All Relations between Alzheimer Disease and microtubule-associated protein tau

Publication Sentence Publish Date Extraction Date Species
Ana Ricobaraza, Mar Cuadrado-Tejedor, Alberto Pérez-Mediavilla, Diana Frechilla, Joaquin Del Río, Ana García-Ost. Phenylbutyrate ameliorates cognitive deficit and reduces tau pathology in an Alzheimer's disease mouse model. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 34. issue 7. 2009-08-03. PMID:19145227. phenylbutyrate ameliorates cognitive deficit and reduces tau pathology in an alzheimer's disease mouse model. 2009-08-03 2023-08-12 mouse
José Luis Vázquez-Higuera, Ignacio Mateo, Pascual Sánchez-Juan, Eloy Rodríguez-Rodríguez, Jon Infante, José Berciano, Onofre Combarro. No association of CDK5 genetic variants with Alzheimer's disease risk. BMC medical genetics. vol 10. 2009-07-30. PMID:19615060. as cyclin-dependent kinase 5 (cdk5) has been implicated in the abnormal hyperphosphorylation of tau in alzheimer's disease (ad) brain, and the development of neurofibrillary tangles, we examined the contribution of this gene to the susceptibility for ad. 2009-07-30 2023-08-12 Not clear
Khalid Iqbal, Fei Liu, Cheng-Xin Gong, Alejandra Del C Alonso, Inge Grundke-Iqba. Mechanisms of tau-induced neurodegeneration. Acta neuropathologica. vol 118. issue 1. 2009-07-29. PMID:19184068. alzheimer disease (ad) and related tauopathies are histopathologically characterized by a specific type of slow and progressive neurodegeneration, which involves the abnormal hyperphosphorylation of the microtubule associated protein (map) tau. 2009-07-29 2023-08-12 Not clear
Norbert Zilka, Miroslava Korenova, Michal Nova. Misfolded tau protein and disease modifying pathways in transgenic rodent models of human tauopathies. Acta neuropathologica. vol 118. issue 1. 2009-07-29. PMID:19238406. human tauopathies represent a heterogeneous group of neurodegenerative disorders such as alzheimer's disease (ad) that are characterized by the presence of intracellular accumulations of abnormal filaments of protein tau. 2009-07-29 2023-08-12 human
C Reitz, L Honig, J P Vonsattel, M-X Tang, R Mayeu. Memory performance is related to amyloid and tau pathology in the hippocampus. Journal of neurology, neurosurgery, and psychiatry. vol 80. issue 7. 2009-07-29. PMID:19258354. to determine the relation of amyloid and tau pathology in the hippocampal formation to decline in memory and other cognitive functions in alzheimer's disease (ad). 2009-07-29 2023-08-12 Not clear
Akio Ojida, Takashi Sakamoto, Masa-aki Inoue, Sho-hei Fujishima, Guy Lippens, Itaru Hamach. Fluorescent BODIPY-based Zn(II) complex as a molecular probe for selective detection of neurofibrillary tangles in the brains of Alzheimer's disease patients. Journal of the American Chemical Society. vol 131. issue 18. 2009-07-27. PMID:19368380. we have developed a new fluorescent binuclear zn(ii) complex for the detection of neurofibrillary tangles (nfts) of hyperphosphorylated tau proteins, a representative hallmark of alzheimer's disease (ad). 2009-07-27 2023-08-12 Not clear
Ryozo Kuwano, Norihiro Takei, Akinori Miyashit. [Genetic basis for dementia]. Nihon rinsho. Japanese journal of clinical medicine. vol 67. issue 6. 2009-07-24. PMID:19507496. three frequent neurodegererative dementias are alzheimer disease, dementia with lewy bodies, and frontotemporal lobar degeneration, characterized by senile plaque with amyloid beta and neurofibrillary tangles with tau, lewy body with alpha-synuclein, tau or tau-negative ubiquitin-immunoreactive neuronal inclusions with tdp-43, respectively. 2009-07-24 2023-08-12 Not clear
Bess Frost, Rachel L Jacks, Marc I Diamon. Propagation of tau misfolding from the outside to the inside of a cell. The Journal of biological chemistry. vol 284. issue 19. 2009-07-21. PMID:19282288. tau aggregation occurs in many diseases, including alzheimer disease and frontotemporal dementia. 2009-07-21 2023-08-12 Not clear
Qian Sun, T Chris Gambli. Pseudohyperphosphorylation causing AD-like changes in tau has significant effects on its polymerization. Biochemistry. vol 48. issue 25. 2009-07-20. PMID:19459590. the microtubule-associated protein tau, in a hyperphosphorylated form, aggregates into insoluble paired-helical filaments (phfs) in alzheimer's disease (ad) and other tauopathies. 2009-07-20 2023-08-12 Not clear
Qian Sun, T Chris Gambli. Pseudohyperphosphorylation causing AD-like changes in tau has significant effects on its polymerization. Biochemistry. vol 48. issue 25. 2009-07-20. PMID:19459590. on the basis of the observations that pseudohyperphosphorylated tau has decreased affinity for microtubules and reduced inducer-initiated rates of nucleation and polymerization, we propose that this combination could be the cause of the increased cytotoxicity of hyperphosphorylated tau in alzheimer's disease and also explain the potentially beneficial role of tau polymerization and nft formation. 2009-07-20 2023-08-12 Not clear
Florence Clavaguera, Tristan Bolmont, R Anthony Crowther, Dorothee Abramowski, Stephan Frank, Alphonse Probst, Graham Fraser, Anna K Stalder, Martin Beibel, Matthias Staufenbiel, Mathias Jucker, Michel Goedert, Markus Tolna. Transmission and spreading of tauopathy in transgenic mouse brain. Nature cell biology. vol 11. issue 7. 2009-07-20. PMID:19503072. hyperphosphorylated tau makes up the filamentous intracellular inclusions of several neurodegenerative diseases, including alzheimer's disease. 2009-07-20 2023-08-12 mouse
Florence Clavaguera, Tristan Bolmont, R Anthony Crowther, Dorothee Abramowski, Stephan Frank, Alphonse Probst, Graham Fraser, Anna K Stalder, Martin Beibel, Matthias Staufenbiel, Mathias Jucker, Michel Goedert, Markus Tolna. Transmission and spreading of tauopathy in transgenic mouse brain. Nature cell biology. vol 11. issue 7. 2009-07-20. PMID:19503072. cognitive impairment becomes manifest when inclusions reach the hippocampus, with abundant neocortical tau inclusions and extracellular beta-amyloid deposits being the defining pathological hallmarks of alzheimer's disease. 2009-07-20 2023-08-12 mouse
Harald Hampel, Michael Ewers, Katharina Bürger, Peter Annas, Anette Mörtberg, Anna Bogstedt, Lutz Frölich, Johannes Schröder, Peter Schönknecht, Matthias W Riepe, Inga Kraft, Thomas Gasser, Thomas Leyhe, Hans-Jürgen Möller, Alexander Kurz, Hans Basu. Lithium trial in Alzheimer's disease: a randomized, single-blind, placebo-controlled, multicenter 10-week study. The Journal of clinical psychiatry. vol 70. issue 6. 2009-07-20. PMID:19573486. since hyperphosphorylation of tau is a core pathological feature in alzheimer's disease, lithium-induced inhibition of gsk-3 activity may have therapeutic effects in alzheimer's disease. 2009-07-20 2023-08-12 Not clear
Mar Perez, Ismael Santa-Maria, Elena Gomez de Barreda, Xiongwei Zhu, Raquel Cuadros, Jose Roman Cabrero, Francisco Sanchez-Madrid, Hana N Dawson, Michael P Vitek, George Perry, Mark A Smith, Jesus Avil. Tau--an inhibitor of deacetylase HDAC6 function. Journal of neurochemistry. vol 109. issue 6. 2009-07-17. PMID:19457097. analysis of brain microtubule protein from patients with alzheimer's disease showed decreased alpha tubulin levels along with increased acetylation of the alpha tubulin subunit, mainly in those microtubules from neurons containing neurofibrillary tau pathology. 2009-07-17 2023-08-12 mouse
Evan Elliott, Offir Laufer, Irith Ginzbur. BAG-1M is up-regulated in hippocampus of Alzheimer's disease patients and associates with tau and APP proteins. Journal of neurochemistry. vol 109. issue 4. 2009-07-16. PMID:19317853. bag-1m is up-regulated in hippocampus of alzheimer's disease patients and associates with tau and app proteins. 2009-07-16 2023-08-12 human
Evan Elliott, Offir Laufer, Irith Ginzbur. BAG-1M is up-regulated in hippocampus of Alzheimer's disease patients and associates with tau and APP proteins. Journal of neurochemistry. vol 109. issue 4. 2009-07-16. PMID:19317853. the accumulation of tau and amyloid beta proteins is the major molecular pathology of alzheimer's disease (ad). 2009-07-16 2023-08-12 human
Magdalena Kuszczyk, Wanda Gordon-Krajcer, Jerzy W Lazarewic. Homocysteine-induced acute excitotoxicity in cerebellar granule cells in vitro is accompanied by PP2A-mediated dephosphorylation of tau. Neurochemistry international. vol 55. issue 1-3. 2009-07-15. PMID:19428823. this contrasts with the previously reported hyperphosphorylation of tau in homocysteine-treated neurons, and with the assumption that hyperhomocysteinemia is one of the risk factors in alzheimer disease, in which abnormal hyperphosphorylation of tau protein leads to neurofibrillary degeneration. 2009-07-15 2023-08-12 rat
Helen Lavretsky, Prabha Siddarth, Vladimir Kepe, Linda M Ercoli, Karen J Miller, Alison C Burggren, Susan Y Bookheimer, Sung-Cheng Huang, Jorge R Barrio, Gary W Smal. Depression and anxiety symptoms are associated with cerebral FDDNP-PET binding in middle-aged and older nondemented adults. The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry. vol 17. issue 6. 2009-07-13. PMID:19472439. amyloid senile plaques and tau neurofibrillary tangles are neuropathologic hallmarks of alzheimer disease, which may be associated with mild cognitive impairment (mci) or mood and anxiety symptoms years before the dementia diagnosis. 2009-07-13 2023-08-12 human
Shaomin Li, Soyon Hong, Nina E Shepardson, Dominic M Walsh, Ganesh M Shankar, Dennis Selko. Soluble oligomers of amyloid Beta protein facilitate hippocampal long-term depression by disrupting neuronal glutamate uptake. Neuron. vol 62. issue 6. 2009-07-09. PMID:19555648. in alzheimer's disease (ad), the impairment of declarative memory coincides with the accumulation of extracellular amyloid-beta protein (abeta) and intraneuronal tau aggregates. 2009-07-09 2023-08-12 human
John Koren, Umesh K Jinwal, Daniel C Lee, Jeffrey R Jones, Cody L Shults, Amelia G Johnson, Laura J Anderson, Chad A Dicke. Chaperone signalling complexes in Alzheimer's disease. Journal of cellular and molecular medicine. vol 13. issue 4. 2009-07-08. PMID:19449461. in the case of alzheimer's disease (ad), a number of studies have recently emerged describing the impact that these chaperones have on the proteotoxic effects of tau and amyloid- beta accumulation. 2009-07-08 2023-08-12 Not clear