All Relations between Alzheimer Disease and microtubule-associated protein tau

Publication Sentence Publish Date Extraction Date Species
Alejandra del C Alonso, Bin Li, Inge Grundke-Iqbal, Khalid Iqba. Polymerization of hyperphosphorylated tau into filaments eliminates its inhibitory activity. Proceedings of the National Academy of Sciences of the United States of America. vol 103. issue 23. 2006-07-19. PMID:16735465. accumulation of abnormally hyperphosphorylated tau (p-tau) in the form of tangles of paired helical filaments and/or straight filaments is one of the hallmarks of alzheimer's disease (ad) and other tauopathies. 2006-07-19 2023-08-12 Not clear
A K Wallin, K Blennow, N Andreasen, L Mintho. CSF biomarkers for Alzheimer's Disease: levels of beta-amyloid, tau, phosphorylated tau relate to clinical symptoms and survival. Dementia and geriatric cognitive disorders. vol 21. issue 3. 2006-07-18. PMID:16391474. csf biomarkers for alzheimer's disease: levels of beta-amyloid, tau, phosphorylated tau relate to clinical symptoms and survival. 2006-07-18 2023-08-12 Not clear
A K Wallin, K Blennow, N Andreasen, L Mintho. CSF biomarkers for Alzheimer's Disease: levels of beta-amyloid, tau, phosphorylated tau relate to clinical symptoms and survival. Dementia and geriatric cognitive disorders. vol 21. issue 3. 2006-07-18. PMID:16391474. cerebrospinal fluid (csf) samples from 21 patients with a clinical diagnosis of alzheimer's disease (ad) participating in a 5-year treatment study with the choline esterase inhibitor tacrin were retrospectively analyzed for the contents of beta-amyloid (abeta42), total tau (t-tau) and phosphorylated tau (p-tau). 2006-07-18 2023-08-12 Not clear
Chad A Dickey, Mei Yue, Wen-Lang Lin, Dennis W Dickson, Judith H Dunmore, Wing C Lee, Cynthia Zehr, Gemma West, Songsong Cao, Amber M K Clark, Guy A Caldwell, Kim A Caldwell, Christopher Eckman, Cam Patterson, Michael Hutton, Leonard Petrucell. Deletion of the ubiquitin ligase CHIP leads to the accumulation, but not the aggregation, of both endogenous phospho- and caspase-3-cleaved tau species. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 26. issue 26. 2006-07-18. PMID:16807328. accumulation of the microtubule-associated protein tau into neurofibrillary lesions is a pathological consequence of several neurodegenerative diseases, including parkinson's disease and alzheimer's disease. 2006-07-18 2023-08-12 mouse
O Weller Roy, Nicola R Cohen, James A R Nicol. Pathophysiology of dementias and implications for therapy. Indian journal of pathology & microbiology. vol 48. issue 3. 2006-07-12. PMID:16761736. intracellular inclusions are of tau protein (alzheimer's disease; and some frontotemporal dementias), alpha-synuclein (dementia with lewy bodies) and huntingtin (huntington's disease). 2006-07-12 2023-08-12 Not clear
Anne Jämsä, Anders Bäckström, Elin Gustafsson, Nodi Dehvari, Gösta Hiller, Richard F Cowburn, Mervi Vasäng. Glutamate treatment and p25 transfection increase Cdk5 mediated tau phosphorylation in SH-SY5Y cells. Biochemical and biophysical research communications. vol 345. issue 1. 2006-07-11. PMID:16678793. neurofibrillary tangles (nft) of hyperphosphorylated tau protein are a major pathological hallmark of alzheimer's disease (ad). 2006-07-11 2023-08-12 Not clear
Janis M Bunker, Kathy Kamath, Leslie Wilson, Mary Ann Jordan, Stuart C Feinstei. FTDP-17 mutations compromise the ability of tau to regulate microtubule dynamics in cells. The Journal of biological chemistry. vol 281. issue 17. 2006-07-05. PMID:16495230. in addition to being required for normal development, maintenance, and function of the nervous system, tau is associated with several neurodegenerative diseases, including alzheimer disease. 2006-07-05 2023-08-12 Not clear
M J Strong, W Yang, W L Strong, C Leystra-Lantz, H Jaffe, H C Pan. Tau protein hyperphosphorylation in sporadic ALS with cognitive impairment. Neurology. vol 66. issue 11. 2006-07-05. PMID:16769962. the authors have characterized frontal cortical tau protein in cognitively intact (4) and cognitively impaired (alsci, 4) als patients and compared it with control (2) or alzheimer disease (ad, 1)- derived tau. 2006-07-05 2023-08-12 Not clear
Gabriel Santpere, Berta Puig, Isidre Ferre. Low molecular weight species of tau in Alzheimer's disease are dependent on tau phosphorylation sites but not on delayed post-mortem delay in tissue processing. Neuroscience letters. vol 399. issue 1-2. 2006-06-30. PMID:16488541. low molecular weight species of tau in alzheimer's disease are dependent on tau phosphorylation sites but not on delayed post-mortem delay in tissue processing. 2006-06-30 2023-08-12 Not clear
Gabriel Santpere, Berta Puig, Isidre Ferre. Low molecular weight species of tau in Alzheimer's disease are dependent on tau phosphorylation sites but not on delayed post-mortem delay in tissue processing. Neuroscience letters. vol 399. issue 1-2. 2006-06-30. PMID:16488541. gel electrophoresis and western blotting of sarkosyl-insoluble fractions enriched in hyper-phosphorylated tau in alzheimer disease (ad) have been used to analyze the pattern of phospho-tau by using different antibodies directed to the amino-terminal, core and carboxyl terminus of tau, and by using samples with increased artificial post-mortem delay in order to gain understanding on the characteristics of the band pattern and its vulnerability to post-mortem degradation. 2006-06-30 2023-08-12 Not clear
Margarita Alvarez-de-la-Rosa, Ivaldo Silva, Jon Nilsen, M M Pérez, Luis Miguel García-Segura, Jesús Avila, Frederick Naftoli. Estradiol prevents neural tau hyperphosphorylation characteristic of Alzheimer's disease. Annals of the New York Academy of Sciences. vol 1052. 2006-06-29. PMID:16024764. estradiol prevents neural tau hyperphosphorylation characteristic of alzheimer's disease. 2006-06-29 2023-08-12 human
James W Simpkins, Yi Wen, Evelyn Perez, Shaohua Yang, Xiaofei Wan. Role of nonfeminizing estrogens in brain protection from cerebral ischemia: an animal model of Alzheimer's disease neuropathology. Annals of the New York Academy of Sciences. vol 1052. 2006-06-29. PMID:16024766. finally, estradiol protected brains from insult-induced alzheimer's disease (ad) neuropathology, including activation of apoptosis, stimulation of abeta production, hyperphosphorylation of tau, activation of cyclin-dependent kinases, and activation of catastrophic attempts at neuronal mitosis. 2006-06-29 2023-08-12 Not clear
Salvatore Oddo, Frank M LaFerl. The role of nicotinic acetylcholine receptors in Alzheimer's disease. Journal of physiology, Paris. vol 99. issue 2-3. 2006-06-28. PMID:16448808. the two hallmark lesions of alzheimer's disease (ad) are extracellular amyloid plaques, mainly formed by a small peptide called amyloid-beta (abeta), and neurofibrillary tangles, which are intracellular inclusions formed by aggregates of hyperphosphorylated tau protein. 2006-06-28 2023-08-12 mouse
Matthias Riemenschneider, Kaj Blennow, Stefan Wagenpfeil, Niels Andreasen, Jonathan A Prince, Simon M Laws, Hans Förstl, Alexander Kur. The cathepsin D rs17571 polymorphism: effects on CSF tau concentrations in Alzheimer disease. Human mutation. vol 27. issue 6. 2006-06-26. PMID:16652347. the cathepsin d rs17571 polymorphism: effects on csf tau concentrations in alzheimer disease. 2006-06-26 2023-08-12 Not clear
Laura E Doglio, Ritu Kanwar, George R Jackson, Mar Perez, Jesús Avila, Colin Dingwall, Carlos G Dotti, Mark E Fortini, Fabián Feigui. gamma-cleavage-independent functions of presenilin, nicastrin, and Aph-1 regulate cell-junction organization and prevent tau toxicity in vivo. Neuron. vol 50. issue 3. 2006-06-26. PMID:16675392. genetic analysis of familial alzheimer's disease has revealed that mutations in the gamma-secretase enzyme presenilin promote toxic abeta secretion; however, presenilin mutations might also influence tau hyperphosphorylation and neurodegeneration through gamma-secretase-independent mechanisms. 2006-06-26 2023-08-12 drosophila_melanogaster
Neelam Shahani, Srinivasa Subramaniam, Tobias Wolf, Christian Tackenberg, Roland Brand. Tau aggregation and progressive neuronal degeneration in the absence of changes in spine density and morphology after targeted expression of Alzheimer's disease-relevant tau constructs in organotypic hippocampal slices. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 26. issue 22. 2006-06-23. PMID:16738255. tau aggregation and progressive neuronal degeneration in the absence of changes in spine density and morphology after targeted expression of alzheimer's disease-relevant tau constructs in organotypic hippocampal slices. 2006-06-23 2023-08-12 Not clear
Neelam Shahani, Srinivasa Subramaniam, Tobias Wolf, Christian Tackenberg, Roland Brand. Tau aggregation and progressive neuronal degeneration in the absence of changes in spine density and morphology after targeted expression of Alzheimer's disease-relevant tau constructs in organotypic hippocampal slices. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 26. issue 22. 2006-06-23. PMID:16738255. alzheimer's disease (ad) is characterized by progressive loss of neurons in selected brain regions, extracellular accumulations of amyloid beta, and intracellular fibrils containing hyperphosphorylated tau. 2006-06-23 2023-08-12 Not clear
Angela L Guillozet-Bongaarts, Michael E Cahill, Vincent L Cryns, Matthew R Reynolds, Robert W Berry, Lester I Binde. Pseudophosphorylation of tau at serine 422 inhibits caspase cleavage: in vitro evidence and implications for tangle formation in vivo. Journal of neurochemistry. vol 97. issue 4. 2006-06-22. PMID:16606369. the tangles of alzheimer's disease (ad) are comprised of the tau protein displaying numerous alterations, including phosphorylation at serine 422 (s422) and truncation at aspartic acid 421 (d421). 2006-06-22 2023-08-12 human
A E Pekary, S A Stevens, A Satti. Rapid modulation of TRH and TRH-like peptide levels in rat brain and peripheral tissues by corticosterone. Neurochemistry international. vol 48. issue 3. 2006-06-19. PMID:16293347. thyrotropin-releasing hormone (trh) is an endogenous antidepressant that reduces the expression of glycogen synthase kinase-3beta (gsk-3beta), an enzyme that hyperphosphorylates tau and is implicated in bipolar depression, diabetes and alzheimer's disease. 2006-06-19 2023-08-12 rat
Diane Cripps, Stefani N Thomas, Young Jeng, Frank Yang, Peter Davies, Austin J Yan. Alzheimer disease-specific conformation of hyperphosphorylated paired helical filament-Tau is polyubiquitinated through Lys-48, Lys-11, and Lys-6 ubiquitin conjugation. The Journal of biological chemistry. vol 281. issue 16. 2006-06-13. PMID:16443603. one of the key pathological hallmarks of alzheimer disease (ad) is the accumulation of paired helical filaments (phfs) of hyperphosphorylated microtubule-associated protein tau. 2006-06-13 2023-08-12 human