| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Wolfgang J Streit, Heiko Braak, Qing-Shan Xue, Ingo Bechman. Dystrophic (senescent) rather than activated microglial cells are associated with tau pathology and likely precede neurodegeneration in Alzheimer's disease. Acta neuropathologica. vol 118. issue 4. 2009-10-08. PMID:19513731. |
using braak staging of alzheimer neuropathology we demonstrate that microglial dystrophy precedes the spread of tau pathology. |
2009-10-08 |
2023-08-12 |
human |
| Rajat Puri, Toshimitsu Suzuki, Kazuhiro Yamakawa, Subramaniam Ganes. Hyperphosphorylation and aggregation of Tau in laforin-deficient mice, an animal model for Lafora disease. The Journal of biological chemistry. vol 284. issue 34. 2009-10-06. PMID:19542233. |
taken together, our study suggests that laforin is one of the critical regulators of tau protein, that the nfts could underlie some of the symptoms seen in ld, and that laforin can contribute to the nft formation in alzheimer disease and other tauopathies. |
2009-10-06 |
2023-08-12 |
mouse |
| N Schuff, N Woerner, L Boreta, T Kornfield, L M Shaw, J Q Trojanowski, P M Thompson, C R Jack, M W Weine. MRI of hippocampal volume loss in early Alzheimer's disease in relation to ApoE genotype and biomarkers. Brain : a journal of neurology. vol 132. issue Pt 4. 2009-10-01. PMID:19251758. |
6-12 months, with mri in the large multicentre setting of the alzheimer's disease neuroimaging initiative (adni); (ii) to determine the extent to which the polymorphism of the apolipoprotein e (apoe) gene modulates hippocampal change; and (iii) to determine if rates of hippocampal loss correlate with cerebrospinal fluid (csf) biomarkers of alzheimer's disease, such as the beta-amyloid (abeta(1-42)) and tau proteins (tau). |
2009-10-01 |
2023-08-12 |
Not clear |
| N Schuff, N Woerner, L Boreta, T Kornfield, L M Shaw, J Q Trojanowski, P M Thompson, C R Jack, M W Weine. MRI of hippocampal volume loss in early Alzheimer's disease in relation to ApoE genotype and biomarkers. Brain : a journal of neurology. vol 132. issue Pt 4. 2009-10-01. PMID:19251758. |
moreover, increased rates of hippocampal loss were associated with presence of the apoe allele epsilon4 gene in alzheimer's disease and lower csf abeta(1-42) in mild cognitive impairment, irrespective of apoe genotype, whereas relations with tau were only trends. |
2009-10-01 |
2023-08-12 |
Not clear |
| Kazuaki Ichihara, Toshiki Uchihara, Ayako Nakamura, Yoshio Suzuki, Tomohiko Mizutan. Selective deposition of 4-repeat tau in cerebral infarcts. Journal of neuropathology and experimental neurology. vol 68. issue 9. 2009-10-01. PMID:19680140. |
to characterize the tau profile in these lesions, 21 brains from autopsied patients with cerebral infarcts were analyzed using immunohistochemistry with rd3, rd4, and the anti-paired helical filament antibody at8 and with gal and cs staining; all of these techniques identify alzheimer disease-type neurofibrillary tangles. |
2009-10-01 |
2023-08-12 |
Not clear |
| Rakez Kayed, George R Jackso. Prefilament tau species as potential targets for immunotherapy for Alzheimer disease and related disorders. Current opinion in immunology. vol 21. issue 3. 2009-09-25. PMID:19482462. |
prefilament tau species as potential targets for immunotherapy for alzheimer disease and related disorders. |
2009-09-25 |
2023-08-12 |
Not clear |
| Yea-Hyun Leem, Hwa-Ja Lim, Sun-Bo Shim, Joon-Yong Cho, Bum-Soo Kim, Pyung-Lim Ha. Repression of tau hyperphosphorylation by chronic endurance exercise in aged transgenic mouse model of tauopathies. Journal of neuroscience research. vol 87. issue 11. 2009-09-21. PMID:19360903. |
the present study was undertaken to investigate whether chronic endurance exercise affects tau phosphorylation levels in the brain with alzheimer's disease (ad)-like pathology. |
2009-09-21 |
2023-08-12 |
mouse |
| Wenkai Li, Jeffrey B Sperry, Alex Crowe, John Q Trojanowski, Amos B Smith, Virginia M-Y Le. Inhibition of tau fibrillization by oleocanthal via reaction with the amino groups of tau. Journal of neurochemistry. vol 110. issue 4. 2009-09-21. PMID:19549281. |
in alzheimer's disease and related tauopathies, tau fibrillizes and aggregates into neurofibrillary tangles. |
2009-09-21 |
2023-08-12 |
Not clear |
| Alex Crowe, Wenwei Huang, Carlo Ballatore, Ronald L Johnson, Anne-Marie L Hogan, Ruili Huang, Jennifer Wichterman, Joshua McCoy, Donna Huryn, Douglas S Auld, Amos B Smith, James Inglese, John Q Trojanowski, Christopher P Austin, Kurt R Brunden, Virginia M-Y Le. Identification of aminothienopyridazine inhibitors of tau assembly by quantitative high-throughput screening. Biochemistry. vol 48. issue 32. 2009-09-21. PMID:19580328. |
inclusions comprised of fibrils of the microtubule- (mt-) associated protein tau are found in the brains of those with alzheimer's disease (ad) and other neurodegenerative tauopathies. |
2009-09-21 |
2023-08-12 |
Not clear |
| Yuanming Lu, Sabah Ansar, Mary L Michaelis, Brian S J Blag. Neuroprotective activity and evaluation of Hsp90 inhibitors in an immortalized neuronal cell line. Bioorganic & medicinal chemistry. vol 17. issue 4. 2009-09-16. PMID:19138859. |
alzheimer's disease (ad) neuropathology is characterized by loss of synapses and neurons, neuritic plaques consisting of beta-amyloid (abeta) peptides, and neurofibrillary tangles consisting of intracellular aggregates of hyperphosphorylated tau protein in susceptible brain regions. |
2009-09-16 |
2023-08-12 |
Not clear |
| Alain Boom, Michèle Authelet, Robert Dedecker, Christelle Frédérick, Roxane Van Heurck, Valery Daubie, Karelle Leroy, Roland Pochet, Jean-Pierre Brio. Bimodal modulation of tau protein phosphorylation and conformation by extracellular Zn2+ in human-tau transfected cells. Biochimica et biophysica acta. vol 1793. issue 6. 2009-09-10. PMID:19111579. |
these results suggest that zinc plays a significant role in the development of tau pathology associated to alzheimer's disease. |
2009-09-10 |
2023-08-12 |
human |
| Sébastien Perreault, Olivier Bousquet, Michel Lauzon, Jacques Paiement, Nicole Lecler. Increased association between rough endoplasmic reticulum membranes and mitochondria in transgenic mice that express P301L tau. Journal of neuropathology and experimental neurology. vol 68. issue 5. 2009-09-10. PMID:19525898. |
in several neurodegenerative diseases, including alzheimer disease, the neuronal microtubule-associated protein tau becomes hyperphosphorylated, accumulates in the somatodendritic compartment, and aggregates into insoluble filaments. |
2009-09-10 |
2023-08-12 |
mouse |
| Sébastien Perreault, Olivier Bousquet, Michel Lauzon, Jacques Paiement, Nicole Lecler. Increased association between rough endoplasmic reticulum membranes and mitochondria in transgenic mice that express P301L tau. Journal of neuropathology and experimental neurology. vol 68. issue 5. 2009-09-10. PMID:19525898. |
the association of hyperphosphorylated tau with er membranes was confirmed by double immunogold labeling of the subfraction enriched in er membranes isolated from alzheimer disease brains. |
2009-09-10 |
2023-08-12 |
mouse |
| Manuela Polydoro, Christopher M Acker, Karen Duff, Pablo E Castillo, Peter Davie. Age-dependent impairment of cognitive and synaptic function in the htau mouse model of tau pathology. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 29. issue 34. 2009-09-10. PMID:19710325. |
a hallmark feature of alzheimer's disease pathology is the presence of neurofibrillary tangles (nfts), which are intracellular aggregates of conformationally abnormal and hyperphosphorylated tau. |
2009-09-10 |
2023-08-12 |
mouse |
| Eric C Petrie, Donna J Cross, Douglas Galasko, Gerard D Schellenberg, Murray A Raskind, Elaine R Peskind, Satoshi Minoshim. Preclinical evidence of Alzheimer changes: convergent cerebrospinal fluid biomarker and fluorodeoxyglucose positron emission tomography findings. Archives of neurology. vol 66. issue 5. 2009-09-09. PMID:19433663. |
alterations in cerebrospinal fluid (csf) tau and beta-amyloid peptide 1-42 (abeta(42)) levels and rates of cerebral glucose metabolism (cmrglu) on fluorodeoxyglucose positron emission tomography (fdg-pet) occur years before clinical symptoms of alzheimer disease (ad) become manifest, but their relationship remains unclear. |
2009-09-09 |
2023-08-12 |
Not clear |
| Barbara J Snider, Anne M Fagan, Catherine Roe, Aarti R Shah, Elizabeth A Grant, Chengjie Xiong, John C Morris, David M Holtzma. Cerebrospinal fluid biomarkers and rate of cognitive decline in very mild dementia of the Alzheimer type. Archives of neurology. vol 66. issue 5. 2009-09-09. PMID:19433664. |
cerebrospinal fluid (csf) levels of abeta peptide 1-42 (abeta 42), tau, and phosphorylated tau (ptau) are potential biomarkers of alzheimer disease. |
2009-09-09 |
2023-08-12 |
Not clear |
| Fei Liu, Jianhua Shi, Hitoshi Tanimukai, Jinhua Gu, Jianlan Gu, Inge Grundke-Iqbal, Khalid Iqbal, Cheng-Xin Gon. Reduced O-GlcNAcylation links lower brain glucose metabolism and tau pathology in Alzheimer's disease. Brain : a journal of neurology. vol 132. issue Pt 7. 2009-09-09. PMID:19451179. |
reduced o-glcnacylation links lower brain glucose metabolism and tau pathology in alzheimer's disease. |
2009-09-09 |
2023-08-12 |
human |
| Fei Liu, Jianhua Shi, Hitoshi Tanimukai, Jinhua Gu, Jianlan Gu, Inge Grundke-Iqbal, Khalid Iqbal, Cheng-Xin Gon. Reduced O-GlcNAcylation links lower brain glucose metabolism and tau pathology in Alzheimer's disease. Brain : a journal of neurology. vol 132. issue Pt 7. 2009-09-09. PMID:19451179. |
more importantly, the decrease in o-glcnac correlated negatively with phosphorylation at most phosphorylation sites of tau protein, which is known to play a crucial role in the neurofibrillary degeneration of alzheimer's disease. |
2009-09-09 |
2023-08-12 |
human |
| Fei Liu, Jianhua Shi, Hitoshi Tanimukai, Jinhua Gu, Jianlan Gu, Inge Grundke-Iqbal, Khalid Iqbal, Cheng-Xin Gon. Reduced O-GlcNAcylation links lower brain glucose metabolism and tau pathology in Alzheimer's disease. Brain : a journal of neurology. vol 132. issue Pt 7. 2009-09-09. PMID:19451179. |
comparison of tau phosphorylation patterns under various conditions suggests that abnormal tau hyperphosphorylation in alzheimer's disease brain may result from downregulation of both o-glcnacylation and protein phosphatase 2a. |
2009-09-09 |
2023-08-12 |
human |
| Fei Liu, Jianhua Shi, Hitoshi Tanimukai, Jinhua Gu, Jianlan Gu, Inge Grundke-Iqbal, Khalid Iqbal, Cheng-Xin Gon. Reduced O-GlcNAcylation links lower brain glucose metabolism and tau pathology in Alzheimer's disease. Brain : a journal of neurology. vol 132. issue Pt 7. 2009-09-09. PMID:19451179. |
these findings suggest that impaired brain glucose metabolism leads to abnormal hyperphosphorylation of tau and neurofibrillary degeneration via downregulation of tau o-glcnacylation in alzheimer's disease. |
2009-09-09 |
2023-08-12 |
human |