All Relations between Alzheimer Disease and microtubule-associated protein tau

Publication Sentence Publish Date Extraction Date Species
b' Daniel Alcolea, Michal Schnaider Beeri, Julio C Rojas, Raquel C Gardner, Alberto Lle\\xc3\\xb. Blood Biomarkers in Neurodegenerative Diseases: Implications for the Clinical Neurologist. Neurology. 2023-03-06. PMID:36878698.' currently, research studies have reported robust assays of blood markers for the detection of amyloid and tau pathologies specific to alzheimer's disease (aß peptides, p-tau), as well as non-specific blood markers of neuronal (neurofilament light, ß-synuclein, ubiquitin-c-terminal-hydrolase-l1) and glial degeneration (glial fibrillary acidic protein) that can measure key pathophysiological processes in several neurodegenerative diseases. 2023-03-06 2023-08-14 Not clear
Andreia Ferreira, Evy Timmerman, An Staes, Marnik Vuylsteke, Louis De Muynck, Kris Gevaer. Protein interactors of 3-O sulfated heparan sulfates in human MCI and age-matched control cerebrospinal fluid. Scientific data. vol 10. issue 1. 2023-03-06. PMID:36879013. 3-o sulfated hs (3s-hs) play a role in several (patho)physiological processes such as blood coagulation, viral pathogenesis and binding and internalization of tau in alzheimer's disease. 2023-03-06 2023-08-14 human
John P Seibyl, Jonathan M DuBois, Annie Racine, Jessica Collins, Qi Guo, Dustin Wooten, Eddie Stage, David Cheng, Roger N Gunn, Lilly Porat, Alex Whittington, Phillip H Kuo, Masanori Ichise, Robert Comley, Laurent Martarello, Cristian Salina. A Visual Interpretation Algorithm for Assessing Brain Tauopathy with Journal of nuclear medicine : official publication, Society of Nuclear Medicine. vol 64. issue 3. 2023-03-06. PMID:36175137. a visual interpretation algorithm for assessing brain tauopathy with in vivo characterization of pathologic deposition of tau protein in the human brain by pet imaging is a promising tool in drug development trials of alzheimer disease (ad). 2023-03-06 2023-09-07 human
Julien Bensalem, Leanne K Hein, Sofia Hassiotis, Paul J Trim, Christopher G Proud, Leonie K Heilbronn, Timothy J Sargean. Modifying dietary protein impacts mTOR signaling and brain deposition of amyloid beta in a knock-in mouse model of Alzheimer's disease. The Journal of nutrition. 2023-03-04. PMID:36870538. alzheimer's disease (ad) is a neurodegenerative condition defined by the build-up of amyloid plaques in the brain and intraneuronal tangles of the protein tau. 2023-03-04 2023-08-14 mouse
Cailin Wang, Yanmin Chang, Jiahui Zhu, Yanqing Wu, Xingjun Jiang, Siyi Zheng, Gang Li, Rong M. AdipoRon mitigates tau pathology and restores mitochondrial dynamics via AMPK-related pathway in a mouse model of Alzheimer's disease. Experimental neurology. 2023-03-03. PMID:36868546. adiporon mitigates tau pathology and restores mitochondrial dynamics via ampk-related pathway in a mouse model of alzheimer's disease. 2023-03-03 2023-08-14 mouse
Ergina Vourkou, Eva D Rouiz Ortega, Sumeet Mahajan, Amrit Mudher, Efthimios Mc Skoulaki. Human Tau aggregates are permissive to Protein Synthesis Dependent Memory in Drosophila Tauopathy models. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2023-03-03. PMID:36868851. tauopathies including alzheimer's disease, are characterized by progressive cognitive decline, neurodegeneration and intraneuronal aggregates comprised largely of the axonal protein tau. 2023-03-03 2023-08-14 human
Kimberly L Fiock, Ryan K Betters, Marco M Heft. Thioflavin S Staining and Amyloid Formation Are Unique to Mixed Tauopathies. The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society. 2023-03-02. PMID:36861683. tau phosphorylation, aggregation, and toxicity are the main drivers of neurodegeneration in multiple tauopathies, including alzheimer's disease (ad) and frontotemporal lobar degeneration with tau. 2023-03-02 2023-08-14 Not clear
Vikas Kotari, Sudeepti Southekal, Michael Navitsky, Ian A Kennedy, Ming Lu, Amanda Morris, Jennifer Ann Zimmer, Adam S Fleisher, Mark A Mintun, Michael D Devous, Michael J Pontecorv. Early tau detection in flortaucipir images: validation in autopsy-confirmed data and implications for disease progression. Alzheimer's research & therapy. vol 15. issue 1. 2023-03-01. PMID:36855201. there is an increasing interest in utilizing tau pet to identify patients early in alzheimer's disease (ad). 2023-03-01 2023-08-14 Not clear
Kyle R Christensen, Benjamin Combs, Collin Richards, Tessa Grabinski, Mohammed M Alhadidy, Nicholas M Kanaa. Phosphomimetics at Ser199/Ser202/Thr205 in Tau Impairs Axonal Transport in Rat Hippocampal Neurons. Molecular neurobiology. 2023-03-01. PMID:36859689. our understanding of the biological functions of the tau protein now includes its role as a scaffolding protein involved in signaling regulation, which also has implications for tau-mediated dysfunction and degeneration in alzheimer's disease and other tauopathies. 2023-03-01 2023-08-14 rat
Rahul Sharma, Prema Mondal, Srinivasa M Srinivasul. CARPs regulate STUB1 and its pathogenic mutants aggregation kinetics by mono-ubiquitination. The FEBS journal. 2023-02-28. PMID:36853170. the development of neurological pathologies is linked to the accumulation of protein aggregates like alpha-synuclein in parkinson's disease and tau protein in alzheimer's disease. 2023-02-28 2023-08-14 Not clear
Kanta Horie, Yan Li, Nicolas R Barthélemy, Brian A Gordon, Jason Hassenstab, Tammie L S Benzinger, Anne M Fagan, John C Morris, Celeste M Karch, Chengjie Xiong, Ricardo Allegri, Patricio Chrem Mendez, Takeshi Ikeuchi, Kensaku Kasuga, James Noble, Martin Farlow, Jasmeer Chhatwal, Gregory S Day, Peter R Schofield, Colin L Masters, Johannes Levin, Mathias Jucker, Jae-Hong Lee, Jee Hoon Roh, Chihiro Sato, Pallavi Sachdev, Akihiko Koyama, Larisa Reyderman, Randall J Bateman, Eric McDad. Change in cerebrospinal fluid tau microtubule binding region detects symptom onset, cognitive decline, tangles, and atrophy in Dominantly Inherited Alzheimer's Disease. Annals of neurology. 2023-02-27. PMID:36843330. change in cerebrospinal fluid tau microtubule binding region detects symptom onset, cognitive decline, tangles, and atrophy in dominantly inherited alzheimer's disease. 2023-02-27 2023-08-14 Not clear
Kanta Horie, Yan Li, Nicolas R Barthélemy, Brian A Gordon, Jason Hassenstab, Tammie L S Benzinger, Anne M Fagan, John C Morris, Celeste M Karch, Chengjie Xiong, Ricardo Allegri, Patricio Chrem Mendez, Takeshi Ikeuchi, Kensaku Kasuga, James Noble, Martin Farlow, Jasmeer Chhatwal, Gregory S Day, Peter R Schofield, Colin L Masters, Johannes Levin, Mathias Jucker, Jae-Hong Lee, Jee Hoon Roh, Chihiro Sato, Pallavi Sachdev, Akihiko Koyama, Larisa Reyderman, Randall J Bateman, Eric McDad. Change in cerebrospinal fluid tau microtubule binding region detects symptom onset, cognitive decline, tangles, and atrophy in Dominantly Inherited Alzheimer's Disease. Annals of neurology. 2023-02-27. PMID:36843330. identifying cerebrospinal fluid measures of the microtubule binding region of tau (mtbr-tau) species that reflect tau aggregation could provide fluid biomarkers that track alzheimer disease related neurofibrillary tau pathological changes. 2023-02-27 2023-08-14 Not clear
Qi Qiu, Xia Lei, Yueying Wang, Hui Xiong, Yanming Xu, Huifeng Sun, Hongdan Xu, Ning Zhan. Naringin Protects against Tau Hyperphosphorylation in A Behavioural neurology. vol 2023. 2023-02-27. PMID:36844418. naringin protects against tau hyperphosphorylation in a alzheimer's disease (ad) is the most common form of dementia and a significant social and economic burden. 2023-02-27 2023-08-14 Not clear
Christian F Pantoja, Alain Ibáñez de Opakua, Maria-Sol Cima-Omori, Markus Zweckstette. Determining the Physico-Chemical Composition of Biomolecular Condensates from Spatially-Resolved NMR. Angewandte Chemie (International ed. in English). 2023-02-27. PMID:36847235. application of spatially-resolved nmr to condensates formed by the alzheimer's disease-associated protein tau demonstrates decreased water content, exclusion of the molecular crowding agent dextran, presence of a specific chemical environment of the small molecule dss, and ~150-fold increased concentration of tau inside the condensate. 2023-02-27 2023-08-14 Not clear
Hiromitsu Tanaka, Hiroaki Matsushita, Keizo Tokuhiro, Atsushi Fukunari, Yukio And. Ingestion of Soybean Sprouts Containing a HASPIN Inhibitor Improves Condition in a Mouse Model of Alzheimer's Disease. Biology. vol 12. issue 2. 2023-02-25. PMID:36829593. therefore, research into the regulation of tau protein phosphorylation is important for understanding alzheimer's disease. 2023-02-25 2023-08-14 mouse
Hiromitsu Tanaka, Hiroaki Matsushita, Keizo Tokuhiro, Atsushi Fukunari, Yukio And. Ingestion of Soybean Sprouts Containing a HASPIN Inhibitor Improves Condition in a Mouse Model of Alzheimer's Disease. Biology. vol 12. issue 2. 2023-02-25. PMID:36829593. to examine whether haspin is involved in the onset of alzheimer's disease through tau protein phosphorylation, we investigated the effects of a diet including soybean sprouts rich in the haspin inhibitor coumestrol in a mouse model of alzheimer's disease (5xfad). 2023-02-25 2023-08-14 mouse
Hiromitsu Tanaka, Hiroaki Matsushita, Keizo Tokuhiro, Atsushi Fukunari, Yukio And. Ingestion of Soybean Sprouts Containing a HASPIN Inhibitor Improves Condition in a Mouse Model of Alzheimer's Disease. Biology. vol 12. issue 2. 2023-02-25. PMID:36829593. these results indicate that haspin may be one of the target molecules for the repression of tau phosphorylation in the treatment of alzheimer's disease. 2023-02-25 2023-08-14 mouse
Eisuke Muto, Toshio Okada, Tsuyoshi Yamanaka, Hiroyuki Uchino, Masato Inaz. Licochalcone E, a β-Amyloid Aggregation Inhibitor, Regulates Microglial M1/M2 Polarization via Inhibition of CTL1-Mediated Choline Uptake. Biomolecules. vol 13. issue 2. 2023-02-25. PMID:36830561. alzheimer's disease (ad) is thought to be a series of neuroinflammatory diseases caused by abnormal deposits of amyloid-β (aβ) and tau protein in the brain as part of its etiology. 2023-02-25 2023-08-14 mouse
Zheng-Kui Weng, Te-Hsien Lin, Kuo-Hsuan Chang, Ya-Jen Chiu, Chih-Hsin Lin, Pei-Hsuan Tseng, Ying-Chieh Sun, Wenwei Lin, Guey-Jen Lee-Chen, Chiung-Mei Che. Using ΔK280 Tau Biomolecules. vol 13. issue 2. 2023-02-25. PMID:36830589. using Δk280 tau misfolded aggregation of the hyperphosphorylated microtubule binding protein tau in the brain is a pathological hallmark of alzheimer's disease (ad). 2023-02-25 2023-08-14 human
Zohreh Mohammadi, Hadi Alizadeh, János Marton, Paul Cummin. The Sensitivity of Tau Tracers for the Discrimination of Alzheimer's Disease Patients and Healthy Controls by PET. Biomolecules. vol 13. issue 2. 2023-02-25. PMID:36830659. the sensitivity of tau tracers for the discrimination of alzheimer's disease patients and healthy controls by pet. 2023-02-25 2023-08-14 Not clear