| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Tadanori Hamano, Tania F Gendron, Ena Causevic, Shu-Hui Yen, Wen-Lang Lin, Ciro Isidoro, Michael Deture, Li-wen K. Autophagic-lysosomal perturbation enhances tau aggregation in transfectants with induced wild-type tau expression. The European journal of neuroscience. vol 27. issue 5. 2008-06-03. PMID:18294209. |
the intracellular assembly of tau aggregates is a pathological hallmark shared by alzheimer's disease and other neurodegenerative disorders known collectively as tauopathies. |
2008-06-03 |
2023-08-12 |
human |
| Kayoko Okuyama, Chisato Nishiura, Fumie Mizushima, Katsuhiko Minoura, Miho Sumida, Taizo Taniguchi, Koji Tomoo, Toshimasa Ishid. Linkage-dependent contribution of repeat peptides to self-aggregation of three- or four-repeat microtubule-binding domains in tau protein. The FEBS journal. vol 275. issue 7. 2008-06-03. PMID:18312411. |
although one of the priorities in alzheimer's research is to clarify the filament formation mechanism for the tau protein, it is still unclear how it is transformed from a normal structure in a neuron. |
2008-06-03 |
2023-08-12 |
Not clear |
| Tamar Amit, Yael Avramovich-Tirosh, Moussa B H Youdim, Silvia Mande. Targeting multiple Alzheimer's disease etiologies with multimodal neuroprotective and neurorestorative iron chelators. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 22. issue 5. 2008-05-28. PMID:18048580. |
dysregulation of brain iron homeostasis is central to early neuropathological events in alzheimer's disease (ad), including oxidative stress, inflammatory processes, amyloid deposition, tau phosphorylation, and neuronal cell cycle regulatory failure, leading to apoptosis. |
2008-05-28 |
2023-08-12 |
Not clear |
| Martyna Songin, Henryk Jeśko, Grzegorz Czapski, Agata Adamczyk, Robert P Strosznajde. GSK-3beta and oxidative stress in aged brain. Role of poly(ADP- -ribose) polymerase-1. Folia neuropathologica. vol 45. issue 4. 2008-05-20. PMID:18176896. |
in alzheimer's disease it is responsible for hyperphosphorylation of tau. |
2008-05-20 |
2023-08-12 |
rat |
| Mirko Bibl, Brit Mollenhauer, Hermann Esselmann, Michael Schneider, Piotr Lewczuk, Volker Welge, Martin Gross, Peter Falkai, Johannes Kornhuber, Jens Wiltfan. Cerebrospinal fluid neurochemical phenotypes in vascular dementias: original data and mini-review. Dementia and geriatric cognitive disorders. vol 25. issue 3. 2008-05-20. PMID:18270488. |
the study evaluated the patterns of cerebrospinal fluid (csf), amyloid-beta (abeta) peptides, total tau and phospho-tau among alzheimer's disease (ad) and vascular dementias (vad). |
2008-05-20 |
2023-08-12 |
Not clear |
| T Engel, P Goñi-Oliver, E Gómez de Barreda, J J Lucas, F Hernández, J Avil. Lithium, a potential protective drug in Alzheimer's disease. Neuro-degenerative diseases. vol 5. issue 3-4. 2008-05-15. PMID:18322403. |
since a main tau kinase is glycogen synthase kinase 3 (gsk-3), the use of specific gsk-3 inhibitors, like lithium, could be a potential therapy in alzheimer's disease. |
2008-05-15 |
2023-08-12 |
Not clear |
| T Engel, P Goñi-Oliver, E Gómez de Barreda, J J Lucas, F Hernández, J Avil. Lithium, a potential protective drug in Alzheimer's disease. Neuro-degenerative diseases. vol 5. issue 3-4. 2008-05-15. PMID:18322403. |
in this short article, we have done a review on tau phosphorylation in alzheimer's disease and other tauopathies, and on the inhibition of kinases like gsk-3, involved in tau modification. |
2008-05-15 |
2023-08-12 |
Not clear |
| Pierrot Nathalie, Octave Jean-Noë. Processing of amyloid precursor protein and amyloid peptide neurotoxicity. Current Alzheimer research. vol 5. issue 2. 2008-05-15. PMID:18393795. |
biochemical analysis of these two proteins in primary cultures of neurons show that phosphorylation of both app and tau can be a factor linking the two characteristic lesions of alzheimer's disease. |
2008-05-15 |
2023-08-12 |
human |
| Bruce A Yankner, Tao Lu, Patrick Loerc. The aging brain. Annual review of pathology. vol 3. 2008-05-13. PMID:18039130. |
toxic protein aggregates have been identified as potential contributory factors, including amyloid beta-protein in alzheimer's disease, tau in frontotemporal dementia, and alpha-synuclein in parkinson's disease. |
2008-05-13 |
2023-08-12 |
Not clear |
| Dick Terwel, David Muyllaert, Ilse Dewachter, Peter Borghgraef, Sophie Croes, Herman Devijver, Fred Van Leuve. Amyloid activates GSK-3beta to aggravate neuronal tauopathy in bigenic mice. The American journal of pathology. vol 172. issue 3. 2008-05-09. PMID:18258852. |
the hypothesis that amyloid pathology precedes and induces the tau pathology of alzheimer's disease is experimentally supported here through the identification of gsk-3 isozymes as a major link in the signaling pathway from amyloid to tau pathology. |
2008-05-09 |
2023-08-12 |
mouse |
| Peter Wostyn, Kurt Audenaert, Peter Paul De Dey. Alzheimer's disease-related changes in diseases characterized by elevation of intracranial or intraocular pressure. Clinical neurology and neurosurgery. vol 110. issue 2. 2008-05-07. PMID:18061341. |
with regard to normal pressure hydrocephalus, evidence suggests that changes in cerebrospinal fluid circulatory dynamics ultimately may result in reduced clearance of neurotoxins, such as beta-amyloid peptides and tau protein, that play a role in the pathogenesis of alzheimer's disease. |
2008-05-07 |
2023-08-12 |
Not clear |
| S G Lindquist, I E Holm, M Schwartz, I Law, J Stokholm, M Batbayli, G Waldemar, J E Nielse. Alzheimer disease-like clinical phenotype in a family with FTDP-17 caused by a MAPT R406W mutation. European journal of neurology. vol 15. issue 4. 2008-05-07. PMID:18284428. |
we report clinical, molecular, neuroimaging and neuropathological features of a danish family with autosomal dominant inherited dementia, a clinical phenotype resembling alzheimer's disease and a pathogenic mutation (r406w) in the microtubule associated protein tau (mapt) gene. |
2008-05-07 |
2023-08-12 |
Not clear |
| Asgar Zaheer, Scott Knight, Ashna Zaheer, Marcus Ahrens, Shailendra K Sahu, Baoli Yan. Glia maturation factor overexpression in neuroblastoma cells activates glycogen synthase kinase-3beta and caspase-3. Brain research. vol 1190. 2008-05-06. PMID:18054898. |
taken together our results imply that gmf is involved in the signaling leading to the activation of gsk-3beta and caspase-3 in n18 cells and strongly suggest its involvement in neurodegeneration since gsk-3beta is known to hyperphosphorylate tau which is associated with the neurotoxicity of neurofibrillary tangles in alzheimer's disease. |
2008-05-06 |
2023-08-12 |
Not clear |
| Theresa J Kannanayakal, Jerry R Mendell, Jeff Kure. Casein kinase 1 alpha associates with the tau-bearing lesions of inclusion body myositis. Neuroscience letters. vol 431. issue 2. 2008-05-02. PMID:18191026. |
inclusion body myositis and alzheimer's disease are age-related disorders characterized in part by the appearance of intracellular lesions composed of filamentous aggregates of the microtubule-associated protein tau. |
2008-05-02 |
2023-08-12 |
Not clear |
| Theresa J Kannanayakal, Jerry R Mendell, Jeff Kure. Casein kinase 1 alpha associates with the tau-bearing lesions of inclusion body myositis. Neuroscience letters. vol 431. issue 2. 2008-05-02. PMID:18191026. |
enzymes implicated in tau hyperphosphorylation in alzheimer's disease include members of the casein kinase 1 family of phosphotransferases, a group of structurally related protein kinases that frequently function in tandem with the ubiquitin modification system. |
2008-05-02 |
2023-08-12 |
Not clear |
| Theresa J Kannanayakal, Jerry R Mendell, Jeff Kure. Casein kinase 1 alpha associates with the tau-bearing lesions of inclusion body myositis. Neuroscience letters. vol 431. issue 2. 2008-05-02. PMID:18191026. |
these findings, which extend the molecular similarities between inclusion body myositis muscle and alzheimer's disease brain, implicate casein kinase 1 alpha as one of the phosphotransferases potentially involved in tau hyperphosphorylation. |
2008-05-02 |
2023-08-12 |
Not clear |
| Niki S M Schoonenboom, Wiesje M van der Flier, Marinus A Blankenstein, Femke H Bouwman, Gerard J Van Kamp, Frederik Barkhof, Philip Schelten. CSF and MRI markers independently contribute to the diagnosis of Alzheimer's disease. Neurobiology of aging. vol 29. issue 5. 2008-04-28. PMID:17208336. |
decreased amyloid beta (1-42) (abeta42) and increased (phosphorylated) tau in cerebrospinal fluid (csf) are considered to be a reflection of plaques, tangles, and neuronal degeneration in alzheimer's disease (ad). |
2008-04-28 |
2023-08-12 |
Not clear |
| Han Zhang, Runzhong Liu, Ruishan Wang, Shuigen Hong, Huaxi Xu, Yun-wu Zhan. Presenilins regulate the cellular level of the tumor suppressor PTEN. Neurobiology of aging. vol 29. issue 5. 2008-04-28. PMID:17222949. |
alzheimer's disease (ad) is characterized by amyloid plaques consisting of beta-amyloid (abeta) peptides and neurofibrillary tangles consisting of hyperphosphorylated tau protein. |
2008-04-28 |
2023-08-12 |
mouse |
| Troy T Rohn, Veera Vyas, Tatiana Hernandez-Estrada, Kathryn E Nichol, Lori-Ann Christie, Elizabeth Hea. Lack of pathology in a triple transgenic mouse model of Alzheimer's disease after overexpression of the anti-apoptotic protein Bcl-2. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 28. issue 12. 2008-04-25. PMID:18354008. |
alzheimer's disease (ad) is characterized by the accumulation of plaques containing beta-amyloid (abeta) and neurofibrillary tangles (nfts) consisting of modified tau. |
2008-04-25 |
2023-08-12 |
mouse |
| Carla L Busceti, Francesca Biagioni, Barbara Riozzi, Giuseppe Battaglia, Marianna Storto, Carlo Cinque, Gemma Molinaro, Roberto Gradini, Andrea Caricasole, Anna Maria Canudas, Valeria Bruno, Ferdinando Nicoletti, Francesco Forna. Enhanced tau phosphorylation in the hippocampus of mice treated with 3,4-methylenedioxymethamphetamine ("Ecstasy"). The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 28. issue 12. 2008-04-25. PMID:18354027. |
we examined whether mdma induces increases in tau protein phosphorylation, which are typically associated with alzheimer's disease and other chronic neurodegenerative disorders. |
2008-04-25 |
2023-08-12 |
mouse |