All Relations between Alzheimer Disease and microtubule-associated protein tau

Publication Sentence Publish Date Extraction Date Species
Kate M Webber, Gemma Casadesus, Xiongwei Zhu, Mark E Obrenovich, Craig S Atwood, George Perry, Richard L Bowen, Mark A Smit. The cell cycle and hormonal fluxes in Alzheimer disease: a novel therapeutic target. Current pharmaceutical design. vol 12. issue 6. 2006-03-31. PMID:16472159. several hypotheses have been proposed attempting to explain the pathogenesis of alzheimer disease (ad) including theories involving amyloid deposition, tau phosphorylation, oxidative stress, metal ion dysregulation and inflammation. 2006-03-31 2023-08-12 Not clear
Tony Lefebvre, Céline Guinez, Vanessa Dehennaut, Olivia Beseme-Dekeyser, Willy Morelle, Jean-Claude Michalsk. Does O-GlcNAc play a role in neurodegenerative diseases? Expert review of proteomics. vol 2. issue 2. 2006-03-30. PMID:15892570. several neuronal proteins have been identified as being modified with o-glcnac; these proteins could form part of the inclusion bodies found, for example, in the most frequently observed neurologic disorder (i.e., alzheimer's disease; tau protein and beta-amyloid peptide are the well known aggregated proteins). 2006-03-30 2023-08-12 Not clear
SeungYong Yoon, JungEun Choi, JuHee Yoon, Jae-Wan Huh, DongHou Ki. Okadaic acid induces JNK activation, bim overexpression and mitochondrial dysfunction in cultured rat cortical neurons. Neuroscience letters. vol 394. issue 3. 2006-03-30. PMID:16260088. apoptosis via tau phosphorylation has been implicated in the selective neuronal losses seen in alzheimer's disease (ad). 2006-03-30 2023-08-12 rat
Daniela C Glatz, Dan Rujescu, Yesheng Tang, Frank J Berendt, Annette M Hartmann, Frank Faltraco, Carlyn Rosenberg, Christine Hulette, Kurt Jellinger, Harald Hampel, Peter Riederer, Hans-J Möller, Athena Andreadis, Kerstin Henkel, Stefan Stam. The alternative splicing of tau exon 10 and its regulatory proteins CLK2 and TRA2-BETA1 changes in sporadic Alzheimer's disease. Journal of neurochemistry. vol 96. issue 3. 2006-03-30. PMID:16371011. the alternative splicing of tau exon 10 and its regulatory proteins clk2 and tra2-beta1 changes in sporadic alzheimer's disease. 2006-03-30 2023-08-12 human
Daniela C Glatz, Dan Rujescu, Yesheng Tang, Frank J Berendt, Annette M Hartmann, Frank Faltraco, Carlyn Rosenberg, Christine Hulette, Kurt Jellinger, Harald Hampel, Peter Riederer, Hans-J Möller, Athena Andreadis, Kerstin Henkel, Stefan Stam. The alternative splicing of tau exon 10 and its regulatory proteins CLK2 and TRA2-BETA1 changes in sporadic Alzheimer's disease. Journal of neurochemistry. vol 96. issue 3. 2006-03-30. PMID:16371011. pathological inclusions containing fibrillar aggregates of hyperphosphorylated tau protein are a characteristic feature in tauopathies, which include alzheimer's disease (ad). 2006-03-30 2023-08-12 human
Kazuo Goto, Masahiko Yasuda, Ayako Sugawara, Takashi Kuramochi, Toshio Itoh, Noriyuki Azuma, Mamoru It. Small eye phenotypes observed in a human tau gene transgenic rat. Current eye research. vol 31. issue 1. 2006-03-30. PMID:16421024. we developed a rat line showing small eye from transgenic rats that were obtained by microinjection of a dna segment containing the human (h)tau cdna (genbank: bc000558: 31-677,774-1180) expressed under control of cag promoter, which is related to alzheimer disease, into the pronuclei rat embryos. 2006-03-30 2023-08-12 human
Chiara D'Ambrosio, Simona Arena, Gabriella Fulcoli, Meir H Scheinfeld, Dawang Zhou, Luciano D'Adamio, Andrea Scalon. Hyperphosphorylation of JNK-interacting protein 1, a protein associated with Alzheimer disease. Molecular & cellular proteomics : MCP. vol 5. issue 1. 2006-03-28. PMID:16195223. this motif is modified by various kinases in aggregates of the microtubule-associated protein tau, which generates typical intraneuronal lesions occurring in alzheimer disease. 2006-03-28 2023-08-12 Not clear
Jian-Ping Guo, Tetsuaki Arai, Judit Miklossy, Patrick L McGee. Abeta and tau form soluble complexes that may promote self aggregation of both into the insoluble forms observed in Alzheimer's disease. Proceedings of the National Academy of Sciences of the United States of America. vol 103. issue 6. 2006-03-23. PMID:16446437. abeta and tau form soluble complexes that may promote self aggregation of both into the insoluble forms observed in alzheimer's disease. 2006-03-23 2023-08-12 Not clear
Brian Webster, Lawrence Hansen, Anthony Adame, Leslie Crews, Magdalena Torrance, Leon Thal, Eliezer Maslia. Astroglial activation of extracellular-regulated kinase in early stages of Alzheimer disease. Journal of neuropathology and experimental neurology. vol 65. issue 2. 2006-03-22. PMID:16462205. characterization of the earliest neuropathologic features of alzheimer disease (ad) indicates that synaptic degeneration accompanied by tau hyperphosphorylation and amyloid deposition might be an important feature. 2006-03-22 2023-08-12 Not clear
Salvatore Oddo, Antonella Caccamo, Levina Tran, Mary P Lambert, Charles G Glabe, William L Klein, Frank M LaFerl. Temporal profile of amyloid-beta (Abeta) oligomerization in an in vivo model of Alzheimer disease. A link between Abeta and tau pathology. The Journal of biological chemistry. vol 281. issue 3. 2006-03-17. PMID:16282321. accumulation of amyloid-beta (abeta) is one of the earliest molecular events in alzheimer disease (ad), whereas tau pathology is thought to be a later downstream event. 2006-03-17 2023-08-12 mouse
Deepa V Dabir, Michael B Robinson, Eric Swanson, Bin Zhang, John Q Trojanowski, Virginia M-Y Lee, Mark S Forma. Impaired glutamate transport in a mouse model of tau pathology in astrocytes. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 26. issue 2. 2006-03-17. PMID:16407562. less robust changes were observed in alzheimer's disease in which neuronal tau pathology predominates. 2006-03-17 2023-08-12 mouse
Khalid Iqbal, Michael Flory, Sabiha Khatoon, Hilkka Soininen, Tuula Pirttila, Maarit Lehtovirta, Irina Alafuzoff, Kaj Blennow, Niels Andreasen, Eugeen Vanmechelen, Inge Grundke-Iqba. Subgroups of Alzheimer's disease based on cerebrospinal fluid molecular markers. Annals of neurology. vol 58. issue 5. 2006-03-14. PMID:16247771. we immunoassayed levels of tau, ubiquitin, and abeta(1-42) in retrospectively collected csf samples of 468 clinically diagnosed alzheimer's disease patients (n = 353) or non-alzheimer's subjects (n = 115). 2006-03-14 2023-08-12 human
Khalid Iqbal, Michael Flory, Sabiha Khatoon, Hilkka Soininen, Tuula Pirttila, Maarit Lehtovirta, Irina Alafuzoff, Kaj Blennow, Niels Andreasen, Eugeen Vanmechelen, Inge Grundke-Iqba. Subgroups of Alzheimer's disease based on cerebrospinal fluid molecular markers. Annals of neurology. vol 58. issue 5. 2006-03-14. PMID:16247771. alzheimer's disease was subdivided into at least five subgroups based on csf levels of abeta(1-42), tau, and ubiquitin; each subgroup presented a different clinical profile. 2006-03-14 2023-08-12 human
Ricardo B Maccioni, Manuel Lavados, Marta Guillón, Cristina Mujica, Ruben Bosch, Gustavo Farías, Patricio Fuente. Anomalously phosphorylated tau and Abeta fragments in the CSF correlates with cognitive impairment in MCI subjects. Neurobiology of aging. vol 27. issue 2. 2006-03-14. PMID:16399209. alzheimer's disease (ad) is a neurodegenerative disorder characterized by the presence of extracellular amyloid deposits, consisting largely of abeta peptide and the presence of intraneuronal aggregates of neurofibillary tangles formed by tau. 2006-03-14 2023-08-12 human
Koji Tomoo, Tian-Ming Yao, Katsuhiko Minoura, Shuko Hiraoka, Miho Sumida, Taizo Taniguchi, Toshimasa Ishid. Possible role of each repeat structure of the microtubule-binding domain of the tau protein in in vitro aggregation. Journal of biochemistry. vol 138. issue 4. 2006-03-10. PMID:16272135. although one of the priorities in alzheimer's research is to clarify the filament formation mechanism of the tau protein, it is currently unclear how it is transformed from a normal structure in a neuron. 2006-03-10 2023-08-12 Not clear
Elena M Ribé, Mar Pérez, Berta Puig, Ignasi Gich, Filip Lim, Mar Cuadrado, Teresa Sesma, Silvia Catena, Belén Sánchez, María Nieto, Pilar Gómez-Ramos, M Asunción Morán, Felipe Cabodevilla, Lluis Samaranch, Lourdes Ortiz, Alberto Pérez, Isidro Ferrer, Jesús Avila, Teresa Gómez-Isl. Accelerated amyloid deposition, neurofibrillary degeneration and neuronal loss in double mutant APP/tau transgenic mice. Neurobiology of disease. vol 20. issue 3. 2006-03-09. PMID:16125396. even though the idea that amyloid beta peptide accumulation is the primary event in the pathogenesis of alzheimer's disease has become the leading hypothesis, the causal link between aberrant amyloid precursor protein processing and tau alterations in this type of dementia remains controversial. 2006-03-09 2023-08-12 mouse
Elena M Ribé, Mar Pérez, Berta Puig, Ignasi Gich, Filip Lim, Mar Cuadrado, Teresa Sesma, Silvia Catena, Belén Sánchez, María Nieto, Pilar Gómez-Ramos, M Asunción Morán, Felipe Cabodevilla, Lluis Samaranch, Lourdes Ortiz, Alberto Pérez, Isidro Ferrer, Jesús Avila, Teresa Gómez-Isl. Accelerated amyloid deposition, neurofibrillary degeneration and neuronal loss in double mutant APP/tau transgenic mice. Neurobiology of disease. vol 20. issue 3. 2006-03-09. PMID:16125396. these findings challenge the idea that tau pathology in alzheimer's disease is merely a downstream effect of amyloid production/deposition and suggest that reciprocal interactions between beta-amyloid and tau alterations may take place in vivo. 2006-03-09 2023-08-12 mouse
Lorella M T Canzoniero, B Joy Snide. Calcium in Alzheimer's disease pathogenesis: too much, too little or in the wrong place? Journal of Alzheimer's disease : JAD. vol 8. issue 2. 2006-03-08. PMID:16308483. the precise biophysical structure of the amyloid beta-peptide that causes neuronal dysfunction remains under investigation, as does the interaction between amyloid peptides and tau hyperphosphorylation, but these two molecules likely play key roles in neuronal dysfunction in alzheimer's disease. 2006-03-08 2023-08-12 Not clear
Randall L Woltjer, P J Cimino, Angela M Boutté, Aimee M Schantz, Kathleen S Montine, Eric B Larson, Thomas Bird, Joseph F Quinn, Jing Zhang, Thomas J Montin. Proteomic determination of widespread detergent-insolubility including Abeta but not tau early in the pathogenesis of Alzheimer's disease. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 19. issue 13. 2006-03-07. PMID:16129700. proteomic determination of widespread detergent-insolubility including abeta but not tau early in the pathogenesis of alzheimer's disease. 2006-03-07 2023-08-12 mouse
Nobuyuki Okamura, Takahiro Suemoto, Shozo Furumoto, Masako Suzuki, Hiroshi Shimadzu, Hiroyasu Akatsu, Takayuki Yamamoto, Hironori Fujiwara, Miyako Nemoto, Masahiro Maruyama, Hiroyuki Arai, Kazuhiko Yanai, Tohru Sawada, Yukitsuka Kud. Quinoline and benzimidazole derivatives: candidate probes for in vivo imaging of tau pathology in Alzheimer's disease. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 25. issue 47. 2006-03-07. PMID:16306398. quinoline and benzimidazole derivatives: candidate probes for in vivo imaging of tau pathology in alzheimer's disease. 2006-03-07 2023-08-12 mouse