All Relations between Alzheimer Disease and microtubule-associated protein tau

Publication Sentence Publish Date Extraction Date Species
Thomas Timm, Kiruthiga Balusamy, Xiaoyu Li, Jacek Biernat, Eckhard Mandelkow, Eva-Maria Mandelko. Glycogen synthase kinase (GSK) 3beta directly phosphorylates Serine 212 in the regulatory loop and inhibits microtubule affinity-regulating kinase (MARK) 2. The Journal of biological chemistry. vol 283. issue 27. 2008-08-19. PMID:18424437. because of its role in abnormal phosphorylation of the tau protein in alzheimer disease, we searched for regulatory kinases. 2008-08-19 2023-08-12 Not clear
Thomas Timm, Kiruthiga Balusamy, Xiaoyu Li, Jacek Biernat, Eckhard Mandelkow, Eva-Maria Mandelko. Glycogen synthase kinase (GSK) 3beta directly phosphorylates Serine 212 in the regulatory loop and inhibits microtubule affinity-regulating kinase (MARK) 2. The Journal of biological chemistry. vol 283. issue 27. 2008-08-19. PMID:18424437. because gsk3beta can also phosphorylate tau at sites outside the repeat domain, the activation of gsk3beta, and concomitant inactivation of mark can shift the pattern of pathological phosphorylation of tau protein in alzheimer disease. 2008-08-19 2023-08-12 Not clear
Seung Yong Yoon, Jung Eun Choi, Jin Myung Choi, Dong Hou Ki. Dynein cleavage and microtubule accumulation in okadaic acid-treated neurons. Neuroscience letters. vol 437. issue 2. 2008-08-18. PMID:18448253. impairment of protein phosphatase 2a (pp2a) activity is implicated in tau hyperphosphorylation and microtubule (mt) instability in alzheimer's disease (ad). 2008-08-18 2023-08-12 rat
Adam R Cole, Marc P M Soutar, Makoto Rembutsu, Lidy van Aalten, C James Hastie, Hilary McLauchlan, Mark Peggie, Martin Balastik, Kun Ping Lu, Calum Sutherlan. Relative resistance of Cdk5-phosphorylated CRMP2 to dephosphorylation. The Journal of biological chemistry. vol 283. issue 26. 2008-08-18. PMID:18460467. we propose that relative resistance to phosphatases might be a common feature of cdk5 substrates and could contribute to the hyperphosphorylation of crmp2 and tau observed in alzheimer disease. 2008-08-18 2023-08-12 mouse
C Hugh Reynolds, Claire J Garwood, Selina Wray, Caroline Price, Stuart Kellie, Timothy Perera, Marketa Zvelebil, Alice Yang, Paul W Sheppard, Ian M Varndell, Diane P Hanger, Brian H Anderto. Phosphorylation regulates tau interactions with Src homology 3 domains of phosphatidylinositol 3-kinase, phospholipase Cgamma1, Grb2, and Src family kinases. The Journal of biological chemistry. vol 283. issue 26. 2008-08-18. PMID:18467332. tau is well known to aggregate to form hyperphosphorylated filamentous deposits in several neurodegenerative diseases (tauopathies) including alzheimer disease. 2008-08-18 2023-08-12 Not clear
C Hugh Reynolds, Claire J Garwood, Selina Wray, Caroline Price, Stuart Kellie, Timothy Perera, Marketa Zvelebil, Alice Yang, Paul W Sheppard, Ian M Varndell, Diane P Hanger, Brian H Anderto. Phosphorylation regulates tau interactions with Src homology 3 domains of phosphatidylinositol 3-kinase, phospholipase Cgamma1, Grb2, and Src family kinases. The Journal of biological chemistry. vol 283. issue 26. 2008-08-18. PMID:18467332. after phosphorylation in vitro or in transfected cells, tau showed reduced binding to sh3 domains; no binding was detected with hyperphosphorylated tau isolated from alzheimer brain, but sh3 binding was restored by phosphatase treatment. 2008-08-18 2023-08-12 Not clear
C Hugh Reynolds, Claire J Garwood, Selina Wray, Caroline Price, Stuart Kellie, Timothy Perera, Marketa Zvelebil, Alice Yang, Paul W Sheppard, Ian M Varndell, Diane P Hanger, Brian H Anderto. Phosphorylation regulates tau interactions with Src homology 3 domains of phosphatidylinositol 3-kinase, phospholipase Cgamma1, Grb2, and Src family kinases. The Journal of biological chemistry. vol 283. issue 26. 2008-08-18. PMID:18467332. these results strongly suggest that tau has a potential role in cell signaling in addition to its accepted role in cytoskeletal assembly, with regulation by phosphorylation that may be disrupted in the tauopathies including alzheimer disease. 2008-08-18 2023-08-12 Not clear
Marisol Espinoza, Rohan de Silva, Dennis W Dickson, Peter Davie. Differential incorporation of tau isoforms in Alzheimer's disease. Journal of Alzheimer's disease : JAD. vol 14. issue 1. 2008-08-18. PMID:18525123. differential incorporation of tau isoforms in alzheimer's disease. 2008-08-18 2023-08-12 human
Marisol Espinoza, Rohan de Silva, Dennis W Dickson, Peter Davie. Differential incorporation of tau isoforms in Alzheimer's disease. Journal of Alzheimer's disease : JAD. vol 14. issue 1. 2008-08-18. PMID:18525123. to further elucidate the complex issue of tau isoform composition in alzheimer's disease (ad) and other neurodegenerative diseases, monoclonal antibodies that differentiate between tau containing residues encoded by exon 10 (4r tau) and tau lacking exon 10 residues (3r tau) were used in single and double labeling immunohistochemistry as well as biochemical analyses of tau isolated from ad and other neurodegenerative diseases. 2008-08-18 2023-08-12 human
Sara Friederike Gloeckner, Felix Meyne, Fabian Wagner, Uta Heinemann, Anna Krasnianski, Bettina Meissner, Inga Zer. Quantitative analysis of transthyretin, tau and amyloid-beta in patients with dementia. Journal of Alzheimer's disease : JAD. vol 14. issue 1. 2008-08-18. PMID:18525124. we carried out a quantitative analysis of transthyretin (ttr), total tau protein and amyloid-beta (abeta) peptide (1-40 and 1-42) in the lumbar cerebrospinal fluid of 106 patients with different forms of dementia including alzheimer's disease (ad), creutzfeldt-jakob-disease (cjd), dementia with lewy bodies (dlb), frontotemporal dementia (ftd) and normal pressure hydrocephalus (nph) in comparison to healthy controls. 2008-08-18 2023-08-12 Not clear
Ann C McKee, Isabel Carreras, Lokman Hossain, Hoon Ryu, William L Klein, Salvatore Oddo, Frank M LaFerla, Bruce G Jenkins, Neil W Kowall, Alpaslan Dedeogl. Ibuprofen reduces Abeta, hyperphosphorylated tau and memory deficits in Alzheimer mice. Brain research. vol 1207. 2008-08-13. PMID:18374906. ibuprofen reduces abeta, hyperphosphorylated tau and memory deficits in alzheimer mice. 2008-08-13 2023-08-12 mouse
Scott A Yuzwa, Matthew S Macauley, Julia E Heinonen, Xiaoyang Shan, Rebecca J Dennis, Yuan He, Garrett E Whitworth, Keith A Stubbs, Ernest J McEachern, Gideon J Davies, David J Vocadl. A potent mechanism-inspired O-GlcNAcase inhibitor that blocks phosphorylation of tau in vivo. Nature chemical biology. vol 4. issue 8. 2008-08-13. PMID:18587388. pathological hyperphosphorylation of the microtubule-associated protein tau is characteristic of alzheimer's disease (ad) and the associated tauopathies. 2008-08-13 2023-08-12 human
Jian-Zhi Wang, Fei Li. Microtubule-associated protein tau in development, degeneration and protection of neurons. Progress in neurobiology. vol 85. issue 2. 2008-08-11. PMID:18448228. therefore, changes in expression of the tau gene, alternative splicing of its mrna and its posttranslational modification can modulate the normal architecture and functions of neurons as well as in a situation of tauopathies, such as alzheimer's disease. 2008-08-11 2023-08-12 Not clear
G Muntané, E Dalfó, A Martinez, I Ferre. Phosphorylation of tau and alpha-synuclein in synaptic-enriched fractions of the frontal cortex in Alzheimer's disease, and in Parkinson's disease and related alpha-synucleinopathies. Neuroscience. vol 152. issue 4. 2008-08-07. PMID:18343584. phosphorylation of tau and alpha-synuclein in synaptic-enriched fractions of the frontal cortex in alzheimer's disease, and in parkinson's disease and related alpha-synucleinopathies. 2008-08-07 2023-08-12 mouse
G Muntané, E Dalfó, A Martinez, I Ferre. Phosphorylation of tau and alpha-synuclein in synaptic-enriched fractions of the frontal cortex in Alzheimer's disease, and in Parkinson's disease and related alpha-synucleinopathies. Neuroscience. vol 152. issue 4. 2008-08-07. PMID:18343584. phosphorylation of tau and phosphorylation of alpha-synuclein are crucial abnormalities in alzheimer's disease (ad) and alpha-synucleinopathies (parkinson's disease: pd, and dementia with lewy bodies: dlb), respectively. 2008-08-07 2023-08-12 mouse
Gabriele Hübinger, Silvia Geis, Sylvie LeCorre, Susanne Mühlbacher, Sandra Gordon, R Paul Fracasso, Fred Hoffman, Sandrine Ferrand, Hans W Klafki, Hanno M Rode. Inhibition of PHF-like tau hyperphosphorylation in SH-SY5Y cells and rat brain slices by K252a. Journal of Alzheimer's disease : JAD. vol 13. issue 3. 2008-08-07. PMID:18430996. abnormal hyperphosphorylation of tau is believed to constitute a critical biochemical event in the process of neurofibrillary degeneration of alzheimer's disease. 2008-08-07 2023-08-12 rat
G D Silverberg, M Mayo, T Saul, J Fellmann, J Carvalho, D McGuir. Continuous CSF drainage in AD: results of a double-blind, randomized, placebo-controlled study. Neurology. vol 71. issue 3. 2008-08-04. PMID:18525029. alzheimer disease (ad) has been associated with abnormal cerebral clearance of macromolecules, such as amyloid and microtubule-associated-protein tau (map-tau). 2008-08-04 2023-08-12 Not clear
Dylan W Peterson, Hongjun Zhou, Frederick W Dahlquist, John Le. A soluble oligomer of tau associated with fiber formation analyzed by NMR. Biochemistry. vol 47. issue 28. 2008-08-01. PMID:18558718. alzheimer's disease (ad) is characterized by the intracellular accumulation of the neurofibrillary tangles comprised mainly of the microtubule-associated protein, tau. 2008-08-01 2023-08-12 human
R Liu, X-W Zhou, H Tanila, C Bjorkdahl, J-Z Wang, Z-Z Guan, Y Cao, J-A Gustafsson, B Winblad, J-J Pe. Phosphorylated PP2A (tyrosine 307) is associated with Alzheimer neurofibrillary pathology. Journal of cellular and molecular medicine. vol 12. issue 1. 2008-07-22. PMID:18208556. down-regulation of protein phosphatase 2a (pp2a) is thought to play a critical role in tau hyperphosphorylation in alzheimer's disease (ad). 2008-07-22 2023-08-12 mouse
Nicolas Sergeant, Alexis Bretteville, Malika Hamdane, Marie-Laure Caillet-Boudin, Pierre Grognet, Stephanie Bombois, David Blum, André Delacourte, Florence Pasquier, Eugeen Vanmechelen, Susanna Schraen-Maschke, Luc Bué. Biochemistry of Tau in Alzheimer's disease and related neurological disorders. Expert review of proteomics. vol 5. issue 2. 2008-07-16. PMID:18466052. biochemistry of tau in alzheimer's disease and related neurological disorders. 2008-07-16 2023-08-12 Not clear