| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| João P Lopes, Catarina R Oliveira, Paula Agostinh. Cdk5 acts as a mediator of neuronal cell cycle re-entry triggered by amyloid-beta and prion peptides. Cell cycle (Georgetown, Tex.). vol 8. issue 1. 2009-02-25. PMID:19158499. |
involved in tau protein hyperphosphorylation and apoptotic neuronal death, two main neuropathological markers of alzheimer's disease (ad) and prion-related encephalopathies (pre), cdk5 also participates in cell cycle regulation. |
2009-02-25 |
2023-08-12 |
Not clear |
| Maria Gulinello, Michael Gertner, Guadalupe Mendoza, Brian P Schoenfeld, Salvatore Oddo, Frank LaFerla, Catherine H Choi, Sean M J McBride, Donald S Fabe. Validation of a 2-day water maze protocol in mice. Behavioural brain research. vol 196. issue 2. 2009-02-24. PMID:18831990. |
we validated this procedure using aged (15-18m) mice expressing three alzheimer's disease-related transgenes, ps1(m146 v), app(swe), and tau(p301l). |
2009-02-24 |
2023-08-12 |
mouse |
| May Gohar, Wencheng Yang, Wendy Strong, Kathryn Volkening, Cheryl Leystra-Lantz, Michael J Stron. Tau phosphorylation at threonine-175 leads to fibril formation and enhanced cell death: implications for amyotrophic lateral sclerosis with cognitive impairment. Journal of neurochemistry. vol 108. issue 3. 2009-02-24. PMID:19046355. |
both soluble and insoluble tau was purified from control, patients with alzheimer's disease (ad), als without cognitive impairment, and alsci and the tendency to fibril formation assayed ex vivo using the thioflavin s fluorescence assay. |
2009-02-24 |
2023-08-12 |
human |
| Ramasamy Thangavel, Gary W Van Hoesen, Asgar Zahee. The abnormally phosphorylated tau lesion of early Alzheimer's disease. Neurochemical research. vol 34. issue 1. 2009-02-23. PMID:18437565. |
the abnormally phosphorylated tau lesion of early alzheimer's disease. |
2009-02-23 |
2023-08-12 |
human |
| Ramasamy Thangavel, Gary W Van Hoesen, Asgar Zahee. The abnormally phosphorylated tau lesion of early Alzheimer's disease. Neurochemical research. vol 34. issue 1. 2009-02-23. PMID:18437565. |
the perirhinal cortex (area 35) is well-known locus for neurofibrillary tangles (nft) in initial alzheimer's disease (ad) and fully developed ad and may contain tau alterations in non-demented elderly. |
2009-02-23 |
2023-08-12 |
human |
| Li Liu, Karen Duf. A technique for serial collection of cerebrospinal fluid from the cisterna magna in mouse. Journal of visualized experiments : JoVE. issue 21. 2009-02-23. PMID:19066529. |
alzheimer's disease (ad) is a progressive neurodegenerative disease that is pathologically characterized by extracellular deposition of beta-amyloid peptide (abeta) and intraneuronal accumulation of hyperphosphorylated tau protein. |
2009-02-23 |
2023-08-12 |
mouse |
| D R Howlett, J C Richardso. The pathology of APP transgenic mice: a model of Alzheimer's disease or simply overexpression of APP? Histology and histopathology. vol 24. issue 1. 2009-02-20. PMID:19012248. |
alzheimer's disease (ad) is characterized by a number of pathological features, notably extracellular senile plaques composed of the beta-amyloid protein (abeta) and neurofibrillary tangles (nft's), which are intracellular inclusions of hyperphosphorylated tau protein. |
2009-02-20 |
2023-08-12 |
mouse |
| Roland Brandt, Aikaterini Gergou, Irene Wacker, Thomas Fath, Harald Hutte. A Caenorhabditis elegans model of tau hyperphosphorylation: induction of developmental defects by transgenic overexpression of Alzheimer's disease-like modified tau. Neurobiology of aging. vol 30. issue 1. 2009-02-19. PMID:17590239. |
a caenorhabditis elegans model of tau hyperphosphorylation: induction of developmental defects by transgenic overexpression of alzheimer's disease-like modified tau. |
2009-02-19 |
2023-08-12 |
human |
| Roland Brandt, Aikaterini Gergou, Irene Wacker, Thomas Fath, Harald Hutte. A Caenorhabditis elegans model of tau hyperphosphorylation: induction of developmental defects by transgenic overexpression of Alzheimer's disease-like modified tau. Neurobiology of aging. vol 30. issue 1. 2009-02-19. PMID:17590239. |
the microtubule-associated tau proteins become functionally and structurally altered in alzheimer's disease (ad). |
2009-02-19 |
2023-08-12 |
human |
| Franziska Denk, Richard Wade-Martin. Knock-out and transgenic mouse models of tauopathies. Neurobiology of aging. vol 30. issue 1. 2009-02-19. PMID:17590238. |
tauopathies, characterized by the dysfunction and aggregation of the microtubule-associated protein tau (mapt), represent some of the most devastating neurodegenerative disorders afflicting the elderly, including alzheimer's disease and progressive supranuclear palsy. |
2009-02-19 |
2023-08-12 |
mouse |
| B Borroni, F Gardoni, L Parnetti, L Magno, M Malinverno, E Saggese, P Calabresi, M G Spillantini, A Padovani, M Di Luc. Pattern of Tau forms in CSF is altered in progressive supranuclear palsy. Neurobiology of aging. vol 30. issue 1. 2009-02-19. PMID:17709155. |
cerebrospinal fluid (csf) total tau levels vary widely in neurodegenerative disorders, thus being not useful in their discrimination over alzheimer disease. |
2009-02-19 |
2023-08-12 |
human |
| B Borroni, F Gardoni, L Parnetti, L Magno, M Malinverno, E Saggese, P Calabresi, M G Spillantini, A Padovani, M Di Luc. Pattern of Tau forms in CSF is altered in progressive supranuclear palsy. Neurobiology of aging. vol 30. issue 1. 2009-02-19. PMID:17709155. |
tau ratio 33 kda/55 kda was significantly decreased in patients with psp (0.46+/-0.16) when compared to controls, including healthy subjects (1.16+/-0.46, p=0.002) and alzheimer disease (1.38+/-0.68, p<0.001), and when compared to frontotemporal dementia (0.98+/-0.30, p=0.008) or corticobasal degeneration syndrome (0.98+/-0.48, p=0.02). |
2009-02-19 |
2023-08-12 |
human |
| Henny Wati, Takeshi Kawarabayashi, Etsuro Matsubara, Ayumi Kasai, Takae Hirasawa, Takeo Kubota, Yasuo Harigaya, Mikio Shoji, Shuichiro Maed. Transthyretin accelerates vascular Abeta deposition in a mouse model of Alzheimer's disease. Brain pathology (Zurich, Switzerland). vol 19. issue 1. 2009-02-19. PMID:18429966. |
it was reported that the lack of neurodegeneration in a transgenic mouse model of alzheimer's disease (ad) (tg2576 mouse) was associated with increased ttr level in the hippocampus, and that chronic infusion of anti-ttr antibody into the hippocampus of tg2576 mice led to increased local abeta deposits, tau hyperphosphorylation and apoptosis. |
2009-02-19 |
2023-08-12 |
mouse |
| Heng-Liang Yeh, Shih-Jen Tsa. Lithium may be useful in the prevention of Alzheimer's disease in individuals at risk of presenile familial Alzheimer's disease. Medical hypotheses. vol 71. issue 6. 2009-02-19. PMID:18760542. |
presenile familial ad (fad) and sporadic alzheimer's disease (sad) have identical brain lesions, containing senile plaques with beta-amyloid (abeta) peptide and neurofibrillary tangles formed by hyperphosphorylation of a microtubule-associated protein known as tau. |
2009-02-19 |
2023-08-12 |
Not clear |
| Clayton A Wiley, Brian J Lopresti, Sriram Venneti, Julie Price, William E Klunk, Steven T DeKosky, Chester A Mathi. Carbon 11-labeled Pittsburgh Compound B and carbon 11-labeled (R)-PK11195 positron emission tomographic imaging in Alzheimer disease. Archives of neurology. vol 66. issue 1. 2009-02-19. PMID:19139300. |
alzheimer disease (ad) is defined neuropathologically by the presence of neurofibrillary tangles and plaques associated with tau and beta-amyloid protein deposition. |
2009-02-19 |
2023-08-12 |
Not clear |
| Peter J Crouch, Lin Wai Hung, Paul A Adlard, Mikhalina Cortes, Varsha Lal, Gulay Filiz, Keyla A Perez, Milawaty Nurjono, Aphrodite Caragounis, Tai Du, Katrina Laughton, Irene Volitakis, Ashley I Bush, Qiao-Xin Li, Colin L Masters, Roberto Cappai, Robert A Cherny, Paul S Donnelly, Anthony R White, Kevin J Barnha. Increasing Cu bioavailability inhibits Abeta oligomers and tau phosphorylation. Proceedings of the National Academy of Sciences of the United States of America. vol 106. issue 2. 2009-02-13. PMID:19122148. |
cognitive decline in alzheimer's disease (ad) involves pathological accumulation of synaptotoxic amyloid-beta (abeta) oligomers and hyperphosphorylated tau. |
2009-02-13 |
2023-08-12 |
mouse |
| Natasha Deters, Lars M Ittner, Jürgen Göt. Substrate-specific reduction of PP2A activity exaggerates tau pathology. Biochemical and biophysical research communications. vol 379. issue 2. 2009-02-13. PMID:19126401. |
disturbance of this balance causes hyperphosphorylation of tau and neurofibrillary tangle formation in alzheimer's disease brain. |
2009-02-13 |
2023-08-12 |
mouse |
| b' Gorana Mandi\\xc4\\x87, Ivanka Markovi\\xc4\\x87, Marija Ostoji\\xc4\\x87, Tanja Stojkovi\\xc4\\x87, Sonja Misirli\\xc4\\x87-Denci\\xc4\\x87, Tatjana Zivanovi\\xc4\\x87-Radni\\xc4\\x87, Rodoljub Stefanovi\\xc4\\x87, Marko Bumbasirevi\\xc4\\x87, Elka Stefanova, Vladimir Kosti\\xc4\\x8. [Cerebrospinal fluid amyloid beta and tau protein: biomarkers for Alzheimer\'s disease]. Vojnosanitetski pregled. vol 65. issue 12. 2009-02-11. PMID:19160984.' |
[cerebrospinal fluid amyloid beta and tau protein: biomarkers for alzheimer's disease]. |
2009-02-11 |
2023-08-12 |
Not clear |
| b' Gorana Mandi\\xc4\\x87, Ivanka Markovi\\xc4\\x87, Marija Ostoji\\xc4\\x87, Tanja Stojkovi\\xc4\\x87, Sonja Misirli\\xc4\\x87-Denci\\xc4\\x87, Tatjana Zivanovi\\xc4\\x87-Radni\\xc4\\x87, Rodoljub Stefanovi\\xc4\\x87, Marko Bumbasirevi\\xc4\\x87, Elka Stefanova, Vladimir Kosti\\xc4\\x8. [Cerebrospinal fluid amyloid beta and tau protein: biomarkers for Alzheimer\'s disease]. Vojnosanitetski pregled. vol 65. issue 12. 2009-02-11. PMID:19160984.' |
introduction of acetylcholine esterase inhibitors as a symptomatic treatment of alzheimer's disease (ad) has additionally highlighted the importance of diagnostic markers in cerebrospinal fluid (csf) for early ad diagnosis: low level of 42 amino acid form of amyloid-beta peptide (abeta42), and levels of tau protein (t-tau) and phosphorylated tau protein (p-tau). |
2009-02-11 |
2023-08-12 |
Not clear |
| Ignacio Mateo, Pascual Sánchez-Juan, Eloy Rodríguez-Rodríguez, Jon Infante, José Luis Vázquez-Higuera, Inés García-Gorostiaga, José Berciano, Onofre Combarro. Synergistic effect of heme oxygenase-1 and tau genetic variants on Alzheimer's disease risk. Dementia and geriatric cognitive disorders. vol 26. issue 4. 2009-02-09. PMID:18841019. |
synergistic effect of heme oxygenase-1 and tau genetic variants on alzheimer's disease risk. |
2009-02-09 |
2023-08-12 |
human |