All Relations between Alzheimer Disease and microtubule-associated protein tau

Publication Sentence Publish Date Extraction Date Species
Simona Capsoni, Cecilia Tiveron, Gianluca Amato, Domenico Vignone, Antonino Cattane. Peripheral neutralization of nerve growth factor induces immunosympathectomy and central neurodegeneration in transgenic mice. Journal of Alzheimer's disease : JAD. vol 20. issue 2. 2010-09-07. PMID:20182028. we previously showed that anti-nerve growth factor (ngf) antibodies expressed in transgenic mice (ad11) elicit a progressive neurodegeneration, comprising the triad of alzheimer's disease (ad) hallmarks: cholinergic loss, tau hyperphosphorylation, and amyloid-beta peptide formation. 2010-09-07 2023-08-12 mouse
Brian R Ott, Ronald A Cohen, Assawin Gongvatana, Ozioma C Okonkwo, Conrad E Johanson, Edward G Stopa, John E Donahue, Gerald D Silverber. Brain ventricular volume and cerebrospinal fluid biomarkers of Alzheimer's disease. Journal of Alzheimer's disease : JAD. vol 20. issue 2. 2010-09-07. PMID:20182051. csf biomarker data (abeta, tau, and phosphorylated tau) as well as direct measurements of whole brain and ventricular volumes were obtained from the alzheimer's disease neuroimaging initiative dataset. 2010-09-07 2023-08-12 human
Jiqing Xu, Shinji Sato, Satoshi Okuyama, Russell J Swan, Michael T Jacobsen, Elena Strunk, Tsuneya Ikez. Tau-tubulin kinase 1 enhances prefibrillar tau aggregation and motor neuron degeneration in P301L FTDP-17 tau-mutant mice. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 24. issue 8. 2010-09-07. PMID:20354135. tau-tubulin kinase-1 (ttbk1) phosphorylates microtubule-associated protein tau at specific serine/threonine residues found in paired helical filaments (phfs), and its expression is up-regulated in the brain in alzheimer disease, suggesting its role in tauopathy pathogenesis. 2010-09-07 2023-08-12 mouse
Juan Deng, Cheng Shen, Yan-Jiang Wang, Meng Zhang, Jing Li, Zhi-Qiang Xu, Chang-Yue Gao, Chuan-Qing Fang, Hua-Dong Zho. Nicotine exacerbates tau phosphorylation and cognitive impairment induced by amyloid-beta 25-35 in rats. European journal of pharmacology. vol 637. issue 1-3. 2010-09-07. PMID:20363218. however, the effect of nicotine on memory and tau pathology in alzheimer's disease has been less studied. 2010-09-07 2023-08-12 rat
Juan Deng, Cheng Shen, Yan-Jiang Wang, Meng Zhang, Jing Li, Zhi-Qiang Xu, Chang-Yue Gao, Chuan-Qing Fang, Hua-Dong Zho. Nicotine exacerbates tau phosphorylation and cognitive impairment induced by amyloid-beta 25-35 in rats. European journal of pharmacology. vol 637. issue 1-3. 2010-09-07. PMID:20363218. the data show that nicotine (1mg/kg in base weight) treatment significantly exacerbates cognitive impairment and tau phosphorylation at ser-202 and thr-231 in the hippocampus compared with abeta25-35 injection groups in the abeta rat model of alzheimer's disease. 2010-09-07 2023-08-12 rat
Cynthia A Massaad, Samir K Amin, Lingyun Hu, Yuan Mei, Eric Klann, Robia G Pautle. Mitochondrial superoxide contributes to blood flow and axonal transport deficits in the Tg2576 mouse model of Alzheimer's disease. PloS one. vol 5. issue 5. 2010-09-07. PMID:20479943. alzheimer's disease (ad) is a neurodegenerative disease characterized by the progressive decline in cognitive functions and the deposition of aggregated amyloid beta (abeta) into senile plaques and the protein tau into tangles. 2010-09-07 2023-08-12 mouse
Lars M Ittner, Yazi D Ke, Fabien Delerue, Mian Bi, Amadeus Gladbach, Janet van Eersel, Heidrun Wölfing, Billy C Chieng, MacDonald J Christie, Ian A Napier, Anne Eckert, Matthias Staufenbiel, Edna Hardeman, Jürgen Göt. Dendritic function of tau mediates amyloid-beta toxicity in Alzheimer's disease mouse models. Cell. vol 142. issue 3. 2010-09-01. PMID:20655099. dendritic function of tau mediates amyloid-beta toxicity in alzheimer's disease mouse models. 2010-09-01 2023-08-12 mouse
Lars M Ittner, Yazi D Ke, Fabien Delerue, Mian Bi, Amadeus Gladbach, Janet van Eersel, Heidrun Wölfing, Billy C Chieng, MacDonald J Christie, Ian A Napier, Anne Eckert, Matthias Staufenbiel, Edna Hardeman, Jürgen Göt. Dendritic function of tau mediates amyloid-beta toxicity in Alzheimer's disease mouse models. Cell. vol 142. issue 3. 2010-09-01. PMID:20655099. alzheimer's disease (ad) is characterized by amyloid-beta (abeta) and tau deposition in brain. 2010-09-01 2023-08-12 mouse
Christian Haass, Eckhard Mandelko. Fyn-tau-amyloid: a toxic triad. Cell. vol 142. issue 3. 2010-09-01. PMID:20691893. the axonal protein tau and amyloid beta-peptide (abeta) are key players in the pathogenesis of alzheimer's disease, and tau mediates abeta toxicity, but it is not clear how. 2010-09-01 2023-08-12 Not clear
Sachin P Patil, Sarah Maki, Santosh A Khedkar, Alan C Rigby, Christina Cha. Withanolide A and asiatic acid modulate multiple targets associated with amyloid-beta precursor protein processing and amyloid-beta protein clearance. Journal of natural products. vol 73. issue 7. 2010-08-27. PMID:20553006. alzheimer's disease (ad) is a progressive, neurodegenerative disease histochemically characterized by extracellular deposits of amyloid beta (abeta) protein and intracellular neurofibrillary tangles of hyperphosphorylated tau protein. 2010-08-27 2023-08-12 rat
Leslie Crews, Eliezer Maslia. Molecular mechanisms of neurodegeneration in Alzheimer's disease. Human molecular genetics. vol 19. issue R1. 2010-08-24. PMID:20413653. alzheimer's disease (ad) is characterized by cognitive impairment, progressive neurodegeneration and formation of amyloid-beta (abeta)-containing plaques and neurofibrillary tangles composed of hyperphosphorylated tau. 2010-08-24 2023-08-12 Not clear
David W Hampton, Daniel J Webber, Bilada Bilican, Michel Goedert, Maria Grazia Spillantini, Siddharthan Chandra. Cell-mediated neuroprotection in a mouse model of human tauopathy. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 30. issue 30. 2010-08-20. PMID:20668182. tau protein in a hyperphosphorylated state makes up the intracellular inclusions of several neurodegenerative diseases, including alzheimer's disease and cases of frontotemporal dementia. 2010-08-20 2023-08-12 mouse
J Bertrand, V Plouffe, P Sénéchal, N Lecler. The pattern of human tau phosphorylation is the result of priming and feedback events in primary hippocampal neurons. Neuroscience. vol 168. issue 2. 2010-08-19. PMID:20394726. tau, an axonal microtubule-associated protein, becomes hyperphosphorylated in several neurodegenerative diseases including alzheimer disease (ad). 2010-08-19 2023-08-12 human
Albert Eugene Pekary, Schetema A Stevens, James D Blood, Albert Satti. Rapid modulation of TRH and TRH-like peptide release in rat brain, pancreas, and testis by a GSK-3beta inhibitor. Peptides. vol 31. issue 6. 2010-08-17. PMID:20338209. thyrotropin-releasing hormone (trh) is an endogenous antidepressant-like neuropeptide that reduces the expression of glycogen synthase kinase-3beta (gsk-3beta), an enzyme that hyperphosphorylates tau and is implicated in bipolar disorder, diabetes and alzheimer's disease. 2010-08-17 2023-08-12 rat
Samira Kocherhans, Amrita Madhusudan, Jana Doehner, Karin S Breu, Roger M Nitsch, Jean-Marc Fritschy, Irene Knuese. Reduced Reelin expression accelerates amyloid-beta plaque formation and tau pathology in transgenic Alzheimer's disease mice. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 30. issue 27. 2010-08-16. PMID:20610758. reduced reelin expression accelerates amyloid-beta plaque formation and tau pathology in transgenic alzheimer's disease mice. 2010-08-16 2023-08-12 mouse
Bo Su, Xinglong Wang, Kelly L Drew, George Perry, Mark A Smith, Xiongwei Zh. Physiological regulation of tau phosphorylation during hibernation. Journal of neurochemistry. vol 105. issue 6. 2010-08-13. PMID:18284615. the microtubule-associated protein tau is abnormally hyperphosphorylated in the brains of individuals with alzheimer disease and other tauopathies, and is believed to play a critical role in the pathogenesis of these diseases. 2010-08-13 2023-08-12 Not clear
Selina Wray, Malcolm Saxton, Brian H Anderton, Diane P Hange. Direct analysis of tau from PSP brain identifies new phosphorylation sites and a major fragment of N-terminally cleaved tau containing four microtubule-binding repeats. Journal of neurochemistry. vol 105. issue 6. 2010-08-13. PMID:18315566. our findings suggest the aggregatory characteristics of psp-tau differ from those of insoluble tau in alzheimer's disease brain and this might be related to the presence of a c-terminal cleavage product of tau. 2010-08-13 2023-08-12 Not clear
J R Bamburg, B W Bernstein, R C Davis, K C Flynn, C Goldsbury, J R Jensen, M T Maloney, I T Marsden, L S Minamide, C W Pak, A E Shaw, I Whiteman, O Wigga. ADF/Cofilin-actin rods in neurodegenerative diseases. Current Alzheimer research. vol 7. issue 3. 2010-08-12. PMID:20088812. they accumulate phosphorylated tau that immunostains for epitopes present in "striated neuropil threads," characteristic of tau pathology in alzheimer disease (ad) brain. 2010-08-12 2023-08-12 Not clear
Jesús Avila, Francisco Wandosell, Félix Hernánde. Role of glycogen synthase kinase-3 in Alzheimer's disease pathogenesis and glycogen synthase kinase-3 inhibitors. Expert review of neurotherapeutics. vol 10. issue 5. 2010-08-11. PMID:20420491. glycogen synthase kinase (gsk)-3 has been proposed as the link between the two histopathological hallmarks of alzheimer's disease, the extracellular senile plaques composed of beta-amyloid and the intracellular neurofibrillary tangles formed from hyperphosphorylated tau. 2010-08-11 2023-08-12 Not clear
Giovanni B Frison. Alzheimer's disease neuroimaging initiative in Europe. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 6. issue 3. 2010-08-11. PMID:20451877. because the adni platform was first imported in europe, thanks to the pilot european adni, several adni-related initiatives have flourished, funded by the european commission's 7th framework programme, national governments, and the alzheimer's association aimed at: (i) collecting fresh data adni style (fp7 addneuromed, innovative medicine initiative pharma-cog/european adni, swedish adni, and italian adni); (ii) developing standard operational procedures for the collection of markers (international harmonization of csf abeta42 and tau, and european alzheimer's disease consortium-adni harmonization of hippocampal volumetry); and (iii) developing infrastructures for the treatment of adni data (fp7 neugrid and outgrid, and the french centre pour l'acquisition et le traitement de l'image). 2010-08-11 2023-08-12 Not clear