All Relations between Alzheimer Disease and microtubule-associated protein tau

Publication Sentence Publish Date Extraction Date Species
Bernd Ibach, Harald Binder, Margarethe Dragon, Stefan Poljansky, Ekkehard Haen, Eberhard Schmitz, Horst Koch, Albert Putzhammer, Hans Kluenemann, Wolf Wieland, Goeran Haja. Cerebrospinal fluid tau and beta-amyloid in Alzheimer patients, disease controls and an age-matched random sample. Neurobiology of aging. vol 27. issue 9. 2006-08-28. PMID:16085339. cerebrospinal fluid tau and beta-amyloid in alzheimer patients, disease controls and an age-matched random sample. 2006-08-28 2023-08-12 Not clear
Bernd Ibach, Harald Binder, Margarethe Dragon, Stefan Poljansky, Ekkehard Haen, Eberhard Schmitz, Horst Koch, Albert Putzhammer, Hans Kluenemann, Wolf Wieland, Goeran Haja. Cerebrospinal fluid tau and beta-amyloid in Alzheimer patients, disease controls and an age-matched random sample. Neurobiology of aging. vol 27. issue 9. 2006-08-28. PMID:16085339. we prospectively evaluated the diagnostic accuracy of cerebrospinal fluid (csf)-beta-amyloid1-42 (abeta42), -total-tau (tau) and -phosphorylated-tau181 (p-tau181) as measured by sandwich elisas in the clinical routine of a community state hospital to discriminate between patients with alzheimer's disease (ad), healthy controls (hc), non-ad-dementias, a group composed of various psychiatric disorders (non-ad-dementias, mental diseases) and an age-matched random sample (rs) (total n=219). 2006-08-28 2023-08-12 Not clear
María Nieto-Bodelón, Gabriel Santpere, Benjamín Torrejón-Escribano, Berta Puig, Isidre Ferre. Expression of transcription factors c-Fos, c-Jun, CREB-1 and ATF-2, and caspase-3 in relation with abnormal tau deposits in Pick's disease. Acta neuropathologica. vol 111. issue 4. 2006-08-24. PMID:16496165. the present findings are in line with the previous studies showing tau products cleaved by caspase-3, as recognized by specific tau-cleaved antibodies, in alzheimer's disease and other tauopathies. 2006-08-24 2023-08-12 Not clear
Xin-Wen Zhou, Xu Li, Cecilia Bjorkdahl, Magnus J Sjogren, Irina Alafuzoff, Hilkka Soininen, Inge Grundke-Iqbal, Khalid Iqbal, Bengt Winblad, Jin-Jing Pe. Assessments of the accumulation severities of amyloid beta-protein and hyperphosphorylated tau in the medial temporal cortex of control and Alzheimer's brains. Neurobiology of disease. vol 22. issue 3. 2006-08-24. PMID:16513361. assessments of the accumulation severities of amyloid beta-protein and hyperphosphorylated tau in the medial temporal cortex of control and alzheimer's brains. 2006-08-24 2023-08-12 Not clear
Marie-Christine Galas, Pierre Dourlen, Séverine Bégard, Kunié Ando, David Blum, Malika Hamdane, Luc Bué. The peptidylprolyl cis/trans-isomerase Pin1 modulates stress-induced dephosphorylation of Tau in neurons. Implication in a pathological mechanism related to Alzheimer disease. The Journal of biological chemistry. vol 281. issue 28. 2006-08-21. PMID:16675464. deregulation of tau phosphorylation is a key question in alzheimer disease pathogenesis. 2006-08-21 2023-08-12 Not clear
Marie-Christine Galas, Pierre Dourlen, Séverine Bégard, Kunié Ando, David Blum, Malika Hamdane, Luc Bué. The peptidylprolyl cis/trans-isomerase Pin1 modulates stress-induced dephosphorylation of Tau in neurons. Implication in a pathological mechanism related to Alzheimer disease. The Journal of biological chemistry. vol 281. issue 28. 2006-08-21. PMID:16675464. recently, pin1, a peptidylprolyl cis/trans-isomerase, was proposed to be a new modulator in tau phosphorylation in alzheimer disease. 2006-08-21 2023-08-12 Not clear
Huiping Ding, Tori A Matthews, Gail V W Johnso. Site-specific phosphorylation and caspase cleavage differentially impact tau-microtubule interactions and tau aggregation. The Journal of biological chemistry. vol 281. issue 28. 2006-08-21. PMID:16687396. the microtubule-associated protein tau is hyperphosphorylated and forms neurofibrillary tangles in alzheimer disease. 2006-08-21 2023-08-12 Not clear
Huiping Ding, Tori A Matthews, Gail V W Johnso. Site-specific phosphorylation and caspase cleavage differentially impact tau-microtubule interactions and tau aggregation. The Journal of biological chemistry. vol 281. issue 28. 2006-08-21. PMID:16687396. additionally caspase-cleaved tau is present in alzheimer disease brains co-localized with fibrillar tau pathologies. 2006-08-21 2023-08-12 Not clear
David Singer, Jörg Lehmann, Katja Hanisch, Wolfgang Härtig, Ralf Hoffman. Neighbored phosphorylation sites as PHF-tau specific markers in Alzheimer's disease. Biochemical and biophysical research communications. vol 346. issue 3. 2006-08-21. PMID:16781671. neurofibrillary tangles, which represent a major pathological hallmark in alzheimer's disease (ad), are deposits of the hyperphosphorylated microtubule-associated tau protein (phf-tau). 2006-08-21 2023-08-12 human
Edward D Huey, Nadeem Mirza, Karen T Putnam, Holly Soares, Gyorgy Csako, James A Levy, Brittany Copenhaver, Robert M Cohen, Trey Sunderlan. Stability of CSF beta-amyloid(1-42) and tau levels by APOE genotype in Alzheimer patients. Dementia and geriatric cognitive disorders. vol 22. issue 1. 2006-08-18. PMID:16682793. stability of csf beta-amyloid(1-42) and tau levels by apoe genotype in alzheimer patients. 2006-08-18 2023-08-12 Not clear
Edward D Huey, Nadeem Mirza, Karen T Putnam, Holly Soares, Gyorgy Csako, James A Levy, Brittany Copenhaver, Robert M Cohen, Trey Sunderlan. Stability of CSF beta-amyloid(1-42) and tau levels by APOE genotype in Alzheimer patients. Dementia and geriatric cognitive disorders. vol 22. issue 1. 2006-08-18. PMID:16682793. cerebrospinal fluid (csf) measures of beta-amyloid(1-42 )and tau differ between patients with alzheimer's disease (ad) and elderly normal controls. 2006-08-18 2023-08-12 Not clear
A Rahman, I Grundke-Iqbal, K Iqba. PP2B isolated from human brain preferentially dephosphorylates Ser-262 and Ser-396 of the Alzheimer disease abnormally hyperphosphorylated tau. Journal of neural transmission (Vienna, Austria : 1996). vol 113. issue 2. 2006-08-16. PMID:15959850. pp2b isolated from human brain preferentially dephosphorylates ser-262 and ser-396 of the alzheimer disease abnormally hyperphosphorylated tau. 2006-08-16 2023-08-12 human
A Rahman, I Grundke-Iqbal, K Iqba. PP2B isolated from human brain preferentially dephosphorylates Ser-262 and Ser-396 of the Alzheimer disease abnormally hyperphosphorylated tau. Journal of neural transmission (Vienna, Austria : 1996). vol 113. issue 2. 2006-08-16. PMID:15959850. we quantitated the dephosphorylation of various sites of alzheimer disease abnormally hyperphosphorylated tau by pp2b purified from six (three alzheimer and three control) autopsied human brains. 2006-08-16 2023-08-12 human
A Rahman, I Grundke-Iqbal, K Iqba. PP2B isolated from human brain preferentially dephosphorylates Ser-262 and Ser-396 of the Alzheimer disease abnormally hyperphosphorylated tau. Journal of neural transmission (Vienna, Austria : 1996). vol 113. issue 2. 2006-08-16. PMID:15959850. estimated by dot-blot analyses, the purified pp2b (on average from six brains) dephosphorylated alzheimer tau at ps199, pt217, ps262, ps396 and ps422 by 38%, 32%, 63%, 78%, and 32%, respectively. 2006-08-16 2023-08-12 human
Brian C Kraemer, Jack K Burgess, Jin H Chen, James H Thomas, Gerard D Schellenber. Molecular pathways that influence human tau-induced pathology in Caenorhabditis elegans. Human molecular genetics. vol 15. issue 9. 2006-08-16. PMID:16600994. in ftdp-17, alzheimer's disease, and other tauopathies, aggregated hyper-phosphorylated tau forms the neurofibrillary tangles characteristic of these disorders. 2006-08-16 2023-08-12 human
Muhammad Omar Chohan, Sabiha Khatoon, Inge-Grundke Iqbal, Khalid Iqba. Involvement of I2PP2A in the abnormal hyperphosphorylation of tau and its reversal by Memantine. FEBS letters. vol 580. issue 16. 2006-08-14. PMID:16806196. the activity of protein phosphatase (pp)-2a, which regulates tau phosphorylation, is compromised in alzheimer disease brain. 2006-08-14 2023-08-12 Not clear
Qingfeng Ma, Yanmei Li, Jintang Du, Huadong Liu, Kenji Kanazawa, Tadashi Nemoto, Hiroshi Nakanishi, Yufen Zha. Copper binding properties of a tau peptide associated with Alzheimer's disease studied by CD, NMR, and MALDI-TOF MS. Peptides. vol 27. issue 4. 2006-08-11. PMID:16225961. copper binding properties of a tau peptide associated with alzheimer's disease studied by cd, nmr, and maldi-tof ms. we have previously reported the copper binding properties of r3 peptide (residues 318-335: vtskcgslgnihhkpggg, according to the longest tau protein) derived from the third repeat microtubule-binding domain of water-soluble tau protein. 2006-08-11 2023-08-12 Not clear
Ian Churche. Tau therapeutic strategies for the treatment of Alzheimer's disease. Current topics in medicinal chemistry. vol 6. issue 6. 2006-08-11. PMID:16712493. tau therapeutic strategies for the treatment of alzheimer's disease. 2006-08-11 2023-08-12 Not clear
Ian Churche. Tau therapeutic strategies for the treatment of Alzheimer's disease. Current topics in medicinal chemistry. vol 6. issue 6. 2006-08-11. PMID:16712493. the two classical pathological hallmarks of alzheimer's disease are deposits of aggregated beta-amyloid (abeta) peptide and neurofibrillary tangles composed of hyperphosphorylated tau protein. 2006-08-11 2023-08-12 Not clear
Ian Churche. Tau therapeutic strategies for the treatment of Alzheimer's disease. Current topics in medicinal chemistry. vol 6. issue 6. 2006-08-11. PMID:16712493. in addition to abeta pathology, an invariant trait of alzheimer's disease, disruption of tau processing is a necessary event in the neurotoxic cascade which eventually leads to neuronal death and subsequent dementia. 2006-08-11 2023-08-12 Not clear