| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Nicholas J Ashton, Marion Moseby-Knappe, Andrea L Benedet, Lana Grötschel, Juan Lantero-Rodriguez, Thomas K Karikari, Christian Hassager, Matt P Wise, Pascal Stammet, Jesper Kjaergaard, Hans Friberg, Niklas Nielsen, Tobias Cronberg, Henrik Zetterberg, Kaj Blenno. Alzheimer Disease Blood Biomarkers in Patients With Out-of-Hospital Cardiac Arrest. JAMA neurology. 2023-03-06. PMID:36877496. |
blood phosphorylated tau (p-tau) and amyloid-β peptides (aβ) are promising peripheral biomarkers of alzheimer disease (ad) pathology. |
2023-03-06 |
2023-08-14 |
Not clear |
| Takuya Murata, Genta Ito, Naoko Utsunomiya-Tat. Site-specific amino acid D-isomerization of Tau R2 and R3 peptides changes the fibril morphology, resulting in attenuation of Tau aggregation inhibitor potency. Biochemical and biophysical research communications. vol 654. 2023-03-06. PMID:36878036. |
tau, a microtubule-binding protein, is a major component of neurofibrillary tangles in the brains of alzheimer's disease patients. |
2023-03-06 |
2023-08-14 |
Not clear |
| Takuya Murata, Genta Ito, Naoko Utsunomiya-Tat. Site-specific amino acid D-isomerization of Tau R2 and R3 peptides changes the fibril morphology, resulting in attenuation of Tau aggregation inhibitor potency. Biochemical and biophysical research communications. vol 654. 2023-03-06. PMID:36878036. |
tau aggregation following fibril formation induces alzheimer's disease pathogenesis. |
2023-03-06 |
2023-08-14 |
Not clear |
| b' Daniel Alcolea, Michal Schnaider Beeri, Julio C Rojas, Raquel C Gardner, Alberto Lle\\xc3\\xb. Blood Biomarkers in Neurodegenerative Diseases: Implications for the Clinical Neurologist. Neurology. 2023-03-06. PMID:36878698.' |
currently, research studies have reported robust assays of blood markers for the detection of amyloid and tau pathologies specific to alzheimer's disease (aß peptides, p-tau), as well as non-specific blood markers of neuronal (neurofilament light, ß-synuclein, ubiquitin-c-terminal-hydrolase-l1) and glial degeneration (glial fibrillary acidic protein) that can measure key pathophysiological processes in several neurodegenerative diseases. |
2023-03-06 |
2023-08-14 |
Not clear |
| Andreia Ferreira, Evy Timmerman, An Staes, Marnik Vuylsteke, Louis De Muynck, Kris Gevaer. Protein interactors of 3-O sulfated heparan sulfates in human MCI and age-matched control cerebrospinal fluid. Scientific data. vol 10. issue 1. 2023-03-06. PMID:36879013. |
3-o sulfated hs (3s-hs) play a role in several (patho)physiological processes such as blood coagulation, viral pathogenesis and binding and internalization of tau in alzheimer's disease. |
2023-03-06 |
2023-08-14 |
human |
| John P Seibyl, Jonathan M DuBois, Annie Racine, Jessica Collins, Qi Guo, Dustin Wooten, Eddie Stage, David Cheng, Roger N Gunn, Lilly Porat, Alex Whittington, Phillip H Kuo, Masanori Ichise, Robert Comley, Laurent Martarello, Cristian Salina. A Visual Interpretation Algorithm for Assessing Brain Tauopathy with Journal of nuclear medicine : official publication, Society of Nuclear Medicine. vol 64. issue 3. 2023-03-06. PMID:36175137. |
a visual interpretation algorithm for assessing brain tauopathy with in vivo characterization of pathologic deposition of tau protein in the human brain by pet imaging is a promising tool in drug development trials of alzheimer disease (ad). |
2023-03-06 |
2023-09-07 |
human |
| Julien Bensalem, Leanne K Hein, Sofia Hassiotis, Paul J Trim, Christopher G Proud, Leonie K Heilbronn, Timothy J Sargean. Modifying dietary protein impacts mTOR signaling and brain deposition of amyloid beta in a knock-in mouse model of Alzheimer's disease. The Journal of nutrition. 2023-03-04. PMID:36870538. |
alzheimer's disease (ad) is a neurodegenerative condition defined by the build-up of amyloid plaques in the brain and intraneuronal tangles of the protein tau. |
2023-03-04 |
2023-08-14 |
mouse |
| Cailin Wang, Yanmin Chang, Jiahui Zhu, Yanqing Wu, Xingjun Jiang, Siyi Zheng, Gang Li, Rong M. AdipoRon mitigates tau pathology and restores mitochondrial dynamics via AMPK-related pathway in a mouse model of Alzheimer's disease. Experimental neurology. 2023-03-03. PMID:36868546. |
adiporon mitigates tau pathology and restores mitochondrial dynamics via ampk-related pathway in a mouse model of alzheimer's disease. |
2023-03-03 |
2023-08-14 |
mouse |
| Ergina Vourkou, Eva D Rouiz Ortega, Sumeet Mahajan, Amrit Mudher, Efthimios Mc Skoulaki. Human Tau aggregates are permissive to Protein Synthesis Dependent Memory in Drosophila Tauopathy models. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2023-03-03. PMID:36868851. |
tauopathies including alzheimer's disease, are characterized by progressive cognitive decline, neurodegeneration and intraneuronal aggregates comprised largely of the axonal protein tau. |
2023-03-03 |
2023-08-14 |
human |
| Kimberly L Fiock, Ryan K Betters, Marco M Heft. Thioflavin S Staining and Amyloid Formation Are Unique to Mixed Tauopathies. The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society. 2023-03-02. PMID:36861683. |
tau phosphorylation, aggregation, and toxicity are the main drivers of neurodegeneration in multiple tauopathies, including alzheimer's disease (ad) and frontotemporal lobar degeneration with tau. |
2023-03-02 |
2023-08-14 |
Not clear |
| Vikas Kotari, Sudeepti Southekal, Michael Navitsky, Ian A Kennedy, Ming Lu, Amanda Morris, Jennifer Ann Zimmer, Adam S Fleisher, Mark A Mintun, Michael D Devous, Michael J Pontecorv. Early tau detection in flortaucipir images: validation in autopsy-confirmed data and implications for disease progression. Alzheimer's research & therapy. vol 15. issue 1. 2023-03-01. PMID:36855201. |
there is an increasing interest in utilizing tau pet to identify patients early in alzheimer's disease (ad). |
2023-03-01 |
2023-08-14 |
Not clear |
| Kyle R Christensen, Benjamin Combs, Collin Richards, Tessa Grabinski, Mohammed M Alhadidy, Nicholas M Kanaa. Phosphomimetics at Ser199/Ser202/Thr205 in Tau Impairs Axonal Transport in Rat Hippocampal Neurons. Molecular neurobiology. 2023-03-01. PMID:36859689. |
our understanding of the biological functions of the tau protein now includes its role as a scaffolding protein involved in signaling regulation, which also has implications for tau-mediated dysfunction and degeneration in alzheimer's disease and other tauopathies. |
2023-03-01 |
2023-08-14 |
rat |
| Rahul Sharma, Prema Mondal, Srinivasa M Srinivasul. CARPs regulate STUB1 and its pathogenic mutants aggregation kinetics by mono-ubiquitination. The FEBS journal. 2023-02-28. PMID:36853170. |
the development of neurological pathologies is linked to the accumulation of protein aggregates like alpha-synuclein in parkinson's disease and tau protein in alzheimer's disease. |
2023-02-28 |
2023-08-14 |
Not clear |
| Kanta Horie, Yan Li, Nicolas R Barthélemy, Brian A Gordon, Jason Hassenstab, Tammie L S Benzinger, Anne M Fagan, John C Morris, Celeste M Karch, Chengjie Xiong, Ricardo Allegri, Patricio Chrem Mendez, Takeshi Ikeuchi, Kensaku Kasuga, James Noble, Martin Farlow, Jasmeer Chhatwal, Gregory S Day, Peter R Schofield, Colin L Masters, Johannes Levin, Mathias Jucker, Jae-Hong Lee, Jee Hoon Roh, Chihiro Sato, Pallavi Sachdev, Akihiko Koyama, Larisa Reyderman, Randall J Bateman, Eric McDad. Change in cerebrospinal fluid tau microtubule binding region detects symptom onset, cognitive decline, tangles, and atrophy in Dominantly Inherited Alzheimer's Disease. Annals of neurology. 2023-02-27. PMID:36843330. |
change in cerebrospinal fluid tau microtubule binding region detects symptom onset, cognitive decline, tangles, and atrophy in dominantly inherited alzheimer's disease. |
2023-02-27 |
2023-08-14 |
Not clear |
| Kanta Horie, Yan Li, Nicolas R Barthélemy, Brian A Gordon, Jason Hassenstab, Tammie L S Benzinger, Anne M Fagan, John C Morris, Celeste M Karch, Chengjie Xiong, Ricardo Allegri, Patricio Chrem Mendez, Takeshi Ikeuchi, Kensaku Kasuga, James Noble, Martin Farlow, Jasmeer Chhatwal, Gregory S Day, Peter R Schofield, Colin L Masters, Johannes Levin, Mathias Jucker, Jae-Hong Lee, Jee Hoon Roh, Chihiro Sato, Pallavi Sachdev, Akihiko Koyama, Larisa Reyderman, Randall J Bateman, Eric McDad. Change in cerebrospinal fluid tau microtubule binding region detects symptom onset, cognitive decline, tangles, and atrophy in Dominantly Inherited Alzheimer's Disease. Annals of neurology. 2023-02-27. PMID:36843330. |
identifying cerebrospinal fluid measures of the microtubule binding region of tau (mtbr-tau) species that reflect tau aggregation could provide fluid biomarkers that track alzheimer disease related neurofibrillary tau pathological changes. |
2023-02-27 |
2023-08-14 |
Not clear |
| Qi Qiu, Xia Lei, Yueying Wang, Hui Xiong, Yanming Xu, Huifeng Sun, Hongdan Xu, Ning Zhan. Naringin Protects against Tau Hyperphosphorylation in A Behavioural neurology. vol 2023. 2023-02-27. PMID:36844418. |
naringin protects against tau hyperphosphorylation in a alzheimer's disease (ad) is the most common form of dementia and a significant social and economic burden. |
2023-02-27 |
2023-08-14 |
Not clear |
| Christian F Pantoja, Alain Ibáñez de Opakua, Maria-Sol Cima-Omori, Markus Zweckstette. Determining the Physico-Chemical Composition of Biomolecular Condensates from Spatially-Resolved NMR. Angewandte Chemie (International ed. in English). 2023-02-27. PMID:36847235. |
application of spatially-resolved nmr to condensates formed by the alzheimer's disease-associated protein tau demonstrates decreased water content, exclusion of the molecular crowding agent dextran, presence of a specific chemical environment of the small molecule dss, and ~150-fold increased concentration of tau inside the condensate. |
2023-02-27 |
2023-08-14 |
Not clear |
| Hiromitsu Tanaka, Hiroaki Matsushita, Keizo Tokuhiro, Atsushi Fukunari, Yukio And. Ingestion of Soybean Sprouts Containing a HASPIN Inhibitor Improves Condition in a Mouse Model of Alzheimer's Disease. Biology. vol 12. issue 2. 2023-02-25. PMID:36829593. |
therefore, research into the regulation of tau protein phosphorylation is important for understanding alzheimer's disease. |
2023-02-25 |
2023-08-14 |
mouse |
| Hiromitsu Tanaka, Hiroaki Matsushita, Keizo Tokuhiro, Atsushi Fukunari, Yukio And. Ingestion of Soybean Sprouts Containing a HASPIN Inhibitor Improves Condition in a Mouse Model of Alzheimer's Disease. Biology. vol 12. issue 2. 2023-02-25. PMID:36829593. |
to examine whether haspin is involved in the onset of alzheimer's disease through tau protein phosphorylation, we investigated the effects of a diet including soybean sprouts rich in the haspin inhibitor coumestrol in a mouse model of alzheimer's disease (5xfad). |
2023-02-25 |
2023-08-14 |
mouse |
| Hiromitsu Tanaka, Hiroaki Matsushita, Keizo Tokuhiro, Atsushi Fukunari, Yukio And. Ingestion of Soybean Sprouts Containing a HASPIN Inhibitor Improves Condition in a Mouse Model of Alzheimer's Disease. Biology. vol 12. issue 2. 2023-02-25. PMID:36829593. |
these results indicate that haspin may be one of the target molecules for the repression of tau phosphorylation in the treatment of alzheimer's disease. |
2023-02-25 |
2023-08-14 |
mouse |