All Relations between Alzheimer Disease and microtubule-associated protein tau

Publication Sentence Publish Date Extraction Date Species
Chad A Dickey, Adeela Kamal, Karen Lundgren, Natalia Klosak, Rachel M Bailey, Judith Dunmore, Peter Ash, Sareh Shoraka, Jelena Zlatkovic, Christopher B Eckman, Cam Patterson, Dennis W Dickson, N Stanley Nahman, Michael Hutton, Francis Burrows, Leonard Petrucell. The high-affinity HSP90-CHIP complex recognizes and selectively degrades phosphorylated tau client proteins. The Journal of clinical investigation. vol 117. issue 3. 2007-05-04. PMID:17304350. a primary pathologic component of alzheimer's disease (ad) is the formation of neurofibrillary tangles composed of hyperphosphorylated tau (p-tau). 2007-05-04 2023-08-12 mouse
Dmitry Goryunov, Ronald K H Lie. CHIP-ping away at tau. The Journal of clinical investigation. vol 117. issue 3. 2007-05-04. PMID:17332887. in alzheimer's disease (ad), a hyperphosphorylated form of the protein tau (p-tau) forms intracellular inclusions known as neurofibrillary tangles. 2007-05-04 2023-08-12 Not clear
Steffen Albrecht, Martine Bourdeau, David Bennett, Elliott J Mufson, Meena Bhattacharjee, Andréa C LeBlan. Activation of caspase-6 in aging and mild cognitive impairment. The American journal of pathology. vol 170. issue 4. 2007-05-04. PMID:17392160. active caspase-6 (csp6) and tau cleaved by csp6 (taudeltacsp6) are abundant in neuritic plaques (nps), neuropil threads (npts), and neurofibrillary tangles (nfts) in end-stage alzheimer's disease (ad) (guo h, albrecht s, bourdeau m, petzke t, bergeron c, leblanc ac: active caspase-6 and caspase-6 cleaved tau in neuropil threads, neuritic plaques and neurofibrillary tangles of alzheimer's disease. 2007-05-04 2023-08-12 human
Steffen Albrecht, Martine Bourdeau, David Bennett, Elliott J Mufson, Meena Bhattacharjee, Andréa C LeBlan. Activation of caspase-6 in aging and mild cognitive impairment. The American journal of pathology. vol 170. issue 4. 2007-05-04. PMID:17392160. given the ability of active csp6 to increase amyloid-beta peptide production and cleave tau and several synaptic proteins (leblanc ac, liu h, goodyer c, bergeron c, hammond j: caspase-6 role in apoptosis of human neurons, amyloidogenesis and alzheimer's disease. 2007-05-04 2023-08-12 human
D A Forero, G Arboleda, J J Yunis, R Pardo, H Arboled. Association study of polymorphisms in LRP1, tau and 5-HTT genes and Alzheimer's disease in a sample of Colombian patients. Journal of neural transmission (Vienna, Austria : 1996). vol 113. issue 9. 2007-05-02. PMID:16362633. association study of polymorphisms in lrp1, tau and 5-htt genes and alzheimer's disease in a sample of colombian patients. 2007-05-02 2023-08-12 human
Zdenek Berger, Hanno Roder, Amanda Hanna, Aaron Carlson, Vijayaraghavan Rangachari, Mei Yue, Zbigniew Wszolek, Karen Ashe, Joshua Knight, Dennis Dickson, Cathy Andorfer, Terrone L Rosenberry, Jada Lewis, Mike Hutton, Christopher Janu. Accumulation of pathological tau species and memory loss in a conditional model of tauopathy. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 27. issue 14. 2007-05-02. PMID:17409229. similar tau multimers were detected in a second mouse model of tauopathy (jnpl3) and in tissue from patients with alzheimer's disease and ftdp-17 (frontotemporal dementia and parkinsonism linked to chromosome 17). 2007-05-02 2023-08-12 mouse
Andrew McShea, Hyoung-gon Lee, Robert B Petersen, Gemma Casadesus, Inez Vincent, Nancy J Linford, Jens-Oliver Funk, Robert A Shapiro, Mark A Smit. Neuronal cell cycle re-entry mediates Alzheimer disease-type changes. Biochimica et biophysica acta. vol 1772. issue 4. 2007-04-26. PMID:17095196. importantly, we also found that cell cycle re-entry in primary neurons leads to tau phosphorylation and conformational changes similar to that seen in alzheimer disease. 2007-04-26 2023-08-12 Not clear
Martin Balastik, Jormay Lim, Lucia Pastorino, Kun Ping L. Pin1 in Alzheimer's disease: multiple substrates, one regulatory mechanism? Biochimica et biophysica acta. vol 1772. issue 4. 2007-04-26. PMID:17317113. furthermore, pin1 is the only gene known so far that, when deleted in mice, can cause both tau and abeta-related pathologies in an age-dependent manner, resembling many aspects of human alzheimer's disease. 2007-04-26 2023-08-12 mouse
Hanno M Roder, Michael L Hutto. Microtubule-associated protein tau as a therapeutic target in neurodegenerative disease. Expert opinion on therapeutic targets. vol 11. issue 4. 2007-04-23. PMID:17373874. this is due, in part, to the discovery of mutations in tau causing a group of aggressively degenerative neurologic disorders characterized by abnormalities of tau very similar to what is seen in alzheimer's disease where mutations in tau are absent. 2007-04-23 2023-08-12 mouse
G L Lace, S B Wharton, P G Inc. A brief history of tau: the evolving view of the microtubule-associated protein tau in neurodegenerative diseases. Clinical neuropathology. vol 26. issue 2. 2007-04-20. PMID:17416103. over the years, opinions regarding the significance of tau in disease pathogenesis, particularly in alzheimer's disease, have fluctuated. 2007-04-20 2023-08-12 Not clear
G L Lace, S B Wharton, P G Inc. A brief history of tau: the evolving view of the microtubule-associated protein tau in neurodegenerative diseases. Clinical neuropathology. vol 26. issue 2. 2007-04-20. PMID:17416103. early caution about the role of tau as a significant factor in neurodegenerative disease, especially alzheimer's disease, has been superseded by acceptance of its key involvement in pathways which led to cell dysfunction and death. 2007-04-20 2023-08-12 Not clear
Deborah R Gustafson, Ingmar Skoog, Lars Rosengren, Henrik Zetterberg, Kaj Blenno. Cerebrospinal fluid beta-amyloid 1-42 concentration may predict cognitive decline in older women. Journal of neurology, neurosurgery, and psychiatry. vol 78. issue 5. 2007-04-19. PMID:17098843. low levels of cerebrospinal fluid (csf) beta-amyloid 1-42 (abeta42) and high total tau (t-tau) are diagnostic for manifest alzheimer's disease. 2007-04-19 2023-08-12 Not clear
Katleen Dillen, Wim Annaer. A two decade contribution of molecular cell biology to the centennial of Alzheimer's disease: are we progressing toward therapy? International review of cytology. vol 254. 2007-04-18. PMID:17148000. alzheimer's disease (ad), described for the first time 100 years ago, is a neurodegenerative disease characterized by two neuropathological hallmarks: neurofibrillary tangles containing hyperphosphorylated tau and senile plaques. 2007-04-18 2023-08-12 Not clear
Yoshiko Ikeda, Koichi Ishiguro, Shinobu C Fujit. Ether stress-induced Alzheimer-like tau phosphorylation in the normal mouse brain. FEBS letters. vol 581. issue 5. 2007-04-17. PMID:17289030. robust phosphorylation of tau was observed immediately and 10min after ether vapor exposure at ser202/thr205 and thr231/ser235, sites typically phosphorylated in alzheimer brains. 2007-04-17 2023-08-12 mouse
Kenichi Oshima, Haruhiko Akiyama, Kuniaki Tsuchiya, Hiromi Kondo, Chie Haga, Yoko Shimomura, Eizo Iseki, Hirotake Uchikado, Masanori Kato, Kazuhiro Niizato, Heii Ara. Relative paucity of tau accumulation in the small areas with abundant Abeta42-positive capillary amyloid angiopathy within a given cortical region in the brain of patients with Alzheimer pathology. Acta neuropathologica. vol 111. issue 6. 2007-04-16. PMID:16718347. relative paucity of tau accumulation in the small areas with abundant abeta42-positive capillary amyloid angiopathy within a given cortical region in the brain of patients with alzheimer pathology. 2007-04-16 2023-08-12 Not clear
Neelima B Chauha. Effect of aged garlic extract on APP processing and tau phosphorylation in Alzheimer's transgenic model Tg2576. Journal of ethnopharmacology. vol 108. issue 3. 2007-04-16. PMID:16842945. effect of aged garlic extract on app processing and tau phosphorylation in alzheimer's transgenic model tg2576. 2007-04-16 2023-08-12 mouse
Björn Kuhla, Cathleen Haase, Katharina Flach, Hans-Joachim Lüth, Thomas Arendt, Gerald Münc. Effect of pseudophosphorylation and cross-linking by lipid peroxidation and advanced glycation end product precursors on tau aggregation and filament formation. The Journal of biological chemistry. vol 282. issue 10. 2007-04-13. PMID:17082178. accumulation of hyperphosphorylated tau protein as paired helical filaments in pyramidal neurons is a major hallmark of alzheimer disease. 2007-04-13 2023-08-12 Not clear
Jian-Zhi Wang, Inge Grundke-Iqbal, Khalid Iqba. Kinases and phosphatases and tau sites involved in Alzheimer neurofibrillary degeneration. The European journal of neuroscience. vol 25. issue 1. 2007-04-05. PMID:17241267. kinases and phosphatases and tau sites involved in alzheimer neurofibrillary degeneration. 2007-04-05 2023-08-12 human
Jian-Zhi Wang, Inge Grundke-Iqbal, Khalid Iqba. Kinases and phosphatases and tau sites involved in Alzheimer neurofibrillary degeneration. The European journal of neuroscience. vol 25. issue 1. 2007-04-05. PMID:17241267. microtubule associated protein (map) tau is abnormally hyperphosphorylated in alzheimer's disease (ad) and related tauopathies; in this form it is the major protein subunit of paired helical filaments (phf)/neurofibrillary tangles. 2007-04-05 2023-08-12 human
Jian-Zhi Wang, Inge Grundke-Iqbal, Khalid Iqba. Kinases and phosphatases and tau sites involved in Alzheimer neurofibrillary degeneration. The European journal of neuroscience. vol 25. issue 1. 2007-04-05. PMID:17241267. we investigated self-assembly and microtubule assembly promoting activities of hyperphosphorylated tau isolated from alzheimer disease brain cytosol, the ad abnormally hyperphosphorylated tau (ad p-tau) before and after dephosphorylation by phosphoseryl/phosphothreonyl protein phosphatase-2a (pp-2a), and then rephosphorylation by cyclic amp-dependent protein kinase (pka), calcium, calmodulin-dependent protein kinase ii (camkii), glycogen synthase kinase-3beta (gsk-3beta) and cyclin-dependent protein kinase 5 (cdk5) in different kinase combinations. 2007-04-05 2023-08-12 human