| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Edda Thies, Eva-Maria Mandelko. Missorting of tau in neurons causes degeneration of synapses that can be rescued by the kinase MARK2/Par-1. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 27. issue 11. 2007-04-05. PMID:17360912. |
early hallmarks of alzheimer's disease include the loss of synapses, which precedes the loss of neurons and the pathological phosphorylation and aggregation of tau protein. |
2007-04-05 |
2023-08-12 |
Not clear |
| Ryo Kimura, Kouzin Kamino, Mitsuko Yamamoto, Aidaralieva Nuripa, Tomoyuki Kida, Hiroaki Kazui, Ryota Hashimoto, Toshihisa Tanaka, Takashi Kudo, Hidehisa Yamagata, Yasuharu Tabara, Tetsuro Miki, Hiroyasu Akatsu, Kenji Kosaka, Eishi Funakoshi, Kouhei Nishitomi, Gaku Sakaguchi, Akira Kato, Hideyuki Hattori, Takeshi Uema, Masatoshi Taked. The DYRK1A gene, encoded in chromosome 21 Down syndrome critical region, bridges between beta-amyloid production and tau phosphorylation in Alzheimer disease. Human molecular genetics. vol 16. issue 1. 2007-04-03. PMID:17135279. |
the dyrk1a gene, encoded in chromosome 21 down syndrome critical region, bridges between beta-amyloid production and tau phosphorylation in alzheimer disease. |
2007-04-03 |
2023-08-12 |
mouse |
| Susanne Hauptmann, Uta Keil, Isabel Scherping, Astrid Bonert, Anne Eckert, Walter E Mülle. Mitochondrial dysfunction in sporadic and genetic Alzheimer's disease. Experimental gerontology. vol 41. issue 7. 2007-03-28. PMID:16677790. |
even though the idea that amyloid beta peptide accumulation is the primary event in the pathogenesis of alzheimer's disease has become the leading hypothesis, the causal link between aberrant amyloid precursor protein and tau alterations in this type of dementia remains controversial. |
2007-03-28 |
2023-08-12 |
Not clear |
| Branislav Kovacech, Eva Kontsekova, Norbert Zilka, Pavol Novak, Rostislav Skrabana, Peter Filipcik, Khalid Iqbal, Michal Nova. A novel monoclonal antibody DC63 reveals that inhibitor 1 of protein phosphatase 2A is preferentially nuclearly localised in human brain. FEBS letters. vol 581. issue 4. 2007-03-27. PMID:17266954. |
abnormal phosphorylation of tau protein represents one of the major candidate pathological mechanisms leading to alzheimer's disease (ad) and related tauopathies. |
2007-03-27 |
2023-08-12 |
human |
| Edward Rockenstein, Magdalena Torrance, Anthony Adame, Michael Mante, Pazit Bar-on, John B Rose, Leslie Crews, Eliezer Maslia. Neuroprotective effects of regulators of the glycogen synthase kinase-3beta signaling pathway in a transgenic model of Alzheimer's disease are associated with reduced amyloid precursor protein phosphorylation. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 27. issue 8. 2007-03-22. PMID:17314294. |
in alzheimer's disease (ad), abnormal activation of this pathway might play an important role in neurodegeneration, and compounds such as lithium that modulate gsk3beta activity have been shown to reduce amyloid production and tau phosphorylation in amyloid precursor protein (app) transgenic (tg) mice. |
2007-03-22 |
2023-08-12 |
mouse |
| Tudor A Fulga, Ilan Elson-Schwab, Vikram Khurana, Michelle L Steinhilb, Tara L Spires, Bradley T Hyman, Mel B Fean. Abnormal bundling and accumulation of F-actin mediates tau-induced neuronal degeneration in vivo. Nature cell biology. vol 9. issue 2. 2007-03-20. PMID:17187063. |
hyperphosphorylated forms of the microtubule-associated protein (map) tau accumulate in alzheimer's disease and related tauopathies and are thought to have an important role in neurodegeneration. |
2007-03-20 |
2023-08-12 |
mouse |
| Tudor A Fulga, Ilan Elson-Schwab, Vikram Khurana, Michelle L Steinhilb, Tara L Spires, Bradley T Hyman, Mel B Fean. Abnormal bundling and accumulation of F-actin mediates tau-induced neuronal degeneration in vivo. Nature cell biology. vol 9. issue 2. 2007-03-20. PMID:17187063. |
finally, we show that the alzheimer's disease-linked human beta-amyloid protein (abeta) synergistically enhances the ability of wild-type tau to promote alterations in the actin cytoskeleton and neurodegeneration. |
2007-03-20 |
2023-08-12 |
mouse |
| Tudor A Fulga, Ilan Elson-Schwab, Vikram Khurana, Michelle L Steinhilb, Tara L Spires, Bradley T Hyman, Mel B Fean. Abnormal bundling and accumulation of F-actin mediates tau-induced neuronal degeneration in vivo. Nature cell biology. vol 9. issue 2. 2007-03-20. PMID:17187063. |
these findings raise the possibility that a direct interaction between tau and actin may be a critical mediator of tau-induced neurotoxicity in alzheimer's disease and related disorders. |
2007-03-20 |
2023-08-12 |
mouse |
| Gianluca Gall. Tau is actin up in Alzheimer's disease. Nature cell biology. vol 9. issue 2. 2007-03-20. PMID:17268475. |
tau is actin up in alzheimer's disease. |
2007-03-20 |
2023-08-12 |
Not clear |
| Lei Gao, Junning Wang, Yingzi Wang, Athena Andreadi. SR protein 9G8 modulates splicing of tau exon 10 via its proximal downstream intron, a clustering region for frontotemporal dementia mutations. Molecular and cellular neurosciences. vol 34. issue 1. 2007-03-16. PMID:17137791. |
aggregated tau is the major component of neurofibrillary tangles (nfts), present in several neurodegenerative diseases, including alzheimer's and frontotemporal dementia with parkinsonism (ftdp). |
2007-03-16 |
2023-08-12 |
Not clear |
| Daniel I Orellana, Rodrigo A Quintanilla, Ricardo B Maccion. Neuroprotective effect of TNFalpha against the beta-amyloid neurotoxicity mediated by CDK5 kinase. Biochimica et biophysica acta. vol 1773. issue 2. 2007-03-16. PMID:17150266. |
tau hyperphosphorylation and neuronal death found in alzheimer disease is mediated by deregulation of the cdk5/p35 complex induced by abeta treatments. |
2007-03-16 |
2023-08-12 |
Not clear |
| Daniel I Orellana, Rodrigo A Quintanilla, Ricardo B Maccion. Neuroprotective effect of TNFalpha against the beta-amyloid neurotoxicity mediated by CDK5 kinase. Biochimica et biophysica acta. vol 1773. issue 2. 2007-03-16. PMID:17150266. |
next, we investigated the alzheimer type phosphorylation of tau protein induced by abeta(42). |
2007-03-16 |
2023-08-12 |
Not clear |
| K Iqbal, M Nova. From tangles to tau protein. Bratislavske lekarske listy. vol 107. issue 9-10. 2007-03-15. PMID:17262984. |
the same year it was shown that tau protein in alzheimer disease brain was abnormally hyperphosphorylated (grundke-iqbal, 1986 b). |
2007-03-15 |
2023-08-12 |
Not clear |
| K Iqbal, M Nova. From tangles to tau protein. Bratislavske lekarske listy. vol 107. issue 9-10. 2007-03-15. PMID:17262984. |
however, detailed studies of the maturation and distribution of nfts, showing correlation with degree of cognitive decline and memory impairment in alzheimer's disease (braak and braak, 1991), together with discovery of tau gene mutations causing fronto-temporal dementia in many families (hutton et al, 1998) promoted tau as the major pathogenic force in neurodegenerative cascade. |
2007-03-15 |
2023-08-12 |
Not clear |
| K Iqbal, M Nova. From tangles to tau protein. Bratislavske lekarske listy. vol 107. issue 9-10. 2007-03-15. PMID:17262984. |
further studies focused on tau dysfunctions revealed truncation and phosphorylation as two major posttranslational modifications responsible for toxic gain of function as an underlying cause of tauopathies including alzheimer's disease (alonso et al, 1996, novak et al, 1989, 1991, 1993, avila et al, 2006). |
2007-03-15 |
2023-08-12 |
Not clear |
| M Pevalova, P Filipcik, M Novak, J Avila, K Iqba. Post-translational modifications of tau protein. Bratislavske lekarske listy. vol 107. issue 9-10. 2007-03-15. PMID:17262986. |
since many data suggest that sporadic ad is the "disease of posttranslational modifications" of tau protein, more detailed investigation of tau protein modifications is urgently needed in order to understand pathogenesis of sporadic alzheimer's disease (fig. |
2007-03-15 |
2023-08-12 |
human |
| R Skrabana, M Skrabanova, N Csokova, J Sevcik, M Nova. Intrinsically disordered tau protein in Alzheimer's tangles: a coincidence or a rule? Bratislavske lekarske listy. vol 107. issue 9-10. 2007-03-15. PMID:17262987. |
intrinsically disordered tau protein in alzheimer's tangles: a coincidence or a rule? |
2007-03-15 |
2023-08-12 |
Not clear |
| R Skrabana, M Skrabanova, N Csokova, J Sevcik, M Nova. Intrinsically disordered tau protein in Alzheimer's tangles: a coincidence or a rule? Bratislavske lekarske listy. vol 107. issue 9-10. 2007-03-15. PMID:17262987. |
tau protein, the major constituent of neurofibrillary tangles in alzheimer's disease (ad) and related tauopathies, is classified as intrinsically disordered protein (idp). |
2007-03-15 |
2023-08-12 |
Not clear |
| Yasumasa Yoshiyama, Makoto Higuchi, Bin Zhang, Shu-Ming Huang, Nobuhisa Iwata, Takaomi C Saido, Jun Maeda, Tetsuya Suhara, John Q Trojanowski, Virginia M-Y Le. Synapse loss and microglial activation precede tangles in a P301S tauopathy mouse model. Neuron. vol 53. issue 3. 2007-03-15. PMID:17270732. |
filamentous tau inclusions are hallmarks of alzheimer's disease (ad) and related tauopathies, but earlier pathologies may herald disease onset. |
2007-03-15 |
2023-08-12 |
mouse |
| Hai-Long Hou, Yu-Xian Shen, Hong-Yan Zhu, Hao Sun, Xue-Bo Yan, Hui Fang, Jiang-Ning Zho. Alterations of hHrd1 expression are related to hyperphosphorylated tau in the hippocampus in Alzheimer's disease. Journal of neuroscience research. vol 84. issue 8. 2007-03-13. PMID:17044033. |
alterations of hhrd1 expression are related to hyperphosphorylated tau in the hippocampus in alzheimer's disease. |
2007-03-13 |
2023-08-12 |
Not clear |