| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| F Liu, Z Liang, C X Gon. Hyperphosphorylation of tau and protein phosphatases in Alzheimer disease. Panminerva medica. vol 48. issue 2. 2006-11-27. PMID:16953147. |
aggregation of abnormal hyperphosphorylated tau to neurofibrillary tangles in affected neurons is one of the hallmarks for alzheimer disease (ad). |
2006-11-27 |
2023-08-12 |
Not clear |
| Tetyana Duka, Milan Rusnak, Robert E Drolet, Valeriy Duka, Christophe Wersinger, John L Goudreau, Anita Sidh. Alpha-synuclein induces hyperphosphorylation of Tau in the MPTP model of parkinsonism. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 20. issue 13. 2006-11-27. PMID:17077307. |
many neurodegenerative diseases associated with functional tau dysregulation, including alzheimer's disease (ad) and other tauopathies, also show alpha-synuclein (alpha-syn) pathology, a protein associated with parkinson's disease (pd) pathology. |
2006-11-27 |
2023-08-12 |
mouse |
| Tetsuro Murakami, Erwan Paitel, Takeshi Kawarabayashi, Masaki Ikeda, M Azhar Chishti, Christopher Janus, Etsuro Matsubara, Atsushi Sasaki, Toshitaka Kawarai, Amie L Phinney, Yasuo Harigaya, Patrick Horne, Nobuaki Egashira, Kenichi Mishima, Amanda Hanna, Jing Yang, Katsunori Iwasaki, Mitsuo Takahashi, Michihiro Fujiwara, Koichi Ishiguro, Catherine Bergeron, George A Carlson, Koji Abe, David Westaway, Peter St George-Hyslop, Mikio Shoj. Cortical neuronal and glial pathology in TgTauP301L transgenic mice: neuronal degeneration, memory disturbance, and phenotypic variation. The American journal of pathology. vol 169. issue 4. 2006-11-24. PMID:17003492. |
these transgenic mice may aid therapeutic development for ftdp-17 and other diseases featuring accumulations of four-repeat tau, such as alzheimer's disease, corticobasal degeneration, and progressive supranuclear palsy. |
2006-11-24 |
2023-08-12 |
mouse |
| Alan M Pittman, Hon-Chung Fung, Rohan de Silv. Untangling the tau gene association with neurodegenerative disorders. Human molecular genetics. vol 15 Spec No 2. 2006-11-20. PMID:16987883. |
pathological tau protein inclusions have long been recognized to define the diverse range of neurodegenerative disorders called the tauopathies, which include alzheimer's disease (ad), progressive supranuclear palsy (psp) and frontotemporal lobar degeneration. |
2006-11-20 |
2023-08-12 |
Not clear |
| Michel Goedert, Maria Grazia Spillantin. A century of Alzheimer's disease. Science (New York, N.Y.). vol 314. issue 5800. 2006-11-20. PMID:17082447. |
amyloid-beta and tau make up the plaques and tangles of alzheimer's disease, where these normally soluble proteins assemble into amyloid-like filaments. |
2006-11-20 |
2023-08-12 |
Not clear |
| Chad A Dickey, Leonard Petrucell. Current strategies for the treatment of Alzheimer's disease and other tauopathies. Expert opinion on therapeutic targets. vol 10. issue 5. 2006-11-14. PMID:16981824. |
the pathological hallmarks of alzheimer's disease (ad) include abnormal intra- and extraneuronal tau and amyloid accumulation, respectively, accompanied by gliosis, oxidative stress and neuron loss. |
2006-11-14 |
2023-08-12 |
Not clear |
| Hirotaka Yoshida, Michel Goeder. Sequential phosphorylation of tau protein by cAMP-dependent protein kinase and SAPK4/p38delta or JNK2 in the presence of heparin generates the AT100 epitope. Journal of neurochemistry. vol 99. issue 1. 2006-11-14. PMID:16987243. |
microtubule-associated protein tau in a hyperphosphorylated state is the major component of the filamentous lesions that define a number of neurodegenerative diseases, including alzheimer's disease, progressive supranuclear palsy, corticobasal degeneration, pick's disease, argyrophilic grain disease and frontotemporal dementia and parkinsonism linked to chromosome 17 (ftdp-17). |
2006-11-14 |
2023-08-12 |
mouse |
| C Duyckaert. [Nosology of dementias: the neuropathologist's point of view]. Revue neurologique. vol 162. issue 10. 2006-11-14. PMID:17028559. |
tauopathy is probably the largest group including alzheimer and pick disease, mutation of the tau gene, progressive supranuclear palsy, corticobasal degeneration, and argyrophilic grain disease. |
2006-11-14 |
2023-08-12 |
Not clear |
| Damian C Crowther, Richard Page, Dhianjali Chandraratna, David A Loma. A Drosophila model of Alzheimer's disease. Methods in enzymology. vol 412. 2006-11-14. PMID:17046662. |
by reconstructing essential steps in alzheimer's pathology, such as amyloid beta peptide and tau overexpression, we can observe clear and rapid phenotypes that are surrogate markers for human disease. |
2006-11-14 |
2023-08-12 |
human |
| Matthew R Reynolds, Juan F Reyes, Yifan Fu, Eileen H Bigio, Angela L Guillozet-Bongaarts, Robert W Berry, Lester I Binde. Tau nitration occurs at tyrosine 29 in the fibrillar lesions of Alzheimer's disease and other tauopathies. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 26. issue 42. 2006-11-14. PMID:17050703. |
tau nitration occurs at tyrosine 29 in the fibrillar lesions of alzheimer's disease and other tauopathies. |
2006-11-14 |
2023-08-12 |
Not clear |
| Matthew R Reynolds, Juan F Reyes, Yifan Fu, Eileen H Bigio, Angela L Guillozet-Bongaarts, Robert W Berry, Lester I Binde. Tau nitration occurs at tyrosine 29 in the fibrillar lesions of Alzheimer's disease and other tauopathies. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 26. issue 42. 2006-11-14. PMID:17050703. |
by western blot analysis, tau-ny29 detects soluble tau and paired helical filament tau from severely affected alzheimer's brain but fails to recognize tau from normal aged brain. |
2006-11-14 |
2023-08-12 |
Not clear |
| Matthew R Reynolds, Juan F Reyes, Yifan Fu, Eileen H Bigio, Angela L Guillozet-Bongaarts, Robert W Berry, Lester I Binde. Tau nitration occurs at tyrosine 29 in the fibrillar lesions of Alzheimer's disease and other tauopathies. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 26. issue 42. 2006-11-14. PMID:17050703. |
in alzheimer's brain, tau-ny29 labels the fibrillar triad of tau lesions, including neurofibrillary tangles, neuritic plaques, and, to a lesser extent, neuropil threads. |
2006-11-14 |
2023-08-12 |
Not clear |
| Nathalie Sibille, Alain Sillen, Arnaud Leroy, Jean-Michel Wieruszeski, Barbara Mulloy, Isabelle Landrieu, Guy Lippen. Structural impact of heparin binding to full-length Tau as studied by NMR spectroscopy. Biochemistry. vol 45. issue 41. 2006-11-08. PMID:17029411. |
the neuronal tau protein is involved in stabilizing microtubules but is also the major component of the paired helical filaments (phfs), the intracellular aggregates that characterize alzheimer's disease (ad) in neurons. |
2006-11-08 |
2023-08-12 |
Not clear |
| Patrick Barré, David Elieze. Folding of the repeat domain of tau upon binding to lipid surfaces. Journal of molecular biology. vol 362. issue 2. 2006-11-07. PMID:16908029. |
the microtubule-associated protein tau is impacted in neurodegeneration and dementia through its deposition in the form of paired helical filaments in alzheimer's disease neurofibrillary tangles and through mutations linking it to the autosomal dominant disorder frontotemporal dementia with parkinsonism. |
2006-11-07 |
2023-08-12 |
Not clear |
| D Allan Butterfield, Hafiz Mohmmad Abdul, Wycliffe Opii, Shelley F Newman, Gururaj Joshi, Mubeen Ahmad Ansari, Rukhsana Sultan. Pin1 in Alzheimer's disease. Journal of neurochemistry. vol 98. issue 6. 2006-11-07. PMID:16945100. |
proteolytic processing and phosphorylation of amyloid precursor protein (app), and hyperphosphorylation of tau protein, have been shown to be increased in alzheimer's disease (ad) brains, leading to increased production of beta-amyloid (abeta) peptides and neurofibrillary tangles, respectively. |
2006-11-07 |
2023-08-12 |
Not clear |
| Anitha Suram, Chitra Venugopal, Annamalai Prakasam, Kumar Sambamurt. Genotoxicity in Alzheimer's disease: role of amyloid. Current Alzheimer research. vol 3. issue 4. 2006-11-03. PMID:17017867. |
alzheimer's disease (ad) is a complex neurodegenerative disorder pathologically identified by the presence of extracellular senile plaques (sp) with a proteinaceous core composed of aggregates of the amyloid peptide (abeta) and intracellular aggregates of the microtubule-associated protein tau (tau) as neurofibrillary tangles (nfts). |
2006-11-03 |
2023-08-12 |
Not clear |
| Kurt A Jellinge. Challenges in neuronal apoptosis. Current Alzheimer research. vol 3. issue 4. 2006-11-03. PMID:17017868. |
recent data suggest that caspases converge amyloid and tau alzheimer pathologies: beta amyloid peptide activates caspases which on turn cleave tau and via phosphorylation of tau initiate tangle pathology in both alzheimer disease and other tauopathies. |
2006-11-03 |
2023-08-12 |
human |
| Danielle David, Olivier Moreaud, Annik Charnalle. [Primary progressive aphasia: clinical aspects]. Psychologie & neuropsychiatrie du vieillissement. vol 4. issue 3. 2006-10-31. PMID:16945849. |
in most cases, no alzheimer type pathology was found in the brain, but tauopathy (mainly in non fluent ppa) or motor neuron disease type pathology - tau negative ubiquitin inclusions (mainly in fluent ppa). |
2006-10-31 |
2023-08-12 |
Not clear |
| Tetyana Duka, Anita Sidh. The neurotoxin, MPP+, induces hyperphosphorylation of Tau, in the presence of alpha-Synuclein, in SH-SY5Y neuroblastoma cells. Neurotoxicity research. vol 10. issue 1. 2006-10-31. PMID:17000465. |
alzheimer's disease (ad) is characterized, in part, by intracellular neurofibrillary tangles composed of hyperphosphorylated filamentous aggregates of the microtubule-associated protein, tau. |
2006-10-31 |
2023-08-12 |
human |
| Eva Carro, Jose Luis Trejo, Carlos Spuch, Delphine Bohl, Jean Michel Heard, Ignacio Torres-Alema. Blockade of the insulin-like growth factor I receptor in the choroid plexus originates Alzheimer's-like neuropathology in rodents: new cues into the human disease? Neurobiology of aging. vol 27. issue 11. 2006-10-26. PMID:16274856. |
in rodents, igf-i receptor impairment led to brain amyloidosis, cognitive disturbance, and hyperphosphorylated tau deposits together with other changes found in alzheimer's disease such as gliosis and synaptic protein loss. |
2006-10-26 |
2023-08-12 |
mouse |