional imaging. Brain communications. vol 5. issue 3. 2023-06-16. PMID:37324243. |
we were able to identify 8103 tau tangles, 132 465 neurons and 299 640 nuclei in tissue samples from three subjects with severe alzheimer's disease (braak v-vi) and 4 tau tangles, 200 447 neurons and 462 715 nuclei in tissue samples from three subjects with no significant tau pathology (braak 0-i). |
2023-06-16 |
2023-08-14 |
human |
| Sopan Nangare, Pravin Pati. Poly(allylamine) coated layer-by-layer assembly decorated 2D carbon backbone for highly sensitive and selective detection of Tau-441 using surface plasmon resonance biosensor. Analytica chimica acta. vol 1271. 2023-06-16. PMID:37328252. |
the determination of clinically significant amounts of tau protein in bodily fluids is a major problem in alzheimer's disease (ad) diagnosis. |
2023-06-16 |
2023-08-14 |
rabbit |
| Mite Mijalkov, Dániel Veréb, Anna Canal-Garcia, Thomas Hinault, Giovanni Volpe, Joana B Pereir. Nonlinear changes in delayed functional network topology in Alzheimer's disease: relationship with amyloid and tau pathology. Alzheimer's research & therapy. vol 15. issue 1. 2023-06-16. PMID:37328909. |
nonlinear changes in delayed functional network topology in alzheimer's disease: relationship with amyloid and tau pathology. |
2023-06-16 |
2023-08-14 |
Not clear |
| Mite Mijalkov, Dániel Veréb, Anna Canal-Garcia, Thomas Hinault, Giovanni Volpe, Joana B Pereir. Nonlinear changes in delayed functional network topology in Alzheimer's disease: relationship with amyloid and tau pathology. Alzheimer's research & therapy. vol 15. issue 1. 2023-06-16. PMID:37328909. |
alzheimer's disease is a neurodegenerative disorder associated with the abnormal deposition of pathological processes, such as amyloid-ß and tau, which produces nonlinear changes in the functional connectivity patterns between different brain regions across the alzheimer's disease continuum. |
2023-06-16 |
2023-08-14 |
Not clear |
| Arthur C Macedo, Cécile Tissot, Joseph Therriault, Stijn Servaes, Yi-Ting Wang, Jaime Fernandez-Arias, Nesrine Rahmouni, Firoza Z Lussier, Marie Vermeiren, Gleb Bezgin, Paolo Vitali, Kok Pin Ng, Eduardo R Zimmer, Marie-Christine Guiot, Tharick A Pascoal, Serge Gauthier, Pedro Rosa-Net. The Use of Tau PET to Stage Alzheimer Disease According to the Braak Staging Framework. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 2023-06-15. PMID:37321820. |
the use of tau pet to stage alzheimer disease according to the braak staging framework. |
2023-06-15 |
2023-08-14 |
Not clear |
| Jiaqian Wan, Yu Zou, Ruiqing Sun, Zhengdong Xu, Jiaxing Tang, Yehong Gong, Guanghong Wei, Qingwen Zhan. Destabilization mechanism of R3-R4 tau protofilament by purpurin: a molecular dynamics study. Physical chemistry chemical physics : PCCP. 2023-06-14. PMID:37314291. |
it has been established that the structure of the tau protofilament in chronic traumatic encephalopathy (cte) is similar to that of alzheimer's disease (ad). |
2023-06-14 |
2023-08-14 |
Not clear |
| Saleha Anwar, Taj Mohammad, Md Khabeer Azhar, Hera Fatima, Afsar Alam, Gulam Mustafa Hasan, Asimul Islam, Punit Kaur, Md Imtaiyaz Hassa. Investigating MARK4 inhibitory potential of Bacopaside II: Targeting Alzheimer's disease. International journal of biological macromolecules. 2023-06-14. PMID:37315665. |
microtubule affinity regulating kinase (mark4) is known to hyperphosphorylate tau protein, which subsequently causes alzheimer's disease (ad). |
2023-06-14 |
2023-08-14 |
Not clear |
| Hao-Lun Sun, Xiu-Qing Yao, Li Lei, Wang-Sheng Jin, Yu-Di Bai, Gui-Hua Zeng, An-Yu Shi, Jun Liang, Li Zhu, Yu-Hui Liu, Yan-Jiang Wang, Xian-Le B. Associations of Blood and Cerebrospinal Fluid Aβ and tau Levels with Renal Function. Molecular neurobiology. 2023-06-13. PMID:37310581. |
amyloid β (aβ) and tau play pivotal roles in the pathogenesis of alzheimer's disease (ad). |
2023-06-13 |
2023-08-14 |
human |
| Ming Yang, Matthew Zinkgraf, Cecilia Fitzgerald-Cook, Benjamin R Harrison, Alexandra Putzier, Daniel E L Promislow, Adrienne M Wan. Using Drosophila to identify naturally occurring genetic modifiers of Aβ42- and tau-induced toxicity. G3 (Bethesda, Md.). 2023-06-13. PMID:37311212. |
alzheimer's disease (ad) is characterized by two pathological proteins, amyloid beta 42 (aβ42) and tau. |
2023-06-13 |
2023-08-14 |
human |
| Saba Eslami, Nafiseh Hosseinzadeh Shakib, Zahra Fooladfar, Sina Nasrollahian, Saman Baghaei, Seyed Ali Mosaddad, Mohammad Motamedifa. The role of periodontitis-associated bacteria in Alzheimer's disease: A narrative review. Journal of basic microbiology. 2023-06-13. PMID:37311215. |
alzheimer's disease (ad) is pathologically characterized by senile plaques comprising beta-amyloid and neurofibrillary tangles (nfts) formed by hyperphosphorylated tau as a microtubule-associated protein with a key role in the pathogenesis of ad. |
2023-06-13 |
2023-08-14 |
Not clear |
| Ariane Bollack, Hugh G Pemberton, Lyduine E Collij, Pawel Markiewicz, David M Cash, Gill Farrar, Frederik Barkho. Longitudinal amyloid and tau PET imaging in Alzheimer's disease: A systematic review of methodologies and factors affecting quantification. Alzheimer's & dementia : the journal of the Alzheimer's Association. 2023-06-12. PMID:37303269. |
longitudinal amyloid and tau pet imaging in alzheimer's disease: a systematic review of methodologies and factors affecting quantification. |
2023-06-12 |
2023-08-14 |
Not clear |
| Yuxing Xia, Brach M Bell, Justin D Kim, Benoit I Giasso. Tau mutation S356T in the three repeat isoform leads to microtubule dysfunction and promotes prion-like seeded aggregation. Frontiers in neuroscience. vol 17. 2023-06-12. PMID:37304025. |
tauopathies are a group of neurodegenerative diseases, which include frontotemporal dementia (ftd) and alzheimer's disease (ad), broadly defined by the development of tau brain aggregates. |
2023-06-12 |
2023-08-14 |
Not clear |
| Rickie Patani, Giles E Hardingham, Shane A Liddelo. Functional roles of reactive astrocytes in neuroinflammation and neurodegeneration. Nature reviews. Neurology. 2023-06-12. PMID:37308616. |
targeting of disease-defining markers in conditions such as alzheimer disease (amyloid-β and tau) or parkinson disease (α-synuclein) has been met with limited success, suggesting that these proteins do not act in isolation but form part of a pathological network. |
2023-06-12 |
2023-08-14 |
human |
| Michael Fassler, Clara Benaim, Jacob Georg. TREM2 Agonism with a Monoclonal Antibody Attenuates Tau Pathology and Neurodegeneration. Cells. vol 12. issue 11. 2023-06-11. PMID:37296669. |
whereas trem2 deletion has been studied extensively in experimental beta-amyloid and tau-based models of alzheimer's disease, its engagement, and subsequent agonism have not been tested in the context of tau pathology. |
2023-06-11 |
2023-08-14 |
mouse |