| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| I Ferrer, T Gomez-Isla, B Puig, M Freixes, E Ribé, E Dalfó, J Avil. Current advances on different kinases involved in tau phosphorylation, and implications in Alzheimer's disease and tauopathies. Current Alzheimer research. vol 2. issue 1. 2005-10-06. PMID:15977985. |
hyperphosphorylation and accumulation of tau in neurons (and glial cells) is one the main pathologic hallmarks in alzheimer's disease (ad) and other tauopathies, including pick's disease (pid), progressive supranuclear palsy, corticobasal degeneration, argyrophilic grain disease and familial frontotemporal dementia and parkinsonism linked to chromosome 17 due to mutations in the tau gene (ftdp-17-tau). |
2005-10-06 |
2023-08-12 |
mouse |
| Peter Klivenyi, Gabrielle Gardian, Noel Y Calingasan, Lichuan Yang, Reid von Borstel, Joel Saydoff, Susan E Browne, M Flint Bea. Neuroprotective effects of oral administration of triacetyluridine against MPTP neurotoxicity. Neuromolecular medicine. vol 6. issue 2-3. 2005-10-05. PMID:15970626. |
tau has previously been shown to be neuroprotective in animal models of huntington's and alzheimer's diseases. |
2005-10-05 |
2023-08-12 |
Not clear |
| Frank Gillardon, Peter Steinlein, Erich Bürger, Tobias Hildebrandt, Christopher Gerne. Phosphoproteome and transcriptome analysis of the neuronal response to a CDK5 inhibitor. Proteomics. vol 5. issue 5. 2005-09-30. PMID:15712243. |
in alzheimer's disease and amyotrophic lateral sclerosis deregulation of cyclin-dependent kinase 5 (cdk5) causes hyperphosphorylation of tau and neurofilament proteins, respectively, leading to neuronal cell death. |
2005-09-30 |
2023-08-12 |
Not clear |
| Xu Li, Irina Alafuzoff, Hilkka Soininen, Bengt Winblad, Jin-Jing Pe. Levels of mTOR and its downstream targets 4E-BP1, eEF2, and eEF2 kinase in relationships with tau in Alzheimer's disease brain. The FEBS journal. vol 272. issue 16. 2005-09-30. PMID:16098202. |
levels of mtor and its downstream targets 4e-bp1, eef2, and eef2 kinase in relationships with tau in alzheimer's disease brain. |
2005-09-30 |
2023-08-12 |
Not clear |
| Erin H Norris, Benoit I Giasso. Role of oxidative damage in protein aggregation associated with Parkinson's disease and related disorders. Antioxidants & redox signaling. vol 7. issue 5-6. 2005-09-27. PMID:15890012. |
it was reported recently that alpha-synuclein can induce the formation of filamentous tau inclusions, which are characteristic of disorders like alzheimer's disease and lewy body variant of alzheimer's disease, suggesting that a similar mechanism may exist between alpha-synuclein fibrillogenesis and tau polymerization. |
2005-09-27 |
2023-08-12 |
Not clear |
| Hyoung-Gon Lee, George Perry, Paula I Moreira, Matthew R Garrett, Quan Liu, Xiongwei Zhu, Atsushi Takeda, Akihiko Nunomura, Mark A Smit. Tau phosphorylation in Alzheimer's disease: pathogen or protector? Trends in molecular medicine. vol 11. issue 4. 2005-09-26. PMID:15823754. |
tau phosphorylation in alzheimer's disease: pathogen or protector? |
2005-09-26 |
2023-08-12 |
Not clear |
| Hyoung-Gon Lee, George Perry, Paula I Moreira, Matthew R Garrett, Quan Liu, Xiongwei Zhu, Atsushi Takeda, Akihiko Nunomura, Mark A Smit. Tau phosphorylation in Alzheimer's disease: pathogen or protector? Trends in molecular medicine. vol 11. issue 4. 2005-09-26. PMID:15823754. |
as such, in alzheimer's disease, phosphorylated tau protein, the major component of neurofibrillary tangles, is considered a central mediator of disease pathogenesis. |
2005-09-26 |
2023-08-12 |
Not clear |
| Frank M LaFerla, Salvatore Odd. Alzheimer's disease: Abeta, tau and synaptic dysfunction. Trends in molecular medicine. vol 11. issue 4. 2005-09-26. PMID:15823755. |
alzheimer's disease: abeta, tau and synaptic dysfunction. |
2005-09-26 |
2023-08-12 |
mouse |
| Rong Liu, Jin-Jing Pei, Xiao-Chuan Wang, Xin-Wen Zhou, Qing Tian, Bengt Winblad, Jian-Zhi Wan. Acute anoxia induces tau dephosphorylation in rat brain slices and its possible underlying mechanisms. Journal of neurochemistry. vol 94. issue 5. 2005-09-22. PMID:15992372. |
abnormal phosphorylation of microtubule-associated protein tau plays a critical role in alzheimer's disease (ad), together with a distinct decrease of energy metabolism in the affected brain regions. |
2005-09-22 |
2023-08-12 |
rat |
| Hideyuki Yamamoto, Yukari Hiragami, Miyuki Murayama, Koko Ishizuka, Masahiro Kawahara, Akihiko Takashim. Phosphorylation of tau at serine 416 by Ca2+/calmodulin-dependent protein kinase II in neuronal soma in brain. Journal of neurochemistry. vol 94. issue 5. 2005-09-22. PMID:16000144. |
interestingly, tau in neuronal soma in alzheimer's disease (ad) brain was strongly immunostained by the antibody. |
2005-09-22 |
2023-08-12 |
human |
| Naruhiko Sahara, Miyuki Murayama, Tatsuya Mizoroki, Makoto Urushitani, Yuzuru Imai, Ryosuke Takahashi, Shigeo Murata, Keiji Tanaka, Akihiko Takashim. In vivo evidence of CHIP up-regulation attenuating tau aggregation. Journal of neurochemistry. vol 94. issue 5. 2005-09-22. PMID:16111477. |
ubiquitinated tau is one component in neurofibrillary tangles (nfts), which are a major histopathological feature of alzheimer's disease (ad). |
2005-09-22 |
2023-08-12 |
mouse |
| Toshiki Uchihara, Charles Duyckaerts, Danielle Seilhean, Ayako Nakamura, Françoise Lazarini, Jean-Jacques Hau. Exclusive induction of tau2 epitope in microglia/macrophages in inflammatory lesions-tautwopathy distinct from degenerative tauopathies. Acta neuropathologica. vol 109. issue 2. 2005-09-21. PMID:15549333. |
tau2 antibody recognizes a phosphorylation-independent epitope that is pathologically modified as tau protein is phosphorylated to form neurofibrillary tangles of alzheimer's disease (ad). |
2005-09-21 |
2023-08-12 |
human |
| J W Connell, T Rodriguez-Martin, G M Gibb, N M Kahn, A J Grierson, D P Hanger, T Revesz, P L Lantos, B H Anderton, J-M Gall. Quantitative analysis of tau isoform transcripts in sporadic tauopathies. Brain research. Molecular brain research. vol 137. issue 1-2. 2005-09-19. PMID:15950767. |
a number of neurodegenerative diseases, including alzheimer's disease (ad), are characterized by intraneuronal accumulation of the tau protein. |
2005-09-19 |
2023-08-12 |
Not clear |
| Robyn A Halverson, Jada Lewis, Shanti Frausto, Mike Hutton, Nancy A Mum. Tau protein is cross-linked by transglutaminase in P301L tau transgenic mice. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 25. issue 5. 2005-09-13. PMID:15689560. |
several lines of evidence suggest that transglutaminase may cross-link tau into stable, insoluble aggregates, leading to the formation of nfts in alzheimer's disease and progressive supranuclear palsy. |
2005-09-13 |
2023-08-12 |
mouse |
| Robyn A Halverson, Jada Lewis, Shanti Frausto, Mike Hutton, Nancy A Mum. Tau protein is cross-linked by transglutaminase in P301L tau transgenic mice. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 25. issue 5. 2005-09-13. PMID:15689560. |
cross-linked, phosphorylated tau from p301l tau transgenic mice runs as high-molecular mass aggregates on western blots, similar to cross-linked tau from paired helical filaments of alzheimer's disease. |
2005-09-13 |
2023-08-12 |
mouse |
| Clive Ballard, Christopher Morris, Rajesh Kalaria, Ian McKeith, Robert Perry, Elaine Perr. The k variant of the butyrylcholinesterase gene is associated with reduced phosphorylation of tau in dementia patients. Dementia and geriatric cognitive disorders. vol 19. issue 5-6. 2005-09-01. PMID:15802910. |
we examined the relationship between the k variant of buche and the severity of deposits of amyloid (abeta(1-42)) and phosphorylated tau in the temporal cortex (ba36) of 30 prospectively studied autopsy-diagnosed dementia (alzheimer's disease and dementia with lewy bodies) patients. |
2005-09-01 |
2023-08-12 |
Not clear |
| Guo-Gang Xu, Yan-Qiu Deng, Shi-Jie Liu, Hong-Lian Li, Jian-Zhi Wan. Prolonged Alzheimer-like tau hyperphosphorylation induced by simultaneous inhibition of phosphoinositol-3 kinase and protein kinase C in N2a cells. Acta biochimica et biophysica Sinica. vol 37. issue 5. 2005-08-23. PMID:15880264. |
we conclude that the simultaneous inhibition of pi3k and pkc can induce gsk-3 overactivation, and further strengthen and prolong the alzheimer-like tau hyperphosphorylation in n2a cells, suggesting the establishment of a cell model with early pathological events of alzheimer's disease. |
2005-08-23 |
2023-08-12 |
rat |
| J P Jia, R Meng, Y X Sun, W J Sun, X M Ji, L F Ji. Cerebrospinal fluid tau, Abeta1-42 and inflammatory cytokines in patients with Alzheimer's disease and vascular dementia. Neuroscience letters. vol 383. issue 1-2. 2005-08-22. PMID:15936505. |
cerebrospinal fluid tau, abeta1-42 and inflammatory cytokines in patients with alzheimer's disease and vascular dementia. |
2005-08-22 |
2023-08-12 |
Not clear |
| J P Jia, R Meng, Y X Sun, W J Sun, X M Ji, L F Ji. Cerebrospinal fluid tau, Abeta1-42 and inflammatory cytokines in patients with Alzheimer's disease and vascular dementia. Neuroscience letters. vol 383. issue 1-2. 2005-08-22. PMID:15936505. |
in this study we aimed to evaluate the possibility of using cerebrospinal fluid (csf) tau, abeta(1-42) and inflammatory cytokines for diagnosis of alzheimer's disease (ad) and vascular dementia (vd). |
2005-08-22 |
2023-08-12 |
Not clear |
| Marco D Mukrasch, Jacek Biernat, Martin von Bergen, Christian Griesinger, Eckhard Mandelkow, Markus Zweckstette. Sites of tau important for aggregation populate {beta}-structure and bind to microtubules and polyanions. The Journal of biological chemistry. vol 280. issue 26. 2005-08-16. PMID:15855160. |
the aggregation of the microtubule-associated tau protein and formation of "neurofibrillary tangles" is one of the hallmarks of alzheimer disease. |
2005-08-16 |
2023-08-12 |
Not clear |