Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
Simona Capsoni, Cecilia Tiveron, Gianluca Amato, Domenico Vignone, Antonino Cattane. Peripheral neutralization of nerve growth factor induces immunosympathectomy and central neurodegeneration in transgenic mice. Journal of Alzheimer's disease : JAD. vol 20. issue 2. 2010-09-07. PMID:20182028. |
we previously showed that anti-nerve growth factor (ngf) antibodies expressed in transgenic mice (ad11) elicit a progressive neurodegeneration, comprising the triad of alzheimer's disease (ad) hallmarks: cholinergic loss, tau hyperphosphorylation, and amyloid-beta peptide formation. |
2010-09-07 |
2023-08-12 |
mouse |
Brian R Ott, Ronald A Cohen, Assawin Gongvatana, Ozioma C Okonkwo, Conrad E Johanson, Edward G Stopa, John E Donahue, Gerald D Silverber. Brain ventricular volume and cerebrospinal fluid biomarkers of Alzheimer's disease. Journal of Alzheimer's disease : JAD. vol 20. issue 2. 2010-09-07. PMID:20182051. |
csf biomarker data (abeta, tau, and phosphorylated tau) as well as direct measurements of whole brain and ventricular volumes were obtained from the alzheimer's disease neuroimaging initiative dataset. |
2010-09-07 |
2023-08-12 |
human |
Jiqing Xu, Shinji Sato, Satoshi Okuyama, Russell J Swan, Michael T Jacobsen, Elena Strunk, Tsuneya Ikez. Tau-tubulin kinase 1 enhances prefibrillar tau aggregation and motor neuron degeneration in P301L FTDP-17 tau-mutant mice. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 24. issue 8. 2010-09-07. PMID:20354135. |
tau-tubulin kinase-1 (ttbk1) phosphorylates microtubule-associated protein tau at specific serine/threonine residues found in paired helical filaments (phfs), and its expression is up-regulated in the brain in alzheimer disease, suggesting its role in tauopathy pathogenesis. |
2010-09-07 |
2023-08-12 |
mouse |
Juan Deng, Cheng Shen, Yan-Jiang Wang, Meng Zhang, Jing Li, Zhi-Qiang Xu, Chang-Yue Gao, Chuan-Qing Fang, Hua-Dong Zho. Nicotine exacerbates tau phosphorylation and cognitive impairment induced by amyloid-beta 25-35 in rats. European journal of pharmacology. vol 637. issue 1-3. 2010-09-07. PMID:20363218. |
however, the effect of nicotine on memory and tau pathology in alzheimer's disease has been less studied. |
2010-09-07 |
2023-08-12 |
rat |
Juan Deng, Cheng Shen, Yan-Jiang Wang, Meng Zhang, Jing Li, Zhi-Qiang Xu, Chang-Yue Gao, Chuan-Qing Fang, Hua-Dong Zho. Nicotine exacerbates tau phosphorylation and cognitive impairment induced by amyloid-beta 25-35 in rats. European journal of pharmacology. vol 637. issue 1-3. 2010-09-07. PMID:20363218. |
the data show that nicotine (1mg/kg in base weight) treatment significantly exacerbates cognitive impairment and tau phosphorylation at ser-202 and thr-231 in the hippocampus compared with abeta25-35 injection groups in the abeta rat model of alzheimer's disease. |
2010-09-07 |
2023-08-12 |
rat |
Cynthia A Massaad, Samir K Amin, Lingyun Hu, Yuan Mei, Eric Klann, Robia G Pautle. Mitochondrial superoxide contributes to blood flow and axonal transport deficits in the Tg2576 mouse model of Alzheimer's disease. PloS one. vol 5. issue 5. 2010-09-07. PMID:20479943. |
alzheimer's disease (ad) is a neurodegenerative disease characterized by the progressive decline in cognitive functions and the deposition of aggregated amyloid beta (abeta) into senile plaques and the protein tau into tangles. |
2010-09-07 |
2023-08-12 |
mouse |
Lars M Ittner, Yazi D Ke, Fabien Delerue, Mian Bi, Amadeus Gladbach, Janet van Eersel, Heidrun Wölfing, Billy C Chieng, MacDonald J Christie, Ian A Napier, Anne Eckert, Matthias Staufenbiel, Edna Hardeman, Jürgen Göt. Dendritic function of tau mediates amyloid-beta toxicity in Alzheimer's disease mouse models. Cell. vol 142. issue 3. 2010-09-01. PMID:20655099. |
dendritic function of tau mediates amyloid-beta toxicity in alzheimer's disease mouse models. |
2010-09-01 |
2023-08-12 |
mouse |
Lars M Ittner, Yazi D Ke, Fabien Delerue, Mian Bi, Amadeus Gladbach, Janet van Eersel, Heidrun Wölfing, Billy C Chieng, MacDonald J Christie, Ian A Napier, Anne Eckert, Matthias Staufenbiel, Edna Hardeman, Jürgen Göt. Dendritic function of tau mediates amyloid-beta toxicity in Alzheimer's disease mouse models. Cell. vol 142. issue 3. 2010-09-01. PMID:20655099. |
alzheimer's disease (ad) is characterized by amyloid-beta (abeta) and tau deposition in brain. |
2010-09-01 |
2023-08-12 |
mouse |
Christian Haass, Eckhard Mandelko. Fyn-tau-amyloid: a toxic triad. Cell. vol 142. issue 3. 2010-09-01. PMID:20691893. |
the axonal protein tau and amyloid beta-peptide (abeta) are key players in the pathogenesis of alzheimer's disease, and tau mediates abeta toxicity, but it is not clear how. |
2010-09-01 |
2023-08-12 |
Not clear |
Sachin P Patil, Sarah Maki, Santosh A Khedkar, Alan C Rigby, Christina Cha. Withanolide A and asiatic acid modulate multiple targets associated with amyloid-beta precursor protein processing and amyloid-beta protein clearance. Journal of natural products. vol 73. issue 7. 2010-08-27. PMID:20553006. |
alzheimer's disease (ad) is a progressive, neurodegenerative disease histochemically characterized by extracellular deposits of amyloid beta (abeta) protein and intracellular neurofibrillary tangles of hyperphosphorylated tau protein. |
2010-08-27 |
2023-08-12 |
rat |
Leslie Crews, Eliezer Maslia. Molecular mechanisms of neurodegeneration in Alzheimer's disease. Human molecular genetics. vol 19. issue R1. 2010-08-24. PMID:20413653. |
alzheimer's disease (ad) is characterized by cognitive impairment, progressive neurodegeneration and formation of amyloid-beta (abeta)-containing plaques and neurofibrillary tangles composed of hyperphosphorylated tau. |
2010-08-24 |
2023-08-12 |
Not clear |
David W Hampton, Daniel J Webber, Bilada Bilican, Michel Goedert, Maria Grazia Spillantini, Siddharthan Chandra. Cell-mediated neuroprotection in a mouse model of human tauopathy. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 30. issue 30. 2010-08-20. PMID:20668182. |
tau protein in a hyperphosphorylated state makes up the intracellular inclusions of several neurodegenerative diseases, including alzheimer's disease and cases of frontotemporal dementia. |
2010-08-20 |
2023-08-12 |
mouse |
J Bertrand, V Plouffe, P Sénéchal, N Lecler. The pattern of human tau phosphorylation is the result of priming and feedback events in primary hippocampal neurons. Neuroscience. vol 168. issue 2. 2010-08-19. PMID:20394726. |
tau, an axonal microtubule-associated protein, becomes hyperphosphorylated in several neurodegenerative diseases including alzheimer disease (ad). |
2010-08-19 |
2023-08-12 |
human |
Albert Eugene Pekary, Schetema A Stevens, James D Blood, Albert Satti. Rapid modulation of TRH and TRH-like peptide release in rat brain, pancreas, and testis by a GSK-3beta inhibitor. Peptides. vol 31. issue 6. 2010-08-17. PMID:20338209. |
thyrotropin-releasing hormone (trh) is an endogenous antidepressant-like neuropeptide that reduces the expression of glycogen synthase kinase-3beta (gsk-3beta), an enzyme that hyperphosphorylates tau and is implicated in bipolar disorder, diabetes and alzheimer's disease. |
2010-08-17 |
2023-08-12 |
rat |
Samira Kocherhans, Amrita Madhusudan, Jana Doehner, Karin S Breu, Roger M Nitsch, Jean-Marc Fritschy, Irene Knuese. Reduced Reelin expression accelerates amyloid-beta plaque formation and tau pathology in transgenic Alzheimer's disease mice. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 30. issue 27. 2010-08-16. PMID:20610758. |
reduced reelin expression accelerates amyloid-beta plaque formation and tau pathology in transgenic alzheimer's disease mice. |
2010-08-16 |
2023-08-12 |
mouse |
Bo Su, Xinglong Wang, Kelly L Drew, George Perry, Mark A Smith, Xiongwei Zh. Physiological regulation of tau phosphorylation during hibernation. Journal of neurochemistry. vol 105. issue 6. 2010-08-13. PMID:18284615. |
the microtubule-associated protein tau is abnormally hyperphosphorylated in the brains of individuals with alzheimer disease and other tauopathies, and is believed to play a critical role in the pathogenesis of these diseases. |
2010-08-13 |
2023-08-12 |
Not clear |
Selina Wray, Malcolm Saxton, Brian H Anderton, Diane P Hange. Direct analysis of tau from PSP brain identifies new phosphorylation sites and a major fragment of N-terminally cleaved tau containing four microtubule-binding repeats. Journal of neurochemistry. vol 105. issue 6. 2010-08-13. PMID:18315566. |
our findings suggest the aggregatory characteristics of psp-tau differ from those of insoluble tau in alzheimer's disease brain and this might be related to the presence of a c-terminal cleavage product of tau. |
2010-08-13 |
2023-08-12 |
Not clear |
J R Bamburg, B W Bernstein, R C Davis, K C Flynn, C Goldsbury, J R Jensen, M T Maloney, I T Marsden, L S Minamide, C W Pak, A E Shaw, I Whiteman, O Wigga. ADF/Cofilin-actin rods in neurodegenerative diseases. Current Alzheimer research. vol 7. issue 3. 2010-08-12. PMID:20088812. |
they accumulate phosphorylated tau that immunostains for epitopes present in "striated neuropil threads," characteristic of tau pathology in alzheimer disease (ad) brain. |
2010-08-12 |
2023-08-12 |
Not clear |
Jesús Avila, Francisco Wandosell, Félix Hernánde. Role of glycogen synthase kinase-3 in Alzheimer's disease pathogenesis and glycogen synthase kinase-3 inhibitors. Expert review of neurotherapeutics. vol 10. issue 5. 2010-08-11. PMID:20420491. |
glycogen synthase kinase (gsk)-3 has been proposed as the link between the two histopathological hallmarks of alzheimer's disease, the extracellular senile plaques composed of beta-amyloid and the intracellular neurofibrillary tangles formed from hyperphosphorylated tau. |
2010-08-11 |
2023-08-12 |
Not clear |
Giovanni B Frison. Alzheimer's disease neuroimaging initiative in Europe. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 6. issue 3. 2010-08-11. PMID:20451877. |
because the adni platform was first imported in europe, thanks to the pilot european adni, several adni-related initiatives have flourished, funded by the european commission's 7th framework programme, national governments, and the alzheimer's association aimed at: (i) collecting fresh data adni style (fp7 addneuromed, innovative medicine initiative pharma-cog/european adni, swedish adni, and italian adni); (ii) developing standard operational procedures for the collection of markers (international harmonization of csf abeta42 and tau, and european alzheimer's disease consortium-adni harmonization of hippocampal volumetry); and (iii) developing infrastructures for the treatment of adni data (fp7 neugrid and outgrid, and the french centre pour l'acquisition et le traitement de l'image). |
2010-08-11 |
2023-08-12 |
Not clear |