| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Anders A F Sim. Encephalopathies: the emerging diabetic complications. Acta diabetologica. vol 47. issue 4. 2011-02-03. PMID:20798963. |
the pathobiology of accumulation of β-amyloid and tau the hallmarks of alzheimer's disease are discussed based on experimental data. |
2011-02-03 |
2023-08-12 |
Not clear |
| Jongyeon Shin, Saet-Byeol Yu, Un Young Yu, Sangmee Ahn Jo, Jung-Hyuck Ah. Swedish mutation within amyloid precursor protein modulates global gene expression towards the pathogenesis of Alzheimer's disease. BMB reports. vol 43. issue 10. 2011-02-02. PMID:21034535. |
the swedish mutation (k595n/m596l) of amyloid precursor protein (app-swe) has been known to increase abnormal cleavage of cellular app by beta-secretase (bace), which causes tau protein hyperphosphorylation and early-onset alzheimer's disease (ad). |
2011-02-02 |
2023-08-12 |
Not clear |
| Mirsada Caušević, Umbreen Farooq, Simon Lovestone, Richard Killic. β-Amyloid precursor protein and tau protein levels are differently regulated in human cerebellum compared to brain regions vulnerable to Alzheimer's type neurodegeneration. Neuroscience letters. vol 485. issue 3. 2011-01-28. PMID:20826196. |
β-amyloid precursor protein and tau protein levels are differently regulated in human cerebellum compared to brain regions vulnerable to alzheimer's type neurodegeneration. |
2011-01-28 |
2023-08-12 |
human |
| Catherine M Cowan, Torsten Bossing, Anton Page, David Shepherd, Amritpal Mudhe. Soluble hyper-phosphorylated tau causes microtubule breakdown and functionally compromises normal tau in vivo. Acta neuropathologica. vol 120. issue 5. 2011-01-25. PMID:20617325. |
it has been hypothesised that tau protein, when hyper-phosphorylated as in alzheimer's disease (ad), does not bind effectively to microtubules and is no longer able to stabilise them; thus microtubules break down, and axonal transport can no longer proceed efficiently in affected brain regions in ad and related tauopathies (tau-microtubule hypothesis). |
2011-01-25 |
2023-08-12 |
human |
| Kelly Zhao, Giulia Ippolito, Lulu Wang, Valerie Price, Mi Hwa Kim, Gavin Cornwell, Stephanie Fulenchek, Gail A Breen, Warren J Goux, Santosh R D'Mell. Neuron-selective toxicity of tau peptide in a cell culture model of neurodegenerative tauopathy: essential role for aggregation in neurotoxicity. Journal of neuroscience research. vol 88. issue 15. 2011-01-25. PMID:20882568. |
intracellular aggregation of tau is a pathological hallmark in alzheimer's disease and other tauopathies. |
2011-01-25 |
2023-08-12 |
Not clear |
| Kajsa Sämgård, Henrik Zetterberg, Kaj Blennow, Oskar Hansson, Lennart Minthon, Elisabet Londo. Cerebrospinal fluid total tau as a marker of Alzheimer's disease intensity. International journal of geriatric psychiatry. vol 25. issue 4. 2011-01-21. PMID:19650161. |
cerebrospinal fluid total tau as a marker of alzheimer's disease intensity. |
2011-01-21 |
2023-08-12 |
Not clear |
| Igor Yakushev, Peter Bartenstein, Thomas Siessmeier, Christoph Hiemke, Armin Scheurich, Johannes Lotz, Andreas Fellgiebel, Matthias J Mülle. Cerebrospinal fluid tau protein levels and 18F-fluorodeoxyglucose positron emission tomography in the differential diagnosis of Alzheimer's disease. Dementia and geriatric cognitive disorders. vol 30. issue 3. 2011-01-21. PMID:20847555. |
cerebrospinal fluid tau protein levels and 18f-fluorodeoxyglucose positron emission tomography in the differential diagnosis of alzheimer's disease. |
2011-01-21 |
2023-08-12 |
Not clear |
| Igor Yakushev, Peter Bartenstein, Thomas Siessmeier, Christoph Hiemke, Armin Scheurich, Johannes Lotz, Andreas Fellgiebel, Matthias J Mülle. Cerebrospinal fluid tau protein levels and 18F-fluorodeoxyglucose positron emission tomography in the differential diagnosis of Alzheimer's disease. Dementia and geriatric cognitive disorders. vol 30. issue 3. 2011-01-21. PMID:20847555. |
in this study, we aimed to compare cerebrospinal fluid (csf) levels of total tau (t-tau), phosphorylated tau (p-tau(181)) and positron emission tomography with (18)f-fluorodeoxyglucose (fdg-pet) in the differential diagnosis of alzheimer's disease (ad) under clinical conditions. |
2011-01-21 |
2023-08-12 |
Not clear |
| Ke-Wu Zeng, Hyeonseok Ko, Hyun Ok Yang, Xue-Mei Wan. Icariin attenuates β-amyloid-induced neurotoxicity by inhibition of tau protein hyperphosphorylation in PC12 cells. Neuropharmacology. vol 59. issue 6. 2011-01-20. PMID:20708632. |
thus, this study promises a great potential agent for alzheimer's disease and other tau pathology-related neuronal degenerative diseases. |
2011-01-20 |
2023-08-12 |
rat |
| Brian R Hoover, Miranda N Reed, Jianjun Su, Rachel D Penrod, Linda A Kotilinek, Marianne K Grant, Rose Pitstick, George A Carlson, Lorene M Lanier, Li-Lian Yuan, Karen H Ashe, Dezhi Lia. Tau mislocalization to dendritic spines mediates synaptic dysfunction independently of neurodegeneration. Neuron. vol 68. issue 6. 2011-01-19. PMID:21172610. |
the microtubule-associated protein tau accumulates in alzheimer's and other fatal dementias, which manifest when forebrain neurons die. |
2011-01-19 |
2023-08-12 |
Not clear |
| Peng Lei, Scott Ayton, David I Finkelstein, Paul A Adlard, Colin L Masters, Ashley I Bus. Tau protein: relevance to Parkinson's disease. The international journal of biochemistry & cell biology. vol 42. issue 11. 2011-01-18. PMID:20678581. |
in alzheimer's and parkinson's diseases, there is a hyperphosphorylation of tau that leads to the intracellular accumulation of tau in the form of neurofibrillary tangles. |
2011-01-18 |
2023-08-12 |
Not clear |
| Philip J Dolan, Gail V W Johnso. The role of tau kinases in Alzheimer's disease. Current opinion in drug discovery & development. vol 13. issue 5. 2011-01-18. PMID:20812151. |
the role of tau kinases in alzheimer's disease. |
2011-01-18 |
2023-08-12 |
Not clear |
| Philip J Dolan, Gail V W Johnso. The role of tau kinases in Alzheimer's disease. Current opinion in drug discovery & development. vol 13. issue 5. 2011-01-18. PMID:20812151. |
a principal feature of the progression of alzheimer's disease (ad) is the appearance of aberrant phosphorylation of the microtubule-associated protein tau in the brains of affected individuals. |
2011-01-18 |
2023-08-12 |
Not clear |
| Kun-Lin Chen, Rey-Yue Yuan, Chaur-Jong Hu, Chung Y Hs. Amyloid-β peptide alteration of tau exon-10 splicing via the GSK3β-SC35 pathway. Neurobiology of disease. vol 40. issue 2. 2011-01-12. PMID:20615469. |
amyloid-beta peptide (aβ) and tau protein are the lead constituents in the pathogenesis of alzheimer's disease (ad). |
2011-01-12 |
2023-08-12 |
Not clear |
| Seung-Yong Yoon, Jeong-Su Park, Jung-Eun Choi, Jin-Myung Choi, Woo-Je Lee, Seong-Who Kim, Dong-Hou Ki. Rosiglitazone reduces tau phosphorylation via JNK inhibition in the hippocampus of rats with type 2 diabetes and tau transfected SH-SY5Y cells. Neurobiology of disease. vol 40. issue 2. 2011-01-12. PMID:20655383. |
hence, rosiglitazone could be used in reducing tau phosphorylation through jnk inactivation for therapeutic effects in type 2 diabetes related alzheimer's disease. |
2011-01-12 |
2023-08-12 |
mouse |
| Iain C Anthony, Katherine E Norrby, Tommy Dingwall, Frances W Carnie, Tracey Millar, Juan Carlos Arango, Roy Robertson, Jeanne E Bel. Predisposition to accelerated Alzheimer-related changes in the brains of human immunodeficiency virus negative opiate abusers. Brain : a journal of neurology. vol 133. issue Pt 12. 2011-01-07. PMID:21126996. |
the present quantitative study of hyperphosphorylated tau and beta amyloid in drug user brains allows comparison with the related pathology in alzheimer's disease. |
2011-01-07 |
2023-08-12 |
human |
| Iain C Anthony, Katherine E Norrby, Tommy Dingwall, Frances W Carnie, Tracey Millar, Juan Carlos Arango, Roy Robertson, Jeanne E Bel. Predisposition to accelerated Alzheimer-related changes in the brains of human immunodeficiency virus negative opiate abusers. Brain : a journal of neurology. vol 133. issue Pt 12. 2011-01-07. PMID:21126996. |
the levels of hyperphosphorylated tau in drug users fell far short of those seen in alzheimer's disease but overlapped with those in elderly controls. |
2011-01-07 |
2023-08-12 |
human |
| Xiumei Huang, Yaomin Chen, Wu-Bo Li, Stanley N Cohen, Francesca-Fang Liao, Limin Li, Huaxi Xu, Yun-Wu Zhan. The Rps23rg gene family originated through retroposition of the ribosomal protein s23 mRNA and encodes proteins that decrease Alzheimer's beta-amyloid level and tau phosphorylation. Human molecular genetics. vol 19. issue 19. 2011-01-04. PMID:20650958. |
the rps23rg gene family originated through retroposition of the ribosomal protein s23 mrna and encodes proteins that decrease alzheimer's beta-amyloid level and tau phosphorylation. |
2011-01-04 |
2023-08-12 |
mouse |
| Xiumei Huang, Yaomin Chen, Wu-Bo Li, Stanley N Cohen, Francesca-Fang Liao, Limin Li, Huaxi Xu, Yun-Wu Zhan. The Rps23rg gene family originated through retroposition of the ribosomal protein s23 mRNA and encodes proteins that decrease Alzheimer's beta-amyloid level and tau phosphorylation. Human molecular genetics. vol 19. issue 19. 2011-01-04. PMID:20650958. |
we recently identified a mouse gene, rps23 retroposed gene 1 (rps23rg1), that regulates beta-amyloid (abeta) level and tau phosphorylation, two major pathological hallmarks of alzheimer's disease (ad), and found that rps23rg1 originated through retroposition of the mouse ribosomal protein s23 (rps23) mrna. |
2011-01-04 |
2023-08-12 |
mouse |
| Nelleke Tolboom, Esther L G E Koedam, Jonathan M Schott, Maqsood Yaqub, Marinus A Blankenstein, Frederik Barkhof, Yolande A L Pijnenburg, Adriaan A Lammertsma, Philip Scheltens, Bart N M van Bercke. Dementia mimicking Alzheimer's disease Owing to a tau mutation: CSF and PET findings. Alzheimer disease and associated disorders. vol 24. issue 3. 2011-01-04. PMID:20683187. |
dementia mimicking alzheimer's disease owing to a tau mutation: csf and pet findings. |
2011-01-04 |
2023-08-12 |
Not clear |