| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Soma Sengupta, Peleg M Horowitz, Stanislav L Karsten, George R Jackson, Daniel H Geschwind, Yifan Fu, Robert W Berry, Lester I Binde. Degradation of tau protein by puromycin-sensitive aminopeptidase in vitro. Biochemistry. vol 45. issue 50. 2007-02-21. PMID:17154549. |
tau, a microtubule associated protein, aggregates into intracellular paired helical filaments (phfs) by an unknown mechanism in alzheimer's disease (ad) and other tauopathies. |
2007-02-21 |
2023-08-12 |
human |
| Stephen I Deutsch, Richard B Rosse, Lynn H Deutsc. Faulty regulation of tau phosphorylation by the reelin signal transduction pathway is a potential mechanism of pathogenesis and therapeutic target in Alzheimer's disease. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 16. issue 8. 2007-02-20. PMID:16504486. |
faulty regulation of tau phosphorylation by the reelin signal transduction pathway is a potential mechanism of pathogenesis and therapeutic target in alzheimer's disease. |
2007-02-20 |
2023-08-12 |
Not clear |
| Stephen I Deutsch, Richard B Rosse, Lynn H Deutsc. Faulty regulation of tau phosphorylation by the reelin signal transduction pathway is a potential mechanism of pathogenesis and therapeutic target in Alzheimer's disease. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 16. issue 8. 2007-02-20. PMID:16504486. |
hyperphosphorylated tau protein is the basic structural component of the neurofibrillary tangle, a histopathological hallmark of alzheimer's disease. |
2007-02-20 |
2023-08-12 |
Not clear |
| Stephen I Deutsch, Richard B Rosse, Lynn H Deutsc. Faulty regulation of tau phosphorylation by the reelin signal transduction pathway is a potential mechanism of pathogenesis and therapeutic target in Alzheimer's disease. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 16. issue 8. 2007-02-20. PMID:16504486. |
ultimately, inhibition of tau phosphorylation may be an important therapeutic target in alzheimer's disease and other neuropsychiatric disorders. |
2007-02-20 |
2023-08-12 |
Not clear |
| Pratap Chand, Jordan Grafman, Dennis Dickson, Keisuke Ishizawa, Irene Litva. Alzheimer's disease presenting as corticobasal syndrome. Movement disorders : official journal of the Movement Disorder Society. vol 21. issue 11. 2007-02-20. PMID:16977625. |
eight years later, neuropathology revealed features of alzheimer's disease, with asymmetrical (right more than left) cortical tau burden with image analysis. |
2007-02-20 |
2023-08-12 |
Not clear |
| Muhammad Omar Chohan, Khalid Iqba. From tau to toxicity: emerging roles of NMDA receptor in Alzheimer's disease. Journal of Alzheimer's disease : JAD. vol 10. issue 1. 2007-02-20. PMID:16988485. |
from tau to toxicity: emerging roles of nmda receptor in alzheimer's disease. |
2007-02-20 |
2023-08-12 |
Not clear |
| Kaihong Mi, Gail V W Johnso. The role of tau phosphorylation in the pathogenesis of Alzheimer's disease. Current Alzheimer research. vol 3. issue 5. 2007-02-20. PMID:17168644. |
the role of tau phosphorylation in the pathogenesis of alzheimer's disease. |
2007-02-20 |
2023-08-12 |
Not clear |
| Kaihong Mi, Gail V W Johnso. The role of tau phosphorylation in the pathogenesis of Alzheimer's disease. Current Alzheimer research. vol 3. issue 5. 2007-02-20. PMID:17168644. |
the microtubule-associated protein tau, which is abundantly expressed in neurons, is deposited in cells in an abnormally phosphorylated state as fibrillar lesions in numerous neurodegenerative diseases, with the most notable being alzheimer's disease. |
2007-02-20 |
2023-08-12 |
Not clear |
| Kaihong Mi, Gail V W Johnso. The role of tau phosphorylation in the pathogenesis of Alzheimer's disease. Current Alzheimer research. vol 3. issue 5. 2007-02-20. PMID:17168644. |
in pathological conditions such as alzheimer's disease and other tauopathies, tau is abnormally phosphorylated, and that this contributes to its dysfunction. |
2007-02-20 |
2023-08-12 |
Not clear |
| Kaihong Mi, Gail V W Johnso. The role of tau phosphorylation in the pathogenesis of Alzheimer's disease. Current Alzheimer research. vol 3. issue 5. 2007-02-20. PMID:17168644. |
given the increasing evidence that a disruption in the normal phosphorylation state of tau followed by conformational changes plays a key role in the pathogenic events that occur in alzheimer's disease and other tauopathies; it is critical to elucidate the regulation of tau phosphorylation. |
2007-02-20 |
2023-08-12 |
Not clear |
| Kaihong Mi, Gail V W Johnso. The role of tau phosphorylation in the pathogenesis of Alzheimer's disease. Current Alzheimer research. vol 3. issue 5. 2007-02-20. PMID:17168644. |
this review focuses on recent literature pertaining to the regulation of tau phosphorylation and function, and the role that a dysregulation of tau phosphorylation may play in the neuronal dysfunction in alzheimer's disease. |
2007-02-20 |
2023-08-12 |
Not clear |
| Tobias Engel, Paloma Goñi-Oliver, José J Lucas, Jesús Avila, Félix Hernánde. Chronic lithium administration to FTDP-17 tau and GSK-3beta overexpressing mice prevents tau hyperphosphorylation and neurofibrillary tangle formation, but pre-formed neurofibrillary tangles do not revert. Journal of neurochemistry. vol 99. issue 6. 2007-02-15. PMID:17059563. |
glycogen synthase kinase-3 (gsk-3) has been proposed as the main kinase able to aberrantly phosphorylate tau in alzheimer's disease (ad) and related tauopathies, raising the possibility of designing novel therapeutic interventions for ad based on gsk-3 inhibition. |
2007-02-15 |
2023-08-12 |
mouse |
| Nathalie Pierrot, Susana Ferrao Santos, Christine Feyt, Marina Morel, Jean-Pierre Brion, Jean-Noël Octav. Calcium-mediated transient phosphorylation of tau and amyloid precursor protein followed by intraneuronal amyloid-beta accumulation. The Journal of biological chemistry. vol 281. issue 52. 2007-02-12. PMID:17085446. |
intraneuronal accumulation of hyperphosphorylated protein tau in paired helical filaments together with amyloid-beta peptide (abeta) deposits confirm the clinical diagnosis of alzheimer disease. |
2007-02-12 |
2023-08-12 |
Not clear |
| Nathalie Pierrot, Susana Ferrao Santos, Christine Feyt, Marina Morel, Jean-Pierre Brion, Jean-Noël Octav. Calcium-mediated transient phosphorylation of tau and amyloid precursor protein followed by intraneuronal amyloid-beta accumulation. The Journal of biological chemistry. vol 281. issue 52. 2007-02-12. PMID:17085446. |
our data demonstrate that an increase in cytosolic calcium concentration induces modifications of neuronal metabolism of app and tau, similar to those found in alzheimer disease. |
2007-02-12 |
2023-08-12 |
Not clear |
| Amitabha Sengupta, Inge Grundke-Iqbal, Khalid Iqba. Regulation of phosphorylation of tau by protein kinases in rat brain. Neurochemical research. vol 31. issue 12. 2007-02-09. PMID:17120162. |
microtubule associated protein tau is abnormally hyperphosphorylated in alzheimer disease (ad) brain. |
2007-02-09 |
2023-08-12 |
rat |
| Kurt A Jellinger, Johannes Attem. Does striatal pathology distinguish Parkinson disease with dementia and dementia with Lewy bodies? Acta neuropathologica. vol 112. issue 3. 2007-02-08. PMID:16804711. |
the basal ganglia from 17 age-matched patients of pdd and dlb each were immunohistochemically examined with variable degrees of associated alzheimer pathology using antibodies to abeta, as, and tau. |
2007-02-08 |
2023-08-12 |
Not clear |
| Ji-Wu Wang, Yuzuru Imai, Bingwei L. Activation of PAR-1 kinase and stimulation of tau phosphorylation by diverse signals require the tumor suppressor protein LKB1. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 27. issue 3. 2007-02-06. PMID:17234589. |
aberrant phosphorylation of tau is associated with a number of neurodegenerative diseases, including alzheimer's disease (ad). |
2007-02-06 |
2023-08-12 |
human |
| Asparouh Iliev Iliev, Sundar Ganesan, Gertrude Bunt, Fred Silvester Wouter. Removal of pattern-breaking sequences in microtubule binding repeats produces instantaneous tau aggregation and toxicity. The Journal of biological chemistry. vol 281. issue 48. 2007-01-30. PMID:17008320. |
aggregated and highly phosphorylated tau protein is a pathological hallmark of alzheimer's disease (ad) and other tauopathies. |
2007-01-30 |
2023-08-12 |
Not clear |
| Stephen I Deutsch, Richard B Rosse, Raj M Lakshma. Dysregulation of tau phosphorylation is a hypothesized point of convergence in the pathogenesis of alzheimer's disease, frontotemporal dementia and schizophrenia with therapeutic implications. Progress in neuro-psychopharmacology & biological psychiatry. vol 30. issue 8. 2007-01-29. PMID:16793187. |
dysregulation of tau phosphorylation is a hypothesized point of convergence in the pathogenesis of alzheimer's disease, frontotemporal dementia and schizophrenia with therapeutic implications. |
2007-01-29 |
2023-08-12 |
Not clear |
| Stephen I Deutsch, Richard B Rosse, Raj M Lakshma. Dysregulation of tau phosphorylation is a hypothesized point of convergence in the pathogenesis of alzheimer's disease, frontotemporal dementia and schizophrenia with therapeutic implications. Progress in neuro-psychopharmacology & biological psychiatry. vol 30. issue 8. 2007-01-29. PMID:16793187. |
importantly, hyperphosphorylated tau comprises the paired helical filament, whose pathological deposition as neurofibrillary tangles is implicated in alzheimer's disease; hyperphosphorylated tau is also implicated in the pathogenesis of other neurodegenerative disorders. |
2007-01-29 |
2023-08-12 |
Not clear |