| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| E Tortosa, J Avila, M Pére. Acetylsalicylic acid decreases tau phosphorylation at serine 422. Neuroscience letters. vol 396. issue 1. 2006-04-28. PMID:16386371. |
tau protein pathology in alzheimer's disease is characterized by the hyperphosphorylation of tau at some specific sites. |
2006-04-28 |
2023-08-12 |
Not clear |
| Sumihiro Maeda, Naruhiko Sahara, Yuko Saito, Shigeo Murayama, Atsushi Ikai, Akihiko Takashim. Increased levels of granular tau oligomers: an early sign of brain aging and Alzheimer's disease. Neuroscience research. vol 54. issue 3. 2006-04-28. PMID:16406150. |
increased levels of granular tau oligomers: an early sign of brain aging and alzheimer's disease. |
2006-04-28 |
2023-08-12 |
Not clear |
| Lucia Pastorino, Anyang Sun, Pei-Jung Lu, Xiao Zhen Zhou, Martin Balastik, Greg Finn, Gerburg Wulf, Jormay Lim, Shi-Hua Li, Xiaojiang Li, Weiming Xia, Linda K Nicholson, Kun Ping L. The prolyl isomerase Pin1 regulates amyloid precursor protein processing and amyloid-beta production. Nature. vol 440. issue 7083. 2006-04-28. PMID:16554819. |
neuropathological hallmarks of alzheimer's disease are neurofibrillary tangles composed of tau and neuritic plaques comprising amyloid-beta peptides (abeta) derived from amyloid precursor protein (app), but their exact relationship remains elusive. |
2006-04-28 |
2023-08-12 |
mouse |
| D I Orellana, R A Quintanilla, C Gonzalez-Billault, R B Maccion. Role of the JAKs/STATs pathway in the intracellular calcium changes induced by interleukin-6 in hippocampal neurons. Neurotoxicity research. vol 8. issue 3-4. 2006-04-27. PMID:16371324. |
additional studies indicate that the increase in cytosolic calcium induces tau protein hyperphosphorylation, as revealed by using specific antibodies against alzheimer phosphoepitopes. |
2006-04-27 |
2023-08-12 |
rat |
| Toshihisa Tanaka, Kenji Isoe-Wada, Hidenaga Yamamori, Kiyoko Kato, Begum Nurun Nessa, Golam Md Sadik, Masatoshi Taked. Neurobiological studies of dementia--biological markers and neuroprotective strategies for Alzheimer disease. Acta neurologica Taiwanica. vol 15. issue 1. 2006-04-27. PMID:16599295. |
tau protein and amyloid s (abeta), two major components of neuropathology in alzheimer disease (ad), have been applied for establishment of more useful biomarkers and therapeutic approaches. |
2006-04-27 |
2023-08-12 |
Not clear |
| Patrice Delobel, Isabelle Lavenir, Bernardino Ghetti, Max Holzer, Michel Goeder. Cell-cycle markers in a transgenic mouse model of human tauopathy: increased levels of cyclin-dependent kinase inhibitors p21Cip1 and p27Kip1. The American journal of pathology. vol 168. issue 3. 2006-04-19. PMID:16507903. |
recent evidence has suggested that an abnormal reactivation of the cell cycle may precede and cause the hyperphosphorylation and filament formation of tau protein in alzheimer's disease and other tauopathies. |
2006-04-19 |
2023-08-12 |
mouse |
| Paula I Moreira, Mark A Smith, Xiongwei Zhu, Maria S Santos, Catarina R Oliveira, George Perr. Therapeutic potential of oxidant mechanisms in Alzheimer's disease. Expert review of neurotherapeutics. vol 4. issue 6. 2006-04-14. PMID:15853526. |
evidence indicates that in the initial phase of alzheimer's disease development, amyloid-beta deposition and hyperphosphorylated tau, hallmarks of the disease, are consequences of oxidative stress. |
2006-04-14 |
2023-08-12 |
Not clear |
| John Q Trojanowski, Amos B Smith, Donna Huryn, Virginia M-Y Le. Microtubule-stabilising drugs for therapy of Alzheimer's disease and other neurodegenerative disorders with axonal transport impairments. Expert opinion on pharmacotherapy. vol 6. issue 5. 2006-04-14. PMID:15934894. |
moreover, in sporadic neurodegenerative disorders such as alzheimer's disease (ad), pathological alterations of the mt-binding protein tau are linked to impaired axonal transport and brain degeneration. |
2006-04-14 |
2023-08-12 |
human |
| Saravanan Panneerselvam, Alexander Marx, Eva-Maria Mandelkow, Eckhard Mandelko. Structure of the catalytic and ubiquitin-associated domains of the protein kinase MARK/Par-1. Structure (London, England : 1993). vol 14. issue 2. 2006-04-14. PMID:16472737. |
the ser/thr kinase mark2 phosphorylates tau protein at sites that cause detachment from microtubules in alzheimer neurofibrillary degeneration. |
2006-04-14 |
2023-08-12 |
human |
| M J de Leon, S DeSanti, R Zinkowski, P D Mehta, D Pratico, S Segal, H Rusinek, J Li, W Tsui, L A Saint Louis, C M Clark, C Tarshish, Y Li, L Lair, E Javier, K Rich, P Lesbre, L Mosconi, B Reisberg, M Sadowski, J F DeBernadis, D J Kerkman, H Hampel, L-O Wahlund, P Davie. Longitudinal CSF and MRI biomarkers improve the diagnosis of mild cognitive impairment. Neurobiology of aging. vol 27. issue 3. 2006-04-13. PMID:16125823. |
the lesions of alzheimer's disease: amyloid beta (abeta) deposits, tau pathology and cellular oxidative damage, affect the hippocampus in the earlier stages causing memory impairment. |
2006-04-13 |
2023-08-12 |
Not clear |
| Li-Qin Chen, Jian-She Wei, Zhi-Nian Lei, Ling-Mei Zhang, Yan Liu, Feng-Yan Su. Induction of Bcl-2 and Bax was related to hyperphosphorylation of tau and neuronal death induced by okadaic acid in rat brain. The anatomical record. Part A, Discoveries in molecular, cellular, and evolutionary biology. vol 287. issue 2. 2006-04-13. PMID:16265626. |
abnormal hyperphosphorylation of the cytoskeletal protein tau is a characteristic feature of neurodegeneration in alzheimer's disease (ad) brain. |
2006-04-13 |
2023-08-12 |
rat |
| Sadasivam Jeganathan, Martin von Bergen, Henrik Brutlach, Heinz-Jürgen Steinhoff, Eckhard Mandelko. Global hairpin folding of tau in solution. Biochemistry. vol 45. issue 7. 2006-04-10. PMID:16475817. |
the microtubule-associated protein tau stabilizes microtubules in its physiological role, whereas it forms insoluble aggregates (paired helical filaments) in alzheimer's disease. |
2006-04-10 |
2023-08-12 |
Not clear |
| Chad A Dickey, Marcia N Gordon, Donna M Wilcock, Donna L Herber, Melissa J Freeman, Dave Morga. Dysregulation of Na+/K+ ATPase by amyloid in APP+PS1 transgenic mice. BMC neuroscience. vol 6. 2006-04-06. PMID:15689237. |
the pathology of alzheimer's disease (ad) is comprised of extracellular amyloid plaques, intracellular tau tangles, dystrophic neurites and neurodegeneration. |
2006-04-06 |
2023-08-12 |
mouse |
| Guy Lippens, Alain Sillen, Caroline Smet, Jean-Michel Wieruszeski, Arnaud Leroy, Luc Buée, Isabelle Landrie. Studying the natively unfolded neuronal Tau protein by solution NMR spectroscopy. Protein and peptide letters. vol 13. issue 3. 2006-04-06. PMID:16515451. |
the neuronal tau protein, whose physiological role is to stabilize the microtubules, is found under the form of aggregated filaments and tangles in alzheimer's diseased neurons. |
2006-04-06 |
2023-08-12 |
Not clear |
| Matthew R Reynolds, Robert W Berry, Lester I Binde. Site-specific nitration differentially influences tau assembly in vitro. Biochemistry. vol 44. issue 42. 2006-04-03. PMID:16229489. |
previously, we reported that the microtubule-associated tau protein, the major constituent of neurofibrillary tangles (nfts) in alzheimer's brain, undergoes site-selective nitration by peroxynitrite (onoo-) and that this event inhibits tau polymerization in vitro [reynolds et al. |
2006-04-03 |
2023-08-12 |
Not clear |
| Taisuke Tomita, Takeshi Iwatsub. gamma-secretase as a therapeutic target for treatment of Alzheimer's disease. Current pharmaceutical design. vol 12. issue 6. 2006-03-31. PMID:16472155. |
alzheimer's disease (ad) is the most common cause of dementia with aging, that is pathologically characterized by senile plaques that contain amyloid-beta peptides (abeta) and neurofibrillary tangles comprised of phosphorylated tau. |
2006-03-31 |
2023-08-12 |
Not clear |
| Kate M Webber, Gemma Casadesus, Xiongwei Zhu, Mark E Obrenovich, Craig S Atwood, George Perry, Richard L Bowen, Mark A Smit. The cell cycle and hormonal fluxes in Alzheimer disease: a novel therapeutic target. Current pharmaceutical design. vol 12. issue 6. 2006-03-31. PMID:16472159. |
several hypotheses have been proposed attempting to explain the pathogenesis of alzheimer disease (ad) including theories involving amyloid deposition, tau phosphorylation, oxidative stress, metal ion dysregulation and inflammation. |
2006-03-31 |
2023-08-12 |
Not clear |
| Tony Lefebvre, Céline Guinez, Vanessa Dehennaut, Olivia Beseme-Dekeyser, Willy Morelle, Jean-Claude Michalsk. Does O-GlcNAc play a role in neurodegenerative diseases? Expert review of proteomics. vol 2. issue 2. 2006-03-30. PMID:15892570. |
several neuronal proteins have been identified as being modified with o-glcnac; these proteins could form part of the inclusion bodies found, for example, in the most frequently observed neurologic disorder (i.e., alzheimer's disease; tau protein and beta-amyloid peptide are the well known aggregated proteins). |
2006-03-30 |
2023-08-12 |
Not clear |
| SeungYong Yoon, JungEun Choi, JuHee Yoon, Jae-Wan Huh, DongHou Ki. Okadaic acid induces JNK activation, bim overexpression and mitochondrial dysfunction in cultured rat cortical neurons. Neuroscience letters. vol 394. issue 3. 2006-03-30. PMID:16260088. |
apoptosis via tau phosphorylation has been implicated in the selective neuronal losses seen in alzheimer's disease (ad). |
2006-03-30 |
2023-08-12 |
rat |
| Daniela C Glatz, Dan Rujescu, Yesheng Tang, Frank J Berendt, Annette M Hartmann, Frank Faltraco, Carlyn Rosenberg, Christine Hulette, Kurt Jellinger, Harald Hampel, Peter Riederer, Hans-J Möller, Athena Andreadis, Kerstin Henkel, Stefan Stam. The alternative splicing of tau exon 10 and its regulatory proteins CLK2 and TRA2-BETA1 changes in sporadic Alzheimer's disease. Journal of neurochemistry. vol 96. issue 3. 2006-03-30. PMID:16371011. |
the alternative splicing of tau exon 10 and its regulatory proteins clk2 and tra2-beta1 changes in sporadic alzheimer's disease. |
2006-03-30 |
2023-08-12 |
human |