Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
Bernd Ibach, Harald Binder, Margarethe Dragon, Stefan Poljansky, Ekkehard Haen, Eberhard Schmitz, Horst Koch, Albert Putzhammer, Hans Kluenemann, Wolf Wieland, Goeran Haja. Cerebrospinal fluid tau and beta-amyloid in Alzheimer patients, disease controls and an age-matched random sample. Neurobiology of aging. vol 27. issue 9. 2006-08-28. PMID:16085339. |
cerebrospinal fluid tau and beta-amyloid in alzheimer patients, disease controls and an age-matched random sample. |
2006-08-28 |
2023-08-12 |
Not clear |
Bernd Ibach, Harald Binder, Margarethe Dragon, Stefan Poljansky, Ekkehard Haen, Eberhard Schmitz, Horst Koch, Albert Putzhammer, Hans Kluenemann, Wolf Wieland, Goeran Haja. Cerebrospinal fluid tau and beta-amyloid in Alzheimer patients, disease controls and an age-matched random sample. Neurobiology of aging. vol 27. issue 9. 2006-08-28. PMID:16085339. |
we prospectively evaluated the diagnostic accuracy of cerebrospinal fluid (csf)-beta-amyloid1-42 (abeta42), -total-tau (tau) and -phosphorylated-tau181 (p-tau181) as measured by sandwich elisas in the clinical routine of a community state hospital to discriminate between patients with alzheimer's disease (ad), healthy controls (hc), non-ad-dementias, a group composed of various psychiatric disorders (non-ad-dementias, mental diseases) and an age-matched random sample (rs) (total n=219). |
2006-08-28 |
2023-08-12 |
Not clear |
María Nieto-Bodelón, Gabriel Santpere, Benjamín Torrejón-Escribano, Berta Puig, Isidre Ferre. Expression of transcription factors c-Fos, c-Jun, CREB-1 and ATF-2, and caspase-3 in relation with abnormal tau deposits in Pick's disease. Acta neuropathologica. vol 111. issue 4. 2006-08-24. PMID:16496165. |
the present findings are in line with the previous studies showing tau products cleaved by caspase-3, as recognized by specific tau-cleaved antibodies, in alzheimer's disease and other tauopathies. |
2006-08-24 |
2023-08-12 |
Not clear |
Xin-Wen Zhou, Xu Li, Cecilia Bjorkdahl, Magnus J Sjogren, Irina Alafuzoff, Hilkka Soininen, Inge Grundke-Iqbal, Khalid Iqbal, Bengt Winblad, Jin-Jing Pe. Assessments of the accumulation severities of amyloid beta-protein and hyperphosphorylated tau in the medial temporal cortex of control and Alzheimer's brains. Neurobiology of disease. vol 22. issue 3. 2006-08-24. PMID:16513361. |
assessments of the accumulation severities of amyloid beta-protein and hyperphosphorylated tau in the medial temporal cortex of control and alzheimer's brains. |
2006-08-24 |
2023-08-12 |
Not clear |
Marie-Christine Galas, Pierre Dourlen, Séverine Bégard, Kunié Ando, David Blum, Malika Hamdane, Luc Bué. The peptidylprolyl cis/trans-isomerase Pin1 modulates stress-induced dephosphorylation of Tau in neurons. Implication in a pathological mechanism related to Alzheimer disease. The Journal of biological chemistry. vol 281. issue 28. 2006-08-21. PMID:16675464. |
deregulation of tau phosphorylation is a key question in alzheimer disease pathogenesis. |
2006-08-21 |
2023-08-12 |
Not clear |
Marie-Christine Galas, Pierre Dourlen, Séverine Bégard, Kunié Ando, David Blum, Malika Hamdane, Luc Bué. The peptidylprolyl cis/trans-isomerase Pin1 modulates stress-induced dephosphorylation of Tau in neurons. Implication in a pathological mechanism related to Alzheimer disease. The Journal of biological chemistry. vol 281. issue 28. 2006-08-21. PMID:16675464. |
recently, pin1, a peptidylprolyl cis/trans-isomerase, was proposed to be a new modulator in tau phosphorylation in alzheimer disease. |
2006-08-21 |
2023-08-12 |
Not clear |
Huiping Ding, Tori A Matthews, Gail V W Johnso. Site-specific phosphorylation and caspase cleavage differentially impact tau-microtubule interactions and tau aggregation. The Journal of biological chemistry. vol 281. issue 28. 2006-08-21. PMID:16687396. |
the microtubule-associated protein tau is hyperphosphorylated and forms neurofibrillary tangles in alzheimer disease. |
2006-08-21 |
2023-08-12 |
Not clear |
Huiping Ding, Tori A Matthews, Gail V W Johnso. Site-specific phosphorylation and caspase cleavage differentially impact tau-microtubule interactions and tau aggregation. The Journal of biological chemistry. vol 281. issue 28. 2006-08-21. PMID:16687396. |
additionally caspase-cleaved tau is present in alzheimer disease brains co-localized with fibrillar tau pathologies. |
2006-08-21 |
2023-08-12 |
Not clear |
David Singer, Jörg Lehmann, Katja Hanisch, Wolfgang Härtig, Ralf Hoffman. Neighbored phosphorylation sites as PHF-tau specific markers in Alzheimer's disease. Biochemical and biophysical research communications. vol 346. issue 3. 2006-08-21. PMID:16781671. |
neurofibrillary tangles, which represent a major pathological hallmark in alzheimer's disease (ad), are deposits of the hyperphosphorylated microtubule-associated tau protein (phf-tau). |
2006-08-21 |
2023-08-12 |
human |
Edward D Huey, Nadeem Mirza, Karen T Putnam, Holly Soares, Gyorgy Csako, James A Levy, Brittany Copenhaver, Robert M Cohen, Trey Sunderlan. Stability of CSF beta-amyloid(1-42) and tau levels by APOE genotype in Alzheimer patients. Dementia and geriatric cognitive disorders. vol 22. issue 1. 2006-08-18. PMID:16682793. |
stability of csf beta-amyloid(1-42) and tau levels by apoe genotype in alzheimer patients. |
2006-08-18 |
2023-08-12 |
Not clear |
Edward D Huey, Nadeem Mirza, Karen T Putnam, Holly Soares, Gyorgy Csako, James A Levy, Brittany Copenhaver, Robert M Cohen, Trey Sunderlan. Stability of CSF beta-amyloid(1-42) and tau levels by APOE genotype in Alzheimer patients. Dementia and geriatric cognitive disorders. vol 22. issue 1. 2006-08-18. PMID:16682793. |
cerebrospinal fluid (csf) measures of beta-amyloid(1-42 )and tau differ between patients with alzheimer's disease (ad) and elderly normal controls. |
2006-08-18 |
2023-08-12 |
Not clear |
A Rahman, I Grundke-Iqbal, K Iqba. PP2B isolated from human brain preferentially dephosphorylates Ser-262 and Ser-396 of the Alzheimer disease abnormally hyperphosphorylated tau. Journal of neural transmission (Vienna, Austria : 1996). vol 113. issue 2. 2006-08-16. PMID:15959850. |
pp2b isolated from human brain preferentially dephosphorylates ser-262 and ser-396 of the alzheimer disease abnormally hyperphosphorylated tau. |
2006-08-16 |
2023-08-12 |
human |
A Rahman, I Grundke-Iqbal, K Iqba. PP2B isolated from human brain preferentially dephosphorylates Ser-262 and Ser-396 of the Alzheimer disease abnormally hyperphosphorylated tau. Journal of neural transmission (Vienna, Austria : 1996). vol 113. issue 2. 2006-08-16. PMID:15959850. |
we quantitated the dephosphorylation of various sites of alzheimer disease abnormally hyperphosphorylated tau by pp2b purified from six (three alzheimer and three control) autopsied human brains. |
2006-08-16 |
2023-08-12 |
human |
A Rahman, I Grundke-Iqbal, K Iqba. PP2B isolated from human brain preferentially dephosphorylates Ser-262 and Ser-396 of the Alzheimer disease abnormally hyperphosphorylated tau. Journal of neural transmission (Vienna, Austria : 1996). vol 113. issue 2. 2006-08-16. PMID:15959850. |
estimated by dot-blot analyses, the purified pp2b (on average from six brains) dephosphorylated alzheimer tau at ps199, pt217, ps262, ps396 and ps422 by 38%, 32%, 63%, 78%, and 32%, respectively. |
2006-08-16 |
2023-08-12 |
human |
Brian C Kraemer, Jack K Burgess, Jin H Chen, James H Thomas, Gerard D Schellenber. Molecular pathways that influence human tau-induced pathology in Caenorhabditis elegans. Human molecular genetics. vol 15. issue 9. 2006-08-16. PMID:16600994. |
in ftdp-17, alzheimer's disease, and other tauopathies, aggregated hyper-phosphorylated tau forms the neurofibrillary tangles characteristic of these disorders. |
2006-08-16 |
2023-08-12 |
human |
Muhammad Omar Chohan, Sabiha Khatoon, Inge-Grundke Iqbal, Khalid Iqba. Involvement of I2PP2A in the abnormal hyperphosphorylation of tau and its reversal by Memantine. FEBS letters. vol 580. issue 16. 2006-08-14. PMID:16806196. |
the activity of protein phosphatase (pp)-2a, which regulates tau phosphorylation, is compromised in alzheimer disease brain. |
2006-08-14 |
2023-08-12 |
Not clear |
Qingfeng Ma, Yanmei Li, Jintang Du, Huadong Liu, Kenji Kanazawa, Tadashi Nemoto, Hiroshi Nakanishi, Yufen Zha. Copper binding properties of a tau peptide associated with Alzheimer's disease studied by CD, NMR, and MALDI-TOF MS. Peptides. vol 27. issue 4. 2006-08-11. PMID:16225961. |
copper binding properties of a tau peptide associated with alzheimer's disease studied by cd, nmr, and maldi-tof ms. we have previously reported the copper binding properties of r3 peptide (residues 318-335: vtskcgslgnihhkpggg, according to the longest tau protein) derived from the third repeat microtubule-binding domain of water-soluble tau protein. |
2006-08-11 |
2023-08-12 |
Not clear |
Ian Churche. Tau therapeutic strategies for the treatment of Alzheimer's disease. Current topics in medicinal chemistry. vol 6. issue 6. 2006-08-11. PMID:16712493. |
tau therapeutic strategies for the treatment of alzheimer's disease. |
2006-08-11 |
2023-08-12 |
Not clear |
Ian Churche. Tau therapeutic strategies for the treatment of Alzheimer's disease. Current topics in medicinal chemistry. vol 6. issue 6. 2006-08-11. PMID:16712493. |
the two classical pathological hallmarks of alzheimer's disease are deposits of aggregated beta-amyloid (abeta) peptide and neurofibrillary tangles composed of hyperphosphorylated tau protein. |
2006-08-11 |
2023-08-12 |
Not clear |
Ian Churche. Tau therapeutic strategies for the treatment of Alzheimer's disease. Current topics in medicinal chemistry. vol 6. issue 6. 2006-08-11. PMID:16712493. |
in addition to abeta pathology, an invariant trait of alzheimer's disease, disruption of tau processing is a necessary event in the neurotoxic cascade which eventually leads to neuronal death and subsequent dementia. |
2006-08-11 |
2023-08-12 |
Not clear |