| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ming Yang, Matthew Zinkgraf, Cecilia Fitzgerald-Cook, Benjamin R Harrison, Alexandra Putzier, Daniel E L Promislow, Adrienne M Wan. Using Drosophila to identify naturally occurring genetic modifiers of Aβ42- and tau-induced toxicity. G3 (Bethesda, Md.). 2023-06-13. PMID:37311212. |
alzheimer's disease (ad) is characterized by two pathological proteins, amyloid beta 42 (aβ42) and tau. |
2023-06-13 |
2023-08-14 |
human |
| Saba Eslami, Nafiseh Hosseinzadeh Shakib, Zahra Fooladfar, Sina Nasrollahian, Saman Baghaei, Seyed Ali Mosaddad, Mohammad Motamedifa. The role of periodontitis-associated bacteria in Alzheimer's disease: A narrative review. Journal of basic microbiology. 2023-06-13. PMID:37311215. |
alzheimer's disease (ad) is pathologically characterized by senile plaques comprising beta-amyloid and neurofibrillary tangles (nfts) formed by hyperphosphorylated tau as a microtubule-associated protein with a key role in the pathogenesis of ad. |
2023-06-13 |
2023-08-14 |
Not clear |
| Ariane Bollack, Hugh G Pemberton, Lyduine E Collij, Pawel Markiewicz, David M Cash, Gill Farrar, Frederik Barkho. Longitudinal amyloid and tau PET imaging in Alzheimer's disease: A systematic review of methodologies and factors affecting quantification. Alzheimer's & dementia : the journal of the Alzheimer's Association. 2023-06-12. PMID:37303269. |
longitudinal amyloid and tau pet imaging in alzheimer's disease: a systematic review of methodologies and factors affecting quantification. |
2023-06-12 |
2023-08-14 |
Not clear |
| Yuxing Xia, Brach M Bell, Justin D Kim, Benoit I Giasso. Tau mutation S356T in the three repeat isoform leads to microtubule dysfunction and promotes prion-like seeded aggregation. Frontiers in neuroscience. vol 17. 2023-06-12. PMID:37304025. |
tauopathies are a group of neurodegenerative diseases, which include frontotemporal dementia (ftd) and alzheimer's disease (ad), broadly defined by the development of tau brain aggregates. |
2023-06-12 |
2023-08-14 |
Not clear |
| Rickie Patani, Giles E Hardingham, Shane A Liddelo. Functional roles of reactive astrocytes in neuroinflammation and neurodegeneration. Nature reviews. Neurology. 2023-06-12. PMID:37308616. |
targeting of disease-defining markers in conditions such as alzheimer disease (amyloid-β and tau) or parkinson disease (α-synuclein) has been met with limited success, suggesting that these proteins do not act in isolation but form part of a pathological network. |
2023-06-12 |
2023-08-14 |
human |
| Michael Fassler, Clara Benaim, Jacob Georg. TREM2 Agonism with a Monoclonal Antibody Attenuates Tau Pathology and Neurodegeneration. Cells. vol 12. issue 11. 2023-06-11. PMID:37296669. |
whereas trem2 deletion has been studied extensively in experimental beta-amyloid and tau-based models of alzheimer's disease, its engagement, and subsequent agonism have not been tested in the context of tau pathology. |
2023-06-11 |
2023-08-14 |
mouse |
| Valentina Latina, Anna Atlante, Francesca Malerba, Federico La Regina, Bijorn Omar Balzamino, Alessandra Micera, Annabella Pignataro, Egidio Stigliano, Sebastiano Cavallaro, Pietro Calissano, Giuseppina Amador. The Cleavage-Specific Tau 12A12mAb Exerts an Anti-Amyloidogenic Action by Modulating the Endocytic and Bioenergetic Pathways in Alzheimer's Disease Mouse Model. International journal of molecular sciences. vol 24. issue 11. 2023-06-11. PMID:37298634. |
the cleavage-specific tau 12a12mab exerts an anti-amyloidogenic action by modulating the endocytic and bioenergetic pathways in alzheimer's disease mouse model. |
2023-06-11 |
2023-08-14 |
mouse |
| Hiroshi Matsuda, Tensho Yama. Tau positron emission tomography in patients with cognitive impairment and suspected Alzheimer's disease. Fukushima journal of medical science. 2023-06-11. PMID:37302841. |
tau positron emission tomography in patients with cognitive impairment and suspected alzheimer's disease. |
2023-06-11 |
2023-08-14 |
Not clear |
| Hiroshi Matsuda, Tensho Yama. Tau positron emission tomography in patients with cognitive impairment and suspected Alzheimer's disease. Fukushima journal of medical science. 2023-06-11. PMID:37302841. |
alzheimer's disease (ad) is diagnosed by the presence of both amyloid β and tau proteins. |
2023-06-11 |
2023-08-14 |
Not clear |
| Lulu Jiang, Rebecca Roberts, Melissa Wong, Lushuang Zhang, Chelsea Joy Webber, Alper Kilci, Matthew Jenkins, Jingjing Sun, Guangxin Sun, Sherif Rashad, Peter C Dedon, Sarah Anne Daley, Weiming Xia, Alejandro Rondón Ortiz, Luke Dorrian, Takashi Saito, Takaomi C Saido, Benjamin Wolozi. Accumulation of m6A exhibits stronger correlation with MAPT than β-amyloid pathology in an APPNL-G-F /MAPTP301S mouse model of Alzheimer's disease. Research square. 2023-06-09. PMID:37292629. |
the study for the pathophysiology study of alzheimer's disease (ad) has been hampered by lack animal models that recapitulate the major ad pathologies, including extracellular β-amyloid (aβ) deposition, intracellular aggregation of microtubule associated protein tau (mapt), inflammation and neurodegeneration. |
2023-06-09 |
2023-08-14 |
mouse |
| Zhao Sun, Ji-Sun Kwon, Yudong Ren, Shawei Chen, Kitra Cates, Xinguo Lu, Courtney K Walker, Hande Karahan, Sanja Sviben, James A J Fitzpatrick, Clarissa Valdez, Henry Houlden, Celeste M Karch, Randall J Bateman, Chihiro Sato, Steven J Mennerick, Marc I Diamond, Jungsu Kim, Rudolph E Tanzi, David M Holtzman, Andrew S Yo. Endogenous recapitulation of Alzheimer's disease neuropathology through human 3D direct neuronal reprogramming. bioRxiv : the preprint server for biology. 2023-06-09. PMID:37292658. |
alzheimer's disease (ad) is a neurodegenerative disorder that primarily affects elderly individuals, and is characterized by hallmark neuronal pathologies including extracellular amyloid-β (aβ) plaque deposition, intracellular tau tangles, and neuronal death. |
2023-06-09 |
2023-08-14 |
human |
| Anika Wuestefeld, Hannah Baumeister, Jenna N Adams, Robin de Flores, Carl Hodgetts, Negar Mazloum-Farzaghi, Rosanna K Olsen, Vyash Puliyadi, Tammy T Tran, Arnold Bakker, Kelsey L Canada, Marshall A Dalton, Ana M Daugherty, Renaud La Joie, Lei Wang, Madigan Bedard, Esther Buendia, Amanda Denning, David J Irwin, Ranjit Ittyerah, Edward B Lee, Sydney Lim, Maria Mercedes Iñiguez de Onzoño Martin, Monica Munoz Lopez, Theresa Schuck, Winifred Trotman, Alicia Vela, Paul Yushkevich, Katrin Amunts, Jean C Augustinack, Song-Lin Ding, Ricardo Insausti, Olga Kedo, David Berron, Laura E M Wiss. Comparison of histological delineations of medial temporal lobe cortices by four independent neuroanatomy laboratories. bioRxiv : the preprint server for biology. 2023-06-09. PMID:37292729. |
the medial temporal lobe (mtl) cortex, located adjacent to the hippocampus, is crucial for memory and prone to the accumulation of certain neuropathologies such as alzheimer's disease neurofibrillary tau tangles. |
2023-06-09 |
2023-08-14 |
human |
| Jigyasha Timsina, Muhammad Ali, Anh Do, Lihua Wang, Yun Ju Sung, Carlos Cruchag. Harmonization of CSF and imaging biomarkers for Alzheimer's disease biomarkers: need and practical applications for genetics studies and preclinical classification. bioRxiv : the preprint server for biology. 2023-06-09. PMID:37292823. |
in alzheimer's disease (ad) research, cerebrospinal fluid (csf) amyloid beta (aβ), tau and ptau are the most accepted and well validated biomarkers. |
2023-06-09 |
2023-08-14 |
Not clear |
| Zhenfeng Song, Kuang-Wei Wang, Hsiao-Tien Chien Hagar, Hong-Ru Chen, Chia-Yi Kuan, Kezhong Zhang, Min-Hao Ku. Hyperphosphorylated tau Inflicts Intracellular Stress Responses That Are Mitigated by Apomorphine. bioRxiv : the preprint server for biology. 2023-06-09. PMID:37292976. |
abnormal phosphorylation of the microtubule-binding protein tau in the brain is a key pathological marker for alzheimer's disease and additional neurodegenerative tauopathies. |
2023-06-09 |
2023-08-14 |
Not clear |
| Chan Chen, Ramhari Kumbhar, Hu Wang, Xiuli Yang, Kundlik Gadhave, Cyrus Rastegar, Yasuyoshi Kimura, Adam Behensky, Sruthi Katakam, Deok Jeong, Liang Wang, Anthony Wang, Rong Chen, Shu Zhang, Lingtao Jin, Creg J Workman, Dario A A Vignali, Olga Pletinkova, David W Nauen, Philip C Wong, Juan C Troncoso, Mingyao Ying, Valina L Dawson, Ted M Dawson, Xiaobo Ma. Pathological Tau transmission initiated by binding lymphocyte-activation gene 3. bioRxiv : the preprint server for biology. 2023-06-09. PMID:37293032. |
accumulated tangles of filamentous tau protein are considered pathogenic lesions of alzheimer's disease (ad) and related tauopathies, including progressive supranuclear palsy, and corticobasal degeneration. |
2023-06-09 |
2023-08-14 |
Not clear |
| Monika Arbaciauskaite, Azady Pirhanov, Erik Ammermann, Yu Lei, Yong Ku Ch. Yeast biopanning against site-specific phosphorylations in tau. Protein engineering, design & selection : PEDS. 2023-06-09. PMID:37294629. |
the detection of site-specific phosphorylation in the microtubule-associated protein tau is emerging as a means to diagnose and monitor the progression of alzheimer's disease (ad) as well as other neurodegenerative diseases. |
2023-06-09 |
2023-08-14 |
Not clear |
| Houfang Long, Shuyi Zeng, Yunpeng Sun, Cong Li. Biochemical and biophysical characterization of pathological aggregation of amyloid proteins. Biophysics reports. vol 8. issue 1. 2023-06-08. PMID:37287686. |
several amyloid proteins including α-synuclein (α-syn), tau, amyloid β (aβ) protein, and tar dna-binding protein 43 kda (tdp-43) form pathological fibrils and deposit in patient brains of different neurodegenerative diseases (nds) such as parkinson's disease (pd), alzheimer's disease (ad) and amyotrophic lateral sclerosis (als). |
2023-06-08 |
2023-08-14 |
human |
| Seong Soo A An, John P Hulm. Plasma amyloid-beta oligomer and phosphorylated tau: diagnostic tools for progressive Alzheimer's disease. Neural regeneration research. vol 18. issue 11. 2023-06-07. PMID:37282463. |
plasma amyloid-beta oligomer and phosphorylated tau: diagnostic tools for progressive alzheimer's disease. |
2023-06-07 |
2023-08-14 |
Not clear |
| Chin-Tong On. Enrichment of novel Tau isoform with altered biochemical properties in Alzheimer's disease. Neural regeneration research. vol 18. issue 11. 2023-06-07. PMID:37282466. |
enrichment of novel tau isoform with altered biochemical properties in alzheimer's disease. |
2023-06-07 |
2023-08-14 |
Not clear |
| Kurt A Jellinge. Neuropathology of the Alzheimer's continuum: an update. Free neuropathology. vol 1. 2023-06-07. PMID:37283686. |
alzheimer's disease (ad), the most common form of dementia worldwide, is a mixed proteinopathy (amyloid and tau). |
2023-06-07 |
2023-08-14 |
Not clear |