| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Steven Lehre. Glioblastoma and dementia may share a common cause. Medical hypotheses. vol 75. issue 1. 2010-09-13. PMID:20181435. |
alzheimer's disease has been identified as a protein misfolding disorder (proteopathy), caused by accumulation of abnormally folded a-beta and tau proteins in the brain. |
2010-09-13 |
2023-08-12 |
Not clear |
| Kisha J Young, James P Bennet. The mitochondrial secret(ase) of Alzheimer's disease. Journal of Alzheimer's disease : JAD. vol 20 Suppl 2. 2010-09-13. PMID:20442493. |
alzheimer's disease (ad) is a neurodegenerative disorder characterized clinically by progressive decline in memory and cognition and pathologically by extracellular amyloid-beta (abeta) deposits and intraneuronal aggregates of hyperphosphorylated tau. |
2010-09-13 |
2023-08-12 |
Not clear |
| Gary E Gibson, Qingli Sh. A mitocentric view of Alzheimer's disease suggests multi-faceted treatments. Journal of Alzheimer's disease : JAD. vol 20 Suppl 2. 2010-09-13. PMID:20463407. |
alzheimer's disease (ad) is defined by senile plaques made of amyloid-beta peptide (abeta), neurofibrillary tangles made of hyperphosphorylated tau proteins, and memory deficits. |
2010-09-13 |
2023-08-12 |
Not clear |
| Johanne Bertrand, Patrick Sénéchal, Mathieu Zummo-Soucy, Vanessa Plouffe, Nicole Lecler. The formation of tau pathological phospho-epitopes in the axon is prevented by the dephosphorylation of selective sites in primary hippocampal neurons over-expressing human tau. Journal of neurochemistry. vol 114. issue 5. 2010-09-13. PMID:20550628. |
in tauopathies including alzheimer's disease, the axonal microtubule-associated protein tau becomes hyperphosphorylated at pathological epitopes and accumulates in the somato-dendritic compartment. |
2010-09-13 |
2023-08-12 |
human |
| Scott D Ryan, Shawn N Whitehead, Leigh Anne Swayne, Tia C Moffat, Weimin Hou, Martin Ethier, André J G Bourgeois, Juliet Rashidian, Alexandre P Blanchard, Paul E Fraser, David S Park, Daniel Figeys, Steffany A L Bennet. Amyloid-beta42 signals tau hyperphosphorylation and compromises neuronal viability by disrupting alkylacylglycerophosphocholine metabolism. Proceedings of the National Academy of Sciences of the United States of America. vol 106. issue 49. 2010-09-08. PMID:19926863. |
acute intraneuronal accumulation of c16:0 paf but not c16:0 lyso-paf initiated cyclin-dependent kinase 5-mediated hyperphosphorylation of tau on alzheimer disease-specific epitopes. |
2010-09-08 |
2023-08-12 |
mouse |
| Janet van Eersel, Yazi D Ke, Xin Liu, Fabien Delerue, Jillian J Kril, Jürgen Götz, Lars M Ittne. Sodium selenate mitigates tau pathology, neurodegeneration, and functional deficits in Alzheimer's disease models. Proceedings of the National Academy of Sciences of the United States of America. vol 107. issue 31. 2010-09-08. PMID:20643941. |
sodium selenate mitigates tau pathology, neurodegeneration, and functional deficits in alzheimer's disease models. |
2010-09-08 |
2023-08-12 |
mouse |
| Janet van Eersel, Yazi D Ke, Xin Liu, Fabien Delerue, Jillian J Kril, Jürgen Götz, Lars M Ittne. Sodium selenate mitigates tau pathology, neurodegeneration, and functional deficits in Alzheimer's disease models. Proceedings of the National Academy of Sciences of the United States of America. vol 107. issue 31. 2010-09-08. PMID:20643941. |
alzheimer's disease (ad) brains are characterized by amyloid-beta-containing plaques and hyperphosphorylated tau-containing neurofibrillary tangles (nfts); however, in frontotemporal dementia, the tau pathology manifests in the absence of overt amyloid-beta plaques. |
2010-09-08 |
2023-08-12 |
mouse |
| Nicolaas A Verwey, Maartje I Kester, Wiesje M van der Flier, Robert Veerhuis, Hans Berkhof, Harry Twaalfhoven, Marinus A Blankenstein, Philip Scheltens And, Yolande A L Pijnenbur. Additional value of CSF amyloid-beta 40 levels in the differentiation between FTLD and control subjects. Journal of Alzheimer's disease : JAD. vol 20. issue 2. 2010-09-07. PMID:20164558. |
to determine the additional value of cerebrospinal fluid (csf)amyloid-beta1-40 (abeta40) next to amyloid-beta1-42 (beta42), total tau (tau), and tau phosphorylated at threonine-181 (ptau) to distinguish patients with frontotemporal lobar degeneration (ftld), alzheimer's disease (ad), and controls, we measured csf levels of abeta40, abeta42, ptau, and tau in 55 patients with ftld, 60 with ad, and 40 control subjects. |
2010-09-07 |
2023-08-12 |
human |
| Simona Capsoni, Cecilia Tiveron, Gianluca Amato, Domenico Vignone, Antonino Cattane. Peripheral neutralization of nerve growth factor induces immunosympathectomy and central neurodegeneration in transgenic mice. Journal of Alzheimer's disease : JAD. vol 20. issue 2. 2010-09-07. PMID:20182028. |
we previously showed that anti-nerve growth factor (ngf) antibodies expressed in transgenic mice (ad11) elicit a progressive neurodegeneration, comprising the triad of alzheimer's disease (ad) hallmarks: cholinergic loss, tau hyperphosphorylation, and amyloid-beta peptide formation. |
2010-09-07 |
2023-08-12 |
mouse |
| Brian R Ott, Ronald A Cohen, Assawin Gongvatana, Ozioma C Okonkwo, Conrad E Johanson, Edward G Stopa, John E Donahue, Gerald D Silverber. Brain ventricular volume and cerebrospinal fluid biomarkers of Alzheimer's disease. Journal of Alzheimer's disease : JAD. vol 20. issue 2. 2010-09-07. PMID:20182051. |
csf biomarker data (abeta, tau, and phosphorylated tau) as well as direct measurements of whole brain and ventricular volumes were obtained from the alzheimer's disease neuroimaging initiative dataset. |
2010-09-07 |
2023-08-12 |
human |
| Jiqing Xu, Shinji Sato, Satoshi Okuyama, Russell J Swan, Michael T Jacobsen, Elena Strunk, Tsuneya Ikez. Tau-tubulin kinase 1 enhances prefibrillar tau aggregation and motor neuron degeneration in P301L FTDP-17 tau-mutant mice. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 24. issue 8. 2010-09-07. PMID:20354135. |
tau-tubulin kinase-1 (ttbk1) phosphorylates microtubule-associated protein tau at specific serine/threonine residues found in paired helical filaments (phfs), and its expression is up-regulated in the brain in alzheimer disease, suggesting its role in tauopathy pathogenesis. |
2010-09-07 |
2023-08-12 |
mouse |
| Juan Deng, Cheng Shen, Yan-Jiang Wang, Meng Zhang, Jing Li, Zhi-Qiang Xu, Chang-Yue Gao, Chuan-Qing Fang, Hua-Dong Zho. Nicotine exacerbates tau phosphorylation and cognitive impairment induced by amyloid-beta 25-35 in rats. European journal of pharmacology. vol 637. issue 1-3. 2010-09-07. PMID:20363218. |
however, the effect of nicotine on memory and tau pathology in alzheimer's disease has been less studied. |
2010-09-07 |
2023-08-12 |
rat |
| Juan Deng, Cheng Shen, Yan-Jiang Wang, Meng Zhang, Jing Li, Zhi-Qiang Xu, Chang-Yue Gao, Chuan-Qing Fang, Hua-Dong Zho. Nicotine exacerbates tau phosphorylation and cognitive impairment induced by amyloid-beta 25-35 in rats. European journal of pharmacology. vol 637. issue 1-3. 2010-09-07. PMID:20363218. |
the data show that nicotine (1mg/kg in base weight) treatment significantly exacerbates cognitive impairment and tau phosphorylation at ser-202 and thr-231 in the hippocampus compared with abeta25-35 injection groups in the abeta rat model of alzheimer's disease. |
2010-09-07 |
2023-08-12 |
rat |
| Cynthia A Massaad, Samir K Amin, Lingyun Hu, Yuan Mei, Eric Klann, Robia G Pautle. Mitochondrial superoxide contributes to blood flow and axonal transport deficits in the Tg2576 mouse model of Alzheimer's disease. PloS one. vol 5. issue 5. 2010-09-07. PMID:20479943. |
alzheimer's disease (ad) is a neurodegenerative disease characterized by the progressive decline in cognitive functions and the deposition of aggregated amyloid beta (abeta) into senile plaques and the protein tau into tangles. |
2010-09-07 |
2023-08-12 |
mouse |
| Lars M Ittner, Yazi D Ke, Fabien Delerue, Mian Bi, Amadeus Gladbach, Janet van Eersel, Heidrun Wölfing, Billy C Chieng, MacDonald J Christie, Ian A Napier, Anne Eckert, Matthias Staufenbiel, Edna Hardeman, Jürgen Göt. Dendritic function of tau mediates amyloid-beta toxicity in Alzheimer's disease mouse models. Cell. vol 142. issue 3. 2010-09-01. PMID:20655099. |
dendritic function of tau mediates amyloid-beta toxicity in alzheimer's disease mouse models. |
2010-09-01 |
2023-08-12 |
mouse |
| Lars M Ittner, Yazi D Ke, Fabien Delerue, Mian Bi, Amadeus Gladbach, Janet van Eersel, Heidrun Wölfing, Billy C Chieng, MacDonald J Christie, Ian A Napier, Anne Eckert, Matthias Staufenbiel, Edna Hardeman, Jürgen Göt. Dendritic function of tau mediates amyloid-beta toxicity in Alzheimer's disease mouse models. Cell. vol 142. issue 3. 2010-09-01. PMID:20655099. |
alzheimer's disease (ad) is characterized by amyloid-beta (abeta) and tau deposition in brain. |
2010-09-01 |
2023-08-12 |
mouse |
| Christian Haass, Eckhard Mandelko. Fyn-tau-amyloid: a toxic triad. Cell. vol 142. issue 3. 2010-09-01. PMID:20691893. |
the axonal protein tau and amyloid beta-peptide (abeta) are key players in the pathogenesis of alzheimer's disease, and tau mediates abeta toxicity, but it is not clear how. |
2010-09-01 |
2023-08-12 |
Not clear |
| Sachin P Patil, Sarah Maki, Santosh A Khedkar, Alan C Rigby, Christina Cha. Withanolide A and asiatic acid modulate multiple targets associated with amyloid-beta precursor protein processing and amyloid-beta protein clearance. Journal of natural products. vol 73. issue 7. 2010-08-27. PMID:20553006. |
alzheimer's disease (ad) is a progressive, neurodegenerative disease histochemically characterized by extracellular deposits of amyloid beta (abeta) protein and intracellular neurofibrillary tangles of hyperphosphorylated tau protein. |
2010-08-27 |
2023-08-12 |
rat |
| Leslie Crews, Eliezer Maslia. Molecular mechanisms of neurodegeneration in Alzheimer's disease. Human molecular genetics. vol 19. issue R1. 2010-08-24. PMID:20413653. |
alzheimer's disease (ad) is characterized by cognitive impairment, progressive neurodegeneration and formation of amyloid-beta (abeta)-containing plaques and neurofibrillary tangles composed of hyperphosphorylated tau. |
2010-08-24 |
2023-08-12 |
Not clear |
| David W Hampton, Daniel J Webber, Bilada Bilican, Michel Goedert, Maria Grazia Spillantini, Siddharthan Chandra. Cell-mediated neuroprotection in a mouse model of human tauopathy. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 30. issue 30. 2010-08-20. PMID:20668182. |
tau protein in a hyperphosphorylated state makes up the intracellular inclusions of several neurodegenerative diseases, including alzheimer's disease and cases of frontotemporal dementia. |
2010-08-20 |
2023-08-12 |
mouse |