| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Edna Grünblatt, Melita Salkovic-Petrisic, Jelena Osmanovic, Peter Riederer, Siegfried Hoye. Brain insulin system dysfunction in streptozotocin intracerebroventricularly treated rats generates hyperphosphorylated tau protein. Journal of neurochemistry. vol 101. issue 3. 2007-07-18. PMID:17448147. |
brain insulin system dysfunction is discussed as possible pathological core in the generation of hyperphosphorylated tau protein as a morphological marker of sporadic alzheimer's disease. |
2007-07-18 |
2023-08-12 |
rat |
| Iwan A T Schaap, Bernd Hoffmann, Carolina Carrasco, Rudolf Merkel, Christoph F Schmid. Tau protein binding forms a 1 nm thick layer along protofilaments without affecting the radial elasticity of microtubules. Journal of structural biology. vol 158. issue 3. 2007-07-16. PMID:17329123. |
although intense research has revealed much about tau function and its involvement in alzheimer's disease during the past years, it still remains unclear how exactly tau binds on microtubules and if the kinetic stabilization of microtubules by tau is accompanied, at least in part, by a mechanical reinforcement of microtubules. |
2007-07-16 |
2023-08-12 |
Not clear |
| Claudie Hooper, Eirini Meimaridou, Mahvash Tavassoli, Gerry Melino, Simon Lovestone, Richard Killic. p53 is upregulated in Alzheimer's disease and induces tau phosphorylation in HEK293a cells. Neuroscience letters. vol 418. issue 1. 2007-07-12. PMID:17399897. |
p53 is upregulated in alzheimer's disease and induces tau phosphorylation in hek293a cells. |
2007-07-12 |
2023-08-12 |
human |
| M Robert, P S Mathuranat. Tau and tauopathies. Neurology India. vol 55. issue 1. 2007-07-09. PMID:17272893. |
tau is a key component of neurofbrillary tangles in alzheimer's disease (ad). |
2007-07-09 |
2023-08-12 |
Not clear |
| Marco D Mukrasch, Phineus Markwick, Jacek Biernat, Martin von Bergen, Pau Bernadó, Christian Griesinger, Eckhard Mandelkow, Markus Zweckstetter, Martin Blackledg. Highly populated turn conformations in natively unfolded tau protein identified from residual dipolar couplings and molecular simulation. Journal of the American Chemical Society. vol 129. issue 16. 2007-07-09. PMID:17385861. |
tau, a natively unstructured protein that regulates the organization of neuronal microtubules, is also found in high concentrations in neurofibrillary tangles of alzheimer's disease and other neurodegenerative disorders. |
2007-07-09 |
2023-08-12 |
Not clear |
| Dominique Langui, François Lachapelle, Charles Duyckaert. [Animal models of neurodegenerative diseases]. Medecine sciences : M/S. vol 23. issue 2. 2007-07-02. PMID:17291428. |
transgenic mice have proven useful in reproducing lesions seen in neurodegenerative disease such as the plaques of alzheimer disease (in the app mouse which has integrated the mutated gene of the amyloid protein precursor), the tau glial and neuronal accumulation (seen in cases of frontotemporal dementias due to tau mutation), the nuclear inclusions caused by cag triplet expansion (seen in the mutation of huntington disease and autosomal dominant spinocerebellar ataxias). |
2007-07-02 |
2023-08-12 |
mouse |
| S M Laws, P Friedrich, J Diehl-Schmid, J Müller, T Eisele, J Bäuml, H Förstl, A Kurz, M Riemenschneide. Fine mapping of the MAPT locus using quantitative trait analysis identifies possible causal variants in Alzheimer's disease. Molecular psychiatry. vol 12. issue 5. 2007-06-26. PMID:17179995. |
in addition to senile plaques, neurofibrillary tangles are characteristic of alzheimer's disease (ad) pathology, suggesting a clear involvement of the microtubule-associated protein tau (mapt) in ad. |
2007-06-26 |
2023-08-12 |
Not clear |
| Shahin Zibaee, O Sumner Makin, Michel Goedert, Louise C Serpel. A simple algorithm locates beta-strands in the amyloid fibril core of alpha-synuclein, Abeta, and tau using the amino acid sequence alone. Protein science : a publication of the Protein Society. vol 16. issue 5. 2007-06-26. PMID:17456743. |
we also report similar significant correlations for the alzheimer's disease-related proteins, abeta and tau. |
2007-06-26 |
2023-08-12 |
Not clear |
| Eckhard Mandelkow, Martin von Bergen, Jacek Biernat, Eva-Maria Mandelko. Structural principles of tau and the paired helical filaments of Alzheimer's disease. Brain pathology (Zurich, Switzerland). vol 17. issue 1. 2007-06-26. PMID:17493042. |
structural principles of tau and the paired helical filaments of alzheimer's disease. |
2007-06-26 |
2023-08-12 |
Not clear |
| Eckhard Mandelkow, Martin von Bergen, Jacek Biernat, Eva-Maria Mandelko. Structural principles of tau and the paired helical filaments of Alzheimer's disease. Brain pathology (Zurich, Switzerland). vol 17. issue 1. 2007-06-26. PMID:17493042. |
tau, a major microtubule-associated protein in brain, forms abnormal fibers in alzheimer's disease and several other neurodegenerative diseases. |
2007-06-26 |
2023-08-12 |
Not clear |
| Eckhard Mandelkow, Martin von Bergen, Jacek Biernat, Eva-Maria Mandelko. Structural principles of tau and the paired helical filaments of Alzheimer's disease. Brain pathology (Zurich, Switzerland). vol 17. issue 1. 2007-06-26. PMID:17493042. |
in the paired helical filaments of alzheimer's disease, small segments of tau adopt a beta-conformation and interact with other tau molecules. |
2007-06-26 |
2023-08-12 |
Not clear |
| Jürgen Götz, Natasha Deters, Amy Doldissen, Laita Bokhari, Yazi Ke, Andreas Wiesner, Nicole Schonrock, Lars M Ittne. A decade of tau transgenic animal models and beyond. Brain pathology (Zurich, Switzerland). vol 17. issue 1. 2007-06-26. PMID:17493043. |
since then, much has been learned about the role of tau in alzheimer's disease and related disorders. |
2007-06-26 |
2023-08-12 |
mouse |
| Jürgen Götz, Natasha Deters, Amy Doldissen, Laita Bokhari, Yazi Ke, Andreas Wiesner, Nicole Schonrock, Lars M Ittne. A decade of tau transgenic animal models and beyond. Brain pathology (Zurich, Switzerland). vol 17. issue 1. 2007-06-26. PMID:17493043. |
they have been instrumental for dissecting the cross-talk between tau and the second hallmark lesion of alzheimer's disease, the abeta peptide-containing amyloid plaque. |
2007-06-26 |
2023-08-12 |
mouse |
| Jürgen Götz, Natasha Deters, Amy Doldissen, Laita Bokhari, Yazi Ke, Andreas Wiesner, Nicole Schonrock, Lars M Ittne. A decade of tau transgenic animal models and beyond. Brain pathology (Zurich, Switzerland). vol 17. issue 1. 2007-06-26. PMID:17493043. |
we discuss how the tau models have been used to unravel the pathophysiology of alzheimer's disease, to search for disease modifiers and to develop novel treatment strategies. |
2007-06-26 |
2023-08-12 |
mouse |
| Jürgen Götz, Natasha Deters, Amy Doldissen, Laita Bokhari, Yazi Ke, Andreas Wiesner, Nicole Schonrock, Lars M Ittne. A decade of tau transgenic animal models and beyond. Brain pathology (Zurich, Switzerland). vol 17. issue 1. 2007-06-26. PMID:17493043. |
while tau has received less attention than abeta, it is rapidly acquiring a more prominent position and the emerging view is one of a synergistic action of abeta and tau in alzheimer's disease. |
2007-06-26 |
2023-08-12 |
mouse |
| Lingjun Zuo, Christopher H van Dyck, Xingguang Luo, Henry R Kranzler, Bao-zhu Yang, Joel Gelernte. Variation at APOE and STH loci and Alzheimer's disease. Behavioral and brain functions : BBF. vol 2. 2007-06-20. PMID:16603077. |
the apolipoprotein e (apoe) and tau proteins play important roles in the pathological development of alzheimer's disease (ad). |
2007-06-20 |
2023-08-12 |
Not clear |
| Natália Csóková, Rostislav Skrabana, L'ubica Urbániková, Branislav Kovácech, Alexander Popov, Jozef Sevcík, Michal Nová. Preparation, crystallization and preliminary X-ray analysis of the Fab fragment of monoclonal antibody MN423, revealing the structural aspects of Alzheimer's paired helical filaments. Protein and peptide letters. vol 13. issue 9. 2007-06-20. PMID:17100650. |
monoclonal antibody (mab) mn423 recognizes alzheimer's disease specific conformation of tau protein assembled into paired helical filaments (phf). |
2007-06-20 |
2023-08-12 |
Not clear |
| Binbin Wang, Feng Jin, Ze Yang, Zeping Lu, Chenguang Zheng, Li Wan. HSPG2 gene C/A polymorphism does not confer susceptibility to Alzheimer's disease in Chinese. Dementia and geriatric cognitive disorders. vol 23. issue 5. 2007-06-20. PMID:17356275. |
human hspg2 participates in the formation of amyloid and tau aggregation in alzheimer's disease (ad). |
2007-06-20 |
2023-08-12 |
human |
| Peter Schönknecht, Johannes Pantel, Elmar Kaiser, Philipp Thomann, Johannes Schröde. Increased tau protein differentiates mild cognitive impairment from geriatric depression and predicts conversion to dementia. Neuroscience letters. vol 416. issue 1. 2007-06-19. PMID:17331644. |
significantly increased cerebrospinal fluid (csf) total tau (t-tau) and phosphorylated at threonine 181 tau (p-tau) levels were frequently found in patients with mild cognitive impairment (mci) who have an increased risk of developing alzheimer's disease (ad). |
2007-06-19 |
2023-08-12 |
human |
| Hong-Lian Li, Hai-Hong Wang, Shi-Jie Liu, Yan-Qiu Deng, Yong-Jie Zhang, Qing Tian, Xiao-Chuan Wang, Xiao-Qian Chen, Ying Yang, Jia-Yu Zhang, Qun Wang, Huaxi Xu, Francesca-Fang Liao, Jian-Zhi Wan. Phosphorylation of tau antagonizes apoptosis by stabilizing beta-catenin, a mechanism involved in Alzheimer's neurodegeneration. Proceedings of the National Academy of Sciences of the United States of America. vol 104. issue 9. 2007-06-13. PMID:17360687. |
phosphorylation of tau antagonizes apoptosis by stabilizing beta-catenin, a mechanism involved in alzheimer's neurodegeneration. |
2007-06-13 |
2023-08-12 |
mouse |