| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| José Luis Vázquez-Higuera, Pascual Sánchez-Juan, Eloy Rodríguez-Rodríguez, Ignacio Mateo, Ana Pozueta, Ana Frank, Isabel Sastre, Fernando Valdivieso, José Berciano, María J Bullido, Onofre Combarro. DYRK1A genetic variants are not linked to Alzheimer's disease in a Spanish case-control cohort. BMC medical genetics. vol 10. 2010-03-25. PMID:19995442. |
as dual-specificity tyrosine phosphorylation-regulated kinase 1a (dyrk1a) has been implicated in the abnormal hyperphosphorylation of tau in alzheimer's disease (ad) brain, and the development of neurofibrillary tangles, we examined the contribution of this gene to the susceptibility for ad. |
2010-03-25 |
2023-08-12 |
Not clear |
| John C Morris, Catherine M Roe, Chengjie Xiong, Anne M Fagan, Alison M Goate, David M Holtzman, Mark A Mintu. APOE predicts amyloid-beta but not tau Alzheimer pathology in cognitively normal aging. Annals of neurology. vol 67. issue 1. 2010-03-25. PMID:20186853. |
apoe predicts amyloid-beta but not tau alzheimer pathology in cognitively normal aging. |
2010-03-25 |
2023-08-12 |
Not clear |
| Anne M Fagan, Mark A Mintun, Aarti R Shah, Patricia Aldea, Catherine M Roe, Robert H Mach, Daniel Marcus, John C Morris, David M Holtzma. Cerebrospinal fluid tau and ptau(181) increase with cortical amyloid deposition in cognitively normal individuals: implications for future clinical trials of Alzheimer's disease. EMBO molecular medicine. vol 1. issue 8-9. 2010-03-10. PMID:20049742. |
cerebrospinal fluid tau and ptau(181) increase with cortical amyloid deposition in cognitively normal individuals: implications for future clinical trials of alzheimer's disease. |
2010-03-10 |
2023-08-12 |
human |
| Masatake Fujimura, Fusako Usuki, Masumi Sawada, Akihiko Takashim. Methylmercury induces neuropathological changes with tau hyperphosphorylation mainly through the activation of the c-jun-N-terminal kinase pathway in the cerebral cortex, but not in the hippocampus of the mouse brain. Neurotoxicology. vol 30. issue 6. 2010-03-09. PMID:19666049. |
western blotting revealed that mehg exposure increased tau phosphorylation at thr-205, ser-396 and ser-422 in the cerebral cortex, consistent with the phosphorylation patterns noted in alzheimer's disease and frontotemporal dementia. |
2010-03-09 |
2023-08-12 |
mouse |
| Jason A Bailey, Debomoy K Lahir. A novel effect of rivastigmine on pre-synaptic proteins and neuronal viability in a neurodegeneration model of fetal rat primary cortical cultures and its implication in Alzheimer's disease. Journal of neurochemistry. vol 112. issue 4. 2010-03-08. PMID:19912467. |
alzheimer's disease (ad) is characterized by deposition of amyloid-beta peptide plaque, disrupted amyloid-beta-precursor protein (app) metabolism, hyperphosphorylation of tau leading to neurofibrillary tangles and associated neurotoxicity. |
2010-03-08 |
2023-08-12 |
rat |
| Anders M Fjell, Kristine B Walhovd, Christine Fennema-Notestine, Linda K McEvoy, Donald J Hagler, Dominic Holland, James B Brewer, Anders M Dal. CSF biomarkers in prediction of cerebral and clinical change in mild cognitive impairment and Alzheimer's disease. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 30. issue 6. 2010-03-05. PMID:20147537. |
brain atrophy and altered csf levels of amyloid beta (abeta(42)) and the microtubule-associated protein tau are potent biomarkers of alzheimer's disease (ad)-related pathology. |
2010-03-05 |
2023-08-12 |
human |
| Cees Mulder, Nicolaas A Verwey, Wiesje M van der Flier, Femke H Bouwman, Astrid Kok, Evert J van Elk, Philip Scheltens, Marinus A Blankenstei. Amyloid-beta(1-42), total tau, and phosphorylated tau as cerebrospinal fluid biomarkers for the diagnosis of Alzheimer disease. Clinical chemistry. vol 56. issue 2. 2010-03-04. PMID:19833838. |
amyloid-beta(1-42), total tau, and phosphorylated tau as cerebrospinal fluid biomarkers for the diagnosis of alzheimer disease. |
2010-03-04 |
2023-08-12 |
Not clear |
| Cees Mulder, Nicolaas A Verwey, Wiesje M van der Flier, Femke H Bouwman, Astrid Kok, Evert J van Elk, Philip Scheltens, Marinus A Blankenstei. Amyloid-beta(1-42), total tau, and phosphorylated tau as cerebrospinal fluid biomarkers for the diagnosis of Alzheimer disease. Clinical chemistry. vol 56. issue 2. 2010-03-04. PMID:19833838. |
to improve ante mortem diagnostic accuracy of alzheimer disease (ad), measurement of the biomarkers amyloid-beta(1-42) (abeta42), total tau (tau), and tau phosphorylated at threonine(181) (ptau) in cerebrospinal fluid (csf) has been proposed. |
2010-03-04 |
2023-08-12 |
Not clear |
| Guo-Qing Zheng, Xiu-Min Wang, Yan Wang, Xiao-Tong Wan. Tau as a potential novel therapeutic target in ischemic stroke. Journal of cellular biochemistry. vol 109. issue 1. 2010-03-02. PMID:19921714. |
based on the "ischemia-reperfusion theory" of alzheimer's disease, some previous studies have focused on the relationship of tau and alzheimer lesions in experimental brain ischemia. |
2010-03-02 |
2023-08-12 |
Not clear |
| Alexei Surguchev, Andrei Surgucho. Conformational diseases: looking into the eyes. Brain research bulletin. vol 81. issue 1. 2010-03-01. PMID:19808079. |
in alzheimer's disease with the deposition of amyloid-beta and tau, in scrapie and bovine spongiform encephalopathy with the accumulation of prion protein, in parkinson's disease with the deposition of alpha-synuclein. |
2010-03-01 |
2023-08-12 |
cattle |
| Ryszard Pluta, Marzena Ułamek, Mirosław Jabłońsk. Alzheimer's mechanisms in ischemic brain degeneration. Anatomical record (Hoboken, N.J. : 2007). vol 292. issue 12. 2010-02-26. PMID:19943340. |
generation and deposition of beta-amyloid peptide and tau protein pathology are important key players involved in mechanisms in ischemic neurodegeneration as well as in alzheimer's disease. |
2010-02-26 |
2023-08-12 |
Not clear |
| David O Azorsa, RiLee H Robeson, Danielle Frost, Bessie Meec hoovet, Gillian R Brautigam, Chad Dickey, Christian Beaudry, Gargi D Basu, David R Holz, Joseph A Hernandez, Kristen M Bisanz, Leslie Gwinn, Andrew Grover, Joseph Rogers, Eric M Reiman, Michael Hutton, Dietrich A Stephan, Spyro Mousses, Travis Dunckle. High-content siRNA screening of the kinome identifies kinases involved in Alzheimer's disease-related tau hyperphosphorylation. BMC genomics. vol 11. 2010-02-26. PMID:20067632. |
high-content sirna screening of the kinome identifies kinases involved in alzheimer's disease-related tau hyperphosphorylation. |
2010-02-26 |
2023-08-12 |
Not clear |
| David O Azorsa, RiLee H Robeson, Danielle Frost, Bessie Meec hoovet, Gillian R Brautigam, Chad Dickey, Christian Beaudry, Gargi D Basu, David R Holz, Joseph A Hernandez, Kristen M Bisanz, Leslie Gwinn, Andrew Grover, Joseph Rogers, Eric M Reiman, Michael Hutton, Dietrich A Stephan, Spyro Mousses, Travis Dunckle. High-content siRNA screening of the kinome identifies kinases involved in Alzheimer's disease-related tau hyperphosphorylation. BMC genomics. vol 11. 2010-02-26. PMID:20067632. |
neurofibrillary tangles (nft), a cardinal neuropathological feature of alzheimer's disease (ad) that is highly correlated with synaptic loss and dementia severity, appear to be partly attributable to increased phosphorylation of the microtubule stabilizing protein tau at certain ad-related residues. |
2010-02-26 |
2023-08-12 |
Not clear |
| Magnus Gisslén, Jan Krut, Ulf Andreasson, Kaj Blennow, Paola Cinque, Bruce J Brew, Serena Spudich, Lars Hagberg, Lars Rosengren, Richard W Price, Henrik Zetterber. Amyloid and tau cerebrospinal fluid biomarkers in HIV infection. BMC neurology. vol 9. 2010-02-24. PMID:20028512. |
because of the emerging intersections of hiv infection and alzheimer's disease, we examined cerebrospinal fluid (csf) biomarkers related of amyloid and tau metabolism in hiv-infected patients. |
2010-02-24 |
2023-08-12 |
Not clear |
| Richard Abraham, Rebecca Sims, Liam Carroll, Paul Hollingworth, Michael C O'Donovan, Julie Williams, Michael J Owe. An association study of common variation at the MAPT locus with late-onset Alzheimer's disease. American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics. vol 150B. issue 8. 2010-02-23. PMID:19308965. |
both psp and cbd cases display tau pathology similar to late-onset alzheimer's disease (load). |
2010-02-23 |
2023-08-12 |
Not clear |
| Yipeng Wang, Marta Martinez-Vicente, Ulrike Krüger, Susmita Kaushik, Esther Wong, Eva-Maria Mandelkow, Ana Maria Cuervo, Eckhard Mandelko. Tau fragmentation, aggregation and clearance: the dual role of lysosomal processing. Human molecular genetics. vol 18. issue 21. 2010-02-22. PMID:19654187. |
aggregation and cleavage are two hallmarks of tau pathology in alzheimer disease (ad), and abnormal fragmentation of tau is thought to contribute to the nucleation of tau paired helical filaments. |
2010-02-22 |
2023-08-12 |
Not clear |
| Christopher Janus, Hans Welz. Mouse models of neurodegenerative diseases: criteria and general methodology. Methods in molecular biology (Clifton, N.J.). vol 602. 2010-02-22. PMID:20012407. |
the major symptom of alzheimer's disease is rapidly progressing dementia, coinciding with the formation of amyloid and tau deposits in the central nervous system, and neuronal death. |
2010-02-22 |
2023-08-12 |
mouse |
| Christopher A Shaw, Michael S Petri. Aluminum hydroxide injections lead to motor deficits and motor neuron degeneration. Journal of inorganic biochemistry. vol 103. issue 11. 2010-02-19. PMID:19740540. |
morin stain detected the presence of aluminum in the cytoplasm of motor neurons with some neurons also testing positive for the presence of hyper-phosphorylated tau protein, a pathological hallmark of various neurological diseases, including alzheimer's disease and frontotemporal dementia. |
2010-02-19 |
2023-08-12 |
mouse |
| Ling-Hui Tu, Jie Ma, Hai-Peng Liu, Rong-Rong Wang, Jing Lu. The neuroprotective effects of ginsenosides on calcineurin activity and tau phosphorylation in SY5Y cells. Cellular and molecular neurobiology. vol 29. issue 8. 2010-02-17. PMID:19517226. |
many findings have shown that calcineurin plays an important role in tau hyperphosphorylation, which is one of the neuropathologic features in the brains of alzheimer's disease (ad). |
2010-02-17 |
2023-08-12 |
human |
| Yury G Kaminsky, Michael W Marlatt, Mark A Smith, Elena A Kosenk. Subcellular and metabolic examination of amyloid-beta peptides in Alzheimer disease pathogenesis: evidence for Abeta(25-35). Experimental neurology. vol 221. issue 1. 2010-02-16. PMID:19751725. |
it aggregates to form the core of alzheimer disease-associated plaques found in coordination with tau deposits in diseased individuals. |
2010-02-16 |
2023-08-12 |
Not clear |