| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Elin S Blom, Vilmantas Giedraitis, Henrik Zetterberg, Hiroaki Fukumoto, Kaj Blennow, Bradley T Hyman, Michael C Irizarry, Lars-Olof Wahlund, Lars Lannfelt, Martin Ingelsso. Rapid progression from mild cognitive impairment to Alzheimer's disease in subjects with elevated levels of tau in cerebrospinal fluid and the APOE epsilon4/epsilon4 genotype. Dementia and geriatric cognitive disorders. vol 27. issue 5. 2009-08-12. PMID:19420940. |
increased cerebrospinal fluid (csf) tau, decreased csf amyloid-beta42 (abeta42) and the apolipoprotein e gene (apoe) epsilon4 allele predict progression from mild cognitive impairment (mci) to alzheimer's disease (ad). |
2009-08-12 |
2023-08-12 |
human |
| Ruth Vukovich, Robert Perneczky, Alexander Drzezga, Hans Förstl, Alexander Kurz, Matthias Riemenschneide. Brain metabolic correlates of cerebrospinal fluid beta-amyloid 42 and tau in Alzheimer's disease. Dementia and geriatric cognitive disorders. vol 27. issue 5. 2009-08-12. PMID:19439965. |
brain metabolic correlates of cerebrospinal fluid beta-amyloid 42 and tau in alzheimer's disease. |
2009-08-12 |
2023-08-12 |
Not clear |
| Ruth Vukovich, Robert Perneczky, Alexander Drzezga, Hans Förstl, Alexander Kurz, Matthias Riemenschneide. Brain metabolic correlates of cerebrospinal fluid beta-amyloid 42 and tau in Alzheimer's disease. Dementia and geriatric cognitive disorders. vol 27. issue 5. 2009-08-12. PMID:19439965. |
the cerebrospinal fluid (csf) proteins beta-amyloid 42 (abeta42) and tau are believed to indirectly reflect some core pathological features of alzheimer's disease (ad). |
2009-08-12 |
2023-08-12 |
Not clear |
| Inés García-Gorostiaga, Pascual Sánchez-Juan, Ignacio Mateo, Eloy Rodríguez-Rodríguez, Coro Sánchez-Quintana, Soraya Curiel del Olmo, José Luis Vázquez-Higuera, José Berciano, Onofre Combarros, Jon Infant. Glycogen synthase kinase-3 beta and tau genes interact in Parkinson's and Alzheimer's diseases. Annals of neurology. vol 65. issue 6. 2009-08-12. PMID:19557862. |
glycogen synthase kinase-3 beta and tau genes interact in parkinson's and alzheimer's diseases. |
2009-08-12 |
2023-08-12 |
Not clear |
| Da-yu Yu, Nan Qiao, Ping Liu, Qun We. Different regulation modes of calcineurin regulatory subunit on its catalytic subunit with RII peptide and tau as substrates. Protein and peptide letters. vol 16. issue 2. 2009-08-10. PMID:19200040. |
the findings shed some light on the role of cnb in controlling phosphorylation of tau in vivo and the pathogenesis of tauopathies such as alzheimer's disease. |
2009-08-10 |
2023-08-12 |
Not clear |
| Mariko Tsukane, Takashi Yamauch. Ca2+/calmodulin-dependent protein kinase II mediates apoptosis of P19 cells expressing human tau during neural differentiation with retinoic acid treatment. Journal of enzyme inhibition and medicinal chemistry. vol 24. issue 2. 2009-08-04. PMID:18830878. |
the involvement of tau phosphorylation in apoptosis resembling alzheimer's disease (ad) was investigated using a cell model of p19 cells stably expressing human tau441 (tau/p19 cells). |
2009-08-04 |
2023-08-12 |
human |
| Tapan K Khan, Thomas J Nelson, Vishal A Verma, Paul A Wender, Daniel L Alko. A cellular model of Alzheimer's disease therapeutic efficacy: PKC activation reverses Abeta-induced biomarker abnormality on cultured fibroblasts. Neurobiology of disease. vol 34. issue 2. 2009-08-04. PMID:19233276. |
pkc signaling is critical for the non-toxic degradation of amyloid precursor protein (app) and inhibition of gsk3beta, which controls phosphorylation of tau protein in alzheimer's disease (ad). |
2009-08-04 |
2023-08-12 |
Not clear |
| Donna M Wilcock, Nastaran Gharkholonarehe, William E Van Nostrand, Judianne Davis, Michael P Vitek, Carol A Colto. Amyloid reduction by amyloid-beta vaccination also reduces mouse tau pathology and protects from neuron loss in two mouse models of Alzheimer's disease. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 29. issue 25. 2009-08-04. PMID:19553436. |
amyloid reduction by amyloid-beta vaccination also reduces mouse tau pathology and protects from neuron loss in two mouse models of alzheimer's disease. |
2009-08-04 |
2023-08-12 |
mouse |
| Ana Ricobaraza, Mar Cuadrado-Tejedor, Alberto Pérez-Mediavilla, Diana Frechilla, Joaquin Del Río, Ana García-Ost. Phenylbutyrate ameliorates cognitive deficit and reduces tau pathology in an Alzheimer's disease mouse model. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 34. issue 7. 2009-08-03. PMID:19145227. |
phenylbutyrate ameliorates cognitive deficit and reduces tau pathology in an alzheimer's disease mouse model. |
2009-08-03 |
2023-08-12 |
mouse |
| José Luis Vázquez-Higuera, Ignacio Mateo, Pascual Sánchez-Juan, Eloy Rodríguez-Rodríguez, Jon Infante, José Berciano, Onofre Combarro. No association of CDK5 genetic variants with Alzheimer's disease risk. BMC medical genetics. vol 10. 2009-07-30. PMID:19615060. |
as cyclin-dependent kinase 5 (cdk5) has been implicated in the abnormal hyperphosphorylation of tau in alzheimer's disease (ad) brain, and the development of neurofibrillary tangles, we examined the contribution of this gene to the susceptibility for ad. |
2009-07-30 |
2023-08-12 |
Not clear |
| Khalid Iqbal, Fei Liu, Cheng-Xin Gong, Alejandra Del C Alonso, Inge Grundke-Iqba. Mechanisms of tau-induced neurodegeneration. Acta neuropathologica. vol 118. issue 1. 2009-07-29. PMID:19184068. |
alzheimer disease (ad) and related tauopathies are histopathologically characterized by a specific type of slow and progressive neurodegeneration, which involves the abnormal hyperphosphorylation of the microtubule associated protein (map) tau. |
2009-07-29 |
2023-08-12 |
Not clear |
| Norbert Zilka, Miroslava Korenova, Michal Nova. Misfolded tau protein and disease modifying pathways in transgenic rodent models of human tauopathies. Acta neuropathologica. vol 118. issue 1. 2009-07-29. PMID:19238406. |
human tauopathies represent a heterogeneous group of neurodegenerative disorders such as alzheimer's disease (ad) that are characterized by the presence of intracellular accumulations of abnormal filaments of protein tau. |
2009-07-29 |
2023-08-12 |
human |
| C Reitz, L Honig, J P Vonsattel, M-X Tang, R Mayeu. Memory performance is related to amyloid and tau pathology in the hippocampus. Journal of neurology, neurosurgery, and psychiatry. vol 80. issue 7. 2009-07-29. PMID:19258354. |
to determine the relation of amyloid and tau pathology in the hippocampal formation to decline in memory and other cognitive functions in alzheimer's disease (ad). |
2009-07-29 |
2023-08-12 |
Not clear |
| Akio Ojida, Takashi Sakamoto, Masa-aki Inoue, Sho-hei Fujishima, Guy Lippens, Itaru Hamach. Fluorescent BODIPY-based Zn(II) complex as a molecular probe for selective detection of neurofibrillary tangles in the brains of Alzheimer's disease patients. Journal of the American Chemical Society. vol 131. issue 18. 2009-07-27. PMID:19368380. |
we have developed a new fluorescent binuclear zn(ii) complex for the detection of neurofibrillary tangles (nfts) of hyperphosphorylated tau proteins, a representative hallmark of alzheimer's disease (ad). |
2009-07-27 |
2023-08-12 |
Not clear |
| Ryozo Kuwano, Norihiro Takei, Akinori Miyashit. [Genetic basis for dementia]. Nihon rinsho. Japanese journal of clinical medicine. vol 67. issue 6. 2009-07-24. PMID:19507496. |
three frequent neurodegererative dementias are alzheimer disease, dementia with lewy bodies, and frontotemporal lobar degeneration, characterized by senile plaque with amyloid beta and neurofibrillary tangles with tau, lewy body with alpha-synuclein, tau or tau-negative ubiquitin-immunoreactive neuronal inclusions with tdp-43, respectively. |
2009-07-24 |
2023-08-12 |
Not clear |
| Bess Frost, Rachel L Jacks, Marc I Diamon. Propagation of tau misfolding from the outside to the inside of a cell. The Journal of biological chemistry. vol 284. issue 19. 2009-07-21. PMID:19282288. |
tau aggregation occurs in many diseases, including alzheimer disease and frontotemporal dementia. |
2009-07-21 |
2023-08-12 |
Not clear |
| Qian Sun, T Chris Gambli. Pseudohyperphosphorylation causing AD-like changes in tau has significant effects on its polymerization. Biochemistry. vol 48. issue 25. 2009-07-20. PMID:19459590. |
the microtubule-associated protein tau, in a hyperphosphorylated form, aggregates into insoluble paired-helical filaments (phfs) in alzheimer's disease (ad) and other tauopathies. |
2009-07-20 |
2023-08-12 |
Not clear |
| Qian Sun, T Chris Gambli. Pseudohyperphosphorylation causing AD-like changes in tau has significant effects on its polymerization. Biochemistry. vol 48. issue 25. 2009-07-20. PMID:19459590. |
on the basis of the observations that pseudohyperphosphorylated tau has decreased affinity for microtubules and reduced inducer-initiated rates of nucleation and polymerization, we propose that this combination could be the cause of the increased cytotoxicity of hyperphosphorylated tau in alzheimer's disease and also explain the potentially beneficial role of tau polymerization and nft formation. |
2009-07-20 |
2023-08-12 |
Not clear |
| Florence Clavaguera, Tristan Bolmont, R Anthony Crowther, Dorothee Abramowski, Stephan Frank, Alphonse Probst, Graham Fraser, Anna K Stalder, Martin Beibel, Matthias Staufenbiel, Mathias Jucker, Michel Goedert, Markus Tolna. Transmission and spreading of tauopathy in transgenic mouse brain. Nature cell biology. vol 11. issue 7. 2009-07-20. PMID:19503072. |
hyperphosphorylated tau makes up the filamentous intracellular inclusions of several neurodegenerative diseases, including alzheimer's disease. |
2009-07-20 |
2023-08-12 |
mouse |
| Florence Clavaguera, Tristan Bolmont, R Anthony Crowther, Dorothee Abramowski, Stephan Frank, Alphonse Probst, Graham Fraser, Anna K Stalder, Martin Beibel, Matthias Staufenbiel, Mathias Jucker, Michel Goedert, Markus Tolna. Transmission and spreading of tauopathy in transgenic mouse brain. Nature cell biology. vol 11. issue 7. 2009-07-20. PMID:19503072. |
cognitive impairment becomes manifest when inclusions reach the hippocampus, with abundant neocortical tau inclusions and extracellular beta-amyloid deposits being the defining pathological hallmarks of alzheimer's disease. |
2009-07-20 |
2023-08-12 |
mouse |