| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| K H Ash. Mechanisms of memory loss in Abeta and tau mouse models. Biochemical Society transactions. vol 33. issue Pt 4. 2005-12-14. PMID:16042551. |
the chief neuropathological changes during alzheimer's disease, namely neurofibrillary tangles and amyloid plaques, have helped us to determine which molecules to focus upon in the animal models, specifically abeta (amyloid beta) and tau. |
2005-12-14 |
2023-08-12 |
mouse |
| K H Ash. Mechanisms of memory loss in Abeta and tau mouse models. Biochemical Society transactions. vol 33. issue Pt 4. 2005-12-14. PMID:16042551. |
this paper presents my perspective on what we have learnt about mechanisms of memory loss from abeta and tau mouse models of alzheimer's disease. |
2005-12-14 |
2023-08-12 |
mouse |
| Toshiki Uchihara, Kuniaki Tsuchiya, Ayako Nakamura, Haruhiko Akiyam. Argyrophilic grains are not always argyrophilic--distinction from neurofibrillary tangles of diffuse neurofibrillary tangles with calcification revealed by comparison between Gallyas and Campbell-Switzer methods. Acta neuropathologica. vol 110. issue 2. 2005-12-13. PMID:15971055. |
pairs of mirror sections were triple-fluorolabeled with an anti-phf tau (at8) antibody, an anti-ubiquitin antibody and thiazin red (tr), a fluorochrome that identifies fibrillary structures such as nfts of alzheimer's disease (ad). |
2005-12-13 |
2023-08-12 |
Not clear |
| Jodie Newman, Robert A Rissman, Floyd Sarsoza, Ronald C Kim, Malcolm Dick, David A Bennett, Carl W Cotman, Troy T Rohn, Elizabeth Hea. Caspase-cleaved tau accumulation in neurodegenerative diseases associated with tau and alpha-synuclein pathology. Acta neuropathologica. vol 110. issue 2. 2005-12-13. PMID:15986225. |
alzheimer's disease (ad), pick's disease (pid), progressive supranuclear palsy (psp), corticobasal degeneration (cbd) and dementia with lewy bodies (dlb) are diseases associated with the accumulation of tau or alpha-synuclein. |
2005-12-13 |
2023-08-12 |
Not clear |
| Michel Goeder. Tau gene mutations and their effects. Movement disorders : official journal of the Movement Disorder Society. vol 20 Suppl 12. 2005-12-13. PMID:16092090. |
tau is the major component of the intracellular filamentous deposits that define a number of neurodegenerative diseases, including the largely sporadic alzheimer's disease, progressive supranuclear palsy, corticobasal degeneration, pick's disease, and argyrophilic grain disease, as well as the inherited frontotemporal dementia and parkinsonism linked to chromosome 17 (ftdp-17). |
2005-12-13 |
2023-08-12 |
Not clear |
| Shigeki Kuzuhara, Yasumasa Kokub. Atypical parkinsonism of Japan: amyotrophic lateral sclerosis-parkinsonism-dementia complex of the Kii peninsula of Japan (Muro disease): an update. Movement disorders : official journal of the Movement Disorder Society. vol 20 Suppl 12. 2005-12-13. PMID:16092099. |
western blot of tau protein showed three bands consisting of six tau isoforms, similar to those of alzheimer's disease. |
2005-12-13 |
2023-08-12 |
Not clear |
| Kiran Bhaskar, Shu-Hui Yen, Gloria Le. Disease-related modifications in tau affect the interaction between Fyn and Tau. The Journal of biological chemistry. vol 280. issue 42. 2005-12-13. PMID:16115884. |
microtubule-associated protein tau is the major component of the neurofibrillary tangles of alzheimer disease (ad) and is genetically linked to frontotemporal dementias (ftdp-17). |
2005-12-13 |
2023-08-12 |
mouse |
| José L Molinuevo, Luis Pintor, Josep M Peri, Alberto Lleó, Rafael Oliva, Teodor Marcos, Rafael Bles. Emotional reactions to predictive testing in Alzheimer's disease and other inherited dementias. American journal of Alzheimer's disease and other dementias. vol 20. issue 4. 2005-12-13. PMID:16136847. |
this work describes the reasons and emotional responses of healthy descendants after counseling for presenilin mutations in early-onset familial alzheimer's disease (eofad), tau mutations in familial frontotemporal dementia (ftd), and prion mutations in fatal familial insomnia (ffi). |
2005-12-13 |
2023-08-12 |
human |
| Jin-Tang Du, Yan-Mei Li, Qing-Feng Ma, Wei Qiang, Yu-Fen Zhao, Hiroshi Abe, Kenji Kanazawa, Xu-Rong Qin, Ryousuke Aoyagi, Yasuko Ishizuka, Tadashi Nemoto, Hiroshi Nakanish. Synthesis and conformational properties of phosphopeptides related to the human tau protein. Regulatory peptides. vol 130. issue 1-2. 2005-12-07. PMID:15869817. |
in the brains of alzheimer's disease patients, the tau protein dissociates from the axonal microtubule and abnormally aggregates to form a paired helical filament (phf). |
2005-12-07 |
2023-08-12 |
human |
| Jin-Tang Du, Yan-Mei Li, Qing-Feng Ma, Wei Qiang, Yu-Fen Zhao, Hiroshi Abe, Kenji Kanazawa, Xu-Rong Qin, Ryousuke Aoyagi, Yasuko Ishizuka, Tadashi Nemoto, Hiroshi Nakanish. Synthesis and conformational properties of phosphopeptides related to the human tau protein. Regulatory peptides. vol 130. issue 1-2. 2005-12-07. PMID:15869817. |
together, these structural changes indicate that phosphorylation may act as a conformational switch in the binding domain of tau protein to alter specificity and affinity of binding to microtubule, particularly in response to the abnormal phosphorylation events associated with alzheimer's disease. |
2005-12-07 |
2023-08-12 |
human |
| Katarina Soltys, Gabriela Rolkova, Lubica Vechterova, Peter Filipcik, Norbert Zilka, Eva Kontsekova, Michal Nova. First insert of tau protein is present in all stages of tau pathology in Alzheimer's disease. Neuroreport. vol 16. issue 15. 2005-12-01. PMID:16189476. |
first insert of tau protein is present in all stages of tau pathology in alzheimer's disease. |
2005-12-01 |
2023-08-12 |
mouse |
| Katarina Soltys, Gabriela Rolkova, Lubica Vechterova, Peter Filipcik, Norbert Zilka, Eva Kontsekova, Michal Nova. First insert of tau protein is present in all stages of tau pathology in Alzheimer's disease. Neuroreport. vol 16. issue 15. 2005-12-01. PMID:16189476. |
immunohistochemical analysis of braak stages with novel antibody revealed the presence of tau aminoterminal n1 insert during evolution of neurofibrillary degeneration from early to late stages of alzheimer's disease. |
2005-12-01 |
2023-08-12 |
mouse |
| Alessandro Stefani, Sergio Bernardini, Marta Panella, Mariangela Pierantozzi, Marzia Nuccetelli, Giacomo Koch, Andrea Urbani, Angela Giordano, Alessandro Martorana, Antonio Orlacchio, Giorgio Federici, Giorgio Bernard. AD with subcortical white matter lesions and vascular dementia: CSF markers for differential diagnosis. Journal of the neurological sciences. vol 237. issue 1-2. 2005-11-30. PMID:15990115. |
we investigated whether the cerebrospinal fluid (csf) biomarkers beta-amyloid 1-42 (abeta1-42), total tau (t-tau) protein and tau protein phosphorylated at threonine 181 (p-tau181) could discriminate alzheimer's disease (ad) from vascular dementia (vd) patients. |
2005-11-30 |
2023-08-12 |
Not clear |
| Moeko Noguchi, Mitsuhiro Yoshita, Yasuko Matsumoto, Kenjiro Ono, Kazuo Iwasa, Masahito Yamad. Decreased beta-amyloid peptide42 in cerebrospinal fluid of patients with progressive supranuclear palsy and corticobasal degeneration. Journal of the neurological sciences. vol 237. issue 1-2. 2005-11-30. PMID:15992827. |
several previous studies have identified biochemical markers for alzheimer's disease (ad): cerebrospinal fluid (csf)-beta-amyloid peptide42 (csf-abeta42), csf-total tau protein (csf-tau) and csf-phosphorylated tau protein (csf-ptau). |
2005-11-30 |
2023-08-12 |
human |
| Christine Feyt, Pascal Kienlen-Campard, Karelle Leroy, Francisca N'Kuli, Pierre J Courtoy, Jean-Pierre Brion, Jean-Noël Octav. Lithium chloride increases the production of amyloid-beta peptide independently from its inhibition of glycogen synthase kinase 3. The Journal of biological chemistry. vol 280. issue 39. 2005-11-30. PMID:16014628. |
glycogen synthase kinase 3 (gsk3) is able to phosphorylate tau at many sites that are found to be phosphorylated in paired helical filaments in alzheimer disease. |
2005-11-30 |
2023-08-12 |
rat |
| Jin Hyeong Jhoo, Woong Yang Park, Ki Woong Kim, Kwang Hyuk Lee, Dong Young Lee, Jong Chul Youn, Il Han Choo, Jeong Sun Seo, Jong Inn Wo. Lack of association of cathepsin D genetic polymorphism with Alzheimer's disease in Koreans. Archives of gerontology and geriatrics. vol 41. issue 2. 2005-11-29. PMID:16085063. |
cathepsin d (catd) is a good candidate susceptibility marker for alzheimer's disease (ad), since it was found to be involved in the processing of the amyloid precursor protein and the formation of the hyperphosphorylated tau. |
2005-11-29 |
2023-08-12 |
Not clear |
| C-X Gong, F Liu, I Grundke-Iqbal, K Iqba. Post-translational modifications of tau protein in Alzheimer's disease. Journal of neural transmission (Vienna, Austria : 1996). vol 112. issue 6. 2005-11-22. PMID:15517432. |
post-translational modifications of tau protein in alzheimer's disease. |
2005-11-22 |
2023-08-12 |
Not clear |
| C-X Gong, F Liu, I Grundke-Iqbal, K Iqba. Post-translational modifications of tau protein in Alzheimer's disease. Journal of neural transmission (Vienna, Austria : 1996). vol 112. issue 6. 2005-11-22. PMID:15517432. |
microtubule-associated protein tau undergoes several post-translational modifications and aggregates into paired helical filaments (phfs) in alzheimer's disease (ad) and other tauopathies. |
2005-11-22 |
2023-08-12 |
Not clear |
| Qing-Feng Ma, Yan-Mei Li, Jin-Tang Du, Kenji Kanazawa, Tadashi Nemoto, Hiroshi Nakanishi, Yu-Fen Zha. Binding of copper (II) ion to an Alzheimer's tau peptide as revealed by MALDI-TOF MS, CD, and NMR. Biopolymers. vol 79. issue 2. 2005-11-22. PMID:15986501. |
binding of copper (ii) ion to an alzheimer's tau peptide as revealed by maldi-tof ms, cd, and nmr. |
2005-11-22 |
2023-08-12 |
human |
| Qing-Feng Ma, Yan-Mei Li, Jin-Tang Du, Kenji Kanazawa, Tadashi Nemoto, Hiroshi Nakanishi, Yu-Fen Zha. Binding of copper (II) ion to an Alzheimer's tau peptide as revealed by MALDI-TOF MS, CD, and NMR. Biopolymers. vol 79. issue 2. 2005-11-22. PMID:15986501. |
the tau protein plays an important role in some neurodegenerative diseases including alzheimer's disease (ad). |
2005-11-22 |
2023-08-12 |
human |