| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Zivar Salehi, Farhad Mashayekhi, Mohammad Naj. Insulin like growth factor-1 and insulin like growth factor binding proteins in the cerebrospinal fluid and serum from patients with Alzheimer's disease. BioFactors (Oxford, England). vol 33. issue 2. 2009-06-18. PMID:19346585. |
alzheimer's disease (ad) is an age-dependent dementia characterized by progressive loss of cognitive functions and by characteristic pathological changes in the brain: the formation of aggregates extracellularly by beta-amyloid (ab) peptide and intracellularly by tau proteins. |
2009-06-18 |
2023-08-12 |
human |
| Bethany L Veo, Les A Krushe. Translation initiation of the human tau mRNA through an internal ribosomal entry site. Journal of Alzheimer's disease : JAD. vol 16. issue 2. 2009-06-17. PMID:19221416. |
neurofibrillary tangles are a pathological phenotype in alzheimer's disease (ad) and are caused by the hyperphosphorylation of the microtubule associated protein tau. |
2009-06-17 |
2023-08-12 |
mouse |
| Matthew A Wozniak, Alison L Frost, Ruth F Itzhak. Alzheimer's disease-specific tau phosphorylation is induced by herpes simplex virus type 1. Journal of Alzheimer's disease : JAD. vol 16. issue 2. 2009-06-17. PMID:19221424. |
alzheimer's disease-specific tau phosphorylation is induced by herpes simplex virus type 1. |
2009-06-17 |
2023-08-12 |
Not clear |
| Matthew A Wozniak, Alison L Frost, Ruth F Itzhak. Alzheimer's disease-specific tau phosphorylation is induced by herpes simplex virus type 1. Journal of Alzheimer's disease : JAD. vol 16. issue 2. 2009-06-17. PMID:19221424. |
neurofibrillary tangles are one of the main neuropathological features of alzheimer's disease (ad) and are composed of abnormally phosphorylated forms of a microtubule-associated protein called tau. |
2009-06-17 |
2023-08-12 |
Not clear |
| Salvatore Oddo, Antonella Caccamo, Bert Tseng, David Cheng, Vitaly Vasilevko, David H Cribbs, Frank M LaFerl. Blocking Abeta42 accumulation delays the onset and progression of tau pathology via the C terminus of heat shock protein70-interacting protein: a mechanistic link between Abeta and tau pathology. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 28. issue 47. 2009-06-09. PMID:19020010. |
the molecular alterations that induce tau pathology in alzheimer disease (ad) are not known, particularly whether this is an amyloid-beta (abeta)-dependent or -independent event. |
2009-06-09 |
2023-08-12 |
mouse |
| Rick A C M Boonen, Paula van Tijn, Danica Zivkovi. Wnt signaling in Alzheimer's disease: up or down, that is the question. Ageing research reviews. vol 8. issue 2. 2009-06-03. PMID:19101658. |
alzheimer's disease (ad) is a progressive neurodegenerative disorder, neuropathologically characterized by amyloid-beta (abeta) plaques and hyperphosphorylated tau accumulation. |
2009-06-03 |
2023-08-12 |
Not clear |
| H Axer, S Hüge, C Wilhelm, M Axer, A Kunze, J R Reichenbach, M Freesmeyer, J Kohlhase, H Sauer, K-J Bä. [Hereditary Alzheimer's disease with amyloid angiopathy caused by amyloid precursor protein locus]. Der Nervenarzt. vol 80. issue 1. 2009-05-29. PMID:18781290. |
the csf showed increased levels of tau protein and decreased amyloid beta (ratio 42:40) typical for alzheimer's disease. |
2009-05-29 |
2023-08-12 |
Not clear |
| Morihisa Saitoh, Jun Kunitomo, Eiji Kimura, Yoji Hayase, Hiromi Kobayashi, Noriko Uchiyama, Tomohiro Kawamoto, Toshimasa Tanaka, Clifford D Mol, Douglas R Dougan, Garret S Textor, Gyorgy P Snell, Fumio Ito. Design, synthesis and structure-activity relationships of 1,3,4-oxadiazole derivatives as novel inhibitors of glycogen synthase kinase-3beta. Bioorganic & medicinal chemistry. vol 17. issue 5. 2009-05-29. PMID:19200745. |
glycogen synthase kinase-3beta (gsk-3beta) is implicated in abnormal hyperphosphorylation of tau protein and its inhibitors are expected to be a promising therapeutic agents for the treatment of alzheimer's disease. |
2009-05-29 |
2023-08-12 |
Not clear |
| Alexis Bretteville, Kunie Ando, Antoine Ghestem, Anne Loyens, Séverine Bégard, Jean-Claude Beauvillain, Nicolas Sergeant, Malika Hamdane, Luc Bué. Two-dimensional electrophoresis of tau mutants reveals specific phosphorylation pattern likely linked to early tau conformational changes. PloS one. vol 4. issue 3. 2009-05-28. PMID:19290042. |
the role of tau phosphorylation in neurofibrillary degeneration linked to alzheimer's disease remains to be established. |
2009-05-28 |
2023-08-12 |
mouse |
| Alexis Bretteville, Kunie Ando, Antoine Ghestem, Anne Loyens, Séverine Bégard, Jean-Claude Beauvillain, Nicolas Sergeant, Malika Hamdane, Luc Bué. Two-dimensional electrophoresis of tau mutants reveals specific phosphorylation pattern likely linked to early tau conformational changes. PloS one. vol 4. issue 3. 2009-05-28. PMID:19290042. |
in fact, this pattern is also displayed before tau pathology onset in a well established mouse model relevant to tau aggregation in alzheimer's disease. |
2009-05-28 |
2023-08-12 |
mouse |
| Tomás L Falzone, Gorazd B Stokin, Concepción Lillo, Elizabeth M Rodrigues, Eileen L Westerman, David S Williams, Lawrence S B Goldstei. Axonal stress kinase activation and tau misbehavior induced by kinesin-1 transport defects. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 29. issue 18. 2009-05-28. PMID:19420244. |
while mutant tau protein in frontotemporal dementia and parkinsonism linked to chromosome 17 (ftdp17) causes aberrant microtubule binding and assembly of tau into filaments, the pathways leading to tau-mediated neurotoxicity in alzheimer's disease and other neurodegenerative disorders in which tau protein is not genetically modified remain unknown. |
2009-05-28 |
2023-08-12 |
mouse |
| Tomás L Falzone, Gorazd B Stokin, Concepción Lillo, Elizabeth M Rodrigues, Eileen L Westerman, David S Williams, Lawrence S B Goldstei. Axonal stress kinase activation and tau misbehavior induced by kinesin-1 transport defects. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 29. issue 18. 2009-05-28. PMID:19420244. |
thus, directly interfering with axonal transport is sufficient to activate stress kinase pathways initiating a biochemical cascade that drives normal tau protein into a pathological state found in a variety of neurodegenerative disorders including alzheimer's disease. |
2009-05-28 |
2023-08-12 |
mouse |
| Maya K Desai, Kelly L Sudol, Michelle C Janelsins, Michael A Mastrangelo, Maria E Frazer, William J Bower. Triple-transgenic Alzheimer's disease mice exhibit region-specific abnormalities in brain myelination patterns prior to appearance of amyloid and tau pathology. Glia. vol 57. issue 1. 2009-05-26. PMID:18661556. |
triple-transgenic alzheimer's disease mice exhibit region-specific abnormalities in brain myelination patterns prior to appearance of amyloid and tau pathology. |
2009-05-26 |
2023-08-12 |
mouse |
| Philipp A Thomann, Elmar Kaiser, Peter Schönknecht, Johannes Pantel, Marco Essig, Johannes Schröde. Association of total tau and phosphorylated tau 181 protein levels in cerebrospinal fluid with cerebral atrophy in mild cognitive impairment and Alzheimer disease. Journal of psychiatry & neuroscience : JPN. vol 34. issue 2. 2009-05-21. PMID:19270764. |
association of total tau and phosphorylated tau 181 protein levels in cerebrospinal fluid with cerebral atrophy in mild cognitive impairment and alzheimer disease. |
2009-05-21 |
2023-08-12 |
Not clear |
| Philipp A Thomann, Elmar Kaiser, Peter Schönknecht, Johannes Pantel, Marco Essig, Johannes Schröde. Association of total tau and phosphorylated tau 181 protein levels in cerebrospinal fluid with cerebral atrophy in mild cognitive impairment and Alzheimer disease. Journal of psychiatry & neuroscience : JPN. vol 34. issue 2. 2009-05-21. PMID:19270764. |
we sought to examine the association of levels of total tau (t-tau) and phosphorylated tau 181 (p-tau181) protein with brain morphology in mild cognitive impairment, as defined by the concept of aging-associated cognitive decline (aacd) and alzheimer disease. |
2009-05-21 |
2023-08-12 |
Not clear |
| Timothy D Vaden, Sally A N Gowers, Lavina C Snoe. Observation of beta-sheet aggregation in a gas-phase tau-peptide dimer. Journal of the American Chemical Society. vol 131. issue 7. 2009-05-18. PMID:19178142. |
in alzheimer's disease, the tau protein forms intracellular amyloid fibrils in which the (306)vqivyk(311) sequence adopts parallel beta-sheets, enabling fibril formation via cross-beta "steric zippers". |
2009-05-18 |
2023-08-12 |
Not clear |
| Xiaoqin Run, Zhihou Liang, Lan Zhang, Khalid Iqbal, Inge Grundke-Iqbal, Cheng-Xin Gon. Anesthesia induces phosphorylation of tau. Journal of Alzheimer's disease : JAD. vol 16. issue 3. 2009-05-18. PMID:19276556. |
abnormal hyperphosphorylation and aggregation of microtubule-associated protein tau play a crucial role in neurodegeneration of alzheimer's disease (ad). |
2009-05-18 |
2023-08-12 |
Not clear |
| Steven D Buckingham, Andrew K Jones, Laurence A Brown, David B Sattell. Nicotinic acetylcholine receptor signalling: roles in Alzheimer's disease and amyloid neuroprotection. Pharmacological reviews. vol 61. issue 1. 2009-05-14. PMID:19293145. |
alzheimer's disease (ad), the major contributor to dementia in the elderly, involves accumulation in the brain of extracellular plaques containing the beta-amyloid protein (abeta) and intracellular neurofibrillary tangles of hyperphosphorylated tau protein. |
2009-05-14 |
2023-08-12 |
Not clear |
| Christoph Laske, Elke Stransky, Andreas Fritsche, Gerhard W Eschweiler, Thomas Leyh. Inverse association of cortisol serum levels with T-tau, P-tau 181 and P-tau 231 peptide levels and T-tau/Abeta 1-42 ratios in CSF in patients with mild Alzheimer's disease dementia. European archives of psychiatry and clinical neuroscience. vol 259. issue 2. 2009-05-13. PMID:18806919. |
hypercortisolemia and increased levels of hyperphosphorylated tau proteins in cerebrospinal fluid (csf) are common features with pathogenic relevance in alzheimer;s disease (ad). |
2009-05-13 |
2023-08-12 |
Not clear |
| Jiang Fang, Rong Liu, Qing Tian, Xiao-ping Hong, Shao-hui Wang, Fu-yuan Cao, Xi-ping Pan, Jian-zhi Wan. Dehydroevodiamine attenuates calyculin A-induced tau hyperphosphorylation in rat brain slices. Acta pharmacologica Sinica. vol 28. issue 11. 2009-05-12. PMID:17959021. |
this study was to investigate the effect of dehydroevodiamine (dhed) on alzheimer's disease (ad)-like tau hyperphosphorylation induced by calyculin a (ca), an inhibitor of protein phosphatase (pp)-2a and pp-1, and the involvement of pp-2a in metabolically competent rat brain slices. |
2009-05-12 |
2023-08-12 |
rat |