| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jian-Zhi Wang, Fei Li. Microtubule-associated protein tau in development, degeneration and protection of neurons. Progress in neurobiology. vol 85. issue 2. 2008-08-11. PMID:18448228. |
therefore, changes in expression of the tau gene, alternative splicing of its mrna and its posttranslational modification can modulate the normal architecture and functions of neurons as well as in a situation of tauopathies, such as alzheimer's disease. |
2008-08-11 |
2023-08-12 |
Not clear |
| G Muntané, E Dalfó, A Martinez, I Ferre. Phosphorylation of tau and alpha-synuclein in synaptic-enriched fractions of the frontal cortex in Alzheimer's disease, and in Parkinson's disease and related alpha-synucleinopathies. Neuroscience. vol 152. issue 4. 2008-08-07. PMID:18343584. |
phosphorylation of tau and alpha-synuclein in synaptic-enriched fractions of the frontal cortex in alzheimer's disease, and in parkinson's disease and related alpha-synucleinopathies. |
2008-08-07 |
2023-08-12 |
mouse |
| G Muntané, E Dalfó, A Martinez, I Ferre. Phosphorylation of tau and alpha-synuclein in synaptic-enriched fractions of the frontal cortex in Alzheimer's disease, and in Parkinson's disease and related alpha-synucleinopathies. Neuroscience. vol 152. issue 4. 2008-08-07. PMID:18343584. |
phosphorylation of tau and phosphorylation of alpha-synuclein are crucial abnormalities in alzheimer's disease (ad) and alpha-synucleinopathies (parkinson's disease: pd, and dementia with lewy bodies: dlb), respectively. |
2008-08-07 |
2023-08-12 |
mouse |
| Gabriele Hübinger, Silvia Geis, Sylvie LeCorre, Susanne Mühlbacher, Sandra Gordon, R Paul Fracasso, Fred Hoffman, Sandrine Ferrand, Hans W Klafki, Hanno M Rode. Inhibition of PHF-like tau hyperphosphorylation in SH-SY5Y cells and rat brain slices by K252a. Journal of Alzheimer's disease : JAD. vol 13. issue 3. 2008-08-07. PMID:18430996. |
abnormal hyperphosphorylation of tau is believed to constitute a critical biochemical event in the process of neurofibrillary degeneration of alzheimer's disease. |
2008-08-07 |
2023-08-12 |
rat |
| G D Silverberg, M Mayo, T Saul, J Fellmann, J Carvalho, D McGuir. Continuous CSF drainage in AD: results of a double-blind, randomized, placebo-controlled study. Neurology. vol 71. issue 3. 2008-08-04. PMID:18525029. |
alzheimer disease (ad) has been associated with abnormal cerebral clearance of macromolecules, such as amyloid and microtubule-associated-protein tau (map-tau). |
2008-08-04 |
2023-08-12 |
Not clear |
| Dylan W Peterson, Hongjun Zhou, Frederick W Dahlquist, John Le. A soluble oligomer of tau associated with fiber formation analyzed by NMR. Biochemistry. vol 47. issue 28. 2008-08-01. PMID:18558718. |
alzheimer's disease (ad) is characterized by the intracellular accumulation of the neurofibrillary tangles comprised mainly of the microtubule-associated protein, tau. |
2008-08-01 |
2023-08-12 |
human |
| R Liu, X-W Zhou, H Tanila, C Bjorkdahl, J-Z Wang, Z-Z Guan, Y Cao, J-A Gustafsson, B Winblad, J-J Pe. Phosphorylated PP2A (tyrosine 307) is associated with Alzheimer neurofibrillary pathology. Journal of cellular and molecular medicine. vol 12. issue 1. 2008-07-22. PMID:18208556. |
down-regulation of protein phosphatase 2a (pp2a) is thought to play a critical role in tau hyperphosphorylation in alzheimer's disease (ad). |
2008-07-22 |
2023-08-12 |
mouse |
| Nicolas Sergeant, Alexis Bretteville, Malika Hamdane, Marie-Laure Caillet-Boudin, Pierre Grognet, Stephanie Bombois, David Blum, André Delacourte, Florence Pasquier, Eugeen Vanmechelen, Susanna Schraen-Maschke, Luc Bué. Biochemistry of Tau in Alzheimer's disease and related neurological disorders. Expert review of proteomics. vol 5. issue 2. 2008-07-16. PMID:18466052. |
biochemistry of tau in alzheimer's disease and related neurological disorders. |
2008-07-16 |
2023-08-12 |
Not clear |
| Rudy J Castellani, Hyoung-Gon Lee, Xiongwei Zhu, George Perry, Mark A Smit. Alzheimer disease pathology as a host response. Journal of neuropathology and experimental neurology. vol 67. issue 6. 2008-07-15. PMID:18520771. |
identification of amyloid-beta and tau as the major protein components of senile plaques and neurofibrillary tangles, respectively, led to an exponential increase in investigations of these proteins and their corresponding metabolic pathways in alzheimer disease (ad). |
2008-07-15 |
2023-08-12 |
Not clear |
| Marta Tajes, Javier Gutierrez-Cuesta, Jaume Folch, Isidre Ferrer, Beatriz Caballero, Mark A Smith, Gemma Casadesus, Antoni Camins, Mercé Pallá. Lithium treatment decreases activities of tau kinases in a murine model of senescence. Journal of neuropathology and experimental neurology. vol 67. issue 6. 2008-07-15. PMID:18520779. |
lithium modulates glycogen synthase kinase 3beta (gsk-3beta), a kinase involved in alzheimer disease-related tau pathology. |
2008-07-15 |
2023-08-12 |
mouse |
| Delphine Boche, James A R Nicol. The role of the immune system in clearance of Abeta from the brain. Brain pathology (Zurich, Switzerland). vol 18. issue 2. 2008-07-10. PMID:18363937. |
in alzheimer's disease (ad), there is abnormal accumulation of abeta and tau proteins in the brain. |
2008-07-10 |
2023-08-12 |
Not clear |
| Erin E Congdon, Sohee Kim, Jonathan Bonchak, Tanakorn Songrug, Anastasios Matzavinos, Jeff Kure. Nucleation-dependent tau filament formation: the importance of dimerization and an estimation of elementary rate constants. The Journal of biological chemistry. vol 283. issue 20. 2008-07-09. PMID:18359772. |
filamentous inclusions composed of the microtubule-associated protein tau are found in alzheimer disease and other tauopathic neurodegenerative diseases, but the mechanisms underlying their formation from full-length protein monomer under physiological conditions are unclear. |
2008-07-09 |
2023-08-12 |
human |
| Jeffrey A Fein, Sophie Sokolow, Carol A Miller, Harry V Vinters, Fusheng Yang, Gregory M Cole, Karen Hoppens Gyly. Co-localization of amyloid beta and tau pathology in Alzheimer's disease synaptosomes. The American journal of pathology. vol 172. issue 6. 2008-07-08. PMID:18467692. |
co-localization of amyloid beta and tau pathology in alzheimer's disease synaptosomes. |
2008-07-08 |
2023-08-12 |
Not clear |
| Jeffrey A Fein, Sophie Sokolow, Carol A Miller, Harry V Vinters, Fusheng Yang, Gregory M Cole, Karen Hoppens Gyly. Co-localization of amyloid beta and tau pathology in Alzheimer's disease synaptosomes. The American journal of pathology. vol 172. issue 6. 2008-07-08. PMID:18467692. |
we examined the regional distribution and co-localization of abeta and phosphorylated tau (p-tau) in synaptic terminals of alzheimer's disease brains. |
2008-07-08 |
2023-08-12 |
Not clear |
| A Rametti, F Esclaire, C Yardin, N Cogné, F Terr. Lithium down-regulates tau in cultured cortical neurons: a possible mechanism of neuroprotection. Neuroscience letters. vol 434. issue 1. 2008-07-03. PMID:18289787. |
in tauopathies such as alzheimer's disease (ad), the moleccular mechanisms of tau protein agregation into neurofibrillary tangles (nfts) and their contribution to neurodegeneration are not fully understood. |
2008-07-03 |
2023-08-12 |
Not clear |
| Andrew J Larne. Mutation negative "early-onset familial Alzheimer disease": consider screening for tau gene mutations. Alzheimer disease and associated disorders. vol 22. issue 2. 2008-07-03. PMID:18525295. |
mutation negative "early-onset familial alzheimer disease": consider screening for tau gene mutations. |
2008-07-03 |
2023-08-12 |
Not clear |
| Andrew J Larne. Mutation negative "early-onset familial Alzheimer disease": consider screening for tau gene mutations. Alzheimer disease and associated disorders. vol 22. issue 2. 2008-07-03. PMID:18525295. |
as these genes prove to be negative in patients with a clinical diagnosis of early-onset familial alzheimer disease, a search for tau gene mutations may be appropriate, as illustrated by the following case. |
2008-07-03 |
2023-08-12 |
Not clear |
| Paula I Moreira, Maria S Santos, Catarina R Oliveira, Justin C Shenk, Akihiko Nunomura, Mark A Smith, Xiongwei Zhu, George Perr. Alzheimer disease and the role of free radicals in the pathogenesis of the disease. CNS & neurological disorders drug targets. vol 7. issue 1. 2008-07-02. PMID:18289026. |
furthermore, it has been suggested that in the initial stages of the development of alzheimer disease, amyloid-beta deposition and hyperphosphorylated tau function as compensatory responses to ensure that neuronal cells do not succumb to oxidative damage. |
2008-07-02 |
2023-08-12 |
Not clear |
| Daniela Galimberti, Eliana Venturelli, Chiara Fenoglio, Ilaria Guidi, Chiara Villa, Luigi Bergamaschini, Francesca Cortini, Diego Scalabrini, Pierluigi Baron, Carlo Vergani, Nereo Bresolin, Elio Scarpin. Intrathecal levels of IL-6, IL-11 and LIF in Alzheimer's disease and frontotemporal lobar degeneration. Journal of neurology. vol 255. issue 4. 2008-07-01. PMID:18204920. |
cerebrospinal fluid (csf) levels of interleukin (il)-6, il-11 and leukaemia inhibitory factor (lif) were evaluated in 43 patients with alzheimer's disease (ad) and 24 patients with frontotemporal lobar degeneration (ftld) as compared with 30 agematched controls (con), and correlated with clinical and demographic data and with csf biomarkers amyloid beta (a beta)42, total tau and tau phosphorylated at position 181 (p-tau). |
2008-07-01 |
2023-08-12 |
Not clear |
| Y-J Zhang, Y-F Xu, X-H Liu, D Li, J Yin, Y-H Liu, X-Q Chen, J-Z Wan. Carboxyl terminus of heat-shock cognate 70-interacting protein degrades tau regardless its phosphorylation status without affecting the spatial memory of the rats. Journal of neural transmission (Vienna, Austria : 1996). vol 115. issue 3. 2008-07-01. PMID:18301957. |
accumulation of the hyperphosphorylated tau is a hallmark pathological event for the formation of neurofibrillary tangles in alzheimer disease (ad). |
2008-07-01 |
2023-08-12 |
rat |