| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Petra Hnilicova, Ema Kantorova, Stanislav Sutovsky, Milan Grofik, Kamil Zelenak, Egon Kurca, Norbert Zilka, Petra Parvanovova, Martin Kolise. Imaging Methods Applicable in the Diagnostics of Alzheimer's Disease, Considering the Involvement of Insulin Resistance. International journal of molecular sciences. vol 24. issue 4. 2023-02-25. PMID:36834741. |
alzheimer's disease (ad) is an incurable neurodegenerative disease and the most frequently diagnosed type of dementia, characterized by (1) perturbed cerebral perfusion, vasculature, and cortical metabolism; (2) induced proinflammatory processes; and (3) the aggregation of amyloid beta and hyperphosphorylated tau proteins. |
2023-02-25 |
2023-08-14 |
Not clear |
| Phoebe S Tsoi, My Diem Quan, Josephine C Ferreon, Allan Chris M Ferreo. Aggregation of Disordered Proteins Associated with Neurodegeneration. International journal of molecular sciences. vol 24. issue 4. 2023-02-25. PMID:36834792. |
the major proteins involved in neurodegeneration include amyloid beta (aβ) and tau in alzheimer's disease, α-synuclein in parkinson's disease, and tar dna-binding protein (tdp-43) in amyotrophic lateral sclerosis (als). |
2023-02-25 |
2023-08-14 |
Not clear |
| Ke Ma, Zi-Run Zheng, Yu Men. Pathogenesis of Chronic Kidney Disease Is Closely Bound up with Alzheimer's Disease, Especially via the Renin-Angiotensin System. Journal of clinical medicine. vol 12. issue 4. 2023-02-25. PMID:36835994. |
alzheimer's disease (ad) is characterized by the extracellular accumulation of misfolded β-amyloid (aβ) proteins into senile plaques and the formation of neurofibrillary tangles (nfts) containing hyperphosphorylated tau. |
2023-02-25 |
2023-08-14 |
Not clear |
| Wei Zhang, Hui-Fu Wang, Kevin Kuo, Linbo Wang, Yuzhu Li, Jintai Yu, Jianfeng Feng, Wei Chen. Contribution of Alzheimer's disease pathology to biological and clinical progression: A longitudinal study across two cohorts. Alzheimer's & dementia : the journal of the Alzheimer's Association. 2023-02-25. PMID:36840615. |
amyloid beta (aβ) deposition, tau accumulation, and brain atrophy occurr in sequence, but the contribution of alzheimer's disease (ad) pathology to biological and clinical progression remains unclear. |
2023-02-25 |
2023-08-14 |
Not clear |
| Zhi-Bo Wang, Lan Tan, Hui-Fu Wang, Shi-Dong Chen, Yan Fu, Pei-Yang Gao, Ya-Hui Ma, Yu Guo, Jia-Hui Hou, Dan-Dan Zhang, Jin-Tai Y. Differences between ante mortem Alzheimer's disease biomarkers in predicting neuropathology at autopsy. Alzheimer's & dementia : the journal of the Alzheimer's Association. 2023-02-25. PMID:36840620. |
this study aimed to assess whether biomarkers related to amyloid, tau, and neurodegeneration can accurately predict alzheimer's disease (ad) neuropathology at autopsy in early and late clinical stages. |
2023-02-25 |
2023-08-14 |
Not clear |
| Xueying Lyu, Michael Tran Duong, Long Xie, Robin de Flores, Hayley Richardson, Gyujoon Hwang, L E M Wisse, Michael DiCalogero, Corey T McMillan, John L Robinson, Sharon X Xie, Murray Grossman, Edward B Lee, David J Irwin, Bradford C Dickerson, Christos Davatzikos, Ilya M Nasrallah, Paul A Yushkevich, David A Wolk, Sandhitsu R Da. Tau-Neurodegeneration medRxiv : the preprint server for health sciences. 2023-02-24. PMID:36824762. |
we studied this variability by partitioning patients within the alzheimer's continuum into data-driven groups based on their regional t-n dissociation, which reflects the residuals after the effect of tau pathology is "removed". |
2023-02-24 |
2023-08-14 |
Not clear |
| Michael O Isei, Peter A Girardi, Joel Rodwell-Bullock, Keith Nehrke, Gail Vw Johnso. Site-specific phosphorylation of tau impacts mitochondrial biology and response to stressors. bioRxiv : the preprint server for biology. 2023-02-24. PMID:36824940. |
phosphorylation of tau at sites associated with alzheimer's disease (ad) likely plays a role in the disease progression. |
2023-02-24 |
2023-08-14 |
Not clear |
| Rosaleena Mohanty, Daniel Ferreira, Agneta Nordberg, Eric Westma. Associations between different tau-PET patterns and longitudinal atrophy in the Alzheimer's disease continuum: biological and methodological perspectives from disease heterogeneity. Alzheimer's research & therapy. vol 15. issue 1. 2023-02-23. PMID:36814346. |
subtypes and patterns are defined using tau-pet (tau pathology) and structural mri (atrophy) in alzheimer's disease (ad). |
2023-02-23 |
2023-08-14 |
Not clear |
| Shuqing Liu, Hongying Li, Yuan Shen, Weikang Zhu, Yong Wang, Junmeng Wang, Ning Zhang, Chenyu Li, Lushuang Xie, Qiaofeng W. Moxibustion improves hypothalamus Frontiers in aging neuroscience. vol 15. 2023-02-23. PMID:36819717. |
in alzheimer's disease (ad), aqp4 loses its normal location and thus reduces the clearance of amyloid-β plaques and tau protein. |
2023-02-23 |
2023-08-14 |
Not clear |
| Dickson O Adedeji, Jasper Holleman, Robert-Paul Juster, Chinedu T Udeh-Momoh, Ingemar Kåreholt, Göran Hagman, Malin Aspö, Sofia Adagunodo, Krister Håkansson, Miia Kivipelto, Alina Solomon, Shireen Sind. Longitudinal study of Alzheimer's disease biomarkers, allostatic load, and cognition among memory clinic patients. Brain, behavior, & immunity - health. vol 28. 2023-02-23. PMID:36820052. |
several dementia and alzheimer's disease (ad) risk factors have been identified, yet little is known about the role of al and its associations with ad biomarkers (e.g., beta-amyloid (aβ) or tau) and cognitive function among memory clinic patients. |
2023-02-23 |
2023-08-14 |
Not clear |
| Yingjia Yao, Yameng Wang, Liang Kong, Yuqing Chen, Jingxian Yan. Retraction notice to "Osthole decreases tau protein phosphorylation via PI3K/AKT/GSK-3β signaling pathway in Alzheimer's disease" [Life Sci. 217 (2019) 16-24]. Life sciences. 2023-02-22. PMID:36804896. |
retraction notice to "osthole decreases tau protein phosphorylation via pi3k/akt/gsk-3β signaling pathway in alzheimer's disease" [life sci. |
2023-02-22 |
2023-08-14 |
Not clear |
| Abhishek Dahal, Karthivashan Govindarajan, Satyabrata Ka. Administration of kainic acid differentially alters astrocyte markers and transiently enhanced phospho-tau level in adult rat hippocampus. Neuroscience. 2023-02-22. PMID:36805001. |
additionally, a role for microtubule associated tau protein, involved in various neurodegenerative diseases including alzheimer's disease, has also been suggested in the development of seizure and/or neurodegeneration in tle pathogenesis. |
2023-02-22 |
2023-08-14 |
human |
| Miguel Moutinho, Israel Coronel, Andy P Tsai, Gonzalo Viana Di Prisco, Taylor Pennington, Brady K Atwood, Shweta S Puntambekar, Daniel C Smith, Pablo Martinez, Seonggyun Han, Younghee Lee, Cristian A Lasagna-Reeves, Bruce T Lamb, Stephanie J Bissel, Kwangsik Nho, Gary E Landret. TREM2 splice isoforms generate soluble TREM2 species that disrupt long-term potentiation. Genome medicine. vol 15. issue 1. 2023-02-22. PMID:36805764. |
trem2 governs the response of microglia to amyloid and tau pathologies in the alzheimer's disease (ad) brain. |
2023-02-22 |
2023-08-14 |
mouse |
| Russell H Swerdlo. The Alzheimer's Disease Mitochondrial Cascade Hypothesis: A Current Overview. Journal of Alzheimer's disease : JAD. 2023-02-22. PMID:36806512. |
viable alzheimer's disease (ad) hypotheses must account for its age-dependence; commonality; association with amyloid precursor protein, tau, and apolipoprotein e biology; connection with vascular, inflammation, and insulin signaling changes; and systemic features. |
2023-02-22 |
2023-08-14 |
Not clear |
| Mingmin Yan, Li Tang, Lijun Dai, Chuntao Lei, Min Xiong, Xingyu Zhang, Mingyang He, Ye Tian, Jing Xiong, Wei Ke, Zhaohui Zhang, Chun Zhang, Xiaorong Deng, Zhentao Zhan. Cofilin promotes tau pathology in Alzheimer's disease. Cell reports. vol 42. issue 2. 2023-02-22. PMID:36807141. |
cofilin promotes tau pathology in alzheimer's disease. |
2023-02-22 |
2023-08-14 |
mouse |
| Bo Pang, Lu-Lu Zhang, Bin Li, Feng-Xian Sun, Zhi-Da Wan. The sodium glucose co-transporter 2 inhibitor ertugliflozin for Alzheimer's disease: inhibition of brain insulin signaling disruption-induced tau hyperphosphorylation. Physiology & behavior. 2023-02-22. PMID:36809844. |
the sodium glucose co-transporter 2 inhibitor ertugliflozin for alzheimer's disease: inhibition of brain insulin signaling disruption-induced tau hyperphosphorylation. |
2023-02-22 |
2023-08-14 |
rat |
| Mohammad Mahdi Ghazimoradi, Ehsan Ghoushi, Mozhgan Ghobadi Pour, Hadise Karimi Ahmadabadi, Mahmoud Rafieian-Kopae. A review on garlic as a supplement for Alzheimer's disease: a mechanistic insight in its direct and indirect effects. Current pharmaceutical design. 2023-02-22. PMID:36809972. |
there are several known hypotheses regarding the pathology of alzheimer's disease, including the amyloid beta hypothesis, tau hypothesis, inflammation hypothesis, and cholinergic hypothesis, which are investigated in different researches to completely elucidate the pathology of ad. |
2023-02-22 |
2023-08-14 |
human |
| Mohammad Mahdi Ghazimoradi, Ehsan Ghoushi, Mozhgan Ghobadi Pour, Hadise Karimi Ahmadabadi, Mahmoud Rafieian-Kopae. A review on garlic as a supplement for Alzheimer's disease: a mechanistic insight in its direct and indirect effects. Current pharmaceutical design. 2023-02-22. PMID:36809972. |
in this review, we discuss the effects of garlic based on its components such as allicin, s-allyl cysteine on alzheimer's disease and the mechanisms that garlic components can be beneficiary for ad patients, including its effects amyloid beta, oxidative stress, tau protein, gene expression, and cholinesterase enzymes. |
2023-02-22 |
2023-08-14 |
human |
| Daniela Jimenez-Harrison, Carol J Huseby, Claire N Hoffman, Steven Sher, Dalton Snyder, Brayden Seal, Chunhua Yuan, Hongjun Fu, Vicki Wysocki, Flaviano Giorgini, Jeff Kure. DJ-1 Molecular Chaperone Activity Depresses Tau Aggregation Propensity through Interaction with Monomers. Biochemistry. 2023-02-22. PMID:36813261. |
tau aggregate-bearing lesions are pathological markers and potential mediators of tauopathic neurodegenerative diseases, including alzheimer's disease. |
2023-02-22 |
2023-08-14 |
Not clear |
| Florin Desp. Bloodborne Pancreatic Amylin, A Therapeutic Target for Alzheimer's Disease. Current Alzheimer research. 2023-02-21. PMID:36803745. |
alzheimer disease (ad) pathology has been linked to brain accumulation of β amyloid (aβ) and neurofibrillary tau tangles. |
2023-02-21 |
2023-08-14 |
human |