| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jin-Tang Du, Yan-Mei Li, Qing-Feng Ma, Wei Qiang, Yu-Fen Zhao, Hiroshi Abe, Kenji Kanazawa, Xu-Rong Qin, Ryousuke Aoyagi, Yasuko Ishizuka, Tadashi Nemoto, Hiroshi Nakanish. Synthesis and conformational properties of phosphopeptides related to the human tau protein. Regulatory peptides. vol 130. issue 1-2. 2005-12-07. PMID:15869817. |
together, these structural changes indicate that phosphorylation may act as a conformational switch in the binding domain of tau protein to alter specificity and affinity of binding to microtubule, particularly in response to the abnormal phosphorylation events associated with alzheimer's disease. |
2005-12-07 |
2023-08-12 |
human |
| Katarina Soltys, Gabriela Rolkova, Lubica Vechterova, Peter Filipcik, Norbert Zilka, Eva Kontsekova, Michal Nova. First insert of tau protein is present in all stages of tau pathology in Alzheimer's disease. Neuroreport. vol 16. issue 15. 2005-12-01. PMID:16189476. |
first insert of tau protein is present in all stages of tau pathology in alzheimer's disease. |
2005-12-01 |
2023-08-12 |
mouse |
| Katarina Soltys, Gabriela Rolkova, Lubica Vechterova, Peter Filipcik, Norbert Zilka, Eva Kontsekova, Michal Nova. First insert of tau protein is present in all stages of tau pathology in Alzheimer's disease. Neuroreport. vol 16. issue 15. 2005-12-01. PMID:16189476. |
immunohistochemical analysis of braak stages with novel antibody revealed the presence of tau aminoterminal n1 insert during evolution of neurofibrillary degeneration from early to late stages of alzheimer's disease. |
2005-12-01 |
2023-08-12 |
mouse |
| Alessandro Stefani, Sergio Bernardini, Marta Panella, Mariangela Pierantozzi, Marzia Nuccetelli, Giacomo Koch, Andrea Urbani, Angela Giordano, Alessandro Martorana, Antonio Orlacchio, Giorgio Federici, Giorgio Bernard. AD with subcortical white matter lesions and vascular dementia: CSF markers for differential diagnosis. Journal of the neurological sciences. vol 237. issue 1-2. 2005-11-30. PMID:15990115. |
we investigated whether the cerebrospinal fluid (csf) biomarkers beta-amyloid 1-42 (abeta1-42), total tau (t-tau) protein and tau protein phosphorylated at threonine 181 (p-tau181) could discriminate alzheimer's disease (ad) from vascular dementia (vd) patients. |
2005-11-30 |
2023-08-12 |
Not clear |
| Moeko Noguchi, Mitsuhiro Yoshita, Yasuko Matsumoto, Kenjiro Ono, Kazuo Iwasa, Masahito Yamad. Decreased beta-amyloid peptide42 in cerebrospinal fluid of patients with progressive supranuclear palsy and corticobasal degeneration. Journal of the neurological sciences. vol 237. issue 1-2. 2005-11-30. PMID:15992827. |
several previous studies have identified biochemical markers for alzheimer's disease (ad): cerebrospinal fluid (csf)-beta-amyloid peptide42 (csf-abeta42), csf-total tau protein (csf-tau) and csf-phosphorylated tau protein (csf-ptau). |
2005-11-30 |
2023-08-12 |
human |
| Christine Feyt, Pascal Kienlen-Campard, Karelle Leroy, Francisca N'Kuli, Pierre J Courtoy, Jean-Pierre Brion, Jean-Noël Octav. Lithium chloride increases the production of amyloid-beta peptide independently from its inhibition of glycogen synthase kinase 3. The Journal of biological chemistry. vol 280. issue 39. 2005-11-30. PMID:16014628. |
glycogen synthase kinase 3 (gsk3) is able to phosphorylate tau at many sites that are found to be phosphorylated in paired helical filaments in alzheimer disease. |
2005-11-30 |
2023-08-12 |
rat |
| Jin Hyeong Jhoo, Woong Yang Park, Ki Woong Kim, Kwang Hyuk Lee, Dong Young Lee, Jong Chul Youn, Il Han Choo, Jeong Sun Seo, Jong Inn Wo. Lack of association of cathepsin D genetic polymorphism with Alzheimer's disease in Koreans. Archives of gerontology and geriatrics. vol 41. issue 2. 2005-11-29. PMID:16085063. |
cathepsin d (catd) is a good candidate susceptibility marker for alzheimer's disease (ad), since it was found to be involved in the processing of the amyloid precursor protein and the formation of the hyperphosphorylated tau. |
2005-11-29 |
2023-08-12 |
Not clear |
| C-X Gong, F Liu, I Grundke-Iqbal, K Iqba. Post-translational modifications of tau protein in Alzheimer's disease. Journal of neural transmission (Vienna, Austria : 1996). vol 112. issue 6. 2005-11-22. PMID:15517432. |
post-translational modifications of tau protein in alzheimer's disease. |
2005-11-22 |
2023-08-12 |
Not clear |
| C-X Gong, F Liu, I Grundke-Iqbal, K Iqba. Post-translational modifications of tau protein in Alzheimer's disease. Journal of neural transmission (Vienna, Austria : 1996). vol 112. issue 6. 2005-11-22. PMID:15517432. |
microtubule-associated protein tau undergoes several post-translational modifications and aggregates into paired helical filaments (phfs) in alzheimer's disease (ad) and other tauopathies. |
2005-11-22 |
2023-08-12 |
Not clear |
| Qing-Feng Ma, Yan-Mei Li, Jin-Tang Du, Kenji Kanazawa, Tadashi Nemoto, Hiroshi Nakanishi, Yu-Fen Zha. Binding of copper (II) ion to an Alzheimer's tau peptide as revealed by MALDI-TOF MS, CD, and NMR. Biopolymers. vol 79. issue 2. 2005-11-22. PMID:15986501. |
binding of copper (ii) ion to an alzheimer's tau peptide as revealed by maldi-tof ms, cd, and nmr. |
2005-11-22 |
2023-08-12 |
human |
| Qing-Feng Ma, Yan-Mei Li, Jin-Tang Du, Kenji Kanazawa, Tadashi Nemoto, Hiroshi Nakanishi, Yu-Fen Zha. Binding of copper (II) ion to an Alzheimer's tau peptide as revealed by MALDI-TOF MS, CD, and NMR. Biopolymers. vol 79. issue 2. 2005-11-22. PMID:15986501. |
the tau protein plays an important role in some neurodegenerative diseases including alzheimer's disease (ad). |
2005-11-22 |
2023-08-12 |
human |
| W Härtig, M Oklejewicz, A M Strijkstra, A S Boerema, J Stieler, T Arend. Phosphorylation of the tau protein sequence 199-205 in the hippocampal CA3 region of Syrian hamsters in adulthood and during aging. Brain research. vol 1056. issue 1. 2005-11-21. PMID:16095576. |
paired helical filaments formed by the abnormally phosphorylated microtubule-associated tau are a main sign of alzheimer's disease and other neurodegenerative disorders. |
2005-11-21 |
2023-08-12 |
Not clear |
| Alexander Kurz, Matthias Riemenschneider, Anders Walli. Potential biological markers for cerebrovascular disease. International psychogeriatrics. vol 15 Suppl 1. 2005-11-15. PMID:16191223. |
among biochemical markers in the csf, tau protein, phospho-tau, and beta amyloid protein are helpful to differentiate vascular dementia from alzheimer's disease. |
2005-11-15 |
2023-08-12 |
Not clear |
| Carolyn A Rankin, Qian Sun, T Chris Gambli. Pseudo-phosphorylation of tau at Ser202 and Thr205 affects tau filament formation. Brain research. Molecular brain research. vol 138. issue 1. 2005-11-14. PMID:15913837. |
the microtubule-associated protein tau aggregates into insoluble filaments in numerous neurodegenerative diseases, most common of which is alzheimer's disease. |
2005-11-14 |
2023-08-12 |
Not clear |
| Carolyn A Rankin, Qian Sun, T Chris Gambli. Pseudo-phosphorylation of tau at Ser202 and Thr205 affects tau filament formation. Brain research. Molecular brain research. vol 138. issue 1. 2005-11-14. PMID:15913837. |
tau aggregation in alzheimer's disease appears to follow a continuum from soluble monomer to an end point of insoluble extracellular tangles with a strong correlation between the amount of fibrillar tau and dementia. |
2005-11-14 |
2023-08-12 |
Not clear |
| Irving E Vega, Li Cui, Josh A Propst, Michael L Hutton, Gloria Lee, Shu-Hui Ye. Increase in tau tyrosine phosphorylation correlates with the formation of tau aggregates. Brain research. Molecular brain research. vol 138. issue 2. 2005-11-14. PMID:15913839. |
mass spectrometry analyses of immunopurified brain tau proteins from jnpl3 and alzheimer's disease affected individual uncovered novel tau tyrosine-phosphorylated sites. |
2005-11-14 |
2023-08-12 |
mouse |
| David E Kang, Il Sang Yoon, Emanuela Repetto, Tracy Busse, Nader Yermian, Listya Ie, Edward H Ko. Presenilins mediate phosphatidylinositol 3-kinase/AKT and ERK activation via select signaling receptors. Selectivity of PS2 in platelet-derived growth factor signaling. The Journal of biological chemistry. vol 280. issue 36. 2005-11-08. PMID:16014629. |
in addition, it has been documented that ps1 positively regulates, whereas ps1 familial alzheimer disease mutations suppress, phosphatidylinositol 3-kinase (pi3k)/akt activation, a pathway known to inactivate glycogen synthase kinase-3 and reduce tau phosphorylation. |
2005-11-08 |
2023-08-12 |
cattle |
| George P Paraskevas, Elisabeth Kapaki, Ioannis Liappas, Ioulia Theotoka, Ioanna Mamali, Christos Zournas, Lefteris Lykoura. The diagnostic value of cerebrospinal fluid tau protein in dementing and nondementing neuropsychiatric disorders. Journal of geriatric psychiatry and neurology. vol 18. issue 3. 2005-11-08. PMID:16100106. |
cerebrospinal fluid (csf) total tau protein (taut) is increased in alzheimer's disease (ad) and may be of some help in the diagnostic work-up of demented patients. |
2005-11-08 |
2023-08-12 |
Not clear |
| Mihaela Necula, Carmen N Chirita, Jeff Kure. Cyanine dye N744 inhibits tau fibrillization by blocking filament extension: implications for the treatment of tauopathic neurodegenerative diseases. Biochemistry. vol 44. issue 30. 2005-11-07. PMID:16042400. |
tau fibrillization is a potential therapeutic target for alzheimer's and other neurodegenerative diseases. |
2005-11-07 |
2023-08-12 |
Not clear |
| Tom Vandebroek, Thomas Vanhelmont, Dick Terwel, Peter Borghgraef, Katleen Lemaire, Johan Snauwaert, Stefaan Wera, Fred Van Leuven, Joris Winderick. Identification and isolation of a hyperphosphorylated, conformationally changed intermediate of human protein tau expressed in yeast. Biochemistry. vol 44. issue 34. 2005-11-01. PMID:16114883. |
hyperphosphorylation and aggregation of protein tau are typical for neurodegenerative tauopathies, including alzheimer's disease (ad). |
2005-11-01 |
2023-08-12 |
human |