| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Richard Abraham, Rebecca Sims, Liam Carroll, Paul Hollingworth, Michael C O'Donovan, Julie Williams, Michael J Owe. An association study of common variation at the MAPT locus with late-onset Alzheimer's disease. American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics. vol 150B. issue 8. 2010-02-23. PMID:19308965. |
both psp and cbd cases display tau pathology similar to late-onset alzheimer's disease (load). |
2010-02-23 |
2023-08-12 |
Not clear |
| Yipeng Wang, Marta Martinez-Vicente, Ulrike Krüger, Susmita Kaushik, Esther Wong, Eva-Maria Mandelkow, Ana Maria Cuervo, Eckhard Mandelko. Tau fragmentation, aggregation and clearance: the dual role of lysosomal processing. Human molecular genetics. vol 18. issue 21. 2010-02-22. PMID:19654187. |
aggregation and cleavage are two hallmarks of tau pathology in alzheimer disease (ad), and abnormal fragmentation of tau is thought to contribute to the nucleation of tau paired helical filaments. |
2010-02-22 |
2023-08-12 |
Not clear |
| Christopher Janus, Hans Welz. Mouse models of neurodegenerative diseases: criteria and general methodology. Methods in molecular biology (Clifton, N.J.). vol 602. 2010-02-22. PMID:20012407. |
the major symptom of alzheimer's disease is rapidly progressing dementia, coinciding with the formation of amyloid and tau deposits in the central nervous system, and neuronal death. |
2010-02-22 |
2023-08-12 |
mouse |
| Christopher A Shaw, Michael S Petri. Aluminum hydroxide injections lead to motor deficits and motor neuron degeneration. Journal of inorganic biochemistry. vol 103. issue 11. 2010-02-19. PMID:19740540. |
morin stain detected the presence of aluminum in the cytoplasm of motor neurons with some neurons also testing positive for the presence of hyper-phosphorylated tau protein, a pathological hallmark of various neurological diseases, including alzheimer's disease and frontotemporal dementia. |
2010-02-19 |
2023-08-12 |
mouse |
| Ling-Hui Tu, Jie Ma, Hai-Peng Liu, Rong-Rong Wang, Jing Lu. The neuroprotective effects of ginsenosides on calcineurin activity and tau phosphorylation in SY5Y cells. Cellular and molecular neurobiology. vol 29. issue 8. 2010-02-17. PMID:19517226. |
many findings have shown that calcineurin plays an important role in tau hyperphosphorylation, which is one of the neuropathologic features in the brains of alzheimer's disease (ad). |
2010-02-17 |
2023-08-12 |
human |
| Yury G Kaminsky, Michael W Marlatt, Mark A Smith, Elena A Kosenk. Subcellular and metabolic examination of amyloid-beta peptides in Alzheimer disease pathogenesis: evidence for Abeta(25-35). Experimental neurology. vol 221. issue 1. 2010-02-16. PMID:19751725. |
it aggregates to form the core of alzheimer disease-associated plaques found in coordination with tau deposits in diseased individuals. |
2010-02-16 |
2023-08-12 |
Not clear |
| Zhong-Ying Mo, Ying-Zhu Zhu, Hai-Li Zhu, Jun-Bao Fan, Jie Chen, Yi Lian. Low micromolar zinc accelerates the fibrillization of human tau via bridging of Cys-291 and Cys-322. The Journal of biological chemistry. vol 284. issue 50. 2010-02-05. PMID:19826005. |
a hallmark of a group of neurodegenerative diseases such as alzheimer disease is the formation of neurofibrillary tangles, which are principally composed of bundles of filaments formed by microtubule-associated protein tau. |
2010-02-05 |
2023-08-12 |
human |
| Chiara Terracciano, Anna Nogalska, W King Engel, Valerie Askana. In AbetaPP-overexpressing cultured human muscle fibers proteasome inhibition enhances phosphorylation of AbetaPP751 and GSK3beta activation: effects mitigated by lithium and apparently relevant to sporadic inclusion-body myositis. Journal of neurochemistry. vol 112. issue 2. 2010-02-05. PMID:19878439. |
in brains of alzheimer's disease (ad) patients and ad transgenic-mouse models, phosphorylation of neuronal abetapp695 (p-abetapp) on thr668 (equivalent to t724 of abetapp751) is considered detrimental because it increases generation of cytotoxic abeta and induces tau phosphorylation. |
2010-02-05 |
2023-08-12 |
human |
| Jose Morales-Corraliza, Matthew J Mazzella, Jason D Berger, Nicole S Diaz, Jennifer H K Choi, Efrat Levy, Yasuji Matsuoka, Emmanuel Planel, Paul M Mathew. In vivo turnover of tau and APP metabolites in the brains of wild-type and Tg2576 mice: greater stability of sAPP in the beta-amyloid depositing mice. PloS one. vol 4. issue 9. 2010-02-01. PMID:19771166. |
the metabolism of the amyloid precursor protein (app) and tau are central to the pathobiology of alzheimer's disease (ad). |
2010-02-01 |
2023-08-12 |
mouse |
| Umesh K Jinwal, John Koren, Sergiy I Borysov, Andreas B Schmid, Jose F Abisambra, Laura J Blair, Amelia G Johnson, Jeffrey R Jones, Cody L Shults, John C O'Leary, Ying Jin, Johannes Buchner, Marc B Cox, Chad A Dicke. The Hsp90 cochaperone, FKBP51, increases Tau stability and polymerizes microtubules. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 30. issue 2. 2010-02-01. PMID:20071522. |
our previous work demonstrated that age-related changes to the cellular chaperone repertoire contributes to abnormal buildup of the microtubule-associated protein tau that accumulates in a group of diseases termed tauopathies, the most common being alzheimer's disease. |
2010-02-01 |
2023-08-12 |
Not clear |
| J Mares, P Kanovsky, R Herzig, D Stejskal, J Vavrouskova, P Hlustik, H Vranova, S Burval, J Zapletalova, V Pidrman, R Obereigneru, A Suchy, J Vesely, J Podivinsky, K Urbane. New laboratory markers in diagnosis of alzheimer dementia. Neurological research. vol 31. issue 10. 2010-01-26. PMID:19589198. |
the aim of our work was to assess the role of tau protein, beta amyloid and cystatin c in diagnosis of alzheimer dementia (ad) and other neurodegenerative diseases (nds). |
2010-01-26 |
2023-08-12 |
Not clear |
| Diane P Hanger, Anjan Seereeram, Wendy Nobl. Mediators of tau phosphorylation in the pathogenesis of Alzheimer's disease. Expert review of neurotherapeutics. vol 9. issue 11. 2010-01-22. PMID:19903024. |
mediators of tau phosphorylation in the pathogenesis of alzheimer's disease. |
2010-01-22 |
2023-08-12 |
Not clear |
| Kenichi Oshima, Dennis W Dickso. Cortical Alzheimer type pathology does not influence tau pathology in progressive supranuclear palsy. International journal of clinical and experimental pathology. vol 2. issue 4. 2010-01-21. PMID:19158937. |
cortical alzheimer type pathology does not influence tau pathology in progressive supranuclear palsy. |
2010-01-21 |
2023-08-12 |
Not clear |
| Carina Weissmann, Hans-Jürgen Reyher, Anne Gauthier, Heinz-Jürgen Steinhoff, Wolfgang Junge, Roland Brand. Microtubule binding and trapping at the tip of neurites regulate tau motion in living neurons. Traffic (Copenhagen, Denmark). vol 10. issue 11. 2010-01-21. PMID:19744140. |
in tauopathies such as alzheimer's disease, tau accumulates in the somatodendritic compartment. |
2010-01-21 |
2023-08-12 |
Not clear |
| Archibaldo Donoso S, Carolina Delgado . [Prevention and treatment of Alzheimer disease]. Revista medica de Chile. vol 137. issue 2. 2010-01-19. PMID:19543654. |
the pharmacological interventions for alzheimer disease should be based in its pathogenic mechanisms such as amyloidogenesis, tau hyperphosphorilation, disturbances in neurotransmission and changes in neuronal trophism. |
2010-01-19 |
2023-08-12 |
Not clear |
| Janet van Eersel, Mian Bi, Yazi D Ke, John R Hodges, John H Xuereb, Gillian C Gregory, Glenda M Halliday, Jürgen Götz, Jillian J Kril, Lars M Ittne. Phosphorylation of soluble tau differs in Pick's disease and Alzheimer's disease brains. Journal of neural transmission (Vienna, Austria : 1996). vol 116. issue 10. 2010-01-14. PMID:19693433. |
phosphorylation of soluble tau differs in pick's disease and alzheimer's disease brains. |
2010-01-14 |
2023-08-12 |
Not clear |
| Janet van Eersel, Mian Bi, Yazi D Ke, John R Hodges, John H Xuereb, Gillian C Gregory, Glenda M Halliday, Jürgen Götz, Jillian J Kril, Lars M Ittne. Phosphorylation of soluble tau differs in Pick's disease and Alzheimer's disease brains. Journal of neural transmission (Vienna, Austria : 1996). vol 116. issue 10. 2010-01-14. PMID:19693433. |
although alzheimer's disease (ad) is also characterised by tau lesions, these are both histologically and biochemically distinct from the tau aggregates found in pid. |
2010-01-14 |
2023-08-12 |
Not clear |
| Virginie Rhein, Xiaomin Song, Andreas Wiesner, Lars M Ittner, Ginette Baysang, Fides Meier, Laurence Ozmen, Horst Bluethmann, Stefan Dröse, Ulrich Brandt, Egemen Savaskan, Christian Czech, Jürgen Götz, Anne Ecker. Amyloid-beta and tau synergistically impair the oxidative phosphorylation system in triple transgenic Alzheimer's disease mice. Proceedings of the National Academy of Sciences of the United States of America. vol 106. issue 47. 2010-01-14. PMID:19897719. |
amyloid-beta and tau synergistically impair the oxidative phosphorylation system in triple transgenic alzheimer's disease mice. |
2010-01-14 |
2023-08-12 |
mouse |
| Jin-Tai Yu, Raymond Chuen-Chung Chang, Lan Ta. Calcium dysregulation in Alzheimer's disease: from mechanisms to therapeutic opportunities. Progress in neurobiology. vol 89. issue 3. 2010-01-12. PMID:19664678. |
though disturbances in calcium homeostasis in cells from alzheimer's disease (ad) patients have been observed for many years, much more attention was focused on amyloid-beta (abeta) and tau as key causative factors for the disease. |
2010-01-12 |
2023-08-12 |
Not clear |
| Nichole E Lapointe, Peleg M Horowitz, Angela L Guillozet-Bongaarts, Andres Silva, Athena Andreadis, Lester I Binde. Tau 6D and 6P isoforms inhibit polymerization of full-length tau in vitro. Biochemistry. vol 48. issue 51. 2010-01-12. PMID:19919107. |
alzheimer's disease and other tauopathies are characterized by the intracellular accumulation of insoluble filaments of the microtubule-associated protein tau. |
2010-01-12 |
2023-08-12 |
Not clear |