| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| D A Forero, G Arboleda, J J Yunis, R Pardo, H Arboled. Association study of polymorphisms in LRP1, tau and 5-HTT genes and Alzheimer's disease in a sample of Colombian patients. Journal of neural transmission (Vienna, Austria : 1996). vol 113. issue 9. 2007-05-02. PMID:16362633. |
association study of polymorphisms in lrp1, tau and 5-htt genes and alzheimer's disease in a sample of colombian patients. |
2007-05-02 |
2023-08-12 |
human |
| Zdenek Berger, Hanno Roder, Amanda Hanna, Aaron Carlson, Vijayaraghavan Rangachari, Mei Yue, Zbigniew Wszolek, Karen Ashe, Joshua Knight, Dennis Dickson, Cathy Andorfer, Terrone L Rosenberry, Jada Lewis, Mike Hutton, Christopher Janu. Accumulation of pathological tau species and memory loss in a conditional model of tauopathy. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 27. issue 14. 2007-05-02. PMID:17409229. |
similar tau multimers were detected in a second mouse model of tauopathy (jnpl3) and in tissue from patients with alzheimer's disease and ftdp-17 (frontotemporal dementia and parkinsonism linked to chromosome 17). |
2007-05-02 |
2023-08-12 |
mouse |
| Andrew McShea, Hyoung-gon Lee, Robert B Petersen, Gemma Casadesus, Inez Vincent, Nancy J Linford, Jens-Oliver Funk, Robert A Shapiro, Mark A Smit. Neuronal cell cycle re-entry mediates Alzheimer disease-type changes. Biochimica et biophysica acta. vol 1772. issue 4. 2007-04-26. PMID:17095196. |
importantly, we also found that cell cycle re-entry in primary neurons leads to tau phosphorylation and conformational changes similar to that seen in alzheimer disease. |
2007-04-26 |
2023-08-12 |
Not clear |
| Martin Balastik, Jormay Lim, Lucia Pastorino, Kun Ping L. Pin1 in Alzheimer's disease: multiple substrates, one regulatory mechanism? Biochimica et biophysica acta. vol 1772. issue 4. 2007-04-26. PMID:17317113. |
furthermore, pin1 is the only gene known so far that, when deleted in mice, can cause both tau and abeta-related pathologies in an age-dependent manner, resembling many aspects of human alzheimer's disease. |
2007-04-26 |
2023-08-12 |
mouse |
| Hanno M Roder, Michael L Hutto. Microtubule-associated protein tau as a therapeutic target in neurodegenerative disease. Expert opinion on therapeutic targets. vol 11. issue 4. 2007-04-23. PMID:17373874. |
this is due, in part, to the discovery of mutations in tau causing a group of aggressively degenerative neurologic disorders characterized by abnormalities of tau very similar to what is seen in alzheimer's disease where mutations in tau are absent. |
2007-04-23 |
2023-08-12 |
mouse |
| G L Lace, S B Wharton, P G Inc. A brief history of tau: the evolving view of the microtubule-associated protein tau in neurodegenerative diseases. Clinical neuropathology. vol 26. issue 2. 2007-04-20. PMID:17416103. |
over the years, opinions regarding the significance of tau in disease pathogenesis, particularly in alzheimer's disease, have fluctuated. |
2007-04-20 |
2023-08-12 |
Not clear |
| G L Lace, S B Wharton, P G Inc. A brief history of tau: the evolving view of the microtubule-associated protein tau in neurodegenerative diseases. Clinical neuropathology. vol 26. issue 2. 2007-04-20. PMID:17416103. |
early caution about the role of tau as a significant factor in neurodegenerative disease, especially alzheimer's disease, has been superseded by acceptance of its key involvement in pathways which led to cell dysfunction and death. |
2007-04-20 |
2023-08-12 |
Not clear |
| Deborah R Gustafson, Ingmar Skoog, Lars Rosengren, Henrik Zetterberg, Kaj Blenno. Cerebrospinal fluid beta-amyloid 1-42 concentration may predict cognitive decline in older women. Journal of neurology, neurosurgery, and psychiatry. vol 78. issue 5. 2007-04-19. PMID:17098843. |
low levels of cerebrospinal fluid (csf) beta-amyloid 1-42 (abeta42) and high total tau (t-tau) are diagnostic for manifest alzheimer's disease. |
2007-04-19 |
2023-08-12 |
Not clear |
| Katleen Dillen, Wim Annaer. A two decade contribution of molecular cell biology to the centennial of Alzheimer's disease: are we progressing toward therapy? International review of cytology. vol 254. 2007-04-18. PMID:17148000. |
alzheimer's disease (ad), described for the first time 100 years ago, is a neurodegenerative disease characterized by two neuropathological hallmarks: neurofibrillary tangles containing hyperphosphorylated tau and senile plaques. |
2007-04-18 |
2023-08-12 |
Not clear |
| Yoshiko Ikeda, Koichi Ishiguro, Shinobu C Fujit. Ether stress-induced Alzheimer-like tau phosphorylation in the normal mouse brain. FEBS letters. vol 581. issue 5. 2007-04-17. PMID:17289030. |
robust phosphorylation of tau was observed immediately and 10min after ether vapor exposure at ser202/thr205 and thr231/ser235, sites typically phosphorylated in alzheimer brains. |
2007-04-17 |
2023-08-12 |
mouse |
| Kenichi Oshima, Haruhiko Akiyama, Kuniaki Tsuchiya, Hiromi Kondo, Chie Haga, Yoko Shimomura, Eizo Iseki, Hirotake Uchikado, Masanori Kato, Kazuhiro Niizato, Heii Ara. Relative paucity of tau accumulation in the small areas with abundant Abeta42-positive capillary amyloid angiopathy within a given cortical region in the brain of patients with Alzheimer pathology. Acta neuropathologica. vol 111. issue 6. 2007-04-16. PMID:16718347. |
relative paucity of tau accumulation in the small areas with abundant abeta42-positive capillary amyloid angiopathy within a given cortical region in the brain of patients with alzheimer pathology. |
2007-04-16 |
2023-08-12 |
Not clear |
| Neelima B Chauha. Effect of aged garlic extract on APP processing and tau phosphorylation in Alzheimer's transgenic model Tg2576. Journal of ethnopharmacology. vol 108. issue 3. 2007-04-16. PMID:16842945. |
effect of aged garlic extract on app processing and tau phosphorylation in alzheimer's transgenic model tg2576. |
2007-04-16 |
2023-08-12 |
mouse |
| Björn Kuhla, Cathleen Haase, Katharina Flach, Hans-Joachim Lüth, Thomas Arendt, Gerald Münc. Effect of pseudophosphorylation and cross-linking by lipid peroxidation and advanced glycation end product precursors on tau aggregation and filament formation. The Journal of biological chemistry. vol 282. issue 10. 2007-04-13. PMID:17082178. |
accumulation of hyperphosphorylated tau protein as paired helical filaments in pyramidal neurons is a major hallmark of alzheimer disease. |
2007-04-13 |
2023-08-12 |
Not clear |
| Jian-Zhi Wang, Inge Grundke-Iqbal, Khalid Iqba. Kinases and phosphatases and tau sites involved in Alzheimer neurofibrillary degeneration. The European journal of neuroscience. vol 25. issue 1. 2007-04-05. PMID:17241267. |
kinases and phosphatases and tau sites involved in alzheimer neurofibrillary degeneration. |
2007-04-05 |
2023-08-12 |
human |
| Jian-Zhi Wang, Inge Grundke-Iqbal, Khalid Iqba. Kinases and phosphatases and tau sites involved in Alzheimer neurofibrillary degeneration. The European journal of neuroscience. vol 25. issue 1. 2007-04-05. PMID:17241267. |
microtubule associated protein (map) tau is abnormally hyperphosphorylated in alzheimer's disease (ad) and related tauopathies; in this form it is the major protein subunit of paired helical filaments (phf)/neurofibrillary tangles. |
2007-04-05 |
2023-08-12 |
human |
| Jian-Zhi Wang, Inge Grundke-Iqbal, Khalid Iqba. Kinases and phosphatases and tau sites involved in Alzheimer neurofibrillary degeneration. The European journal of neuroscience. vol 25. issue 1. 2007-04-05. PMID:17241267. |
we investigated self-assembly and microtubule assembly promoting activities of hyperphosphorylated tau isolated from alzheimer disease brain cytosol, the ad abnormally hyperphosphorylated tau (ad p-tau) before and after dephosphorylation by phosphoseryl/phosphothreonyl protein phosphatase-2a (pp-2a), and then rephosphorylation by cyclic amp-dependent protein kinase (pka), calcium, calmodulin-dependent protein kinase ii (camkii), glycogen synthase kinase-3beta (gsk-3beta) and cyclin-dependent protein kinase 5 (cdk5) in different kinase combinations. |
2007-04-05 |
2023-08-12 |
human |
| Jian-Zhi Wang, Inge Grundke-Iqbal, Khalid Iqba. Kinases and phosphatases and tau sites involved in Alzheimer neurofibrillary degeneration. The European journal of neuroscience. vol 25. issue 1. 2007-04-05. PMID:17241267. |
we found that (i) dephosphorylation of ad p-tau by pp-2a inhibits its polymerization into phf/straight filaments (sf) and restores its binding and ability to promote assembly of tubulin into microtubules; (ii) rephosphorylation of pp-2a-dephosphorylated ad p-tau by sequential phosphorylation by pka, camkii and gsk-3beta or cdk5, and as well as by cdk5 and gsk-3beta, promotes its self-assembly into tangles of phf similar to those seen in alzheimer brain, and (iii) phosphorylation of tau sites required for this pathology are thr231 and ser262, along with several sites flanking the microtubule binding repeat region. |
2007-04-05 |
2023-08-12 |
human |
| Wolfgang Härtig, Jens Stieler, Ate S Boerema, Jennifer Wolf, Udo Schmidt, Jana Weissfuss, Torsten Bullmann, Arjen M Strijkstra, Thomas Arend. Hibernation model of tau phosphorylation in hamsters: selective vulnerability of cholinergic basal forebrain neurons - implications for Alzheimer's disease. The European journal of neuroscience. vol 25. issue 1. 2007-04-05. PMID:17241268. |
hibernation model of tau phosphorylation in hamsters: selective vulnerability of cholinergic basal forebrain neurons - implications for alzheimer's disease. |
2007-04-05 |
2023-08-12 |
Not clear |
| Wolfgang Härtig, Jens Stieler, Ate S Boerema, Jennifer Wolf, Udo Schmidt, Jana Weissfuss, Torsten Bullmann, Arjen M Strijkstra, Thomas Arend. Hibernation model of tau phosphorylation in hamsters: selective vulnerability of cholinergic basal forebrain neurons - implications for Alzheimer's disease. The European journal of neuroscience. vol 25. issue 1. 2007-04-05. PMID:17241268. |
neurofibrillar tangles made up of 'paired helical filaments' (phfs) consisting of hyperphosphorylated microtubule-associated protein tau are major hallmarks of alzheimer's disease (ad). |
2007-04-05 |
2023-08-12 |
Not clear |
| Estelle Sontag, Viyada Nunbhakdi-Craig, Jean-Marie Sontag, Ramon Diaz-Arrastia, Egon Ogris, Sanjana Dayal, Steven R Lentz, Erland Arning, Teodoro Bottiglier. Protein phosphatase 2A methyltransferase links homocysteine metabolism with tau and amyloid precursor protein regulation. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 27. issue 11. 2007-04-05. PMID:17360897. |
alzheimer's disease (ad) neuropathology is characterized by the accumulation of phosphorylated tau and amyloid-beta peptides derived from the amyloid precursor protein (app). |
2007-04-05 |
2023-08-12 |
mouse |