All Relations between Alzheimer Disease and microtubule-associated protein tau

Publication Sentence Publish Date Extraction Date Species
Chang-Jun Lin, Han-Chang Huang, Zhao-Feng Jian. Cu(II) interaction with amyloid-beta peptide: a review of neuroactive mechanisms in AD brains. Brain research bulletin. vol 82. issue 5-6. 2010-11-01. PMID:20598459. alzheimer's disease (ad) is a progressive neurodegenerative disease characterized by the dys-homeostasis of biometal metabolism, the extracellular accumulation of neurotoxic amyloid-beta (abeta) peptide, the intracellular accumulation of hyperphosphorylated tau and the loss of synapses. 2010-11-01 2023-08-12 Not clear
Michael Demars, Yuan-Shih Hu, Archana Gadadhar, Orly Lazaro. Impaired neurogenesis is an early event in the etiology of familial Alzheimer's disease in transgenic mice. Journal of neuroscience research. vol 88. issue 10. 2010-10-26. PMID:20209626. interestingly, levels of hyperphosphorylated tau, the cytotoxic precursor of the alzheimer's disease hallmark neurofibrillary tangles, are particularly high in the neurogenic niches. 2010-10-26 2023-08-12 mouse
Michael Demars, Yuan-Shih Hu, Archana Gadadhar, Orly Lazaro. Impaired neurogenesis is an early event in the etiology of familial Alzheimer's disease in transgenic mice. Journal of neuroscience research. vol 88. issue 10. 2010-10-26. PMID:20209626. finally, hyperphosphorylation of the microtubule-associated protein tau, a critical player in cell proliferation, neuronal maturation, and axonal transport, is a major contributor to impaired neurogenesis in alzheimer's disease. 2010-10-26 2023-08-12 mouse
Alejandra D Alonso, John Di Clerico, Bin Li, Christopher P Corbo, Maria E Alaniz, Inge Grundke-Iqbal, Khalid Iqba. Phosphorylation of tau at Thr212, Thr231, and Ser262 combined causes neurodegeneration. The Journal of biological chemistry. vol 285. issue 40. 2010-10-26. PMID:20663882. abnormal hyperphosphorylation of the microtubule-associated protein tau is a hallmark of alzheimer disease and related diseases called tauopathies. 2010-10-26 2023-08-12 Not clear
Zhang Zhang, James W Simpkin. Okadaic acid induces tau phosphorylation in SH-SY5Y cells in an estrogen-preventable manner. Brain research. vol 1345. 2010-10-21. PMID:20457142. one of the pathological hallmarks of alzheimer's disease (ad) is neurofibrillary tangles (nfts), which are composed of abnormally hyperphosphorylated tau, but the mechanism of tau hyperphosphorylation in ad is still unclear. 2010-10-21 2023-08-12 Not clear
Sébastien Feuillette, Vincent Deramecourt, Annie Laquerriere, Charles Duyckaerts, Marie-Bernadette Delisle, Claude-Alain Maurage, David Blum, Luc Buée, Thierry Frébourg, Dominique Campion, Magalie Lecourtoi. Filamin-A and Myosin VI colocalize with fibrillary Tau protein in Alzheimer's disease and FTDP-17 brains. Brain research. vol 1345. 2010-10-21. PMID:20460118. filamin-a and myosin vi colocalize with fibrillary tau protein in alzheimer's disease and ftdp-17 brains. 2010-10-21 2023-08-12 mouse
Koichi Iijima, Anthony Gatt, Kanae Iijima-And. Tau Ser262 phosphorylation is critical for Abeta42-induced tau toxicity in a transgenic Drosophila model of Alzheimer's disease. Human molecular genetics. vol 19. issue 15. 2010-10-21. PMID:20466736. tau ser262 phosphorylation is critical for abeta42-induced tau toxicity in a transgenic drosophila model of alzheimer's disease. 2010-10-21 2023-08-12 human
Koichi Iijima, Anthony Gatt, Kanae Iijima-And. Tau Ser262 phosphorylation is critical for Abeta42-induced tau toxicity in a transgenic Drosophila model of Alzheimer's disease. Human molecular genetics. vol 19. issue 15. 2010-10-21. PMID:20466736. the amyloid-beta 42 (abeta42) peptide has been suggested to promote tau phosphorylation and toxicity in alzheimer's disease (ad) pathogenesis; however, the underlying mechanisms are not fully understood. 2010-10-21 2023-08-12 human
Niall M Corcoran, Daniel Martin, Birgit Hutter-Paier, Manfred Windisch, Thanh Nguyen, Lina Nheu, Lars E Sundstrom, Anthony J Costello, Christopher M Hoven. Sodium selenate specifically activates PP2A phosphatase, dephosphorylates tau and reverses memory deficits in an Alzheimer's disease model. Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia. vol 17. issue 8. 2010-10-19. PMID:20537899. sodium selenate specifically activates pp2a phosphatase, dephosphorylates tau and reverses memory deficits in an alzheimer's disease model. 2010-10-19 2023-08-12 mouse
Niall M Corcoran, Daniel Martin, Birgit Hutter-Paier, Manfred Windisch, Thanh Nguyen, Lina Nheu, Lars E Sundstrom, Anthony J Costello, Christopher M Hoven. Sodium selenate specifically activates PP2A phosphatase, dephosphorylates tau and reverses memory deficits in an Alzheimer's disease model. Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia. vol 17. issue 8. 2010-10-19. PMID:20537899. neurofibrillary tangles composed of abnormally hyperphosphorylated tau protein are a hallmark of alzheimer's disease (ad) and related tauopathies. 2010-10-19 2023-08-12 mouse
Giulio Maria Pasinetti, Hanna Ksiezak-Reding, Ismael Santa-Maria, Jun Wang, Lap H. Development of a grape seed polyphenolic extract with anti-oligomeric activity as a novel treatment in progressive supranuclear palsy and other tauopathies. Journal of neurochemistry. vol 114. issue 6. 2010-10-19. PMID:20569300. recent studies from our laboratory reveal that grape seed-derived polyphenolic extracts (gspe) potently prevent tau fibrillization into neurotoxic aggregates and therapeutically promote the dissociation of preformed tau aggregates [j. alzheimer's dis. 2010-10-19 2023-08-12 Not clear
Sang-Won Min, Seo-Hyun Cho, Yungui Zhou, Sebastian Schroeder, Vahram Haroutunian, William W Seeley, Eric J Huang, Yong Shen, Eliezer Masliah, Chandrani Mukherjee, David Meyers, Philip A Cole, Melanie Ott, Li Ga. Acetylation of tau inhibits its degradation and contributes to tauopathy. Neuron. vol 67. issue 6. 2010-10-15. PMID:20869593. neurodegenerative tauopathies characterized by hyperphosphorylated tau include frontotemporal dementia and parkinsonism linked to chromosome 17 (ftdp-17) and alzheimer's disease (ad). 2010-10-15 2023-08-12 mouse
Delphine Boche, Jane Donald, Seth Love, Scott Harris, James W Neal, Clive Holmes, James A R Nicol. Reduction of aggregated Tau in neuronal processes but not in the cell bodies after Abeta42 immunisation in Alzheimer's disease. Acta neuropathologica. vol 120. issue 1. 2010-10-14. PMID:20532897. reduction of aggregated tau in neuronal processes but not in the cell bodies after abeta42 immunisation in alzheimer's disease. 2010-10-14 2023-08-12 Not clear
Delphine Boche, Jane Donald, Seth Love, Scott Harris, James W Neal, Clive Holmes, James A R Nicol. Reduction of aggregated Tau in neuronal processes but not in the cell bodies after Abeta42 immunisation in Alzheimer's disease. Acta neuropathologica. vol 120. issue 1. 2010-10-14. PMID:20532897. alzheimer's disease (ad) pathology is characterised by aggregation in the brain of amyloid-beta (abeta) peptide and hyperphosphorylated tau (phospho-tau), although how these proteins interact in disease pathogenesis is unclear. 2010-10-14 2023-08-12 Not clear
Lotta Agholme, Tobias Lindström, Katarina Kågedal, Jan Marcusson, Martin Hallbec. An in vitro model for neuroscience: differentiation of SH-SY5Y cells into cells with morphological and biochemical characteristics of mature neurons. Journal of Alzheimer's disease : JAD. vol 20. issue 4. 2010-10-12. PMID:20413890. these cells also expresses adult splicing forms of tau with neuronal localization, making this cellular in vitro model useful in many areas of neuroscience research, particularly the alzheimer's disease field. 2010-10-12 2023-08-12 human
Akihiko Takashim. [Significance of tau in the development of Alzheimer's disease]. Brain and nerve = Shinkei kenkyu no shinpo. vol 62. issue 7. 2010-10-07. PMID:20675874. [significance of tau in the development of alzheimer's disease]. 2010-10-07 2023-08-12 mouse
Hans Zempel, Edda Thies, Eckhard Mandelkow, Eva-Maria Mandelko. Abeta oligomers cause localized Ca(2+) elevation, missorting of endogenous Tau into dendrites, Tau phosphorylation, and destruction of microtubules and spines. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 30. issue 36. 2010-10-04. PMID:20826658. aggregation of amyloid-beta (abeta) and tau protein are hallmarks of alzheimer's disease (ad), and according to the abeta-cascade hypothesis, abeta is considered toxic for neurons and tau a downstream target of abeta. 2010-10-04 2023-08-12 Not clear
Ram Prasad Bora, Rajeev Prabhaka. Translational, rotational and internal dynamics of amyloid beta-peptides (Abeta40 and Abeta42) from molecular dynamics simulations. The Journal of chemical physics. vol 131. issue 15. 2010-09-29. PMID:20568886. in this study, diffusion constants [translational (d(t)) and rotational (d(r))], correlation times [rotational (tau(rot)) and internal (tau(int))], and the intramolecular order parameters (s(2)) of the alzheimer amyloid-beta peptides abeta40 and abeta42 have been calculated from 150 ns molecular dynamics simulations in aqueous solution. 2010-09-29 2023-08-12 Not clear
Or A Shemesh, Micha E Spir. Hallmark cellular pathology of Alzheimer's disease induced by mutant human tau expression in cultured Aplysia neurons. Acta neuropathologica. vol 120. issue 2. 2010-09-28. PMID:20422200. hallmark cellular pathology of alzheimer's disease induced by mutant human tau expression in cultured aplysia neurons. 2010-09-28 2023-08-12 human
Or A Shemesh, Micha E Spir. Hallmark cellular pathology of Alzheimer's disease induced by mutant human tau expression in cultured Aplysia neurons. Acta neuropathologica. vol 120. issue 2. 2010-09-28. PMID:20422200. using live confocal imaging to follow cytoskeletal elements, autophagosomes, lysosomes, anterogradely and retrogradely transported organelles, complemented with electron microscopy, we demonstrate that the expression of mutant human tau in cultured aplysia neurons leads to the development of hallmark alzheimer disease (ad) pathologies. 2010-09-28 2023-08-12 human