| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Zhenyi Hu, Po-Han Chen, Wenxue Li, Todd Douglas, John Hines, Yansheng Liu, Craig M Crew. Targeted Dephosphorylation of Tau by Phosphorylation Targeting Chimeras (PhosTACs) as a Therapeutic Modality. Journal of the American Chemical Society. 2023-02-08. PMID:36753634. |
hyperphosphorylation of the microtubule-associated protein tau plays an important pathological role in the development of alzheimer's disease and other tauopathies. |
2023-02-08 |
2023-08-14 |
Not clear |
| Ying-Ying Yang, Yan-Tao Ren, Meng-Yu Jia, Chen-Yang Bai, Xiu-Ting Liang, Hui-Ling Gao, Man-Li Zhong, Tao Wang, Chuang Gu. The human islet amyloid polypeptide reduces hippocampal tauopathy and behavioral impairments in P301S mice without inducing neurotoxicity or seeding amyloid aggregation. Experimental neurology. 2023-02-07. PMID:36750170. |
recent evidence suggests that human islet amyloid polypeptide (h-iapp) accumulates in the brains of alzheimer's disease (ad) patients and may interact with aβ or microtubule associated protein tau to associate with the neurodegenerative process. |
2023-02-07 |
2023-08-14 |
mouse |
| Rohit Shukla, Anuj Kumar, David J Kelvin, Tiratha Raj Sing. Disruption of DYRK1A-induced hyperphosphorylation of amyloid-beta and tau protein in Alzheimer's disease: An integrative molecular modeling approach. Frontiers in molecular biosciences. vol 9. 2023-02-06. PMID:36741918. |
disruption of dyrk1a-induced hyperphosphorylation of amyloid-beta and tau protein in alzheimer's disease: an integrative molecular modeling approach. |
2023-02-06 |
2023-08-14 |
Not clear |
| Jasmeet Pannu Hayes, Meghan E Pierce, Emma Brown, David Salat, Mark W Logue, Julie Constantinescu, Kate Valerio, Mark W Miller, Richard Sherva, Bertrand Russell Huber, William Milberg, Regina McGlinche. Genetic Risk for Alzheimer Disease and Plasma Tau Are Associated With Accelerated Parietal Cortex Thickness Change in Middle-Aged Adults. Neurology. Genetics. vol 9. issue 1. 2023-02-06. PMID:36742995. |
genetic risk for alzheimer disease and plasma tau are associated with accelerated parietal cortex thickness change in middle-aged adults. |
2023-02-06 |
2023-08-14 |
Not clear |
| Jasmeet Pannu Hayes, Meghan E Pierce, Emma Brown, David Salat, Mark W Logue, Julie Constantinescu, Kate Valerio, Mark W Miller, Richard Sherva, Bertrand Russell Huber, William Milberg, Regina McGlinche. Genetic Risk for Alzheimer Disease and Plasma Tau Are Associated With Accelerated Parietal Cortex Thickness Change in Middle-Aged Adults. Neurology. Genetics. vol 9. issue 1. 2023-02-06. PMID:36742995. |
neuroimaging and biomarker studies in alzheimer disease (ad) have shown well-characterized patterns of cortical thinning and altered biomarker concentrations of tau and β-amyloid (aβ). |
2023-02-06 |
2023-08-14 |
Not clear |
| Bin Wang, Xiaofang Zhong, Lauren Fields, Haiyan Lu, Zexin Zhu, Lingjun L. Structural Proteomic Profiling of Cerebrospinal Fluids to Reveal Novel Conformational Biomarkers for Alzheimer's Disease. Journal of the American Society for Mass Spectrometry. 2023-02-06. PMID:36745855. |
alzheimer's disease (ad) is the most common representation of dementia, with brain pathological hallmarks of protein abnormal aggregation, such as with amyloid beta and tau protein. |
2023-02-06 |
2023-08-14 |
human |
| Steven S Hou, Joyce Yang, Jeong Heon Lee, Yeseo Kwon, Maria Calvo-Rodriguez, Kai Bao, Sung Ahn, Satoshi Kashiwagi, Anand T N Kumar, Brian J Bacskai, Hak Soo Cho. Near-infrared fluorescence lifetime imaging of amyloid-β aggregates and tau fibrils through the intact skull of mice. Nature biomedical engineering. 2023-02-06. PMID:36747008. |
in transgenic mouse models of alzheimer's disease, we compare the performance of zw800-1c with that of the two spectrally similar heptamethine fluorophores zw800-1a and indocyanine green, and show that zw800-1c undergoes a longer fluorescence-lifetime shift when bound to amyloid-β and tau aggregates than when circulating in blood vessels. |
2023-02-06 |
2023-08-14 |
mouse |
| Kathrin Wenger, Arthur Viode, Christoph N Schlaffner, Patrick van Zalm, Long Cheng, Tammy Dellovade, Xavier Langlois, Anthony Bannon, Rui Chang, Theresa R Connors, Derek Oakley, Bernhard Renard, Juri Rappsilber, Bradley Hyman, Hanno Steen, Judith A Stee. Common mouse models of tauopathy reflect early but not late human disease. Molecular neurodegeneration. vol 18. issue 1. 2023-02-03. PMID:36732784. |
mouse models that overexpress human mutant tau (p301s and p301l) are commonly used in preclinical studies of alzheimer's disease (ad) and while several drugs showed therapeutic effects in these mice, they were ineffective in humans. |
2023-02-03 |
2023-08-14 |
mouse |
| Hana Florian, Deli Wang, Steven E Arnold, Mercè Boada, Qi Guo, Ziyi Jin, Hui Zheng, Nahome Fisseha, Hari Varun Kalluri, Beatrice Rendenbach-Mueller, Kumar Budur, Michael Gol. Tilavonemab in early Alzheimer's disease: results from a phase 2, randomized, double-blind study. Brain : a journal of neurology. 2023-02-02. PMID:36730056. |
tau accumulation in patients with alzheimer's disease tracks closely with cognitive decline and plays a role in the later stages of disease progression. |
2023-02-02 |
2023-08-14 |
Not clear |
| Pamela J McMillan, Sarah J Benbow, Rikki Uhrich, Aleen Saxton, Misa Baum, Timothy Strovas, Jeanna M Wheeler, Jeremy Baker, Nicole F Liachko, C Dirk Keene, Caitlin S Latimer, Brian C Kraeme. Tau-RNA complexes inhibit microtubule polymerization and drive disease-relevant conformation change. Brain : a journal of neurology. 2023-02-02. PMID:36732296. |
alzheimer's disease and related disorders feature neurofibrillary tangles and other neuropathological lesions composed of detergent-insoluble tau protein. |
2023-02-02 |
2023-08-14 |
mouse |
| Pamela J McMillan, Sarah J Benbow, Rikki Uhrich, Aleen Saxton, Misa Baum, Timothy Strovas, Jeanna M Wheeler, Jeremy Baker, Nicole F Liachko, C Dirk Keene, Caitlin S Latimer, Brian C Kraeme. Tau-RNA complexes inhibit microtubule polymerization and drive disease-relevant conformation change. Brain : a journal of neurology. 2023-02-02. PMID:36732296. |
trc35 exhibits specificity for alzheimer's disease-derived detergent insoluble tau relative to soluble recombinant tau. |
2023-02-02 |
2023-08-14 |
mouse |
| Itika Saha, Patricia Yuste-Checa, Miguel Da Silva Padilha, Qiang Guo, Roman Körner, Hauke Holthusen, Victoria A Trinkaus, Irina Dudanova, Rubén Fernández-Busnadiego, Wolfgang Baumeister, David W Sanders, Saurabh Gautam, Marc I Diamond, F Ulrich Hartl, Mark S Hip. The AAA+ chaperone VCP disaggregates Tau fibrils and generates aggregate seeds in a cellular system. Nature communications. vol 14. issue 1. 2023-02-02. PMID:36732333. |
amyloid-like aggregates of the microtubule-associated protein tau are associated with several neurodegenerative disorders including alzheimer's disease. |
2023-02-02 |
2023-08-14 |
Not clear |
| Lulu Jiang, Pijush Chakraborty, Lushuang Zhang, Melissa Wong, Shannon E Hill, Chelsea Joy Webber, Jenna Libera, Laura J Blair, Benjamin Wolozin, Markus Zweckstette. Chaperoning of specific tau structure by immunophilin FKBP12 regulates the neuronal resilience to extracellular stress. Science advances. vol 9. issue 5. 2023-02-01. PMID:36724228. |
alzheimer's disease and related tauopathies are characterized by the pathogenic misfolding and aggregation of the microtubule-associated protein tau. |
2023-02-01 |
2023-08-14 |
mouse |
| Jie Wen, Yangyang Wang, Chuanling Wang, Minghao Yuan, Fei Chen, Qian Zou, Zhiyou Cai, Bin Zha. Dietary High-Fat Promotes Cognitive Impairment by Suppressing Mitophagy. Oxidative medicine and cellular longevity. vol 2023. 2023-01-31. PMID:36718278. |
dietary habits contribute to the characteristics of alzheimer's disease (ad) and cognitive impairment, which are partly induced by the accumulation of hyperphosphorylated tau, a microtubule-associated protein. |
2023-01-31 |
2023-08-14 |
mouse |
| Anne-Marie Jacobsen, Nico C van de Merbel, Dorte K Ditlevsen, Ketil Tvermosegaard, Frank Schalk, Wietske Lambert, Christoffer Bundgaard, Jan T Pedersen, Nina Rosenqvis. A Quantitative LC-MS/MS Method for Distinguishing the Tau Protein Forms Phosphorylated and Nonphosphorylated at Serine-396. Journal of the American Society for Mass Spectrometry. 2023-01-31. PMID:36719168. |
hyperphosphorylated tau protein is well-known to be involved in the formation of neurofibrillary tangles and the progression of age-related neurodegenerative diseases (tauopathies), including alzheimer's disease (ad). |
2023-01-31 |
2023-08-14 |
mouse |
| Christopher Pham Pacia, Jinyun Yuan, Yimei Yue, Eric C Leuthardt, Tammie L S Benzinger, Arash Nazeri, Hong Che. Focused Ultrasound-mediated Liquid Biopsy in a Tauopathy Mouse Model. Radiology. 2023-01-31. PMID:36719290. |
background neurodegenerative disorders (such as alzheimer disease) characterized by the deposition of various pathogenic forms of tau protein in the brain are collectively referred to as tauopathies. |
2023-01-31 |
2023-08-14 |
mouse |
| Emily A Largent, Joshua Grill, Kyra O'Brien, David Wolk, Kristin Harkins, Jason Karlawis. Testing for Alzheimer Disease Biomarkers and Disclosing Results Across the Disease Continuum. Neurology. 2023-01-31. PMID:36720642. |
three pathological processes define or are characteristic of alzheimer's disease (ad): amyloid-β, hyperphosphorylated tau, and neurodegeneration. |
2023-01-31 |
2023-08-14 |
human |
| Cherie Strikwerda-Brown, Hazal Ozlen, Alexa Pichet Binette, Marianne Chapleau, Natalie L Marchant, John C S Breitner, Sylvia Villeneuv. Trait Mindfulness Is Associated With Less Amyloid, Tau, and Cognitive Decline in Individuals at Risk for Alzheimer's Disease. Biological psychiatry global open science. vol 3. issue 1. 2023-01-30. PMID:36712573. |
trait mindfulness is associated with less amyloid, tau, and cognitive decline in individuals at risk for alzheimer's disease. |
2023-01-30 |
2023-08-14 |
Not clear |
| Tushar Dubey, Preethi Kushawa, H V Thulasiram, Madhura Chandrashekar, Subashchandrabose Chinnathamb. Bacopa monnieri reduces Tau aggregation and Tau-mediated toxicity in cells. International journal of biological macromolecules. 2023-01-30. PMID:36716837. |
the overall results of the present study suggested that bacopa monnieri could be considered a potent herb against tau phosphorylation and tau aggregation, which projects it as a promising formulation for alzheimer's disease. |
2023-01-30 |
2023-08-14 |
Not clear |
| Longfei Li, Jin Miao, Yanli Jiang, Chun-Ling Dai, Khalid Iqbal, Fei Liu, Dandan Ch. Passive immunization inhibits tau phosphorylation and improves recognition learning and memory in 3xTg-AD mice. Experimental neurology. 2023-01-30. PMID:36717015. |
tau pathology is essential in the pathogenesis of alzheimer's disease (ad) and related tauopathies. |
2023-01-30 |
2023-08-14 |
mouse |