| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Karin L Meeker, Patrick H Luckett, Nicolas R Barthélemy, Diana A Hobbs, Charles Chen, James Bollinger, Vitaliy Ovod, Shaney Flores, Sarah Keefe, Rachel L Henson, Elizabeth M Herries, Eric McDade, Jason J Hassenstab, Chengjie Xiong, Carlos Cruchaga, Tammie L S Benzinger, David M Holtzman, Suzanne E Schindler, Randall J Bateman, John C Morris, Brian A Gordon, Beau M Ance. Comparison of cerebrospinal fluid, plasma and neuroimaging biomarker utility in Alzheimer's disease. Brain communications. vol 6. issue 2. 2024-03-20. PMID:38505230. |
four clusters emerged reflecting: core alzheimer's disease pathology (amyloid and tau), neurodegeneration, at8 antibody-associated phosphorylated tau sites and neuronal dysfunction. |
2024-03-20 |
2024-03-23 |
human |
| Sheng Chen, Anuradhika Puri, Braxton Bell, Joseph Fritsche, Hector H Palacios, Maurie Balch, Macy L Sprunger, Matthew K Howard, Jeremy J Ryan, Jessica N Haines, Gary J Patti, Albert A Davis, Meredith E Jackre. HTRA1 disaggregates α-synuclein amyloid fibrils and converts them into non-toxic and seeding incompetent species. Nature communications. vol 15. issue 1. 2024-03-19. PMID:38499535. |
the pdz serine protease htra1 degrades fibrillar tau, which is associated with alzheimer's disease, and inactivating mutations to mitochondrial htra2 are implicated in pd. |
2024-03-19 |
2024-03-21 |
Not clear |
| Pratima Srivastava, Dhananjay Yadav, Santosh Kumar Singh, Sung Hae Kim, Shivendra Singh, Shweta Katiyar, Minseok Son. Investigating Bacopa monnieri L. Therapeutic Potential for the Treatment of Neurological Diseases. Current pharmaceutical design. 2024-03-19. PMID:38500283. |
alzheimer's disease is a neurological condition caused by the production of reactive oxygen species, which also causes amyloid-beta (a) and tau protein aggregation and increases neuro-inflammation and neurotoxicity. |
2024-03-19 |
2024-03-21 |
Not clear |
| Yongna Yuan, Xuqi Mao, Xiaohang Pan, Ruisheng Zhang, Wei S. Kinetic Ensemble of Tau Protein through the Markov State Model and Deep Learning Analysis. Journal of chemical theory and computation. 2024-03-19. PMID:38501645. |
the ordered assembly of tau protein into filaments characterizes alzheimer's and other neurodegenerative diseases, and thus, stabilization of tau protein is a promising avenue for tauopathies therapy. |
2024-03-19 |
2024-03-21 |
Not clear |
| Haichao Wei, Joseph Withrow, Jyotirmoy Rakshit, Faiz Ul Amin, Joshua Nahm, Francesca E Mowry, Zhengmei Mao, Meenakshi B Bhattacharjee, Jay-Jiguang Zhu, Yongjie Yang, Jia Qian W. The identification of a Distinct Astrocyte Subtype that Diminishes in Alzheimer's Disease. Aging and disease. 2024-03-19. PMID:38502590. |
alzheimer's disease (ad) is characterized by the presence of two hallmark pathologies: the accumulation of amyloid beta (aβ) and tau proteins in the brain. |
2024-03-19 |
2024-03-23 |
mouse |
| Sharif Arar, Md Anzarul Haque, Nemil Bhatt, Yingxin Zhao, Rakez Kaye. Effect of Natural Osmolytes on Recombinant Tau Monomer: Propensity of Oligomerization and Aggregation. ACS chemical neuroscience. 2024-03-19. PMID:38503425. |
the pathological misfolding and aggregation of the microtubule associated protein tau (mapt), a full length tau2n4r with 441aa, is considered the principal disease relevant constituent in tauopathies including alzheimer's disease (ad) with an imbalanced ratio in 3r/4r isoforms. |
2024-03-19 |
2024-03-23 |
Not clear |
| Qi Guo, Lingyan Ping, Eric B Dammer, Luming Yin, Kaiming Xu, Anantharaman Shantaraman, Edward J Fox, Todd E Golde, Erik C B Johnson, Blaine R Roberts, James J Lah, Allan I Levey, Nicholas T Seyfrie. Heparin-enriched plasma proteome is significantly altered in Alzheimer's Disease. Research square. 2024-03-18. PMID:38464223. |
heparin binding proteins (hbps) with roles in extracellular matrix assembly are strongly correlated to β-amyloid (aβ) and tau pathology in alzheimer's disease (ad) brain and cerebrospinal fluid (csf). |
2024-03-18 |
2024-03-20 |
Not clear |
| Hunsica J Jayaprakash, Akiko Mizuno, Beth E Snitz, Ann D Cohen, Willian E Klunk, Howard J Aizenstein, Helmet T Kari. Voxel-wise hemispheric Amyloid Asymmetry and its association with cerebral metabolism and grey matter density in cognitively normal older adults. medRxiv : the preprint server for health sciences. 2024-03-18. PMID:38496561. |
alzheimer's disease (ad) is a neurodegenerative disorder characterized by changes in beta amyloid (aß) and tau as well as changes in cerebral glucose metabolism and gray matter volume. |
2024-03-18 |
2024-03-20 |
Not clear |
| Chaitali Anand, Justin Torok, Farras Abdelnour, Pedro D Maia, Ashish Ra. Selective vulnerability and resilience to Alzheimer's disease tauopathy as a function of genes and the connectome. bioRxiv : the preprint server for biology. 2024-03-18. PMID:38496606. |
brain regions in alzheimer's (ad) exhibit distinct vulnerability to the disease's hallmark pathology, with the entorhinal cortex and hippocampus succumbing early to tau tangles while others like primary sensory cortices remain resilient. |
2024-03-18 |
2024-03-20 |
Not clear |
| Chaitali Anand, Justin Torok, Farras Abdelnour, Pedro D Maia, Ashish Ra. Selective vulnerability and resilience to Alzheimer's disease tauopathy as a function of genes and the connectome. bioRxiv : the preprint server for biology. 2024-03-18. PMID:38496606. |
we therefore employed an extended network diffusion model (endm) and tested it on tau pathology pet data from 196 ad patients from the alzheimer's disease neuroimaging initiative (adni). |
2024-03-18 |
2024-03-20 |
Not clear |
| Elettra Capogna, Øystein Sørensen, Leiv Otto Watne, James Roe, Marie Strømstad, Ane Victoria Idland, Nathalie Bodd Halaas, Kaj Blennow, Henrik Zetterberg, Kristine Beate Walhovd, Anders Martin Fjell, Didac Vidal-Piñeir. Subtypes of brain change in aging and their associations with cognition and Alzheimer's disease biomarkers. bioRxiv : the preprint server for biology. 2024-03-18. PMID:38496633. |
specifically, we tested (1) which brain structural changes over time predict cognitive change in older age (2) whether these are associated with core cerebrospinal fluid (csf) alzheimer's disease (ad) biomarkers phosphorylated tau (p-tau) and amyloid-β (aβ42), and (3) the degree of overlap between clusters derived from different structural features. |
2024-03-18 |
2024-03-20 |
Not clear |
| Zheng Liang, Xiaokang Gong, Yang Zhao, Yanna Zhao, Jing Yu, Tiantian Huang, Chaoqing Yang, Liangwei Wu, Mengbing Huang, Xiaochuan Wang, Xiji Shu, Jian Ba. Long-Term High-Fat Diet Consumption Aggravates β-Amyloid Deposition and Tau Pathology Accompanied by Microglial Activation in an Alzheimer's Disease Model. Molecular nutrition & food research. 2024-03-16. PMID:38491393. |
long-term high-fat diet consumption aggravates β-amyloid deposition and tau pathology accompanied by microglial activation in an alzheimer's disease model. |
2024-03-16 |
2024-03-19 |
mouse |
| Radek Crha, Aneta Kozeleková, Alena Hofrová, Lucia Iľkovičová, Norbert Gašparik, Pavel Kadeřávek, Jozef Hrit. Hiding in plain sight: Complex interaction patterns between Tau and 14-3-3ζ protein variants. International journal of biological macromolecules. 2024-03-16. PMID:38492709. |
tau protein is an intrinsically disordered protein that plays a key role in alzheimer's disease (ad). |
2024-03-16 |
2024-03-19 |
Not clear |
| Lun Zhang, Yongkang Gai, Yushuang Liu, Dongli Meng, Yi Zeng, Yong Luo, Huiliang Zhang, Zhuoqun Wang, Mengzhe Yang, Yunfan Li, Yi Liu, Yiwen Lai, Jiayu Yang, Gang Wu, Yu Chen, Jingtan Zhu, Shaojun Liu, Tingting Yu, Ji Zeng, Jianzhi Wang, Dan Zhu, Xiaochuan Wang, Xiaoli Lan, Rong Li. Tau induces inflammasome activation and microgliosis through acetylating NLRP3. Clinical and translational medicine. vol 14. issue 3. 2024-03-15. PMID:38488468. |
alzheimer's disease (ad) and related tauopathies are characterised by the pathologically hyperphosphorylated and aggregated microtubule-associated protein tau, which is accompanied by neuroinflammation mediated by activated microglia. |
2024-03-15 |
2024-03-17 |
Not clear |
| Wagner S Brum, Nicholas C Cullen, Joseph Therriault, Shorena Janelidze, Nesrine Rahmouni, Jenna Stevenson, Stijn Servaes, Andrea L Benedet, Eduardo R Zimmer, Erik Stomrud, Sebastian Palmqvist, Henrik Zetterberg, Giovanni B Frisoni, Nicholas J Ashton, Kaj Blennow, Niklas Mattsson-Carlgren, Pedro Rosa-Neto, Oskar Hansso. A blood-based biomarker workflow for optimal tau-PET referral in memory clinic settings. Nature communications. vol 15. issue 1. 2024-03-15. PMID:38486040. |
blood-based biomarkers for screening may guide tau positrion emissition tomography (pet) scan referrals to optimize prognostic evaluation in alzheimer's disease. |
2024-03-15 |
2024-03-17 |
human |
| Julian D Dallmeier, Ryan Gober, Regina T Vontell, Ayled Barreda, Daniel A Dorfsman, David A Davis, Xiaoyan Sun, Daniel Brzostowicki, Illiana Bennett, Susanna P Garamszegi, Connor M Wander, Todd Cohen, William K Scot. Corpora amylacea negatively correlate with hippocampal tau pathology in Alzheimer's disease. Frontiers in neuroscience. vol 18. 2024-03-15. PMID:38486969. |
corpora amylacea negatively correlate with hippocampal tau pathology in alzheimer's disease. |
2024-03-15 |
2024-03-17 |
Not clear |
| Julian D Dallmeier, Ryan Gober, Regina T Vontell, Ayled Barreda, Daniel A Dorfsman, David A Davis, Xiaoyan Sun, Daniel Brzostowicki, Illiana Bennett, Susanna P Garamszegi, Connor M Wander, Todd Cohen, William K Scot. Corpora amylacea negatively correlate with hippocampal tau pathology in Alzheimer's disease. Frontiers in neuroscience. vol 18. 2024-03-15. PMID:38486969. |
severity and distribution of aggregated tau and neurofibrillary tangles (nft) are strongly correlated with the clinical presentation of alzheimer's disease (ad). |
2024-03-15 |
2024-03-17 |
Not clear |
| Ali Aljassabi, Tarek Zieneldien, Janice Kim, Deepika Regmi, Chuanhai Ca. Alzheimer's Disease Immunotherapy: Current Strategies and Future Prospects. Journal of Alzheimer's disease : JAD. 2024-03-15. PMID:38489183. |
alzheimer's disease (ad) is an extremely complex and heterogeneous pathology influenced by many factors contributing to its onset and progression, including aging, amyloid-beta (aβ) plaques, tau fibril accumulation, inflammation, etc. |
2024-03-15 |
2024-03-18 |
Not clear |
| Yu Zou, Lulu Guan, Jingwang Tan, Bote Qi, Yunxiang Sun, Fengjuan Huang, Qingwen Zhan. Molecular Insights into the Differential Effects of Acetylation on the Aggregation of Tau Microtubule-Binding Repeats. Journal of chemical information and modeling. 2024-03-15. PMID:38489841. |
aggregation of tau protein into intracellular fibrillary inclusions is characterized as the hallmark of tauopathies, including alzheimer's disease and chronic traumatic encephalopathy. |
2024-03-15 |
2024-03-18 |
Not clear |
| James Naude, Meng Wang, Rebeca Leon, Eric Smith, Zahinoor Ismai. Tau-PET in early cortical Alzheimer brain regions in relation to mild behavioral impairment in older adults with either normal cognition or mild cognitive impairment. Neurobiology of aging. vol 138. 2024-03-15. PMID:38490074. |
phosphorylated tau (p-tau) is a hallmark biological manifestation of alzheimer disease (ad). |
2024-03-15 |
2024-03-18 |
human |