| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Cristina d'Abramo, Roberta Ricciarelli, Maria A Pronzato, Peter Davie. Troglitazone, a peroxisome proliferator-activated receptor-gamma agonist, decreases tau phosphorylation in CHOtau4R cells. Journal of neurochemistry. vol 98. issue 4. 2006-09-21. PMID:16787414. |
a 24 h treatment with troglitazone significantly reduced phosphorylation of tau at ser202 and ser396/404, residues of early and later stages of neurofibrillary tangle accumulation in alzheimer's disease and other neurodegenerative disorders. |
2006-09-21 |
2023-08-12 |
Not clear |
| Kim N Green, Lauren M Billings, Benno Roozendaal, James L McGaugh, Frank M LaFerl. Glucocorticoids increase amyloid-beta and tau pathology in a mouse model of Alzheimer's disease. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 26. issue 35. 2006-09-21. PMID:16943563. |
glucocorticoids increase amyloid-beta and tau pathology in a mouse model of alzheimer's disease. |
2006-09-21 |
2023-08-12 |
mouse |
| F Raynaud, A Marcilha. Implication of calpain in neuronal apoptosis. A possible regulation of Alzheimer's disease. The FEBS journal. vol 273. issue 15. 2006-09-20. PMID:16884489. |
alzheimer's disease is characterized by extracellular plaques of amyloid-beta peptide aggregates and intracellular neurofibrillary tangles composed of hyperphosphorylated tau leading to apoptotic cell death. |
2006-09-20 |
2023-08-12 |
Not clear |
| A-M Shiarli, R Jennings, J Shi, K Bailey, Y Davidson, J Tian, E H Bigio, B Ghetti, J R Murrell, M B Delisle, S Mirra, B Crain, P Zolo, K Arima, E Iseki, S Murayama, H Kretzschmar, M Neumann, C Lippa, G Halliday, J Mackenzie, N Khan, R Ravid, D Dickson, Z Wszolek, T Iwatsubo, S M Pickering-Brown, D M A Man. Comparison of extent of tau pathology in patients with frontotemporal dementia with Parkinsonism linked to chromosome 17 (FTDP-17), frontotemporal lobar degeneration with Pick bodies and early onset Alzheimer's disease. Neuropathology and applied neurobiology. vol 32. issue 4. 2006-09-19. PMID:16866983. |
comparison of extent of tau pathology in patients with frontotemporal dementia with parkinsonism linked to chromosome 17 (ftdp-17), frontotemporal lobar degeneration with pick bodies and early onset alzheimer's disease. |
2006-09-19 |
2023-08-12 |
Not clear |
| A-M Shiarli, R Jennings, J Shi, K Bailey, Y Davidson, J Tian, E H Bigio, B Ghetti, J R Murrell, M B Delisle, S Mirra, B Crain, P Zolo, K Arima, E Iseki, S Murayama, H Kretzschmar, M Neumann, C Lippa, G Halliday, J Mackenzie, N Khan, R Ravid, D Dickson, Z Wszolek, T Iwatsubo, S M Pickering-Brown, D M A Man. Comparison of extent of tau pathology in patients with frontotemporal dementia with Parkinsonism linked to chromosome 17 (FTDP-17), frontotemporal lobar degeneration with Pick bodies and early onset Alzheimer's disease. Neuropathology and applied neurobiology. vol 32. issue 4. 2006-09-19. PMID:16866983. |
in order to gain insight into the pathogenesis of frontotemporal lobar degeneration (ftld), the mean tau load in frontal cortex was compared in 34 patients with frontotemporal dementia linked to chromosome 17 (ftdp-17) with 12 different mutations in the tau gene (mapt), 11 patients with sporadic ftld with pick bodies and 25 patients with early onset alzheimer's disease (eoad). |
2006-09-19 |
2023-08-12 |
Not clear |
| X Li, F Lu, Q Tian, Y Yang, Q Wang, J-Z Wan. Activation of glycogen synthase kinase-3 induces Alzheimer-like tau hyperphosphorylation in rat hippocampus slices in culture. Journal of neural transmission (Vienna, Austria : 1996). vol 113. issue 1. 2006-09-15. PMID:15959856. |
formation of neurofibrillary tangle from hyperphosphorylated tau is one of the hallmark lesions seen in alzheimer's disease (ad) brain, and neuronal deregulation of glycogen synthase kinase-3 (gsk-3) activity plays key role in tau hyperphosphorylation. |
2006-09-15 |
2023-08-12 |
rat |
| Rudy J Castellani, Hyoung-Gon Lee, George Perry, Mark A Smit. Antioxidant protection and neurodegenerative disease: the role of amyloid-beta and tau. American journal of Alzheimer's disease and other dementias. vol 21. issue 2. 2006-09-12. PMID:16634469. |
in alzheimer's disease (ad), the major components of senile plaques and neurofibrillary tangles, amyloid-beta and tau, respectively, are thought by many to play a key role in disease initiation and progression. |
2006-09-12 |
2023-08-12 |
Not clear |
| Daniëlle de Jong, René W M M Jansen, Berry P H Kremer, Marcel M Verbee. Cerebrospinal fluid amyloid beta42/phosphorylated tau ratio discriminates between Alzheimer's disease and vascular dementia. The journals of gerontology. Series A, Biological sciences and medical sciences. vol 61. issue 7. 2006-09-12. PMID:16870640. |
cerebrospinal fluid amyloid beta42/phosphorylated tau ratio discriminates between alzheimer's disease and vascular dementia. |
2006-09-12 |
2023-08-12 |
Not clear |
| Malika Hamdane, Pierre Dourlen, Alexis Bretteville, Anne-Véronique Sambo, Stéphanie Ferreira, Kunie Ando, Olivier Kerdraon, Séverine Bégard, Linda Geay, Guy Lippens, Nicolas Sergeant, André Delacourte, Claude-Alain Maurage, Marie-Christine Galas, Luc Bué. Pin1 allows for differential Tau dephosphorylation in neuronal cells. Molecular and cellular neurosciences. vol 32. issue 1-2. 2006-09-07. PMID:16697218. |
among abnormal tau phosphorylation sites, pthr231 is of particular interest since it is associated with early stages of alzheimer's disease and is a binding site of pin1, a peptidyl-prolyl cis/trans isomerase mainly involved in cell cycle regulation. |
2006-09-07 |
2023-08-12 |
Not clear |
| Wolfgang Härtig, Jörg Lehmann, Jens Stieler, David Singer, Jens Grosche, Thomas Arendt, Ralf Hoffman. Simultaneous detection of tau phospho-epitopes with haptenylated antibodies. Neuroreport. vol 17. issue 9. 2006-09-05. PMID:16738478. |
neurofibrillary tangles as a neuropathological hallmark of alzheimer's disease are mainly composed of abnormally phosphorylated microtubule-associated protein tau. |
2006-09-05 |
2023-08-12 |
Not clear |
| Wolfgang Härtig, Jörg Lehmann, Jens Stieler, David Singer, Jens Grosche, Thomas Arendt, Ralf Hoffman. Simultaneous detection of tau phospho-epitopes with haptenylated antibodies. Neuroreport. vol 17. issue 9. 2006-09-05. PMID:16738478. |
at8-immunolabelling of phospho-serine 202 and phospho-threonine 205 combined with hpt-1 and hpt-101-staining revealed similar distribution patterns of the three double-phosphorylated tau epitopes in the neocortex of patients with alzheimer's disease. |
2006-09-05 |
2023-08-12 |
Not clear |
| Sara Johansson, Anne Jämsä, Mervi Vasänge, Bengt Winblad, Johan Luthman, Richard F Cowbur. Increased tau phosphorylation at the Ser396 epitope after amyloid beta-exposure in organotypic cultures. Neuroreport. vol 17. issue 9. 2006-09-05. PMID:16738486. |
the hallmarks of alzheimer's disease include extracellular plaques primarily consisting of amyloid-beta peptide and intracellular neurofibrillary tangles composed of highly phosphorylated tau protein. |
2006-09-05 |
2023-08-12 |
Not clear |
| A Rubio, M Pérez, Jesús Avil. Acetylcholine receptors and tau phosphorylation. Current molecular medicine. vol 6. issue 4. 2006-09-05. PMID:16900665. |
alzheimer's disease (ad) is characterized by the presence, in the brain of the patients, of two aberrant structures: intracellular neurofibrillary tangles (nfts), containing an abnormal hyperphosphorylated form of tau protein, and extracellular senile plaques (sps), mainly composed by fibrillar amyloid beta peptide. |
2006-09-05 |
2023-08-12 |
Not clear |
| Katharina Schindowski, Alexis Bretteville, Karelle Leroy, Séverine Bégard, Jean-Pierre Brion, Malika Hamdane, Luc Bué. Alzheimer's disease-like tau neuropathology leads to memory deficits and loss of functional synapses in a novel mutated tau transgenic mouse without any motor deficits. The American journal of pathology. vol 169. issue 2. 2006-09-01. PMID:16877359. |
alzheimer's disease-like tau neuropathology leads to memory deficits and loss of functional synapses in a novel mutated tau transgenic mouse without any motor deficits. |
2006-09-01 |
2023-08-12 |
mouse |
| Katharina Schindowski, Alexis Bretteville, Karelle Leroy, Séverine Bégard, Jean-Pierre Brion, Malika Hamdane, Luc Bué. Alzheimer's disease-like tau neuropathology leads to memory deficits and loss of functional synapses in a novel mutated tau transgenic mouse without any motor deficits. The American journal of pathology. vol 169. issue 2. 2006-09-01. PMID:16877359. |
tau transgenic mice are valuable models to investigate the role of tau protein in alzheimer's disease and other tauopathies. |
2006-09-01 |
2023-08-12 |
mouse |
| Katharina Schindowski, Alexis Bretteville, Karelle Leroy, Séverine Bégard, Jean-Pierre Brion, Malika Hamdane, Luc Bué. Alzheimer's disease-like tau neuropathology leads to memory deficits and loss of functional synapses in a novel mutated tau transgenic mouse without any motor deficits. The American journal of pathology. vol 169. issue 2. 2006-09-01. PMID:16877359. |
thy-tau22 shows hyperphosphorylation of tau on several alzheimer's disease-relevant tau epitopes (at8, at100, at180, at270, 12e8, tau-pser396, and ap422), neurofibrillary tangle-like inclusions (gallyas and mc1-positive) with rare ghost tangles and phf-like filaments, as well as mild astrogliosis. |
2006-09-01 |
2023-08-12 |
mouse |
| Bernd Ibach, Harald Binder, Margarethe Dragon, Stefan Poljansky, Ekkehard Haen, Eberhard Schmitz, Horst Koch, Albert Putzhammer, Hans Kluenemann, Wolf Wieland, Goeran Haja. Cerebrospinal fluid tau and beta-amyloid in Alzheimer patients, disease controls and an age-matched random sample. Neurobiology of aging. vol 27. issue 9. 2006-08-28. PMID:16085339. |
cerebrospinal fluid tau and beta-amyloid in alzheimer patients, disease controls and an age-matched random sample. |
2006-08-28 |
2023-08-12 |
Not clear |
| Bernd Ibach, Harald Binder, Margarethe Dragon, Stefan Poljansky, Ekkehard Haen, Eberhard Schmitz, Horst Koch, Albert Putzhammer, Hans Kluenemann, Wolf Wieland, Goeran Haja. Cerebrospinal fluid tau and beta-amyloid in Alzheimer patients, disease controls and an age-matched random sample. Neurobiology of aging. vol 27. issue 9. 2006-08-28. PMID:16085339. |
we prospectively evaluated the diagnostic accuracy of cerebrospinal fluid (csf)-beta-amyloid1-42 (abeta42), -total-tau (tau) and -phosphorylated-tau181 (p-tau181) as measured by sandwich elisas in the clinical routine of a community state hospital to discriminate between patients with alzheimer's disease (ad), healthy controls (hc), non-ad-dementias, a group composed of various psychiatric disorders (non-ad-dementias, mental diseases) and an age-matched random sample (rs) (total n=219). |
2006-08-28 |
2023-08-12 |
Not clear |
| María Nieto-Bodelón, Gabriel Santpere, Benjamín Torrejón-Escribano, Berta Puig, Isidre Ferre. Expression of transcription factors c-Fos, c-Jun, CREB-1 and ATF-2, and caspase-3 in relation with abnormal tau deposits in Pick's disease. Acta neuropathologica. vol 111. issue 4. 2006-08-24. PMID:16496165. |
the present findings are in line with the previous studies showing tau products cleaved by caspase-3, as recognized by specific tau-cleaved antibodies, in alzheimer's disease and other tauopathies. |
2006-08-24 |
2023-08-12 |
Not clear |
| Xin-Wen Zhou, Xu Li, Cecilia Bjorkdahl, Magnus J Sjogren, Irina Alafuzoff, Hilkka Soininen, Inge Grundke-Iqbal, Khalid Iqbal, Bengt Winblad, Jin-Jing Pe. Assessments of the accumulation severities of amyloid beta-protein and hyperphosphorylated tau in the medial temporal cortex of control and Alzheimer's brains. Neurobiology of disease. vol 22. issue 3. 2006-08-24. PMID:16513361. |
assessments of the accumulation severities of amyloid beta-protein and hyperphosphorylated tau in the medial temporal cortex of control and alzheimer's brains. |
2006-08-24 |
2023-08-12 |
Not clear |