| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Natasha Deters, Lars M Ittner, Jürgen Göt. Divergent phosphorylation pattern of tau in P301L tau transgenic mice. The European journal of neuroscience. vol 28. issue 1. 2008-10-20. PMID:18662339. |
aggregates of hyperphosphorylated tau are prominent in brains of patients with alzheimer's disease or frontotemporal dementia (ftd). |
2008-10-20 |
2023-08-12 |
mouse |
| J L Whitwell, K A Josephs, M E Murray, K Kantarci, S A Przybelski, S D Weigand, P Vemuri, M L Senjem, J E Parisi, D S Knopman, B F Boeve, R C Petersen, D W Dickson, C R Jac. MRI correlates of neurofibrillary tangle pathology at autopsy: a voxel-based morphometry study. Neurology. vol 71. issue 10. 2008-10-20. PMID:18765650. |
neurofibrillary tangles (nfts), composed of hyperphosphorylated tau proteins, are one of the pathologic hallmarks of alzheimer disease (ad). |
2008-10-20 |
2023-08-12 |
Not clear |
| Hiroshige Fujishiro, Yoshio Tsuboi, Wen-Lang Lin, Hirotake Uchikado, Dennis W Dickso. Co-localization of tau and alpha-synuclein in the olfactory bulb in Alzheimer's disease with amygdala Lewy bodies. Acta neuropathologica. vol 116. issue 1. 2008-10-14. PMID:18446351. |
co-localization of tau and alpha-synuclein in the olfactory bulb in alzheimer's disease with amygdala lewy bodies. |
2008-10-14 |
2023-08-12 |
Not clear |
| Fernanda G De Felice, Diana Wu, Mary P Lambert, Sara J Fernandez, Pauline T Velasco, Pascale N Lacor, Eileen H Bigio, Jasna Jerecic, Paul J Acton, Paul J Shughrue, Elizabeth Chen-Dodson, Gene G Kinney, William L Klei. Alzheimer's disease-type neuronal tau hyperphosphorylation induced by A beta oligomers. Neurobiology of aging. vol 29. issue 9. 2008-10-13. PMID:17403556. |
alzheimer's disease-type neuronal tau hyperphosphorylation induced by a beta oligomers. |
2008-10-13 |
2023-08-12 |
Not clear |
| Fernanda G De Felice, Diana Wu, Mary P Lambert, Sara J Fernandez, Pauline T Velasco, Pascale N Lacor, Eileen H Bigio, Jasna Jerecic, Paul J Acton, Paul J Shughrue, Elizabeth Chen-Dodson, Gene G Kinney, William L Klei. Alzheimer's disease-type neuronal tau hyperphosphorylation induced by A beta oligomers. Neurobiology of aging. vol 29. issue 9. 2008-10-13. PMID:17403556. |
alzheimer's disease (ad) is characterized by presence of extracellular fibrillar a beta in amyloid plaques, intraneuronal neurofibrillary tangles consisting of aggregated hyperphosphorylated tau and elevated brain levels of soluble a beta oligomers (addls). |
2008-10-13 |
2023-08-12 |
Not clear |
| Justyna Maria Czarna Bahl, Søren Skov Jensen, Martin R Larsen, Niels H H Heegaar. Characterization of the human cerebrospinal fluid phosphoproteome by titanium dioxide affinity chromatography and mass spectrometry. Analytical chemistry. vol 80. issue 16. 2008-10-09. PMID:18702456. |
in alzheimer's disease, hyperphosphorylation of the tau protein is a characteristic feature and thus a comprehensive characterization of the phosphoproteome of the csf may be pursued to obtain a complete picture of phosphorylation aberrations in health and disease. |
2008-10-09 |
2023-08-12 |
human |
| Giacomina Rossi, Leda Dalprà, Francesca Crosti, Sara Lissoni, Francesca L Sciacca, Marcella Catania, Giuseppe Di Fede, Michela Mangieri, Giorgio Giaccone, Danilo Croci, Fabrizio Tagliavin. A new function of microtubule-associated protein tau: involvement in chromosome stability. Cell cycle (Georgetown, Tex.). vol 7. issue 12. 2008-10-07. PMID:18583940. |
an altered tau produces cytoskeleton pathology resulting in neurodegenerative diseases such as alzheimer's disease and tauopathies. |
2008-10-07 |
2023-08-12 |
human |
| T Arakawa, Y Kita, T Niikur. A rescue factor for Alzheimer's diseases: discovery, activity, structure, and mechanism. Current medicinal chemistry. vol 15. issue 21. 2008-10-07. PMID:18781936. |
alzheimer's disease (ad) is a complex disease, involving multiple factors such as the production of aggregation-prone amyloid beta (abeta) peptides, the formation of fibrillarly tangles of microtubule-associating proteins, tau, and the polymorphism of cholesterol binding protein, apoe4. |
2008-10-07 |
2023-08-12 |
Not clear |
| Gonzalo I Cancino, Enrique M Toledo, Nancy R Leal, Diego E Hernandez, L Fernanda Yévenes, Nibaldo C Inestrosa, Alejandra R Alvare. STI571 prevents apoptosis, tau phosphorylation and behavioural impairments induced by Alzheimer's beta-amyloid deposits. Brain : a journal of neurology. vol 131. issue Pt 9. 2008-10-06. PMID:18559370. |
sti571 prevents apoptosis, tau phosphorylation and behavioural impairments induced by alzheimer's beta-amyloid deposits. |
2008-10-06 |
2023-08-12 |
mouse |
| Hai-Rong Shi, Ling-Qiang Zhu, Shao-Hui Wang, Xin-An Liu, Qing Tian, Qi Zhang, Qun Wang, Jian-Zhi Wan. 17beta-estradiol attenuates glycogen synthase kinase-3beta activation and tau hyperphosphorylation in Akt-independent manner. Journal of neural transmission (Vienna, Austria : 1996). vol 115. issue 6. 2008-10-03. PMID:18217188. |
decline of estrogen is associated with high incidence of alzheimer's disease (ad) characterized pathologically with tau hyperphosphorylation, and glycogen synthase kinase-3beta (gsk-3beta) is a major tau kinase. |
2008-10-03 |
2023-08-12 |
Not clear |
| Carl Julien, Cyntia Tremblay, Farid Bendjelloul, Alix Phivilay, Marie-Andrée Coulombe, Vincent Emond, Frédéric Calo. Decreased drebrin mRNA expression in Alzheimer disease: correlation with tau pathology. Journal of neuroscience research. vol 86. issue 10. 2008-09-30. PMID:18338803. |
decreased drebrin mrna expression in alzheimer disease: correlation with tau pathology. |
2008-09-30 |
2023-08-12 |
Not clear |
| Alicia Rubio, Mar Pérez, Luis de Lecea, Jesús Avil. Effect of cortistatin on tau phosphorylation at Ser262 site. Journal of neuroscience research. vol 86. issue 11. 2008-09-30. PMID:18438934. |
the development of intraneuronal lesions as a result of the progressive deposition of hyperphosphorylated tau at specific brain regions (such as hippocampus and cortex) plays a key role in the pathological process of alzheimer's disease. |
2008-09-30 |
2023-08-12 |
mouse |
| Alicia Rubio, Mar Pérez, Luis de Lecea, Jesús Avil. Effect of cortistatin on tau phosphorylation at Ser262 site. Journal of neuroscience research. vol 86. issue 11. 2008-09-30. PMID:18438934. |
both somatostatin and cortistatin induce tau phosphorylation at ser262, a site modified in alzheimer's disease, although with different kinetics in cortex. |
2008-09-30 |
2023-08-12 |
mouse |
| Alicia Rubio, Mar Pérez, Luis de Lecea, Jesús Avil. Effect of cortistatin on tau phosphorylation at Ser262 site. Journal of neuroscience research. vol 86. issue 11. 2008-09-30. PMID:18438934. |
our results suggest an important role for cortistatin in the regulation of tau phosphorylation that may be associated with the pathophysiology of alzheimer's disease in regions such as the cerebral cortex. |
2008-09-30 |
2023-08-12 |
mouse |
| Binbin Wang, Sirui Zhou, Ze Yang, Yan-Chen Xie, Jing Wang, Peng Zhang, Zeping Lv, Chenguang Zheng, Xu M. Genetic analysis of tumor necrosis factor-alpha (TNF-alpha) G-308A and Saitohin Q7R polymorphisms with Alzheimer's disease. Journal of the neurological sciences. vol 270. issue 1-2. 2008-09-24. PMID:18396294. |
neuroinflammation and abnormal phosphorylation of tau proteins have been implicated in the etiology of alzheimer's disease (ad). |
2008-09-24 |
2023-08-12 |
Not clear |
| Inmaculada Cuchillo-Ibanez, Anjan Seereeram, Helen L Byers, Kit-Yi Leung, Malcolm A Ward, Brian H Anderton, Diane P Hange. Phosphorylation of tau regulates its axonal transport by controlling its binding to kinesin. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 22. issue 9. 2008-09-24. PMID:18511549. |
we investigated the effect of phosphorylation on the axonal transport of tau, a neuronal protein that stabilizes microtubules and is hyperphosphorylated and mislocalized in alzheimer's disease. |
2008-09-24 |
2023-08-12 |
rat |
| Inmaculada Cuchillo-Ibanez, Anjan Seereeram, Helen L Byers, Kit-Yi Leung, Malcolm A Ward, Brian H Anderton, Diane P Hange. Phosphorylation of tau regulates its axonal transport by controlling its binding to kinesin. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 22. issue 9. 2008-09-24. PMID:18511549. |
hyperphosphorylated tau in alzheimer's disease appearing first in distal portions of axons may result from aberrant axonal transport of phosphorylated tau reported here. |
2008-09-24 |
2023-08-12 |
rat |
| J A P van de Nes, R Nafe, W Schlot. Non-tau based neuronal degeneration in Alzheimer's disease -- an immunocytochemical and quantitative study in the supragranular layers of the middle temporal neocortex. Brain research. vol 1213. 2008-09-19. PMID:18455153. |
in alzheimer's disease (ad), cortical neurons develop neurofibrillary tangles (nfts) consisting of hyperphosphorylated tau. |
2008-09-19 |
2023-08-12 |
human |
| Kavon Rezai-Zadeh, Gary W Arendash, Huayan Hou, Frank Fernandez, Maren Jensen, Melissa Runfeldt, R Douglas Shytle, Jun Ta. Green tea epigallocatechin-3-gallate (EGCG) reduces beta-amyloid mediated cognitive impairment and modulates tau pathology in Alzheimer transgenic mice. Brain research. vol 1214. 2008-09-19. PMID:18457818. |
green tea epigallocatechin-3-gallate (egcg) reduces beta-amyloid mediated cognitive impairment and modulates tau pathology in alzheimer transgenic mice. |
2008-09-19 |
2023-08-12 |
mouse |
| Quan-Guang Zhang, Ruimin Wang, Mohammad Khan, Virendra Mahesh, Darrell W Bran. Role of Dickkopf-1, an antagonist of the Wnt/beta-catenin signaling pathway, in estrogen-induced neuroprotection and attenuation of tau phosphorylation. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 28. issue 34. 2008-09-16. PMID:18716201. |
tau hyperphosphorylation has been implicated to have a prodeath role in alzheimer's disease and cerebral ischemia, and e2 attenuates tau hyperphosphorylation. |
2008-09-16 |
2023-08-12 |
Not clear |