All Relations between Alzheimer Disease and microtubule-associated protein tau

Publication Sentence Publish Date Extraction Date Species
Alyson L Peel, Noah Sorscher, Joseph Y Kim, Veronica Galvan, Sylvia Chen, Dale E Bredese. Tau phosphorylation in Alzheimer's disease: potential involvement of an APP-MAP kinase complex. Neuromolecular medicine. vol 5. issue 3. 2005-05-03. PMID:15626821. tau phosphorylation in alzheimer's disease: potential involvement of an app-map kinase complex. 2005-05-03 2023-08-12 Not clear
Neelima B Chauhan, George J Siegel, Douglas L Feinstei. Propentofylline attenuates tau hyperphosphorylation in Alzheimer's Swedish mutant model Tg2576. Neuropharmacology. vol 48. issue 1. 2005-04-28. PMID:15617731. propentofylline attenuates tau hyperphosphorylation in alzheimer's swedish mutant model tg2576. 2005-04-28 2023-08-12 mouse
Neelima B Chauhan, George J Siegel, Douglas L Feinstei. Propentofylline attenuates tau hyperphosphorylation in Alzheimer's Swedish mutant model Tg2576. Neuropharmacology. vol 48. issue 1. 2005-04-28. PMID:15617731. key pathological hallmarks of alzheimer's disease (ad) are the deposition of amyloid plaques containing abeta-peptides and the formation of neurofibrillary tangles containing hyperphosphorylated tau. 2005-04-28 2023-08-12 mouse
Li-Wen Ko, Toni Rush, Naruhiko Sahara, Jay S Kersh, Colin Easson, Michael Deture, Wen-Lang Lin, Yamicia D Connor, Shu-Hui C Ye. Assembly of filamentous tau aggregates in human neuronal cells. Journal of Alzheimer's disease : JAD. vol 6. issue 6. 2005-04-26. PMID:15665401. intraneuronal deposition of microtubule-associated protein tau in filamentous aggregates constitutes a pathological hallmark of neurofibrillary degeneration that is characteristic of alzheimer's disease (ad) and related disorders known collectively as tauopathies. 2005-04-26 2023-08-12 human
Mark A Lovell, Shuling Xiong, Chengsong Xie, Peter Davies, William R Markesber. Induction of hyperphosphorylated tau in primary rat cortical neuron cultures mediated by oxidative stress and glycogen synthase kinase-3. Journal of Alzheimer's disease : JAD. vol 6. issue 6. 2005-04-26. PMID:15665406. neurofibrillary tangles (nft) containing paired helical filaments (phf) composed of abnormally phosphorylated tau are one of the hallmark lesions of the alzheimer's disease (ad) brain. 2005-04-26 2023-08-12 rat
M Pérez, E Ribe, A Rubio, F Lim, M A Morán, P Gómez Ramos, I Ferrer, M T G Isla, J Avil. Characterization of a double (amyloid precursor protein-tau) transgenic: tau phosphorylation and aggregation. Neuroscience. vol 130. issue 2. 2005-04-25. PMID:15664690. also, they suggest that different types of tau filamentous polymers can occur in different mouse models for tauopathies, like those used for alzheimer's disease or ftdp-17. 2005-04-25 2023-08-12 mouse
Yi-Gang Che. Specific tau phosphorylation sites in hippocampus correlate with impairment of step-down inhibitory avoidance task in rats. Behavioural brain research. vol 158. issue 2. 2005-04-19. PMID:15698894. microtubule associated protein tau is abnormally phosphorylated in alzheimer's disease (ad) and aggregates as paired helical filaments (phfs) in neurofibrillary tangles (nfts), which are one of the pathological signatures of ad and their presence correlates with severity of dementia. 2005-04-19 2023-08-12 rat
Tetsuaki Arai, Jian-Ping Guo, Patrick L McGee. Proteolysis of non-phosphorylated and phosphorylated tau by thrombin. The Journal of biological chemistry. vol 280. issue 7. 2005-04-18. PMID:15542598. the microtubule-associated protein tau aggregates intracellularly by unknown mechanisms in alzheimer's disease and other tauopathies. 2005-04-18 2023-08-12 human
Tetsuaki Arai, Jian-Ping Guo, Patrick L McGee. Proteolysis of non-phosphorylated and phosphorylated tau by thrombin. The Journal of biological chemistry. vol 280. issue 7. 2005-04-18. PMID:15542598. furthermore, paired helical filament tau prepared from alzheimer's disease brain was more resistant to thrombin proteolysis than following dephosphorylation by alkaline phosphatase. 2005-04-18 2023-08-12 human
Ya-Li Zheng, Sashi Kesavapany, Maneth Gravell, Rebecca S Hamilton, Manfred Schubert, Niranjana Amin, Wayne Albers, Philip Grant, Harish C Pan. A Cdk5 inhibitory peptide reduces tau hyperphosphorylation and apoptosis in neurons. The EMBO journal. vol 24. issue 1. 2005-04-18. PMID:15592431. the extracellular aggregation of amyloid beta (abeta) peptides and the intracellular hyperphosphorylation of tau at specific epitopes are pathological hallmarks of neurodegenerative diseases such as alzheimer's disease (ad). 2005-04-18 2023-08-12 Not clear
Su Jeon Shin, Sung-Eun Lee, Jung Hyun Boo, Mihyang Kim, Young-Dae Yoon, Su-il Kim, Inhee Mook-Jun. Profiling proteins related to amyloid deposited brain of Tg2576 mice. Proteomics. vol 4. issue 11. 2005-04-13. PMID:15378736. alzheimer's disease (ad) is an age-related neurodegenerative disorder that is characterized by the extracellular deposition of beta-amyloid and intracellular hyperphosphorylation of tau in the cortex and hippocampus of the brain. 2005-04-13 2023-08-12 mouse
Fei Liu, Khalid Iqbal, Inge Grundke-Iqbal, Sandra Rossie, Cheng-Xin Gon. Dephosphorylation of tau by protein phosphatase 5: impairment in Alzheimer's disease. The Journal of biological chemistry. vol 280. issue 3. 2005-04-13. PMID:15546861. dephosphorylation of tau by protein phosphatase 5: impairment in alzheimer's disease. 2005-04-13 2023-08-12 human
Fei Liu, Khalid Iqbal, Inge Grundke-Iqbal, Sandra Rossie, Cheng-Xin Gon. Dephosphorylation of tau by protein phosphatase 5: impairment in Alzheimer's disease. The Journal of biological chemistry. vol 280. issue 3. 2005-04-13. PMID:15546861. pp5 dephosphorylated tau at all 12 alzheimer's disease (ad)-associated abnormal phosphorylation sites studied, with different efficiency toward each site. 2005-04-13 2023-08-12 human
David Eliezer, Patrick Barré, Muris Kobaslija, Dylan Chan, Xiaohua Li, Lauren Heen. Residual structure in the repeat domain of tau: echoes of microtubule binding and paired helical filament formation. Biochemistry. vol 44. issue 3. 2005-04-12. PMID:15654759. the microtubule-associated protein tau is found aggregated into paired helical filaments in the intraneuronal neurofibrillary tangle deposits of victims of alzheimer's disease (ad) and other related dementias. 2005-04-12 2023-08-12 Not clear
A Boldyrev, E Bulygina, A Makhr. Glutamate receptors modulate oxidative stress in neuronal cells. A mini-review. Neurotoxicity research. vol 6. issue 7-8. 2005-04-08. PMID:15639790. selective dysfunction of mglu ii receptors may also lead to abnormal protein phosphorylation (i.e., tau phosphorylation), culminating in neurodegenerative disorders (i.e., alzheimer disease). 2005-04-08 2023-08-12 human
Sayuri Taniguchi, Nobuyuki Suzuki, Masami Masuda, Shin-ichi Hisanaga, Takeshi Iwatsubo, Michel Goedert, Masato Hasegaw. Inhibition of heparin-induced tau filament formation by phenothiazines, polyphenols, and porphyrins. The Journal of biological chemistry. vol 280. issue 9. 2005-04-07. PMID:15611092. tau protein is the major component of the intraneuronal filamentous inclusions that constitute defining neuropathological characteristics of alzheimer's disease and other tauopathies. 2005-04-07 2023-08-12 Not clear
Peleg M Horowitz, Kristina R Patterson, Angela L Guillozet-Bongaarts, Matthew R Reynolds, Christopher A Carroll, Susan T Weintraub, David A Bennett, Vincent L Cryns, Robert W Berry, Lester I Binde. Early N-terminal changes and caspase-6 cleavage of tau in Alzheimer's disease. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 24. issue 36. 2005-04-05. PMID:15356202. early n-terminal changes and caspase-6 cleavage of tau in alzheimer's disease. 2005-04-05 2023-08-12 Not clear
Peleg M Horowitz, Kristina R Patterson, Angela L Guillozet-Bongaarts, Matthew R Reynolds, Christopher A Carroll, Susan T Weintraub, David A Bennett, Vincent L Cryns, Robert W Berry, Lester I Binde. Early N-terminal changes and caspase-6 cleavage of tau in Alzheimer's disease. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 24. issue 36. 2005-04-05. PMID:15356202. alzheimer's disease (ad) is a progressive amnestic dementia that involves post-translational hyperphosphorylation, enzymatic cleavage, and conformational alterations of the microtubule-associated protein tau. 2005-04-05 2023-08-12 Not clear
Peleg M Horowitz, Kristina R Patterson, Angela L Guillozet-Bongaarts, Matthew R Reynolds, Christopher A Carroll, Susan T Weintraub, David A Bennett, Vincent L Cryns, Robert W Berry, Lester I Binde. Early N-terminal changes and caspase-6 cleavage of tau in Alzheimer's disease. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 24. issue 36. 2005-04-05. PMID:15356202. collectively, these results suggest a role for caspase-6 and n-terminal truncation of tau during neurofibrillary tangle evolution and the progression of alzheimer's disease. 2005-04-05 2023-08-12 Not clear
Taizo Taniguchi, Miho Sumida, Shuko Hiraoka, Koji Tomoo, Tomoko Kakehi, Katsuhiko Minoura, Shigeru Sugiyama, Koji Inaka, Toshimasa Ishida, Naoaki Saito, Chikako Tanak. Effects of different anti-tau antibodies on tau fibrillogenesis: RTA-1 and RTA-2 counteract tau aggregation. FEBS letters. vol 579. issue 6. 2005-04-01. PMID:15733848. tau is the major antigenic component of neurofibrillary pathology in tauopathy, including alzheimer's disease. 2005-04-01 2023-08-12 Not clear